Folate and Vitamin B12 Status in Latin America and the Caribbean: An Update

Food and Nutrition Bulletin

Volumn 36, Issue 2, 2015, Pages S109-S118

  Brito, Alex ^a   Mujica Coopman, Maria F ^b   Olivares, Manuel ^b   de Romaña, Daniel López ^c   Cori, Héctor ^d   Allen, Lindsay H ^a  

^a U S DEPARTMENT OF AGRICULTURE   (United States)

^b UNIVERSITY OF CHILE   (Chile)

^c MICRONUTRIENT INITIATIVE   (Canada)

^d DSM NUTRITIONAL PRODUCTS LTD   (Switzerland)

Author keywords

folate; folic acid; Latin America; prevalence; vitamin; vitamin B12

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID;

ADOLESCENT; ADULT; AGED; BLOOD; CARIBBEAN; CHILD; DIET SUPPLEMENTATION; FEMALE; FOLIC ACID DEFICIENCY; HUMAN; MALE; NUTRITIONAL STATUS; PREGNANCY; PRESCHOOL CHILD; SOUTH AND CENTRAL AMERICA; VITAMIN B 12 DEFICIENCY;

ADOLESCENT; ADULT; AGED; CARIBBEAN REGION; CHILD; CHILD, PRESCHOOL; FEMALE; FOLIC ACID; FOLIC ACID DEFICIENCY; FOOD, FORTIFIED; HUMANS; LATIN AMERICA; MALE; NUTRITIONAL STATUS; PREGNANCY; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 84938684109     PISSN: 03795721     EISSN: 15648265     Source Type: Journal    
DOI: 10.1177/0379572115585772     Document Type: Article

References (69)

