Antialbuminuric actions of calcilytics in the remnant kidney

American Journal of Physiology - Renal Physiology

Volumn 309, Issue 3, 2015, Pages F216-F226

  Takenaka, Tsuneo ^a   Inoue, Tsutomu ^b   Miyazaki, Takashi ^b   Nishiyama, Akira ^c   Ishii, Naohito ^d   Hayashi, Matsuhiko ^e   Suzuki, Hiromichi ^b  

^a INTERNATIONAL UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^b SAITAMA MEDICAL UNIVERSITY   (Japan)

^c KAGAWA UNIVERSITY   (Japan)

^d KITASATO UNIVERSITY   (Japan)

^e KEIO UNIVERSITY   (Japan)

Author keywords

Calcium sensing receptor; Klotho; Phosphate; Transient receptor potential channel 6; Vitamin D

Indexed keywords

8 ISOPROSTAGLANDIN F2 ALPHA; CALCITRIOL; CALCIUM ION; CALCIUM SENSING RECEPTOR; CREATININE; FIBROBLAST GROWTH FACTOR 23; KLOTHO PROTEIN; NEPHRIN; PARATHYROID HORMONE; PHOSPHATE; RONACALERET; TECALCET; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; CALCIUM PHOSPHATE; INDAN DERIVATIVE; MEMBRANE PROTEIN; PHENYLPROPIONIC ACID DERIVATIVE; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPC6 PROTEIN, RAT; VITAMIN D;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; CREATININE CLEARANCE; CREATININE URINE LEVEL; DOSE RESPONSE; DRUG DOSE INCREASE; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY INJURY; MALE; NONHUMAN; OXIDATIVE STRESS; PHOSPHATE BLOOD LEVEL; PHOSPHATE METABOLISM; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UNINEPHRECTOMY; ACUTE KIDNEY INJURY; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DRUG EFFECTS; KIDNEY; KIDNEY ARTERY; METABOLISM; NEPHRECTOMY; PATHOLOGY; WISTAR RAT;

ACUTE KIDNEY INJURY; ALBUMINURIA; ANIMALS; CALCIUM PHOSPHATES; INDANS; KIDNEY; MALE; MEMBRANE PROTEINS; NEPHRECTOMY; PHENYLPROPIONATES; RATS; RATS, WISTAR; RECEPTORS, CALCIUM-SENSING; RENAL ARTERY; TRPC CATION CHANNELS; VITAMIN D;

EID: 84938571665     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00003.2015     Document Type: Article

References (45)

