Antiseptic effect of vicenin-2 and scolymoside from Cyclopia subternata (honeybush) in response to HMGB1 as a late sepsis mediator in vitro and in vivo

Canadian Journal of Physiology and Pharmacology

Volumn 93, Issue 8, 2015, Pages 709-720

  Lee, Wonhwa ^a,b   Yoon, Eun Kyung ^a   Kim, Kyung Min ^a   Park, Dong Ho ^b   Bae, Jong Sup ^a  

^a Kyungpook National University   (South Korea)

^b Kyungpook National University School of Medicine   (South Korea)

Author keywords

HMGB1; Inflammation; Scolymoside; Sepsis; Vicenin 2

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; ANTIINFECTIVE AGENT; CILASTATIN; CREATININE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FLAVONOID; GAMMA INTERFERON; HIGH MOBILITY GROUP B1 PROTEIN; IMIPENEM; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MACROPHAGE MIGRATION INHIBITION FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; NEUTRALIZING ANTIBODY; SCOLYMOSIDE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VICENIN 2; ANTIINFLAMMATORY AGENT; APIGENIN; APIGENIN-6,8-DI-C-GLYCOPYRANOSIDE; AUTACOID; GLUCOSIDE; HMGB1 PROTEIN, HUMAN; LIPOPOLYSACCHARIDE, ESCHERICHIA COLI 0111 B4; LUTEOLIN; TOPICAL ANTIINFECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTISEPSIS; ARTICLE; BLOOD VESSEL PERMEABILITY; CELL ADHESION; CELL MIGRATION; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; CYCLOPIA SUBTERNATA; CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE; LEUKOCYTE MIGRATION; MALE; MEDICINAL PLANT; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPSIS; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULITIS; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; CELL MEMBRANE PERMEABILITY; CELL MOTION; CHEMISTRY; COCULTURE; CYCLOPIA (GENUS); DRUG EFFECTS; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; PHYTOTHERAPY;

ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; ANTI-INFLAMMATORY AGENTS; APIGENIN; CELL ADHESION; CELL MEMBRANE PERMEABILITY; CELL MOVEMENT; CELLS, CULTURED; COCULTURE TECHNIQUES; CYCLOPIA PLANT; GLUCOSIDES; HMGB1 PROTEIN; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; LUTEOLIN; MALE; MICE, INBRED C57BL; NEUTROPHILS; PHYTOTHERAPY; PLANTS, MEDICINAL; SEPSIS; SIGNAL TRANSDUCTION;

EID: 84938569482     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/cjpp-2015-0021     Document Type: Article

References (76)