1. 6, and polymorphisms. Food Nutr Bull 2008;29: 5-16.
2. Carmel R, Green R, Rosenblatt DS, Watkins D. Update on cobalamin, folate and homocysteine. Hematology 2003;1:62-81.
3. MRC Vitamin Study Research Group. Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study. Lancet 1991; 338:131-7.
4. Czeizel AE, Dudás I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 1992; 327:1832-5.
5. Berry RJ, Li Z, Erickson JD, Li S, Moore CA, Wang H, Mulinare J, Zhao P, Wong L, Gindler J, Hong S, Hao L, Gunter E, Correa A. Prevention of neural-tube defects with folic acid in China. N Engl J Med 1999;341:1485-90.
6. Institute of Medicine. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, DC: National Academies Press, 2006.
7. 12 and folate deficiency. Food Nutr Bull 2008;29:20-34.
8. Aslinia F, Mazza JJ, Yale SH. Megaloblastic anemia and other causes of macrocytosis. Clin Med Res 2006;4:236-41.
9. Lindenbaum J, Healton EB, Savage DG, Brust JC, Garrett TJ, Podell ER, Margell PD, Stabler SP, Allen RH. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med 1988;318:1720-8.
10. 12 status in the Americas. Nutr Rev 2004;62:29-33.
11. 12 deficiencies worldwide. Food Nutr Bull 2008;29:38-51.
12. Institute of Medicine. Dietary Reference Intakes: Thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. Washington, DC: National Academies Press, 2000.
13. R. Core Team. R: A language and environment for statistical computing. Auckland, New Zealand: University of Auckland, 2014.
14. Villalpando S, Montalvo-Velarde I, Zambrano N, Garcia-Guerra A, Ramirez-Silva CI, Shamah-Levy T, Rivera JA. Vitamins A, and C and folate status in Mexican children under 12 years and women 12–49 years: A probabilistic national survey. Salud Publica Mex 2003;45:508-19.
15. Cunningham L, Blanco A, Rodríguez S, Ascencio M. Prevalencia de anemia, deficiencia de hierro y folatos en niños menores de siete años. Costa Rica, 1996. Arch Latinoam Nutr 2001;51:37-43.
16. 12 en niños, adolescentes y mujeres embarazadas en Venezuela. An Venez Nutr 2005;18:145-54.
17. 12 deficiencies in infants, children, adolescents and pregnant women in Venezuela. Eur J Clin Nutr 2005;59: 1064-70.
18. Rodriguez S, Blanco A, Cunningham L, Ascencio M, Chavez M, Munoz L. Prevalencia de las anemias nutricionales de mujeres en edad fertil. Costa Rica. Encuesta Nacional de Nutrición, 1996. Arch Latinoam Nutr 2001;51:19-24.
19. Blanco A, Rodriguez S, Cunningham L. Anemias nutricionales en mujeres lactantes de Costa Rica. Arch Latinoam Nutr 2003;53:28-34.
20. Maulen-Radovan I, Villagomez S, Soler E, Villicaña R, Hernandez L, Rosado JL. Impacto nutricio del consumo de una leche entera adicionada con vitaminas y minerales en niños. Salud Publica Mex 1999;41:389-96.
21. Diez-Ewald M, Calvo E, Biglieri A. Anemia en poblaciones indígenas del Occidente de Venezuela. Invest Clin 1999;40:203-13.
22. Black A, Allen L, Pelto G, De Mata M, Chavez A. Iron, vitamin B-12 and folate status in Mexico: Associated factors in men and women and during pregnancy and lactation. J Nutr 1994;124:1179-88.
23. 12 y hierro en adolescentes embarazadas. Arch Latinoam Nutr 2003; 53:150-6.
24. Martí-Carvajal A, Peña-Martí G, Comunian G, Muñoz S. Prevalence of anemia during pregnancy: Results of Valencia (Venezuela) anemia during pregnancy study. Arch Latinoam Nutr 2002;52:5-11.
25. Nogueira N, Vaz J, Franciscato S. Mudanças na concentração plasmática de zinco e ácido fólico em adolescentes grávidas submetidas a diferentes esquemas de suplementação. Cad Saude Publica 2003;19:155-60.
26. Casterline JE, Allen LH, Ruel MT. Vitamin B-12 deficiency is very prevalent in lactating Guatemalan women and their infants at three months postpartum. J Nutr 1997;127:1966-72.
27. 12 en mujeres Mexicanas urbanas en edad reproductiva. Reprod Hum 2000;14:192-6.
