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Volumn 112, Issue 7, 2015, Pages 1141-1156

Proteomic and metabonomic biomarkers for hepatocellular carcinoma: A comprehensive review

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; BILE ACID; BIOLOGICAL MARKER; CARNITINE; ESTER DERIVATIVE; FATTY ACID; LYSOPHOSPHATIDYLCHOLINE; NUCLEOTIDE; PROTEIN DERIVATIVE; TUMOR MARKER;

EID: 84938529503     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2015.38     Document Type: Review
Times cited : (98)

References (103)
  • 1
    • 84862930256 scopus 로고    scopus 로고
    • A multiplex lectin-channel monitoring method for human serum glycoproteins by quantitative mass spectrometry
    • Ahn YH, Ji ES, Shin PM, Kim KH, Kim YS, Ko JH, Yoo JS (2012a) A multiplex lectin-channel monitoring method for human serum glycoproteins by quantitative mass spectrometry. Analyst 137: 691-703.
    • (2012) Analyst , vol.137 , pp. 691-703
    • Ahn, Y.H.1    Ji, E.S.2    Shin, P.M.3    Kim, K.H.4    Kim, Y.S.5    Ko, J.H.6    Yoo, J.S.7
  • 2
    • 84865540669 scopus 로고    scopus 로고
    • A lectin-coupled, targeted proteomic mass spectrometry (MRM MS) platform for identification of multiple liver cancer biomarkers in human plasma
    • Ahn YH, Shin PM, Oh NR, Park GW, Kim H, Yoo JS (2012b) A lectin-coupled, targeted proteomic mass spectrometry (MRM MS) platform for identification of multiple liver cancer biomarkers in human plasma. J Proteomics 75: 5507-5515.
    • (2012) J Proteomics , vol.75 , pp. 5507-5515
    • Ahn, Y.H.1    Shin, P.M.2    Oh, N.R.3    Park, G.W.4    Kim, H.5    Yoo, J.S.6
  • 3
    • 33750105559 scopus 로고    scopus 로고
    • Study of serum haptoglobin and its glycoforms in the diagnosis of hepatocellular carcinoma: A glycoproteomic approach
    • Ang IL, Poon TC, Lai PB, Chan AT, Ngai SM, Hui AY, Johnson PJ, Sung JJ (2006) Study of serum haptoglobin and its glycoforms in the diagnosis of hepatocellular carcinoma: a glycoproteomic approach. J Proteome Res 5: 2691-2700.
    • (2006) J Proteome Res , vol.5 , pp. 2691-2700
    • Ang, I.L.1    Poon, T.C.2    Lai, P.B.3    Chan, A.T.4    Ngai, S.M.5    Hui, A.Y.6    Johnson, P.J.7    Sung, J.J.8
  • 11
    • 84879605962 scopus 로고    scopus 로고
    • Tissue metabolomics of hepatocellular carcinoma: Tumor energy metabolism and the role of transcriptomic classification
    • Beyoʇlu D, Imbeaud S, Maurhofer O, Bioulac-Sage P, Zucman-Rossi J, Dufour JF, Idle JR (2013) Tissue metabolomics of hepatocellular carcinoma: tumor energy metabolism and the role of transcriptomic classification. Hepatology 58: 229-238.
    • (2013) Hepatology , vol.58 , pp. 229-238
    • Beyoʇlu, D.1    Imbeaud, S.2    Maurhofer, O.3    Bioulac-Sage, P.4    Zucman-Rossi, J.5    Dufour, J.F.6    Idle, J.R.7
  • 16
    • 79952231921 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma: An update
    • Bruix J, Sherman M. American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma: an update (2011) Hepatology 53: 1020-1022.
    • (2011) Hepatology , vol.53 , pp. 1020-1022
    • Bruix, J.1    Sherman, M.2
  • 17
    • 30544442097 scopus 로고    scopus 로고
    • Acetylcarnitine and cellular stress response: Roles in nutritional redox homeostasis and regulation of longevity genes
    • Calabrese V, Giuffrida Stella AM, Calvani M, Butterfield DA (2006) Acetylcarnitine and cellular stress response: roles in nutritional redox homeostasis and regulation of longevity genes. J Nutr Biochem 17: 73-88.