1. Akeson, A.L., and Woods, C.W. 1993. A fluorometric assay for the quantitation of cell adherence to endothelial cells. J. Immunol. Methods, 163(2): 181-185. doi:10.1016/0022-1759(93)90121-M. PMID:8354887.
2. Andersson, U., and Tracey, K.J. 2011. HMGB1 is a therapeutic target for sterile inflammation and infection. Annu. Rev. Immunol. 29: 139-162. doi:10.1146/annurev-immunol-030409-101323. PMID:21219181.
3. Andersson, U., Wang, H., Palmblad, K., Aveberger, A.C., Bloom, O., Erlandsson-Harris, H., et al. 2000. High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J. Exp. Med. 192(4): 565-570. doi:10.1084/jem.192.4.565. PMID:10952726.
4. Astiz, M.E., and Rackow, E.C. 1998. Septic shock. Lancet, 351(9114): 1501-1505. doi:10.1016/S0140-6736(98)01134-9. PMID:9605819.
5. Bae, J.S. 2012. Role of high mobility group box 1 in inflammatory disease: Focus on sepsis. Arch. Pharm. Res. 35(9): 1511-1523. doi:10.1007/s12272-012-0901-5. PMID:23054707.
6. Bae, J.W., and Bae, J.S. 2011. Barrier protective effects of lycopene in human endothelial cells. Inflamm. Res. 60(8): 751-758. doi:10.1007/s00011-011-0330-9. PMID:21487789.
7. Bae, J.S., and Rezaie, A.R. 2011. Activated protein C inhibits high mobility group box 1 signaling in endothelial cells. Blood, 118(14): 3952-3959. doi:10.1182/blood-2011-06-360701. PMID:21849480.
8. Bae, J.S., Lee, W., and Rezaie, A.R. 2012. Polyphosphate elicits pro-inflammatory responses that are counteracted by activated protein C in both cellular and animal models. J. Thromb. Haemost. 10(6): 1145-1151. doi:10.1111/j.1538-7836.2012.04671.x. PMID:22372856.
9. Bae, J.S., Lee, W., Nam, J.O., Kim, J.E., Kim, S.W., and Kim, I.S. 2014. Transforming growth factor beta-induced protein promotes severe vascular inflammatory responses. Am. J. Respir. Crit. Care Med. 189(7): 779-786. doi:10.1164/rccm.201311-2033OC. PMID:24506343.
10. Bhatia, M., He, M., Zhang, H., and Moochhala, S. 2009. Sepsis as a model of SIRS. Front. Biosci. 14: 4703-4711. doi:10.2741/3561. PMID:19273383.
11. Blackwell, T.S., and Christman, J.W. 1996. Sepsis and cytokines: current status. Br. J. Anaesth. 77(1): 110-117. doi:10.1093/bja/77.1.110. PMID:8703620.
12. Borghi, S.M., Carvalho, T.T., Staurengo-Ferrari, L., Hohmann, M.S., Pinge-Filho, P., Casagrande, R., and Verri, W.A., Jr. 2013. Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines. J. Nat. Prod. 76(6): 1141-1149. doi:10.1021/np400222v. PMID:23742617.
13. Branen, L., Hovgaard, L., Nitulescu, M., Bengtsson, E., Nilsson, J., and Jovinge, S. 2004. Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E knockout mice. Arterioscler. Thromb. Vasc. Biol. 24(11): 2137-2142. doi:10.1161/01.ATV.0000143933.20616.1b. PMID:15345516.
14. Buras, J.A., Holzmann, B., and Sitkovsky, M. 2005. Animal models of sepsis: setting the stage. Nat. Rev. Drug Discov. 4(10): 854-865. doi:10.1038/nrd1854. PMID:16224456.
15. Che, W., Lerner-Marmarosh, N., Huang, Q., Osawa, M., Ohta, S., Yoshizumi, M., et al. 2002. Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression. Circ. Res. 90(11): 1222-1230. doi:10.1161/01.RES.0000021127.83364.7D. PMID:12065326.
16. Chen, G., Li, J., Ochani, M., Rendon-Mitchell, B., Qiang, X., Susarla, S., et al. 2004. Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14-and TNF-dependent mechanisms. J. Leukoc. Biol. 76(5): 994-1001. doi:10.1189/jlb.0404242. PMID:15331624.
17. Cohen, J. 2002. The immunopathogenesis of sepsis. Nature, 420(6917): 885-891. doi:10.1038/nature01326. PMID:12490963.
18. Diener, K.R., Al-Dasooqi, N., Lousberg, E.L., and Hayball, J.D. 2013. The multifunctional alarmin HMGB1 with roles in the pathophysiology of sepsis and cancer. Immunol. Cell Biol. 91(7): 443-450. doi:10.1038/icb.2013.25. PMID: 23797067.