28. O’Connor DL, Latulippe ME, Campos C, Merlos C, Villalpando S, Frances Picciano M. Folate deficiency does not alter the usefulness of the serum transferrin receptor concentration as an index for the detection of iron deficiency in Mexican women during early lactation. J Nutr 2005;135:144-9.
29. Hernandez IG, du Defaix Gomez HG, Antunez AS, Barrios MF. Deficiencia de hierro y acido folico en mujeres en edad fertil. Rev Cubana Hematol Immunol Hemoter 1998;14:143-9.
30. Hertrampf E, Cortés F, Erickson JD, Cayazzo M, Freire W, Bailey LB, Howson C, Kauwell GP, Pfeiffer C. Consumption of folic acid–fortified bread improves folate status in women of reproductive age in Chile. J Nutr 2003;133:3166-9.
31. Arnaud J, Fleites-Mestre P, Chassagne M, Verdura T, Garcia Garcia I, Hernandez-Fernandez T, Gautier H, Favier A, Pérez-Cristià R, Barnouin J. Vitamin B intake and status in healthy Havanan men, 2 years after the Cuban neuropathy epidemic. Br J Nutr 2001;85:741-8.
32. Soberón M, Charaja A, Agüero Y, Oriondo R, Sandoval M, Nuñez M. Estudio de los niveles plasmáticos de homocisteína, ácido fólico y vitamina B-12 en una población limeña dejóvenes adultos. Anales de la Facultad de Medicina 2004;65:89-96.
33. King J, Mazariesgos M, Valdez C, Castañeda C, Solomons NW. National status indicators and their interactions in rural Guatemalan elderly: A study in San Pedro Ayampuc. Am J Clin Nutr 1997;66: 795-802.
34. 12 en adultos mayores Venezolanos. Arch Latinoam Nutr 2007;57;26-32.
35. Hamer D, Sempértegui F, Estrella B, Tucker KL, Rodríguez A, Egas J, Dallal GE, Selhub J, Griffiths JK, Meydani SN. Micronutrient deficiencies are associated with impaired immune response and higher burden of respiratory infections in elderly Ecuadorians. J Nutr 2009;139:113-9.
36. Olivares M, Hertrampf E, Capurro MT, Wegner D. Prevalence of anemia in elderly subjects living at home: Role of micronutrient deficiency and inflammation. Eur J Clin Nutr 2000;54:834-9.
37. 12 deficiency in Mexican children aged 1 to 6 years in a population-based survey. Salud Publica Mex 2012;54:116-24.
38. Ministerio de Salud. Encuesta de Salud Nacional Costa Rica 2008. San Jose, Costa Rica: Ministerio de Salud, 2009.
39. Ministerio de Salud. Encuesta Nacional de Nutrición y Salud Argentina 2007. Buenos Aires, Argentina: Ministerio de Salud, 2007.
40. Ministerio de Salud. Encuesta Nacional de Salud Chile 2009–2010. Santiago, Chile: Ministerio de Salud, 2010.
41. Bojórquez-Chapela I, Mendoza-Flores M, Tolentino M, Morales R, De-Regil L. Las conductas alimentaríasderiesgonoseasociancon deficiencias de micronutrimentos en mujeres en edad reproductiva de la ciudad de México. Arch Latinoam Nutr 2010;60:64-9.
42. Nguyen P, Grajeda R, Melgar P, Marcinkevage J, Flores R, Martorell R. Weekly may be as efficacious as daily folic acid supplementation in improving folate status and lowering serum homocysteine concentrations in Guatemalan women. J Nutr 2008;138:1491-8.
43. Hirsch S, de la Maza P, Barrera G, Gattas V, Petermann M, Bunout D. The Chilean flour folic acid fortification program reduces serum homocysteine levels and masks vitamin B-12 deficiency in elderly people. J Nutr 2002;132:289-91.
44. Monárrez-Espino J, Martínez H, Martínez V, Greiner T. Nutritional status of indigenous children at boarding schools in northern Mexico. Eur J Clin Nutr 2004;58:532-40.
45. 12 y folato en adultos mayores urbanos no institucionalizado. Arch Latinoam Nutr 2006;56: 135-40.
46. Rogers L, Boy E, Miller JW, Green R, Sabel JC, Allen LH. High prevalence of cobalamin deficiency in Guatemalan schoolchildren: Associations with low plasma holotranscobalamin II and elevated serum methylmalonic acid and plasma homocysteine concentrations. Am J Clin Nutr 2003;77:433-40.
47. Jones KM, Ramirez-Zea M, Zuleta C, Allen LH. Prevalent vitamin B-12 deficiency in twelvemonth-old Guatemalan infants is predicted by maternal B-12 deficiency and infant diet. J Nutr 2007;5:1307-13.
