Functional effects of eggs, naturally enriched with conjugated linoleic acid, on the blood lipid profile, development of atherosclerosis and composition of atherosclerotic plaque in apolipoprotein E and low-density lipoprotein receptor double-knockout mice (apoE/LDLR-/-)

British Journal of Nutrition

Volumn 99, Issue 1, 2008, Pages 49-58

  Franczyk Zarów, Magdalena ^a   Kostogrys, Renata B ^a   Szymczyk, Beata ^b   Jawień, Jacek ^c   Gajda, Mariusz ^c   Cichocki, Tadeusz ^c   Wojnar, Leszek ^d   Chlopicki, Stefan ^c   Pisulewski, Paweł M ^a  

^a UNIVERSITY OF AGRICULTURE IN KRAKOW   (Poland)

^b Ecology and Economy of Animal Production   (Poland)

^c JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^d CRACOW UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

ApoE LDLR ; Atherosclerosis; Composition of aortic plaque; Conjugated linoleic acid

Indexed keywords

APOLIPOPROTEIN E; CASEIN; CHOLESTEROL; CHOLINE; CONJUGATED LINOLEIC ACID; LIPID; LOW DENSITY LIPOPROTEIN RECEPTOR; LUTA CLA; MINERAL; SOYBEAN OIL; STARCH; SUCROSE; TERT BUTYLHYDROQUINONE; UNCLASSIFIED DRUG; VITAMIN;

ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; AORTA ATHEROSCLEROSIS; AORTA ROOT; ARTICLE; ATHEROSCLEROTIC PLAQUE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIETARY INTAKE; EGG YOLK; EXPERIMENTAL DESIGN; FUNCTIONAL FOOD; ISOMER; KNOCKOUT MOUSE; LIPID BLOOD LEVEL; LIPID COMPOSITION; MACROPHAGE; MOUSE; NONHUMAN; RANDOM SAMPLE; SMOOTH MUSCLE FIBER;

ANIMALS; AORTA; AORTA, THORACIC; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CHICKENS; DIET; DIETARY SUPPLEMENTS; EGGS; IMMUNOHISTOCHEMISTRY; LINOLEIC ACIDS, CONJUGATED; LIPIDS; MICE; MICE, KNOCKOUT; RANDOM ALLOCATION; RECEPTORS, LDL;

MUS;

EID: 37349030725     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114507793893     Document Type: Article

References (60)