19. El Gazzar, M. 2007. HMGB1 modulates inflammatory responses in LPS-activated macrophages. Inflamm. Res. 56(4): 162-167. doi:10.1007/s00011-006-6112-0. PMID:17522814.
20. Fiuza, C., Bustin, M., Talwar, S., Tropea, M., Gerstenberger, E., Shelhamer, J.H and Suffredini, A.F. 2003. Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells. Blood, 101(7): 2652-2660. doi:10.1182/blood-2002-05-1300. PMID:12456506.
21. Gibot, S., Massin, F., Cravoisy, A., Barraud, D., Nace, L., Levy, B., and Bollaert, P.E. 2007. High-mobility group box 1 protein plasma concentrations during septic shock. Intensive Care Med. 33(8): 1347-1353. doi:10.1007/s00134-007-0691-2. PMID:17525840.
22. Harris, H.E., and Raucci, A. 2006. Alarmin(g) news about danger: workshop on innate danger signals and HMGB1. EMBO Rep. 7(8): 774-778. doi:10.1038/sj.embor.7400759. PMID:16858429.
23. Hofbauer, R., Moser, D., Salfinger, H., Frass, M., and Kapiotis, S. 1998. Sufentanil inhibits migration of human leukocytes through human endothelial cell monolayers. Anesth. Analg. 87(5): 1181-1185. doi:10.1097/00000539-199811000-00038. PMID:9806705.
24. Joubert, E., Joubert, M.E., Bester, C., De Beer, D., and De Lange, J.H. 2011. Honeybush (Cyclopia spp.): From local cottage industry to global markets — The catalytic and supporting role of research. S. Afr. J. Bot. 77(4): 887-907. doi:10.1016/j.sajb.2011.05.014.
25. Kazuno, S., Yanagida, M., Shindo, N., and Murayama, K. 2005. Mass spectrometric identification and quantification of glycosyl flavonoids, including dihydrochalcones with neutral loss scan mode. Anal. Biochem. 347(2): 182-192. doi:10.1016/j.ab.2005.09.020. PMID:16269127.
26. Kim, I., Moon, S.O., Kim, S.H., Kim, H.J., Koh, Y.S., and Koh, G.Y. 2001. Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells. J. Biol. Chem. 276(10): 7614-7620. doi:10.1074/jbc.M009705200. PMID:11108718.
27. Kim, T.H., Ku, S.K., Lee, I.C., and Bae, J.S. 2012. Anti-inflammatory functions of purpurogallin in LPS-activated human endothelial cells. BMB Rep. 45(3): 200-205. doi:10.5483/BMBRep.2012.45.3.200. PMID:22449709.
28. King, M.D., Laird, M.D., Ramesh, S.S., Youssef, P., Shakir, B., Vender, J.R., et al. 2010. Elucidating novel mechanisms of brain injury following subarachnoid hemorrhage: an emerging role for neuroproteomics. Neurosurg. Focus, 28(1): E10. doi:10.3171/2009.10.FOCUS09223. PMID:20043714.
29. Ku, S.K., and Bae, J.S. 2014. Antithrombotic activities of sulforaphane via inhibiting platelet aggregation and FIIa/FXa. Arch. Pharm. Res. 37(11): 1454-1463. doi:10.1007/s12272-014-0403-8. PMID:24817443.
30. Ku, S.K., Han, M.S., Lee, M.Y., Lee, Y.M., and Bae, J.S. 2014. Inhibitory effects of oroxylin A on endothelial protein C receptor shedding in vitro and in vivo. BMB Rep. 47(6): 336-341. doi:10.5483/BMBRep.2014.47.6.198. PMID:24286327.
31. Landsman, D., and Bustin, M. 1993. A signature for the HMG-1 box DNA-binding proteins. Bioessays, 15(8): 539-546. doi:10.1002/bies.950150807. PMID: 8135767.
32. Lee, J.D., Huh, J.E., Jeon, G., Yang, H.R., Woo, H.S., Choi, D.Y., and Park, D.S. 2009. Flavonol-rich RVHxR from Rhus verniciflua Stokes and its major compound fisetin inhibits inflammation-related cytokines and angiogenic factor in rheumatoid arthritic fibroblast-like synovial cells and in vivo models. Int. Immunopharmacol. 9(3): 268-276. doi:10.1016/j.intimp.2008.11.005. PMID: 19111632.
33. Lee, W., Kim, T.H., Ku, S.K., Min, K.J., Lee, H.S., Kwon, T.K., and Bae, J.S. 2012. Barrier protective effects of withaferin A in HMGB1-induced inflammatory responses in both cellular and animal models. Toxicol. Appl. Pharmacol. 262(1): 91-98. doi:10.1016/j.taap.2012.04.025. PMID:22561332.
