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Volumn 132, Issue 5, 2015, Pages 559-571

The role of cytosolic phospholipase A2α in amyloid precursor protein induction by amyloid beta1-42: Implication for neurodegeneration

Author keywords

APP; cortical neurons; cytosolic phospholipase A2

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BUCLADESINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLOOXYGENASE 2; CYTOSOLIC PHOSPHOLIPASE A2ALPHA; ESTERASE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROSTAGLANDIN E2; SERINE; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); PEPTIDE FRAGMENT; PHOSPHOLIPASE A2 GROUP IV;

EID: 84938739897     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.13012     Document Type: Article
Times cited : (28)

References (52)
  • 2
    • 0346434148 scopus 로고    scopus 로고
    • The expression of brain cyclooxygenase-2 is down-regulated in the cytosolic phospholipase A2 knockout mouse
    • Bosetti F., and, Weerasinghe G. R., (2003) The expression of brain cyclooxygenase-2 is down-regulated in the cytosolic phospholipase A2 knockout mouse. J. Neurochem. 87, 1471-1477.
    • (2003) J. Neurochem. , vol.87 , pp. 1471-1477
    • Bosetti, F.1    Weerasinghe, G.R.2
  • 3
    • 0024109574 scopus 로고
    • Immunocytochemical localization of the precursor protein for beta-amyloid in the rat central nervous system
    • Card J. P., Meade R. P., and, Davis L. G., (1988) Immunocytochemical localization of the precursor protein for beta-amyloid in the rat central nervous system. Neuron 1, 835-846.
    • (1988) Neuron , vol.1 , pp. 835-846
    • Card, J.P.1    Meade, R.P.2    Davis, L.G.3
  • 4
    • 79551473183 scopus 로고    scopus 로고
    • 5-Lipoxygenase as an endogenous modulator of amyloid beta formation in vivo
    • Chu J., and, Pratico D., (2011) 5-lipoxygenase as an endogenous modulator of amyloid beta formation in vivo. Ann. Neurol. 69, 34-46.
    • (2011) Ann. Neurol. , vol.69 , pp. 34-46
    • Chu, J.1    Pratico, D.2
  • 5
    • 0025107548 scopus 로고
    • Purification of a 110-kilodalton cytosolic phospholipase A2 from the human monocytic cell line U937
    • Clark J. D., Milona N., and, Knopf J. L., (1990) Purification of a 110-kilodalton cytosolic phospholipase A2 from the human monocytic cell line U937. Proc. Natl Acad. Sci. USA 87, 7708-7712.
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 7708-7712
    • Clark, J.D.1    Milona, N.2    Knopf, J.L.3
  • 6
    • 0029940686 scopus 로고    scopus 로고
    • Reactive glia express cytosolic phospholipase A2 after transient global forebrain ischemia in the rat
    • see comments
    • Clemens J. A., Stephenson D. T., Smalstig E. B., Roberts E. F., Johnstone E. M., Sharp J. D., Little S. P., and, Kramer R. M., (1996) Reactive glia express cytosolic phospholipase A2 after transient global forebrain ischemia in the rat [see comments]. Stroke 27, 527-535 issn: 0039-2499.
    • (1996) Stroke , vol.27 , pp. 527-535
    • Clemens, J.A.1    Stephenson, D.T.2    Smalstig, E.B.3    Roberts, E.F.4    Johnstone, E.M.5    Sharp, J.D.6    Little, S.P.7    Kramer, R.M.8
  • 7
    • 0009763035 scopus 로고
    • In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease
    • Cohen M. L., Golde T. E., Usiak M. F., Younkin L. H., and, Younkin S. G., (1988) In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease. Proc. Natl Acad. Sci. USA 85, 1227-1231.
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 1227-1231
    • Cohen, M.L.1    Golde, T.E.2    Usiak, M.F.3    Younkin, L.H.4    Younkin, S.G.5
  • 8
    • 0037010289 scopus 로고    scopus 로고
    • Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: Transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling
    • Colangelo V., Schurr J., Ball M. J., Pelaez R. P., Bazan N. G., and, Lukiw W. J., (2002) Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling. J. Neurosci. Res. 70, 462-473.