1. Griinari JM & Bauman DE (1999) Biosynthesis of conjugated linoleic acid and its incorporation into meat and milk in ruminants. In Advances in Conjugated Linoleic Acid Research, pp. 180-199 [MP Yurawecz, MM Mossoba, JKG Kramer, MW Pariza and GJ Nelson, editors]. Champaign, IL: AOCS Press.
2. Evans M, Brown J & McIntosh M (2002) Isomer-specific effects of conjugated linoleic acid (CLA) on adiposity and lipid metabolism. J Nutr Biochem 13, 508-516.
3. Terpstra AH, Javadi M, Beynen AC, Kocsis S, Lankhorst AE, Lemmens AG & Mohede IC (2003) Dietary conjugated linoleic acids as free fatty acids and triacylglycerols similarly affect body composition and energy balance in mice. J Nutr 133, 3181-3186.
4. Wang Y & Jones PJH (2004) The role of conjugated linoleic acid in human health. Dietary conjugated linoleic acid and body composition. Am J Clin Nutr 79, 1153S-1158S.
5. Gaullier JM, Halse J, Hoye K, Kristiansen K, Fagertun H, Vik H & Gudmumdsen O (2005) Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans. J Nutr 135, 778-784.
6. Belury MA (2002) Inhibition of carcinogenesis by conjugated linoleic acid: Potential mechanisms of action. J Nutr 132, 2995-2998.
7. Field CJ & Schley PD (2004) Evidence for potential mechanisms for the effect of conjugated linoleic acid on tumor metabolism and immune function: Lessons from n-3 fatty acids. Am J Clin Nutr 79, 1190S-1198S.
8. Cho HJ, Kim EJ, Lim SS, Kim MK, Sung MK, Kim JS & Park JHY (2006) Trans- 10,cis-12, not cis-9,trans-11, conjugated linoleic acid inhibits G1-S progression in HT-29 human colon cancer cells. J Nutr 136, 893-898.
9. Kritchevsky D, Tepper SA, Wright S, Tso P & Czarnecki SK (2000) Influence of conjugated linoleic acid (CLA) on establishment and progression of atherosclerosis in rabbits. J Am Coll Nutr 19 472S-477S.
10. Kritchevsky D, Tepper SA, Wright S & Czarnecki SK (2002) Influence of graded levels of conjugated linoleic acid (CLA) on experimental atherosclerosis in rabbits. Nutr Res 22, 1275-1279.
11. Noone EJ, Roche HM, Nugent AP & Gibney MJ (2002) The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects. Br J Nutr 88, 243-251.
12. Tricon S, Burdge GC, Kew S, et al. (2004) Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humans. Am J Clin Nutr 80, 614-620.
13. Valeille K, Gripois D, Blouquit MF, Souidi M, Riottot M, Bouthegourd JC, Serougne C & Martin JC (2004) Lipid atherogenic risk markers can be more favourably influenced by the cis-9 trans-11-octadecadienoate isomer than a conjugated linoleic acid mixture or fish oil in hamsters. Br J Nutr 91, 191-199.
14. Arbonés-Mainar JM, Navarro MA, Acín S, Guzmán MA, Arnal C, Surra JC, Carnicer R, Roche HM & Osada J (2006) Trans-10, cis-12- and cis-9, trans-11-Conjugated linoleic acid isomers selectively modify HDL-apolipoprotein composition in apolipoprotein E knockout mice. J Nutr 136, 353-359.
15. Toomey S, Harhen B, Roche HM, Fitzgerald D & Belton O (2006) Profound resolution of early atherosclerosis with conjugated-linoleic acid. Atherosclerosis 187, 40-49.
16. O'Shea M, Bassaganya-Riera J & Mohede ICM (2004) Immunomodulatory properties of conjugated linoleic acid. Am J Clin Nutr 79, 1199S-1206S.
17. Tricon S, Burdge GC, Kew S, Banerjee T, Russell JJ, Grimble RF, Williams ChM, Calder PC & Yaqoob P (2004) Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid on immune cell function in healthy humans. Am J Clin Nutr 80, 1626-1633.
18. Aggett PJ, Antoine JM, Asp NG, et al. (2005) PASSCLAIM process for the assessment of scientific support for claims on foods, Consensus on Criteria. Eur J Nutr 44, 1S-30S.
19. Azain MJ (2003) Conjugated linoleic acid and its effects on animal products and health in single stomached animals. Proc Nutr Soc 62, 319-328.
