Calcitriol supplementation improves endothelium-dependent vasodilation in rat hypertensive renal injury

Kidney and Blood Pressure Research

Volumn 39, Issue 1, 2014, Pages 17-27

  Takenaka, Tsuneo ^a   Inoue, Tsutomu ^b   Ohno, Yoichi ^b   Miyazaki, Takashi ^b   Nishiyama, Akira ^c   Ishii, Naohito ^d   Suzuki, Hiromichi ^b  

^a INTERNATIONAL UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^b SAITAMA MEDICAL UNIVERSITY   (Japan)

^c KAGAWA UNIVERSITY   (Japan)

^d KITASATO UNIVERSITY   (Japan)

Author keywords

Endothelium dependent vasodilation; Insulin like growth factor; Klotho; Superoxide dismutase; Transient receptor potential channels

Indexed keywords

ALBUMIN; ANGIOTENSIN II; CALCITRIOL; CALCIUM; CREATININE; IRBESARTAN; KLOTHO PROTEIN; PHOSPHATE; PROSTAGLANDIN F2; SOMATOMEDIN; SUPEROXIDE DISMUTASE; TRANSIENT RECEPTOR POTENTIAL CHANNEL; VITAMIN D; 8-EPI-PROSTAGLANDIN F2ALPHA; ANTIHYPERTENSIVE AGENT; BETA GLUCURONIDASE; BIPHENYL DERIVATIVE; PROSTAGLANDIN F2 ALPHA; TETRAZOLE DERIVATIVE; VITAMIN; 8 ISOPROSTAGLANDIN F2 ALPHA; ACETYLCHOLINE;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOLOSCLEROSIS; ARTICLE; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; CREATININE URINE LEVEL; ENDOTHELIUM CELL; GLOMERULOSCLEROSIS; GLOMERULUS FILTRATION RATE; HIGH SODIUM INTAKE; HISTOPATHOLOGY; HYPERTENSION; IMMUNOHISTOCHEMISTRY; KIDNEY HYPERTROPHY; KIDNEY INJURY; MALE; NEPHROSCLEROSIS; NONHUMAN; OXIDATIVE STRESS; PHOSPHATE BLOOD LEVEL; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; SALT LOADING; STROKE PRONE SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE; URINARY EXCRETION; VASCULAR ENDOTHELIUM; VASODILATATION; VITAMIN SUPPLEMENTATION; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD PRESSURE; COMPLICATION; DIET SUPPLEMENTATION; DISEASE MODEL; DRUG EFFECTS; KIDNEY; KIDNEY DISEASES; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SPONTANEOUSLY HYPERTENSIVE RAT; ANGIOTENSIN BLOOD LEVEL; ENDOTHELIUM; IN VIVO STUDY; SUPPLEMENTATION;

ANGIOTENSIN II; ANIMALS; ANTIHYPERTENSIVE AGENTS; BIPHENYL COMPOUNDS; BLOOD PRESSURE; CALCITRIOL; DIETARY SUPPLEMENTS; DINOPROST; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; GLUCURONIDASE; HYPERTENSION; KIDNEY; KIDNEY DISEASES; MALE; OXIDATIVE STRESS; RATS; RATS, INBRED SHR; TETRAZOLES; VASODILATION; VITAMINS;

EID: 84899770392     PISSN: 14204096     EISSN: 14230143     Source Type: Journal    
DOI: 10.1159/000355773     Document Type: Article

References (40)