    • (2002) J. Neurosci. Res. , vol.70 , pp. 462-473
    • Colangelo, V.1    Schurr, J.2    Ball, M.J.3    Pelaez, R.P.4    Bazan, N.G.5    Lukiw, W.J.6
  • 9
    • 16544394140 scopus 로고    scopus 로고
    • Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human beta-amyloid in a murine model of neuroinflammation
    • Craft J. M., Van Eldik L. J., Zasadzki M., Hu W., and, Watterson D. M., (2004a) Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human beta-amyloid in a murine model of neuroinflammation. J. Mol. Neurosci. 24, 115-122.
    • (2004) J. Mol. Neurosci. , vol.24 , pp. 115-122
    • Craft, J.M.1    Van Eldik, L.J.2    Zasadzki, M.3    Hu, W.4    Watterson, D.M.5
  • 10
    • 4644316149 scopus 로고    scopus 로고
    • Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo
    • Craft J. M., Watterson D. M., Frautschy S. A., and, Van Eldik L. J., (2004b) Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo. Neurobiol. Aging 25, 1283-1292.
    • (2004) Neurobiol. Aging , vol.25 , pp. 1283-1292
    • Craft, J.M.1    Watterson, D.M.2    Frautschy, S.A.3    Van Eldik, L.J.4
  • 11
    • 33645420706 scopus 로고    scopus 로고
    • Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration
    • Craft J. M., Watterson D. M., and, Van Eldik L. J., (2006) Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration. Glia 53, 484-490.
    • (2006) Glia , vol.53 , pp. 484-490
    • Craft, J.M.1    Watterson, D.M.2    Van Eldik, L.J.3
  • 12
    • 0037200117 scopus 로고    scopus 로고
    • Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability
    • Dahlgren K., Manelli A., Blaine Stine Jr. S., Baker L., Krafft G., and, LaDu M., (2002) Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability. J. Biol. Chem. 277, 32046-32053.
    • (2002) J. Biol. Chem. , vol.277 , pp. 32046-32053
    • Dahlgren, K.1    Manelli, A.2    Blaine Stine, S.3    Baker, L.4    Krafft, G.5    Ladu, M.6
  • 13
    • 84859511924 scopus 로고    scopus 로고
    • Critical role of cPLA2 in Abeta oligomer-induced neurodegeneration and memory deficit
    • Desbene C., Malaplate-Armand C., Youssef I., et al,. (2012) Critical role of cPLA2 in Abeta oligomer-induced neurodegeneration and memory deficit. Neurobiol. Aging 33, 1123. e1117-e1129.
    • (2012) Neurobiol. Aging , vol.33 , pp. 1123e1117-e1129
    • Desbene, C.1    Malaplate-Armand, C.2    Youssef, I.3
  • 14
    • 0029934027 scopus 로고    scopus 로고
    • Rodent models of Alzheimer's disease: Rat a beta infusion approaches to amyloid deposits
    • Frautschy S. A., Yang F., Calderon L., and, Cole G. M., (1996) Rodent models of Alzheimer's disease: rat A beta infusion approaches to amyloid deposits. Neurobiol. Aging 17, 311-321.
    • (1996) Neurobiol. Aging , vol.17 , pp. 311-321
    • Frautschy, S.A.1    Yang, F.2    Calderon, L.3    Cole, G.M.4
  • 15
    • 0035686083 scopus 로고    scopus 로고
    • Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology
    • Frautschy S. A., Hu W., Kim P., Miller S. A., Chu T., Harris-White M. E., and, Cole G. M., (2001) Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Neurobiol. Aging 22, 993-1005.