34. Lee, W., Ku, S.K., and Bae, J.S. 2014a. Vascular barrier protective effects of orientin and isoorientin in LPS-induced inflammation in vitro and in vivo. Vascul. Pharmacol. 62(1): 3-14. doi:10.1016/j.vph.2014.04.006. PMID:24792192.
35. Lee, W., Ku, S.K., Lee, Y.M., and Bae, J.S. 2014b. Antiseptic effects of glyceollins in HMGB1-induced inflammatory responses in vitro and in vivo. Food Chem. Toxicol. 63: 1-8. doi:10.1016/j.fct.2013.10.034. PMID:24184598.
36. Leiro, J.M., Alvarez, E., Arranz, J.A., Siso, I.G., and Orallo, F. 2003. In vitro effects of mangiferin on superoxide concentrations and expression of the inducible nitric oxide synthase, tumour necrosis factor-alpha and transforming growth factor-beta genes. Biochem. Pharmacol. 65(8): 1361-1371. doi:10.1016/S0006-2952(03)00041-8. PMID:12694877.
37. Lin, C.M., Huang, S.T., Liang, Y.C., Lin, M.S., Shih, C.M., Chang, Y.C., et al. 2005. Isovitexin suppresses lipopolysaccharide-mediated inducible nitric oxide synthase through inhibition of NF-kappa B in mouse macrophages. Planta Med. 71(8): 748-753. doi:10.1055/s-2005-871287. PMID:16142640.
38. Lin, W.N., Luo, S.F., Wu, C.B., Lin, C.C., and Yang, C.M. 2008. Lipopolysaccharide induces VCAM-1 expression and neutrophil adhesion to human tracheal smooth muscle cells: involvement of Src/EGFR/PI3-K/Akt pathway. Toxicol. Appl. Pharmacol. 228(2): 256-268. doi:10.1016/j.taap.2007.11.026. PMID: 18182168.
39. Liu, F., Zhang, Y., Peng, Z., Gao, H., Xu, L., and Chen, M. 2012. High expression of high mobility group box 1 (HMGB1) predicts poor prognosis for hepatocellular carcinoma after curative hepatectomy. J. Transl. Med. 10: 135. doi:10.1186/1479-5876-10-135. PMID:22747650.
40. Lockyer, J.M., Colladay, J.S., Alperin-Lea, W.L., Hammond, T., and Buda, A.J. 1998. Inhibition of nuclear factor-kappaB-mediated adhesion molecule expression in human endothelial cells. Circ. Res. 82(3): 314-320. doi:10.1161/01.RES.82.3.314. PMID:9486659.
41. Mackman, N., Brand, K., and Edgington, T.S. 1991. Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor kappa B binding sites. J. Exp. Med. 174(6): 1517-1526. doi:10.1084/jem.174.6.1517. PMID: 1744583.
42. Marui, N., Offermann, M.K., Swerlick, R., Kunsch, C., Rosen, C.A., Ahmad, M., et al. 1993. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J. Clin. Invest. 92(4): 1866-1874. doi:10.1172/JCI116778. PMID:7691889.
43. Mullins, G.E., Sunden-Cullberg, J., Johansson, A.S., Rouhiainen, A., Erlandsson-Harris, H., Yang, H., et al. 2004. Activation of human umbilical vein endothelial cells leads to relocation and release of high-mobility group box chromosomal protein 1. Scand. J. Immunol. 60(6): 566-573. doi:10.1111/j.0300-9475.2004.01518.x. PMID:15584967.
44. Nooteboom, A., Hendriks, T., Otteholler, I., and van der Linden, C.J. 2000. Permeability characteristics of human endothelial monolayers seeded on different extracellular matrix proteins. Mediators Inflamm. 9(5): 235-241. doi:10.1080/09629350020025755. PMID:11200364.
45. Ozdulger, A., Cinel, I., Koksel, O., Cinel, L., Avlan, D., Unlu, A., et al. 2003. The protective effect of N-acetylcysteine on apoptotic lung injury in cecal ligation and puncture-induced sepsis model. Shock, 19(4): 366-372. doi:10.1097/00024382-200304000-00012. PMID:12688549.
46. Palumbo, R., Galvez, B.G., Pusterla, T., De Marchis, F., Cossu, G., Marcu, K.B., and Bianchi, M.E. 2007. Cells migrating to sites of tissue damage in response to the danger signal HMGB1 require NF-kappaB activation. J. Cell Biol. 179(1): 33-40. doi:10.1083/jcb.200704015. PMID:17923528.