1. de Borst MH, Vervloet MG, ter Wee PM, Navis G: Cross talk between the renin-angiotensinaldosterone system and vitamin D-FGF-23-klotho in chronic kidney disease. J Am Soc Nephrol 2011;22:1603-1609
2. Takenaka T, Suzuki H, Furukawa T, Ogata Y, Saruta T: Role of intrarenal renin-angiotensin system on pressure-natriuresis in spontaneously hypertensive rats. Clin Exp Hypertens 1990;12:1377-1394
3. Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP: 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 2002;110:229-238
4. Deb DK, Sun T, Wong KE, Zhang Z, Ning G, Zhang Y, Kong J, Shi H, Chang A, Li YC: Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes. Kidney Int 2010;77:1000-1009
5. Zhang Z, Zhang Y, Ning G, Deb DK, Kong J, Li YC: Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy. Proc Natl Acad Sci USA 2008;105:15896-15901
6. Fried LF, Emanuele N, Zhang JH, Brophy M, Conner TA, Duckworth W, Leehey DJ, McCullough PA, O'Connor T, Palevsky PM, Reilly RF, Seliger SL, Warren SR, Watnick S, Peduzzi P, Guarino P; VA NEPHRON-D Investigators: Combined Angiotensin inhibition for the treatment of diabetic nephropathy. N Engl J Med 2013;369:1892-1903
7. Wolden-Kirk H, Gysemans C, Verstuyf A, Mathieu C: Extraskeletal effects of vitamin D. Endocrinol Metab Clin North Am 2012;41:571-594
8. Kurosu H, Ogawa Y, Miyoshi M, Yamamoto M, Nandi A, Rosenblatt KP, Baum MG, Schiavi S, Hu M-C, Moe OW, Kuro-o M: Regulation of Fibroblast Growth Factor-23 Signaling by Klotho. J Biol Chem 2006;281:6120-6123
9. Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, Fujita T, Fukumoto S, Yamashita T: Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 2006;444:770-774
10. Mitani H, Ishizaka N, Aizawa T, Ohno M, Usui S, Suzuki T, Amaki T, Mori I, Nakamura Y, Sato M, Nangaku M, Hirata Y, Nagai R: In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage. Hypertension 2002;39:838-843
11. Haruna Y, Kashihara N, Satoh M, Tomita N, Namikoshi T, Sasaki T, Fujimori T, Xie P, Kanwar YS: Amelioration of progressive renal injury by genetic manipulation of Klotho gene. Proc Natl Acad Sci USA 2007;104:2331-2336
12. Chen TH, Kuro-O M, Chen CH, Sue YM, Chen YC, Wu HH, Cheng CY: The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant mice. Eur J Pharmacol 2013;698:67-73
13. Takenaka T, Watanabe Y, Inoue T, Miyazaki T, Suzuki H: Fibroblast growth factor 23 enhances renal klotho abundance. Pflugers Arch 2013;465:935-943
14. Mashimo T, Nabika T, Kitada K, Serikawa T, Matsumoto C, Ikeda K, Nara Y, Masuda J, Yamori Y, Ohno Y, Saruta T: Mapping of four simple sequence repeat (SSR) markers on rat chromosome 4. Hypertens Res 2000;23:47-50
15. Fukui T, Munemura C, Maeta S, Ishida C, Murawaki Y: The effects of olmesartan and alfacalcidol on renoprotection and klotho gene expression in 5/6 nephrectomized spontaneously hypertensive rats. Yonago Acta Med 2011;54:49-58
16. Razzaque MS: Phosphate toxicity: new insights into an old problem. Clin Sci (Lond) 2011;120:91-97
17. Kanno Y, Okada H, Takenaka T, Saruta T, Suzuki H: Influence of the timing of initiating antihypertensive therapy in hypertensive rats with renal failure. Clin Exp Hypertens 2000;22:521- 529
18. Takenaka T, Suzuki H, Sakamaki Y, Itaya Y, Saruta T: Contribution of prostaglandins to pressure natriuresis in Dahl salt-sensitive rats. Am J Hypertens 1991;4:489-493
19. Nishiyama A, Seth DM, Navar LG: Renal interstitial fluid concentrations of angiotensins I and II in anesthetized rats. Hypertension 2002;39:129-134
20. Takenaka T, Inoue T, Ohno Y, Miyazaki T, Nishiyama A, Ishii N, Suzuki H: Elucidating mechanisms underlying altered renal autoregulation in diabetes. Am J Physiol Regul Integr Comp Physiol 2012;303:R495-R504