1. Balan G, Bauman J, Bhattacharya S, Castrodad M, Healy DR, Herr M, Humphries P, Jennings S, Kalgutkar AS, Kapinos B, Khot V, Lazarra K, Li M, Li Y, Neagu C, Oliver R, Piotrowski DW, Price D, Qi H, Simmons HA, Southers J, Wei L, Zhang Y, Paralkar VM. The discovery of novel calcium sensing receptor negative allosteric modulators. Bioorg Med Chem Lett 19: 3328-3332, 2009.
2. Bidani AK, Mitchell KD, Schwartz MM, Navar LG, Lewis EJ. Absence of glomerular injury or nephron loss in a normotensive rat remnant kidney model. Kidney Int 38: 28-38, 1990.
3. 2+-sensing receptor from bovine parathyroid. Nature 366: 575-580, 1993.
4. Brown EM, MacLeod RJ. Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev 81: 239-297, 2001.
5. Chen TH, Kuroo M, Chen CH, Sue YM, Chen YC, Wu HH, Cheng CY. The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant mice. Eur J Pharmacol 698: 67-73, 2013.
6. Deb DK, Wang Y, Zhang Z, Nie H, Huang X, Yuan Z, Chen Y, Zhao Q, Li YC. Molecular mechanism underlying 1,25-dihydroxyvitamin D regulation of nephrin gene expression. J Biol Chem 286: 32011-32017, 2011.
7. Doi S, Zou Y, Togao O, Pastor JV, John GB, Wang L, Shiizaki K, Gotschall R, Schiavi S, Yorioka N, Takahashi M, Boothman DA, Kuroo M. Klotho inhibits transforming growth factor-β1 (TGF-β1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem 286: 8655-8665, 2011.
8. Finne K, Vethe H, Skogstrand T, Leh S, Dahl TD, Tenstad O, Berven FS, Reed RK, Vikse BE. Proteomic analysis of formalin-fixed paraffinembedded glomeruli suggests depletion of glomerular filtration barrier proteins in two-kidney, one-clip hypertensive rats. Nephrol Dial Transplant 29: 2217-2227, 2014.
9. 2+-sensing receptor rescues pulmonary hypertension in rats and mice. Hypertens Res 37: 116-124, 2014.
10. Haruna Y, Kashihara N, Satoh M, Tomita N, Namikoshi T, Sasaki T, Fujimori T, Xie P, Kanwar YS. Amelioration of progressive renal injury by genetic manipulation of Klotho gene. Proc Natl Acad Sci USA 104: 2331-2336, 2007.
11. Hirahara I, Ishibashi Y, Kaname S, Kusano E, Fujita T. Methylglyoxal induces peritoneal thickening by mesenchymal-like mesothelial cells in rats. Nephrol Dial Transplant 24: 437-447, 2009.
12. Hu MC, Shi M, Zhang J, Pastor J, Nakatani T, Lanske B, Razzaque MS, Rosenblatt KP, Baum MG, Kuroo M, Moe OW. Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. FASEB J 24: 3438-3450, 2010.
13. Inoue T, Umezawa A, Takenaka T, Suzuki H, Okada H. The contribution of epithelial-mesenchymal transition to renal fibrosis differs among kidney disease models. Kidney Int 87: 233-238, 2015.
14. Johnson RJ, Alpers CE, Yoshimura A, Lombardi D, Pritzl P, Floege J, Schwartz SM. Renal injury from angiotensin II-mediated hypertension. Hypertension 19: 464-474, 1992.
15. Kriz W. The pathogenesis of "classic" focal segmental glomerulosclerosis- lessons from rat models. Nephrol Dial Transplant 18, Suppl 6: vi39- vi44, 2003.
16. Kurdián M, Herrero-Fresneda I, Lloberas N, Gimenez-Bonafe P, Coria V, Grande MT, Boggia J, Malacrida L, Torras J, Arévalo MA, González-Martínez F, López-Novoa JM, Grinyó J, Noboa O. Delayed mTOR inhibition with low dose of everolimus reduces TGFβ expression, attenuates proteinuria and renal damage in the renal mass reduction model. PLos One 7: e32516, 2012.
17. Kuroo M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390: 45-51, 1997.
18. Kuroo M. Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism. Nat Rev Nephrol 9: 650-660, 2013.
19. 2+ channel to maintain endothelial integrity. Proc Natl Acad Sci USA 107: 19308- 19313, 2010.
20. Löwik MM, Groenen PJ, Levtchenko EN, Monnens LA, van den Heuvel LP. Molecular genetic analysis of podocyte genes in focal segmental glomerulosclerosis-a review. Eur J Pediatr 168: 1291-1304, 2009.
21. Mitani H, Ishizaka N, Aizawa T, Ohno M, Usui S, Suzuki T, Amaki T, Mori I, Nakamura Y, Sato M, Nangaku M, Hirata Y, Nagai R. In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage. Hypertension 39: 838-843, 2002.
22. Miyazaki T, Takenaka T, Inoue T, Sato M, Eiki Y, Nodera M, Hanyu M, Ohno Y, S, Suzuki H. Zinc deficiency may accelerate aging by inhibiting Klotho mRNA expression. Trace Nutrients Res 26: 74-78, 2009.