    • (2006) J Nutr Biochem , vol.17 , pp. 73-88
    • Calabrese, V.1    Giuffrida Stella, A.M.2    Calvani, M.3    Butterfield, D.A.4
  • 19
    • 80255124795 scopus 로고    scopus 로고
    • Identification of serum biomarkers of hepatocarcinoma through liquid chromatography/mass spectrometry-based metabonomic method
    • Chen F, Xue J, Zhou L, Wu S, Chen Z (2011a) Identification of serum biomarkers of hepatocarcinoma through liquid chromatography/mass spectrometry-based metabonomic method. Anal Bioanal Chem 401: 1899-1904.
    • (2011) Anal Bioanal Chem , vol.401 , pp. 1899-1904
    • Chen, F.1    Xue, J.2    Zhou, L.3    Wu, S.4    Chen, Z.5
  • 20
    • 69249140995 scopus 로고    scopus 로고
    • Metabonomics study of liver cancer based on ultra performance liquid chromatography coupled to mass spectrometry with HILIC and RPLC separations
    • Chen J, Wang W, Lv S, Yin P, Zhao X, Lu X, Zhang F, Xu G (2009) Metabonomics study of liver cancer based on ultra performance liquid chromatography coupled to mass spectrometry with HILIC and RPLC separations. Anal Chim Acta 650: 3-9.
    • (2009) Anal Chim Acta , vol.650 , pp. 3-9
    • Chen, J.1    Wang, W.2    Lv, S.3    Yin, P.4    Zhao, X.5    Lu, X.6    Zhang, F.7    Xu, G.8
  • 21
    • 84883486388 scopus 로고    scopus 로고
    • Pseudotargeted metabolomics method and its application in serum biomarker discovery for hepatocellular carcinoma based on ultra high-performance liquid chromatography/triple quadrupole mass spectrometry
    • Chen S, Kong H, Lu X, Li Y, Yin P, Zeng Z, Xu G (2013a) Pseudotargeted metabolomics method and its application in serum biomarker discovery for hepatocellular carcinoma based on ultra high-performance liquid chromatography/triple quadrupole mass spectrometry. Anal Chem 85: 8326-8333.
    • (2013) Anal Chem , vol.85 , pp. 8326-8333
    • Chen, S.1    Kong, H.2    Lu, X.3    Li, Y.4    Yin, P.5    Zeng, Z.6    Xu, G.7
  • 22
    • 84884978238 scopus 로고    scopus 로고
    • Serum lipid profiling of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma by ultra fast LC/IT-TOF MS
    • Chen S, Yin P, Zhao X, Xing W, Hu C, Zhou L, Xu G (2013b) Serum lipid profiling of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma by ultra fast LC/IT-TOF MS. Electrophoresis 34: 2848-2856.
    • (2013) Electrophoresis , vol.34 , pp. 2848-2856
    • Chen, S.1    Yin, P.2    Zhao, X.3    Xing, W.4    Hu, C.5    Zhou, L.6    Xu, G.7
  • 24
    • 84867204808 scopus 로고    scopus 로고
    • Differences between the metabolic profiles of decompensated and compensated cirrhosis patients with hepatitis B virus infections under high-performance liquid chromatography-mass spectrometry
    • Chen Y, Xu Z, Kong H, Chen N, Chen J, Zhou L, Wang F, Dong Y, Zheng S, Chen Z, Xu G, Li L (2012) Differences between the metabolic profiles of decompensated and compensated cirrhosis patients with hepatitis B virus infections under high-performance liquid chromatography-mass spectrometry. Metabolomics 8(5): 845-853.
    • (2012) Metabolomics , vol.8 , Issue.5 , pp. 845-853
    • Chen, Y.1    Xu, Z.2    Kong, H.3    Chen, N.4    Chen, J.5    Zhou, L.6    Wang, F.7    Dong, Y.8    Zheng, S.9    Chen, Z.10    Xu, G.11    Li, L.12
  • 27
    • 0024834475 scopus 로고
    • Alterations of serum and urinary carnitine profiles in cancer patients: Hypothesis of possible significance
    • Dodson WL, Sachan DS, Krauss S, Hanna W (1989) Alterations of serum and urinary carnitine profiles in cancer patients: hypothesis of possible significance. J Am Coll Nutr 8: 133-142.