    • (2001) Neurobiol. Aging , vol.22 , pp. 993-1005
    • Frautschy, S.A.1    Hu, W.2    Kim, P.3    Miller, S.A.4    Chu, T.5    Harris-White, M.E.6    Cole, G.M.7
  • 16
    • 0027374493 scopus 로고
    • Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules
    • Haass C., Hung A. Y., Schlossmacher M. G., Oltersdorf T., Teplow D. B., and, Selkoe D. J., (1993) Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules. Ann. N. Y. Acad. Sci. 695, 109-116.
    • (1993) Ann. N. Y. Acad. Sci. , vol.695 , pp. 109-116
    • Haass, C.1    Hung, A.Y.2    Schlossmacher, M.G.3    Oltersdorf, T.4    Teplow, D.B.5    Selkoe, D.J.6
  • 17
    • 79251584041 scopus 로고    scopus 로고
    • Endothelial ICAM-1 protein induction is regulated by cytosolic phospholipase A2alpha via both NF-kappaB and CREB transcription factors
    • Hadad N., Tuval L., Elgazar-Carmom V., Levy R., and, Levy R., (2011) Endothelial ICAM-1 protein induction is regulated by cytosolic phospholipase A2alpha via both NF-kappaB and CREB transcription factors. J. Immunol. 186, 1816-1827.
    • (2011) J. Immunol. , vol.186 , pp. 1816-1827
    • Hadad, N.1    Tuval, L.2    Elgazar-Carmom, V.3    Levy, R.4    Levy, R.5
  • 18
    • 33748163485 scopus 로고    scopus 로고
    • Induction of Fc gammaRIIA expression in myeloid PLB cells during differentiation depends on cytosolic phospholipase A2 activity and is regulated via activation of CREB by PGE2
    • Hazan-Eitan Z., Weinstein Y., Hadad N., Konforty A., and, Levy R., (2006) Induction of Fc gammaRIIA expression in myeloid PLB cells during differentiation depends on cytosolic phospholipase A2 activity and is regulated via activation of CREB by PGE2. Blood 108, 1758-1766.
    • (2006) Blood , vol.108 , pp. 1758-1766
    • Hazan-Eitan, Z.1    Weinstein, Y.2    Hadad, N.3    Konforty, A.4    Levy, R.5
  • 19
    • 79952375934 scopus 로고    scopus 로고
    • Prolonged exposure of cortical neurons to oligomeric amyloid-beta impairs NMDA receptor function via NADPH oxidase-mediated ROS production: Protective effect of green tea (-)-epigallocatechin-3-gallate
    • He Y., Cui J., Lee J., et al,. (2011) Prolonged exposure of cortical neurons to oligomeric amyloid-beta impairs NMDA receptor function via NADPH oxidase-mediated ROS production: protective effect of green tea (-)-epigallocatechin-3-gallate. ASN Neuro 3, 13e-24e.
    • (2011) ASN Neuro , vol.3 , pp. 13e-24e
    • He, Y.1    Cui, J.2    Lee, J.3
  • 20
    • 0031860393 scopus 로고    scopus 로고
    • Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL
    • Heinemeyer T., Wingender E., Reuter I., et al,. (1998) Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL. Nucleic Acids Res. 26, 362-367.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 362-367
    • Heinemeyer, T.1    Wingender, E.2    Reuter, I.3
  • 22
    • 36349029592 scopus 로고    scopus 로고
    • Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo
    • Hoshino T., Nakaya T., Homan T., et al,. (2007) Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo. J. Biol. Chem. 282, 32676-32688.
    • (2007) J. Biol. Chem. , vol.282 , pp. 32676-32688
    • Hoshino, T.1    Nakaya, T.2    Homan, T.3
  • 23
    • 33744900653 scopus 로고    scopus 로고
    • Neuron-derived D-serine release provides a novel means to activate N-methyl-D-aspartate receptors
    • Kartvelishvily E., Shleper M., Balan L., Dumin E., and, Wolosker H., (2006) Neuron-derived D-serine release provides a novel means to activate N-methyl-D-aspartate receptors. J. Biol. Chem. 281, 14151-14162.