23. Montenegro J, Cornago I, Gallardo I, García-Ledesma P, Hernando A, Martinez I, Muñoz RI, Romero MA. Efficacy and safety of cinacalcet for the treatment of secondary hyperparathyroidism in patients with advanced chronic kidney disease before initiation of regular dialysis. Nephrology (Carlton) 17: 26-31, 2012.
24. Mukerji N, Damodaran TV, Winn MP. TRPC6 and FSGS: the latest TRP channelopathy. Biochim Biophys Acta 1772: 859-868, 2007.
25. Nagasawa Y, Takenaka M, Matsuoka Y, Imai E, Hori M. Quantitation of mRNA expression in glomeruli using laser-manipulated microdissection and laser pressure catapulting. Kidney Int 57: 717-723, 2000.
26. Oh J, Beckmann J, Bloch J, Hettgen V, Mueller J, Li L, Hoemme M, Gross ML, Penzel R, Mundel P, Schaefer F, Schmitt CP. Stimulation of the calcium-sensing receptor stabilizes the podocyte cytoskeleton, improves cell survival, and reduces toxin-induced glomerulosclerosis. Kidney Int 80: 483-492, 2011.
27. Okada H, Moriwaki K, Kalluri R, Takenaka T, Imai H, Ban S, Takahama M, Suzuki H. Osteopontin expressed by renal tubular epithelium mediates interstitial monocyte infiltration in rats. Am J Physiol Renal Physiol 278: F110-F121, 2000.
28. 3 pathway and the ryanodine receptor. Am J Physiol Renal Physiol 304: F248-F256, 2013.
29. Piecha G, Kokeny G, Nakagawa K, Koleganova N, Geldyyev A, Berger I, Ritz E, Schmitt CP, Gross ML. Calcimimetic R-568 or calcitriol: equally beneficial on progression of renal damage in subtotally nephrectomized rats. Am J Physiol Renal Physiol 294: F748-F757, 2008.
30. Razzaque MS. Phosphate toxicity: new insights into an old problem. Clin Sci (Lond) 120: 91-97, 2011.
31. Renkema KY, Velic A, Dijkman HB, Verkaart S, van der Kemp AW, Nowik M, Timmermans K, Doucet A, Wagner CA, Bindels RJ, Hoenderop JG. The calcium-sensing receptor promotes urinary acidification to prevent nephrolithiasis. J Am Soc Nephrol 20: 1705-1713, 2009.
32. Riccardi D, Brown EM. Physiology and pathophysiology of the calciumsensing receptor in the kidney. Am J Physiol Renal Physiol 298: F485- F499, 2010.
33. Sands JM, Naruse M, Baum M, Jo I, Hebert SC, Brown EM, Harris HW. Apical extracellular calcium/polyvalent cation-sensing receptor regulates vasopressin-elicited water permeability in rat kidney inner medullary collecting duct. J Clin Invest 99: 1399-1405, 1997.
34. Takenaka T, Inoue T, Kanno Y, Okada H, Meaney KR, Hill CE, Suzuki H. Expression and role of connexins in the rat renal vasculature. Kidney Int 73: 415-422, 2008.
35. Takenaka T, Inoue T, Ohno Y, Miyazaki T, Nishiyama A, Ishii N, Suzuki H. Calcitriol supplementation improves endothelium-dependent vasodilation in rat hypertensive renal injury. Kidney Blood Press Res 39: 17-27, 2014.
36. Takenaka T, Inoue T, Ohno Y, Miyazaki T, Nishiyama A, Ishii N, Suzuki H. Elucidating mechanisms underlying altered renal autoregulation in diabetes. Am J Physiol Regul Integr Comp Physiol 303: R495- R504, 2012.
37. Takenaka T, Takane H, Kikuta T, Watanabe Y, Suzuki H. Statin improves flow-mediated vasodilation in chronic kidney diseases. Int J Hypertens 2013: 876865, 2013.
38. Takenaka T, Watanabe Y, Inoue T, Miyazaki T, Suzuki H. Fibroblast growth factor 23 enhances renal klotho abundance. Pflügers Arch 465: 935-943, 2013.
39. 2+ channel TRPV5. Cell Calcium 45: 331-339, 2009.
40. Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, Fujita T, Fukumoto S, Yamashita T. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444: 770-774, 2006.
41. Wada Furuya Y M, Sakiyama J, Kobayashi N, Miyata S, Ishii H, Nagano N. The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. Control of parathyroid cell growth via a calcium receptor. J Clin Invest 100: 2977-2983, 1997.
42. Xie J, Cha SK, An SW, Kuro-OM, Birnbaumer L, Huang CL. Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart. Nat Commun 3: 1238, 2012.
43. Yang HC, Deleuze S, Zuo Y, Potthoff SA, Ma LJ, Fogo AB. The PPARγ agonist pioglitazone ameliorates aging-related progressive renal injury. J Am Soc Nephrol 20: 2380-2388, 2009.
44. Zeisberg M, Kalluri R. Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis. Am J Physiol Cell Physiol 304: C216-C225, 2013.
45. Zhang H, Li Y, Fan Y, Wu J, Zhao B, Guan Y, Chien S, Wang N. Klotho is a target gene of PPAR-γ. Kidney Int 74: 732-739, 2008.