    • (1989) J Am Coll Nutr , vol.8 , pp. 133-142
    • Dodson, W.L.1    Sachan, D.S.2    Krauss, S.3    Hanna, W.4
  • 28
    • 78650102876 scopus 로고    scopus 로고
    • Clinical significance of plasma osteopontin level in Egyptian patients with hepatitis C virus-related hepatocellular carcinoma
    • El-Din Bessa SS, Elwan NM, Suliman GA, El-Shourbagy SH (2010) Clinical significance of plasma osteopontin level in Egyptian patients with hepatitis C virus-related hepatocellular carcinoma. Arch Med Res 41: 541-547.
    • (2010) Arch Med Res , vol.41 , pp. 541-547
    • El-Din Bessa, S.S.1    Elwan, N.M.2    Suliman, G.A.3    El-Shourbagy, S.H.4
  • 29
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
    • El-Serag HB, Rudolph KL (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132: 2557-2576.
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 30
    • 84858658381 scopus 로고    scopus 로고
    • EASL-EORTC clinical practice guidelines: Management of hepatocellular carcinoma
    • European Association for the Study of the LiverEuropean Organisation for Research and Treatment of Cancer
    • European Association for the Study of the LiverEuropean Organisation for Research and Treatment of Cancer (2012) EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol 56: 908-943.
    • (2012) J Hepatol , vol.56 , pp. 908-943
  • 37
    • 67449085093 scopus 로고    scopus 로고
    • Application of 1H NMR-based metabonomics in the study of metabolic profiling of human hepatocellular carcinoma and liver cirrhosis
    • Gao H, Lu Q, Liu X, Cong H, Zhao L, Wang H, Lin D (2009) Application of 1H NMR-based metabonomics in the study of metabolic profiling of human hepatocellular carcinoma and liver cirrhosis. Cancer Sci 100: 782-785.
    • (2009) Cancer Sci , vol.100 , pp. 782-785
    • Gao, H.1    Lu, Q.2    Liu, X.3    Cong, H.4    Zhao, L.5    Wang, H.6    Lin, D.7
  • 39
    • 39049137614 scopus 로고    scopus 로고
    • Toward the proteomic identification of biomarkers for the prediction of HBV related hepatocellular carcinoma
    • He QY, Zhu R, Lei T, Ng MY, Luk JM, Sham P, Lau GK, Chiu JF (2008) Toward the proteomic identification of biomarkers for the prediction of HBV related hepatocellular carcinoma. J Cell Biochem 103: 740-752.
    • (2008) J Cell Biochem , vol.103 , pp. 740-752
    • He, Q.Y.1    Zhu, R.2    Lei, T.3    Ng, M.Y.4    Luk, J.M.5    Sham, P.6    Lau, G.K.7    Chiu, J.F.8
  • 41
    • 33644827806 scopus 로고    scopus 로고
    • Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor
    • Hoi PM, Hiley CR (2006) Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor. Br J Pharmacol 147: 560-568.
    • (2006) Br J Pharmacol , vol.147 , pp. 560-568
    • Hoi, P.M.1    Hiley, C.R.2
  • 42
    • 0037385059 scopus 로고    scopus 로고
    • The role of carnitine in normal and altered fatty acid metabolism
    • Hoppel C (2003) The role of carnitine in normal and altered fatty acid metabolism. Am J Kidney Dis 41: S4-S12.
    • (2003) Am J Kidney Dis , vol.41 , pp. S4-S12
    • Hoppel, C.1
  • 43
    • 80053897654 scopus 로고    scopus 로고
    • Secreted ERBB3 isoforms are serum markers for early hepatoma in patients with chronic hepatitis and cirrhosis
    • Hsieh SY, He JR, Yu MC, Lee WC, Chen TC, Lo SJ, Bera R, Sung CM, Chiu CT (2011) Secreted ERBB3 isoforms are serum markers for early hepatoma in patients with chronic hepatitis and cirrhosis. J Proteome Res 10: 4715-4724.