20. Raes K, De Smet S & Demeyer D (2004) Effects of dietary fatty acids on incorporation of long chain polyunsaturated fatty acids and conjugated linoleic acid in lamb, beef and pork meat. Anim Feed Sci Tech 113, 199-221.
21. Givens DI (2005) The role of animal nutrition in improving the nutritive value of animal-derived foods in relation to chronic disease. Proc Nutr Soc 64, 395-402.
22. Pisulewski PM, Franczyk M & Kostogrys RB (2005) Heath-related effects of nutritionally modified foods of animal origin. J Anim Feed Sci 14, 71S-85S.
23. Schmid A, Collomb M, Sieber R & Bee G (2006) Conjugated linoleic acid in meat and meat products: A review. Meat Sci 73, 29-41.
24. Szymczyk B & Pisulewski P (2002) Feeding conjugated linoleic acid-enriched egg yolks alters serum lipid profile in adult rats. Ann Anim Sci 2, 171-178.
25. Jawien J, Gajda M, Rudling M, Mateuszuk L, Olszanecki R, Guzik TJ, Cichocki T, Chlopicki S & Korbut R (2006) Inhibition of five lipoxygenase activating protein (FLAP) by MK-886 decreases atherosclerosis in apoE/LDLR-double knockout mice. Eur J Clin Invest 36, 141-146.
26. Olszanecki R, Jawien J, Gajda M, Mateuszuk L, Gebska A, Korabiowska M, Chlopicki S & Korbut R (2005) Effect of curcumin on atherosclerosis in apoE/LDLR-double knockout mice. J Physiol Pharmacol 56, 627-635.
27. Jawien J, Csanyi G, Gajda M, Mateuszuk L, Lomnicka M, Korbut R & Chlopicki S (2007) Ticlopidine attenuates progression of atherosclerosis in apolipoprotein E and low density lipoprotein receptor double knockout mice. Eur J Pharmacol 556, 129-135.
28. Szymczyk B & Pisulewski PM (2003) Effects of dietary conjugated linoleic acid on fatty acid composition and cholesterol content of hen egg yolks. Br J Nutr 90, 93-99.
29. -/-) feeding CLA-enriched egg yolks PhD Thesis (in Polish)
30. Ishibashi S, Herz J, Maeda N, Goldstein JL & Brown MS (1994) The two-receptor model of lipoprotein clearance: Tests of the hypothesis in 'knockout' mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins. Proc Natl Acad Sci U S A 91 4431-4435.
31. Reeves PG, Nielsen FH & Fahey GC (1993) AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc Writing Committee on the reformulation of the AIN-76A rodent diet. J Nutr 123, 1939-1951.
32. Nicoletti A, Kaveri S, Caligiuri G, Bariety J & Hansson GK (1998) Immunoglobulin treatment reduces atherosclerosis in apo E knockout mice. J Clin Invest 102, 910-918.
33. Elhage R, Jawien J, Rudling M, Ljunggren HG, Takeda KS, Akira S, Bayard F & Hansson GK (2003) Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E - knockout mice. Cardiovasc Res 59 234-240.
34. Robertson AK, Rudling M, Zhou X, Gorelik L, Flavell RA & Hansson GK (2003) Disruption of TGF-beta signaling in T cells accelerates atherosclerosis. J Clin Invest 112, 1342-1350.
35. Bellisle F, Diplock AT, Hornstra G, Koletzko B, Roberfroid M, Salminen S & Saris WHM (1998) Functional food science in Europe. Br J Nutr 80, 1S-193S.
36. Roberfroid MB (2002) Global view on functional foods: European perspectives. Br J Nutr 88, S133-S138.
37. Schäfer K, Männer K, Sagredos A, Eder K & Simon O (2001) Incorporation of dietary linoleic acid and conjugated linoleic acids and related effects on eggs of laying hens. Lipids 36, 1217-1222.
38. Raes K, Heyghebaert G, De Smet S, Nollet L, Arnouts S & Demeyer D (2002) The deposition of conjugated linoleic acid in eggs of laying hens fed diets varying in fat level and fatty acid profile. J Nutr 132 182-189.
39. Shang XG, Wang FL, Li DF, Yin JD & Li JY (2004) Effects of dietary conjugated linoleic acid on the productivity of laying hens and egg quality during refrigerated storage. Poult Sci 83, 1688-1695.
40. Cachaldora P, Garcia-Rebollar P, Alvarez C, Mendel J & de Blas JC (2005) Effect of conjugated linoleic acid, high-oleic sunflower oil and fish oil dietary supplementation on laying hen egg quality. Spanish J Agric Res 3, 74-82.