    • (2006) J. Biol. Chem. , vol.281 , pp. 14151-14162
    • Kartvelishvily, E.1    Shleper, M.2    Balan, L.3    Dumin, E.4    Wolosker, H.5
  • 26
    • 0025768998 scopus 로고
    • Assay and purification of phospholipase A2 from human synovial fluid in rheumatoid arthritis
    • Kramer R. M., and, Pepinsky R. B., (1991) Assay and purification of phospholipase A2 from human synovial fluid in rheumatoid arthritis. Methods Enzymol. 197, 373-381.
    • (1991) Methods Enzymol. , vol.197 , pp. 373-381
    • Kramer, R.M.1    Pepinsky, R.B.2
  • 27
    • 19944428712 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2 mediates neuronal apoptosis induced by soluble oligomers of the amyloid-beta peptide
    • Kriem B., Sponne I., Fifre A., et al,. (2005) Cytosolic phospholipase A2 mediates neuronal apoptosis induced by soluble oligomers of the amyloid-beta peptide. FASEB J. 19, 85-87.
    • (2005) FASEB J. , vol.19 , pp. 85-87
    • Kriem, B.1    Sponne, I.2    Fifre, A.3
  • 28
    • 0033231262 scopus 로고    scopus 로고
    • Neurodegenerative tauopathies: Human disease and transgenic mouse models
    • Lee V. M., and, Trojanowski J. Q., (1999) Neurodegenerative tauopathies: human disease and transgenic mouse models. Neuron 24, 507-510.
    • (1999) Neuron , vol.24 , pp. 507-510
    • Lee, V.M.1    Trojanowski, J.Q.2
  • 29
    • 3242791073 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2 is responsible for prostaglandin E2 and leukotriene B4 formation in phagocyte-like PLB-985 cells: Studies of differentiated cPLA2-deficient PLB-985 cells
    • Liberty I., Raichel L., Hazan-Eitan Z., Pessach I., Hadad N., Schlaeffer F., and, Levy R., (2004) Cytosolic phospholipase A2 is responsible for prostaglandin E2 and leukotriene B4 formation in phagocyte-like PLB-985 cells: studies of differentiated cPLA2-deficient PLB-985 cells. J. Leukoc. Biol. 76, 176-184.
    • (2004) J. Leukoc. Biol. , vol.76 , pp. 176-184
    • Liberty, I.1    Raichel, L.2    Hazan-Eitan, Z.3    Pessach, I.4    Hadad, N.5    Schlaeffer, F.6    Levy, R.7
  • 31
    • 0027447286 scopus 로고
    • Neurodegeneration induced by beta-amyloid peptides in vitro: The role of peptide assembly state
    • Pike C. J., Burdick D., Walencewicz A. J., Glabe C. G., and, Cotman C. W., (1993) Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state. J. Neurosci. 13, 1676-1687.
    • (1993) J. Neurosci. , vol.13 , pp. 1676-1687
    • Pike, C.J.1    Burdick, D.2    Walencewicz, A.J.3    Glabe, C.G.4    Cotman, C.W.5
  • 32
    • 2942598274 scopus 로고    scopus 로고
    • Prostaglandin E2 regulates amyloid precursor protein expression via the EP2 receptor in cultured rat microglia
    • Pooler A. M., Arjona A. A., Lee R. K., and, Wurtman R. J., (2004) Prostaglandin E2 regulates amyloid precursor protein expression via the EP2 receptor in cultured rat microglia. Neurosci. Lett. 362, 127-130.
    • (2004) Neurosci. Lett. , vol.362 , pp. 127-130
    • Pooler, A.M.1    Arjona, A.A.2    Lee, R.K.3    Wurtman, R.J.4
  • 33
    • 80051791713 scopus 로고    scopus 로고
    • Downregulation of CREB expression in Alzheimer's brain and in Abeta-treated rat hippocampal neurons
    • Pugazhenthi S., Wang M., Pham S., Sze C. I., and, Eckman C. B., (2011) Downregulation of CREB expression in Alzheimer's brain and in Abeta-treated rat hippocampal neurons. Mol. Neurodegener. 6, 60.