47. Pardo Andreu, G.L., Maurmann, N., Reolon, G.K., de Farias, C.B., Schwartsmann, G., Delgado, R., and Roesler, R. 2010. Mangiferin, a naturally occurring glucoxilxanthone improves long-term object recognition memory in rats. Eur. J. Pharmacol. 635(1-3): 124-128. doi:10.1016/j.ejphar.2010.03.011. PMID:20303935.
48. Park, J.S., Arcaroli, J., Yum, H.K., Yang, H., Wang, H., Yang, K.Y., et al. 2003. Activation of gene expression in human neutrophils by high mobility group box 1 protein. Am. J. Physiol. Cell Physiol. 284(4): C870-C879. doi:10.1152/ajpcell.00322.2002. PMID:12620891.
49. Park, J.S., Gamboni-Robertson, F., He, Q., Svetkauskaite, D., Kim, J.Y., Strassheim, D., et al. 2006. High mobility group box 1 protein interacts with multiple Toll-like receptors. Am. J. Physiol. Cell Physiol. 290(3): C917-C924. doi:10.1152/ajpcell.00401.2005. PMID:16267105.
50. Pinsky, M.R., Vincent, J.L., Deviere, J., Alegre, M., Kahn, R.J., and Dupont, E. 1993. Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality. Chest, 103(2): 565-575. doi:10.1378/chest.103.2.565. PMID:8432155.
51. Prior, R.L., and Cao, G. 1999. Antioxidant capacity and polyphenolic components of teas: implications for altering in vivo antioxidant status. Proc. Soc. Exp. Biol. Med. 220(4): 255-261. doi:10.3181/00379727-220-44376. PMID:10202399.
52. Qin, Y.H., Dai, S.M., Tang, G.S., Zhang, J., Ren, D., Wang, Z.W., and Shen, Q. 2009. HMGB1 enhances the proinflammatory activity of lipopolysaccharide by promoting the phosphorylation of MAPK p38 through receptor for advanced glycationendproducts. J.Immunol.183(10):6244-6250.doi:10.4049/jimmunol.0900390. PMID:19890065.
53. Qureshi, S.H., Manithody, C., Bae, J.S., Yang, L., and Rezaie, A.R. 2008. Autolysis loop restricts the specificity of activated protein C: analysis by FRET and functional assays. Biophys. Chem. 134(3): 239-245. doi:10.1016/j.bpc.2008.02.012. PMID:18329782.
54. Rittirsch, D., Huber-Lang, M.S., Flierl, M.A., and Ward, P.A. 2009. Immunodesign of experimental sepsis by cecal ligation and puncture. Nat. Protoc. 4(1): 31-36. doi:10.1038/nprot.2008.214. PMID:19131954.
55. Rose, B.A., Force, T., and Wang, Y. 2010. Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale. Physiol. Rev. 90(4): 1507-1546. doi:10.1152/physrev.00054.2009. PMID:20959622.
56. Ruiz-Torres, M.P., Perez-Rivero, G., Rodriguez-Puyol, M., Rodriguez-Puyol, D., and Diez-Marques, M.L. 2006. The leukocyte-endothelial cell interactions are modulated by extracellular matrix proteins. Cell. Physiol. Biochem. 17(5-6): 221-232. doi:10.1159/000094127. PMID:16790998.
57. Sama, A.E., D’Amore, J., Ward, M.F., Chen, G., and Wang, H. 2004. Bench to bedside: HMGB1-a novel proinflammatory cytokine and potential therapeutic target for septic patients in the emergency department. Acad. Emerg. Med. 11(8): 867-873. doi:10.1197/j.aem.2004.03.011. PMID:15289194.
58. Sanchez, G.M., Re, L., Giuliani, A., Nunez-Selles, A.J., Davison, G.P., and Leon-Fernandez, O.S. 2000. Protective effects of Mangifera indica L. extract, mangiferin and selected antioxidants against TPA-induced biomolecules oxidation and peritoneal macrophage activation in mice. Pharmacol. Res. 42(6): 565-573. doi:10.1006/phrs.2000.0727. PMID:11058410.
59. Seo, K.H., Park, M.J., Ra, J.E., Han, S.I., Nam, M.H., Kim, J.H., et al. 2014. Saponarin from barley sprouts inhibits NF-kappaB and MAPK on LPS-induced RAW 264.7 cells. Food Funct. 5(11): 3005-3013. doi:10.1039/C4FO00612G. PMID: 25238253.
60. Sluiter, W., Pietersma, A., Lamers, J.M., and Koster, J.F. 1993. Leukocyte adhesion molecules on the vascular endothelium: their role in the pathogenesis of cardiovascular disease and the mechanisms underlying their expression. J. Cardiovasc. Pharmacol. 22(Suppl. 4): S37-S44. doi:10.1097/00005344-199322004-00006. PMID:7523771.