21. Miyazaki T, Takenaka T, Inoue T, Sato M, Eiki Y, Nodera M, Hanyu M, Ohno Y, Shibasaki S, Suzuki H: Zinc deficiency may accelerate aging by inhibiting klotho mRNA expression. Trace Nutr Res 2009;26:74-78
22. Takenaka T, Inoue T, Kanno Y, Okada H, Meaney KR, Hill CE, Suzuki H: Expression and role of connexins in the rat renal vasculature. Kidney Int 2008;73:415-422
23. Kassi E, Adamopoulos C, Basdra EK, Papavassiliou AG: Role of vitamin D in atherosclerosis. Circulation 2013;128:2517-2531
24. de Zeeuw D, Agarwal R, Amdahl M, Audhya P, Coyne D, Garimella T, Parving HH, Pritchett Y, Remuzzi G, Ritz E, Andress D: Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study). Lancet 2010;376:1543-1551
25. de Borst MH, Hajhosseiny R, Tamez H, Wenger J, Thadhani R, Goldsmith DJ: Active vitamin D treatment for reduction of residual proteinuria: a systematic review. J Am Soc Nephrol 2013;24:1863-1871
26. Saito Y, Yamagishi T, Nakamura T, Ohyama Y, Aizawa H, Suga T, Matsumura Y, Masuda H, Kurabayashi M, Kuro-o M, Nabeshima Y, Nagai R: Klotho protein protects against endothelial dysfunction. Biochem Biophys Res Commun 1998;248:324-329
27. Kusaba T, Okigaki M, Matui A, Murakami M, Ishikawa K, Kimura T, Sonomura K, Adachi Y, Shibuya M, Shirayama T, Tanda S, Hatta T, Sasaki S, Mori Y, Matsubara H: Klotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca2+ channel to maintain endothelial integrity. Proc Natl Acad Sci USA 2010;107:19308-19313
28. Xie J, Cha S-K, An S-W, Kuro-o M, Birnbaumer L, Huang C-L: Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart. Nat Commun 2012;3:1238
29. Doi S, Zou Y, Togao O, Pastor JV, John GB, Wang L, Shiizaki K, Gotschall R, Schiavi S, Yorioka N, Takahashi M, Boothman DA, Kuro-o M: Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem 2011;286:8655- 8665
30. Liu H, Fergusson MM, Castilho RM, Liu J, Cao L, Chen J, Malide D, Rovira II, Schimel D, Kuo CJ, Gutkind JS, Hwang PM, Finkel T: Augmented Wnt signaling in a mammalian model of accelerated aging. Science 2007;317:803-806
31. Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, Kuro-o M: Suppression of aging in mice by the hormone Klotho. Science 2005;309:1829-1833
32. Takenaka T, Suzuki H, Okada H, Inoue T, Kanno Y, Ozawa Y, Hayashi K, Saruta T: Transient receptor potential channels in rat renal microcirculation: actions of angiotensin II. Kidney Int 2002;62:558- 565
33. Fellner SK, Arendshorst WJ: Angiotensin II-stimulated Ca2+ entry mechanisms in afferent arterioles: role of transient receptor potential canonical channels and reverse Na+/Ca2+ exchange. Am J Physiol 2008;294:F212-F219
34. Mukerji N, Damodaran TV, Winn MP: TRPC6 and FSGS: the latest TRP channelopathy. Biochim Biophys Acta 2007;1772:859-868
35. Nakamura T, Saito Y, Ohyama Y, Masuda H, Sumino H, Kuro-o M, Nabeshima Y, Nagai R, Kurabayashi M: Production of nitric oxide, but not prostacyclin, is reduced in klotho mice. Jpn J Pharmacol 2002;89:149-156
36. Thai H, Wollmuth J, Goldman S, Gaballa M: Angiotensin subtype 1 Receptor (AT1) blockade improves vasorelaxation in heart failure by up-regulation of endothelial nitric-oxide synthase via activation of the AT2 receptor. J Pharmacol Exp Ther 2003;307:1171-1178
37. Kobori H, Nangaku M, Navar LG, Nishiyama A: The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev 2007;59:251- 287
38. Yoon HE, Ghee JY, Piao S, Song JH, Han DH, Kim S, Ohashi N, Kobori H, Kuro-o M, Yang CW: Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy. Nephrol Dial Transplant 2011;26:800-813
39. Mitobe M, Yoshida T, Sugiura H, Shirota S, Tsuchiya K, Nihei H: Oxidative stress decreases klotho expression in a mouse kidney cell line. Nephron Exp Nephrol 2005;101:e67-e74
40. Abe M, O'Connor P, Kaldunski M, Liang M, Roman RJ, Cowley AW Jr.: Effect of sodium delivery on superoxide and nitric oxide in the medullary thick ascending limb. Am J Physiol 2006;291:F350-F357