    • (2011) Mol. Neurodegener. , vol.6 , pp. 60
    • Pugazhenthi, S.1    Wang, M.2    Pham, S.3    Sze, C.I.4    Eckman, C.B.5
  • 34
    • 9144219644 scopus 로고    scopus 로고
    • Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity
    • Qin W., Ho L., Pompl P., et al,. (2003) Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity. J. Biol. Chem. 278, 50970-50977.
    • (2003) J. Biol. Chem. , vol.278 , pp. 50970-50977
    • Qin, W.1    Ho, L.2    Pompl, P.3
  • 36
    • 32544456878 scopus 로고    scopus 로고
    • Glia as a therapeutic target: Selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration
    • Ralay Ranaivo H., Craft J. M., Hu W., Guo L., Wing L. K., Van Eldik L. J., and, Watterson D. M., (2006) Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration. J. Neurosci. 26, 662-670.
    • (2006) J. Neurosci. , vol.26 , pp. 662-670
    • Ralay Ranaivo, H.1    Craft, J.M.2    Hu, W.3    Guo, L.4    Wing, L.K.5    Van Eldik, L.J.6    Watterson, D.M.7
  • 37
    • 84885440280 scopus 로고    scopus 로고
    • Cytosolic phospholipase aalpha upregulation mediates apoptotic neuronal death induced by aggregated amyloid-beta peptide
    • Sagy-Bross C., Hadad N., and, Levy R., (2013) Cytosolic phospholipase aalpha upregulation mediates apoptotic neuronal death induced by aggregated amyloid-beta peptide. Neurochem. Int. 63, 541-550.
    • (2013) Neurochem. Int. , vol.63 , pp. 541-550
    • Sagy-Bross, C.1    Hadad, N.2    Levy, R.3
  • 39
    • 54949130109 scopus 로고    scopus 로고
    • Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease
    • Sanchez-Mejia R., Newman J., Toh S., et al,. (2008) Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease. Nat. Neurosci. 11, 1311-1318.
    • (2008) Nat. Neurosci. , vol.11 , pp. 1311-1318
    • Sanchez-Mejia, R.1    Newman, J.2    Toh, S.3
  • 40
    • 78649993978 scopus 로고    scopus 로고
    • Phosphorylation of APP-CTF-AICD domains and interaction with adaptor proteins: Signal transduction and/or transcriptional role-relevance for Alzheimer pathology
    • Schettini G., Govoni S., Racchi M., and, Rodriguez G., (2010) Phosphorylation of APP-CTF-AICD domains and interaction with adaptor proteins: signal transduction and/or transcriptional role-relevance for Alzheimer pathology. J. Neurochem. 115, 1299-1308.
    • (2010) J. Neurochem. , vol.115 , pp. 1299-1308
    • Schettini, G.1    Govoni, S.2    Racchi, M.3    Rodriguez, G.4
  • 41
    • 45249097300 scopus 로고    scopus 로고
    • Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons
    • Shelat P., Chalimoniuk M., Wang J., Strosznajder J., Lee J., Sun A., Simonyi A., and, Sun G., (2008) Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons. J. Neurochem. 106, 45-55.
    • (2008) J. Neurochem. , vol.106 , pp. 45-55
    • Shelat, P.1    Chalimoniuk, M.2    Wang, J.3    Strosznajder, J.4    Lee, J.5    Sun, A.6    Simonyi, A.7    Sun, G.8
  • 42
    • 0025312290 scopus 로고
    • Amyloid beta-protein precursor accumulates in dystrophic neurites of senile plaques in Alzheimer-type dementia
    • Shoji M., Hirai S., Yamaguchi H., Harigaya Y., and, Kawarabayashi T., (1990) Amyloid beta-protein precursor accumulates in dystrophic neurites of senile plaques in Alzheimer-type dementia. Brain Res. 512, 164-168.
    • (1990) Brain Res. , vol.512 , pp. 164-168
    • Shoji, M.1    Hirai, S.2    Yamaguchi, H.3    Harigaya, Y.4    Kawarabayashi, T.5
  • 43
    • 0029657725 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain
    • Stephenson D. T., Lemere C. A., Selkoe D. J., and, Clemens J. A., (1996) Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain. Neurobiol. Dis. 3, 51-63.