61. Spiecker, M., Darius, H., and Liao, J.K. 2000. A functional role of I kappa B-epsilonin endothelial cell activation. J. Immunol. 164(6): 3316-3322. doi:10.4049/jimmunol.164.6.3316. PMID:10706725.
62. Sun, C., Liang, C., Ren, Y., Zhen, Y., He, Z., Wang, H., et al. 2009. Advanced glycation end products depress function of endothelial progenitor cells via p38 and ERK 1/2 mitogen-activated protein kinase pathways. Basic Res. Cardiol. 104(1): 42-49. doi:10.1007/s00395-008-0738-8. PMID:18622638.
63. Sunden-Cullberg, J., Norrby-Teglund, A., Rouhiainen, A., Rauvala, H., Herman, G., Tracey, K.J., et al. 2005. Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock. Crit. Care Med. 33(3): 564-573. doi:10.1097/01.CCM.0000155991.88802.4D. PMID:15753748.
64. Takeda, R., Suzuki, E., Satonaka, H., Oba, S., Nishimatsu, H., Omata, M., et al. 2005. Blockade of endogenous cytokines mitigates neointimal formation in obese Zucker rats. Circulation, 111(11): 1398-1406. doi:10.1161/01.CIR.0000158482.83179.DB. PMID:15781751.
65. Tracey, K.J., Fong, Y., Hesse, D.G., Manogue, K.R., Lee, A.T., Kuo, G.C., et al. 1987. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature, 330(6149): 662-664. doi:10.1038/330662a0. PMID: 3317066.
66. Treutiger, C.J., Mullins, G.E., Johansson, A.S., Rouhiainen, A., Rauvala, H.M., Erlandsson-Harris, H., et al. 2003. High mobility group 1 B-box mediates activation ofhumanendothelium. J. Intern. Med. 254(4): 375-385. doi:10.1046/j.1365-2796.2003.01204.x. PMID:12974876.
67. Ulloa, L., and Tracey, K.J. 2005. The “cytokine profile”: a code for sepsis. Trends Mol. Med. 11(2): 56-63. doi:10.1016/j.molmed.2004.12.007. PMID:15694867.
68. Wang, H., Liao, H., Ochani, M., Justiniani, M., Lin, X., Yang, L., et al. 2004. Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat. Med. 10(11): 1216-1221. doi:10.1038/nm1124. PMID: 15502843.
69. Wang, S.C., Klein, R.D., Wahl, W.L., Alarcon, W.H., Garg, R.J., Remick, D.G., and Su, G.L. 1998. Tissue coexpression of LBP and CD14 mRNA in a mouse model of sepsis. J Surg. Res. 76(1): 67-73. doi:10.1006/jsre.1998.5290. PMID:9695742.
70. Wang, X., Feuerstein, G.Z., Gu, J.L., Lysko, P.G., and Yue, T.L. 1995. Interleukin-1 beta induces expression of adhesion molecules in human vascular smooth muscle cells and enhances adhesion of leukocytes to smooth muscle cells. Atherosclerosis, 115(1): 89-98. doi:10.1016/0021-9150(94)05503-B. PMID:7545398.
71. Warren, C.P. 1999. Antioxidant effects of herbs. Lancet, 353(9153): 676. doi:10.1016/S0140-6736(05)75477-5. PMID:10030367.
72. Wolfson, R.K., Chiang, E.T., and Garcia, J.G. 2011. HMGB1 induces human lung endothelial cell cytoskeletal rearrangement and barrier disruption. Microvasc. Res. 81(2): 189-197. doi:10.1016/j.mvr.2010.11.010. PMID:21146549.
73. Yang, H., and Tracey, K.J. 2010. Targeting HMGB1 in inflammation. Biochim. Biophys. Acta, 1799(1-2): 149-156. doi:10.1016/j.bbagrm.2009.11.049. PMID: 19948257.
74. Yang, H., Wang, H., Czura, C.J., and Tracey, K.J. 2005. The cytokine activity of HMGB1. J. Leukoc. Biol. 78(1): 1-8. doi:10.1189/jlb.1104648. PMID:15734795.
75. Yao, X., Zhao, G., Yang, H., Hong, X., Bie, L., and Liu, G. 2010. Overexpression of high-mobility group box 1 correlates with tumor progression and poor prognosis in human colorectal carcinoma. J. Cancer Res. Clin. Oncol. 136(5): 677-684. doi:10.1007/s00432-009-0706-1. PMID:19898867.
76. Yoo, H., Ku, S.K., Lee, T., and Bae, J.S. 2014. Orientin inhibits HMGB1-induced inflammatory responses in HUVECs and in murine polymicrobial sepsis. Inflammation, 37(5): 1705-1717. doi:10.1007/s10753-014-9899-9. PMID:24771074.