48. Holst I, Monge R, Cambronero P, Brenes G. Genetic, dietary, and other lifestyle determinants of serum homocysteine levels in young adults in Costa Rica. Pan Am J Public Health 2005;17:263-70.
49. Sanchez H, Albala C, Lera L, Dangour A, Uauy R. Effectiveness of the National Program of Complementary Feeding for older adults in Chile on vitamin B12 status in older adults; secondary outcome analysis from the Cenex study (ISRCTN48153354). Nutr J 2013;12:124. doi: 10.1186/1475-2891-12-124.
50. Sánchez H, Albala C, Hertrampf E, Verdugo R, Lavados M, Castillo JL, Lera L, Uauy R. Déficit de vitamina B-12 en adultos mayores: ¿Un problema de salud pública en Chile? Rev Med Chile 2010;138:44-52.
51. Allen LH, Rosado JL, Casterline JE, Martinez H, Lopez P, Munoz E, Black AK. Vitamin B-12 deficiency and malabsorption are highly prevalent in rural Mexican communities. Am J Clin Nutr 1995;62:1013-9.
52. 12 en relación anemia, en adolescentes de una zona con alta incidencia de malformaciones congénitas en Venezuela. Arch Latinoam Nutr 2005;55:118-23.
53. Ministerio de Proteccion Social. Encuesta Nacional de Salud Colombia 2010. Bogota, Colombia: Ministerio de Proteccion Social, 2010.
54. Encuesta de Salud, Bienestar y Envejecimiento SABE Nacional de Salud Ecuador 2009. Quito, Ecuador: Encuesta de Salud, 2009.
55. Calvo E, Biglieri A. Impacto de la fortificación con ácido fólico sobre el estado nutricional en mujeres y la prevalencia de defectos del tubo neural. Arch Argent Pediatr 2008;106:492-8.
56. Arsenault JE, Mora-Plazas M, Forero Y, Lopez Arana S, Jáuregui G, Baylin A, Gordon PM, Villamor E. Micronutrient and anthropometric status indicators are associated with physical fitness in Colombian school children. Br J Nutr 2011;105: 1832-42.
57. 12 deficiency in rural and urban Costa Rican young adults. Pan Am J Public Health 2007;22:396-401.
58. Food Fortification Initiative. 2015. http://www.ffi network.org/about/.
59. Morris MS, Jacques PF, Rosenberg IH, Selhub J. Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr 2007;85:193-200.
60. Miller JW, Garrod MG, Allen LH, Haan MN, Green R. Metabolic evidence of vitamin B-12 deficiency, including high homocysteine and methylmalonic acid and low holotranscobalamin, is more pronounced in older adults with elevated plasma folate. Am J Clin Nutr 2009;90:1586-92.
61. Brito A, Miller J, Fedosov S, Shahab-Ferdows, Sanchez H, Albala C, Uauy R, Allen L. Low vitamin B12 status and less response to vitamin B12 treatment in Chilean B12-deficient elderly with high serum folate. FASEB J 2014;28:135-8.
62. Kim Y. Will mandatory folic acid fortification prevent or promote cancer? Am J Clin Nutr 2004,80: 1123-8.
63. Miller JW, Ulrich CM. Folic acid and cancerwhere are we today? Lancet 2013;381:974-6.
64. Troen AM, Mitchell B, Sorensen B, Wener MH, Johnston A, Wood Brent, Selhub J, McTiernan A, Yasui Y, Oral E, Potter JD, Ulrich CM. Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr 2006;136:189-94.
65. 12 fortification of flour. Food Nutr Bull 2010;31: 36-46.
66. Quanhe Y, Cogswell ME, Hamner HC, Carriquiry A, Bailey LB, Pfeiffer CM, Berry RJ. Folic acid source, usual intake, and folate and vitamin B-12 status in US adults: National Health and Nutrition Examination Survey (NHANES) 2003–2006. Am J Clin Nutr 2010;91:64-72.
67. Pfeiffer CM, Hughes JP, Durazo-Arvizu RA, Lacher DA, Sempos CT, Zhang M, Yetley EA, Johnson CL. Changes in measurement procedure from a radioassay to a microbiologic assay necessitate adjustment of serum and RBC folate concentrations in the U.S. population from the NHANES 1988–2010. J Nutr 2012;142:894-900.
68. Crider KS, Devine O, Hao L, Dowling NF, Li Song, Molloy AM, Li Z, Zhu J, Berry RJ. Population red blood cell folate concentrations for prevention of neural tube defects: Bayesian model. BMJ 2014;349:g4554.
69. 12 status: Modification for missing biomarkers and folate status, and recommendations for revised cutpoints. Clin Chem Lab Med 2015 (in press). doi: 10.1515/cclm-2014-0818.