    • (1996) Neurobiol. Dis. , vol.3 , pp. 51-63
    • Stephenson, D.T.1    Lemere, C.A.2    Selkoe, D.J.3    Clemens, J.A.4
  • 44
    • 0032588897 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2 is induced in reactive glia following different forms of neurodegeneration
    • Stephenson D., Rash K., Smalstig B., et al,. (1999) Cytosolic phospholipase A2 is induced in reactive glia following different forms of neurodegeneration. Glia 27, 110-128.
    • (1999) Glia , vol.27 , pp. 110-128
    • Stephenson, D.1    Rash, K.2    Smalstig, B.3
  • 45
    • 84911002483 scopus 로고    scopus 로고
    • Role of cytosolic phospholipase a in oxidative and inflammatory signaling pathways in different cell types in the central nervous system
    • Sun G. Y., Chuang D. Y., Zong Y., Jiang J., Lee J. C., Gu Z., and, Simonyi A., (2014) Role of cytosolic phospholipase A in oxidative and inflammatory signaling pathways in different cell types in the central nervous system. Mol. Neurobiol. 50, 6-14.
    • (2014) Mol. Neurobiol. , vol.50 , pp. 6-14
    • Sun, G.Y.1    Chuang, D.Y.2    Zong, Y.3    Jiang, J.4    Lee, J.C.5    Gu, Z.6    Simonyi, A.7
  • 46
    • 71249160483 scopus 로고    scopus 로고
    • Regulatory role of cytosolic phospholipase A2alpha in NADPH oxidase activity and in inducible nitric oxide synthase induction by aggregated Abeta1-42 in microglia
    • Szaingurten-Solodkin I., Hadad N., and, Levy R., (2009) Regulatory role of cytosolic phospholipase A2alpha in NADPH oxidase activity and in inducible nitric oxide synthase induction by aggregated Abeta1-42 in microglia. Glia 57, 1727-1740.
    • (2009) Glia , vol.57 , pp. 1727-1740
    • Szaingurten-Solodkin, I.1    Hadad, N.2    Levy, R.3
  • 47
    • 57649221135 scopus 로고    scopus 로고
    • Amyloid precursor protein trafficking, processing, and function
    • Thinakaran G., and, Koo E. H., (2008) Amyloid precursor protein trafficking, processing, and function. J. Biol. Chem. 283, 29615-29619.
    • (2008) J. Biol. Chem. , vol.283 , pp. 29615-29619
    • Thinakaran, G.1    Koo, E.H.2
  • 48
    • 0036792096 scopus 로고    scopus 로고
    • Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: Reversibility by drugs that enhance cAMP signaling
    • Vitolo O. V., Sant'Angelo A., Costanzo V., Battaglia F., Arancio O., and, Shelanski M., (2002) Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling. Proc. Natl Acad. Sci. USA 99, 13217-13221.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 13217-13221
    • Vitolo, O.V.1    Sant'Angelo, A.2    Costanzo, V.3    Battaglia, F.4    Arancio, O.5    Shelanski, M.6
  • 49
    • 0036424134 scopus 로고    scopus 로고
    • Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology
    • Xiang Z., Ho L., Yemul S., et al,. (2002) Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology. Gene Expr. 10, 271-278.
    • (2002) Gene Expr. , vol.10 , pp. 271-278
    • Xiang, Z.1    Ho, L.2    Yemul, S.3
  • 50
    • 0033541589 scopus 로고    scopus 로고
    • Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type
    • Yamamoto-Sasaki M., Ozawa H., Saito T., Rosler M., and, Riederer P., (1999) Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type. Brain Res. 824, 300-303.
    • (1999) Brain Res. , vol.824 , pp. 300-303
    • Yamamoto-Sasaki, M.1    Ozawa, H.2    Saito, T.3    Rosler, M.4    Riederer, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.