41. Hasler CM (2000) The changing face of functional foods. J Am Coll Nutr 19, 499S-506S.
42. Surai PF & Sparks NHC (2001) Designer eggs: From improvement of egg composition to functional food. Trends Food Sci Technol 12, 7-16.
43. Kramer JK, Cruz-Hernandez C, Deng Z, Zhou J, Jahreis G & Dugan ME (2004) Analysis of conjugated linoleic acid and trans 18:1 isomers in synthetic and animal products. Am J Clin Nutr 79, 1137S-1145S.
44. Belury MA, Mahon A & Banni S (2003) The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus. J Nutr 133, 257S-260S.
45. Burdge GC, Lupoli B, Russell JJ, et al. (2004) Incorporation of cis-9, trans-11 or trans-10,cis-12 conjugated linoleic acid into plasma and cellular lipids in healthy men. J Lipid Res 45, 736-741.
46. Payet M, Esmail MH, Polichetti E, le Brun G, Adjemout L, Donnarel G, Portugal H & Pieroni G (2004) Docosahexaenoic acid-enriched egg consumption induces accretion of arachidonic acid in erythrocytes of elderly patients. Br J Nutr 91, 789-796.
47. Lee KN, Kritchevsky D & Pariza MW (1994) Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis 108, 19-25.
48. Nicolosi RJ, Rogers EJ, Kritchevsky D, Scimeca JA & Huth PJ (1997) Dietary conjugated linoleic acid reduces plasma lipoproteins and early atherosclerosis in hypercholesterolemic hamsters. Artery 22, 266-277.
49. Munday JS, Thompson KG & James KAC (1999) Dietary conjugated linoleic acids promote fatty streak formation in the C57BL/6 mouse atherosclerosis model. Br J Nutr 81, 251-255.
50. Lock AL, Horne CA, Bauman DE & Salter AM (2005) Butter naturally enriched in conjugated linoleic acid and vaccenic acid alters tissue fatty acids and improves the plasma lipoprotein profile in cholesterol-fed hamsters. J Nutr 135, 1934-1939.
51. Valeille K, Ferezou J, Parquet M, Amsler G, Gripois D, Quignard-Boulange A & Martin JC (2006) The natural concentration of the conjugated linoleic acid, cis-9,trans-11, in milk fat has antiatherogenic effects in hyperlipidemic hamsters. J Nutr 136, 1305-1310.
52. Desroches S, Chouinard PY, Galibois I, Corneau L, Delisle J, Lamarche B, Couture P & Bergeron N (2005) Lack of effect of dietary conjugated linoleic acids naturally incorporated into butter on the lipid profile and body composition of overweight and obese men. Am J Clin Nutr 82, 309-319.
53. Tricon S, Burdge GC, Jones EL, et al. (2006) Effects of dairy products naturally enriched with cis-9,trans-11 conjugated linoleic acid on the blood lipid profile in healthy middle-aged men. Am J Clin Nutr 83, 744-753.
54. Yotosumoto H, Hara E & Naka S (1999) 10 trans, 12 cis linoleic acid reduces apolipoprotein B secretion in HepG2 cells. Food Res Int 31, 403-409.
55. Grundy SM & Denke MA (1990) Dietary influences on serum lipids and lipoproteins. J Lipid Res 31, 1149-1172.
56. Yeung ChH, Yang L & Huang Y (2000) Dietary conjugated linoleic acid mixture affects the activity of intestinal acyl coenzyme A: Cholesterol acyltransferase in hamsters. Br J Nutr 84, 935-941.
57. Fernandez ML & West KL (2005) Mechanisms by which dietary fatty acids modulate plasma lipids. J Nutr 135, 2075-2078.
58. Thies F, Garry JMC, Yaqoob P, Rerkasem K, Williams J, Shearman CP, Gallager PJ, Calder PC & Grimble RF (2003) Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: A randomized controlled trial. Lancet 361, 477-485.
59. Ringseis R, Muller A, Dusterloh K, Schleser S, Eder K & Steinhart H (2006) Formation of conjugated linoleic acid metabolites in human vascular endothelial cells. Biochim Biophys Acta 1761, 377-383.
60. Hamer M & Steptoe A (2006) Influence of specific nutrients on progression of atherosclerosis, vascular function, haemostasis and inflammation in coronary heart disease patients: A systematic review. Br J Nutr 95, 849-859.