    • (2011) J Proteome Res , vol.10 , pp. 4715-4724
    • Hsieh, S.Y.1    He, J.R.2    Yu, M.C.3    Lee, W.C.4    Chen, T.C.5    Lo, S.J.6    Bera, R.7    Sung, C.M.8    Chiu, C.T.9
  • 44
    • 84882632229 scopus 로고    scopus 로고
    • Metabolic characterization of hepatocellular carcinoma using non-targeted tissue metabolomics
    • Huang Q, Tan Y, Yin P, Ye G, Gao P, Lu X, Wang H, Xu G (2013) Metabolic characterization of hepatocellular carcinoma using non-targeted tissue metabolomics. Cancer Res 73: 4992-5002.
    • (2013) Cancer Res , vol.73 , pp. 4992-5002
    • Huang, Q.1    Tan, Y.2    Yin, P.3    Ye, G.4    Gao, P.5    Lu, X.6    Wang, H.7    Xu, G.8
  • 45
    • 80052024809 scopus 로고    scopus 로고
    • Development of quantitative plasma N-glycoproteomics using label-free 2-D LC-MALDI MS and its applicability for biomarker discovery in hepatocellular carcinoma
    • Ishihara T, Fukuda I, Morita A, Takinami Y, Okamoto H, Nishimura S, Numata Y (2011) Development of quantitative plasma N-glycoproteomics using label-free 2-D LC-MALDI MS and its applicability for biomarker discovery in hepatocellular carcinoma. J Proteomics 74: 2159-2168.
    • (2011) J Proteomics , vol.74 , pp. 2159-2168
    • Ishihara, T.1    Fukuda, I.2    Morita, A.3    Takinami, Y.4    Okamoto, H.5    Nishimura, S.6    Numata, Y.7
  • 46
    • 77954620003 scopus 로고    scopus 로고
    • Serum protein biomarkers screening in HCC patients with liver cirrhosis by ICAT-LC-MS/MS
    • Kang X, Sun L, Guo K, Shu H, Yao J, Qin X, Liu Y (2010) Serum protein biomarkers screening in HCC patients with liver cirrhosis by ICAT-LC-MS/MS. J Cancer Res Clin Oncol 136: 1151-1159.
    • (2010) J Cancer Res Clin Oncol , vol.136 , pp. 1151-1159
    • Kang, X.1    Sun, L.2    Guo, K.3    Shu, H.4    Yao, J.5    Qin, X.6    Liu, Y.7
  • 49
    • 0030569025 scopus 로고    scopus 로고
    • Carnitine metabolism in chronic liver disease
    • Krähenbühl S (1996) Carnitine metabolism in chronic liver disease. Life Sci 59: 1579-1599.
    • (1996) Life Sci , vol.59 , pp. 1579-1599
    • Krähenbühl, S.1
  • 52
    • 33646730482 scopus 로고    scopus 로고
    • Identification of complement C3a as a candidate biomarker in human chronic hepatitis C and HCV-related hepatocellular carcinoma using a proteomics approach
    • Lee IN, Chen CH, Sheu JC, Lee HS, Huang GT, Chen DS, Yu CY, Wen CL, Lu FJ, Chow LP (2006) Identification of complement C3a as a candidate biomarker in human chronic hepatitis C and HCV-related hepatocellular carcinoma using a proteomics approach. Proteomics 6: 2865-2873.
    • (2006) Proteomics , vol.6 , pp. 2865-2873
    • Lee, I.N.1    Chen, C.H.2    Sheu, J.C.3    Lee, H.S.4    Huang, G.T.5    Chen, D.S.6    Yu, C.Y.7    Wen, C.L.8    Lu, F.J.9    Chow, L.P.10
  • 53
    • 83055168517 scopus 로고    scopus 로고
    • Targeted mass spectrometric approach for biomarker discovery and validation with nonglycosylated tryptic peptides from N-linked glycoproteins in human plasma
    • Lee JY, Kim JY, Park GW, Cheon MH, Kwon KH, Ahn YH, Moon MH, Lee HJ, Paik YK, Yoo JS (2011) Targeted mass spectrometric approach for biomarker discovery and validation with nonglycosylated tryptic peptides from N-linked glycoproteins in human plasma. Mol Cell Proteomics 10: M111 009290.
    • (2011) Mol Cell Proteomics , vol.10 , pp. M111009290
    • Lee, J.Y.1    Kim, J.Y.2    Park, G.W.3    Cheon, M.H.4    Kwon, K.H.5    Ahn, Y.H.6    Moon, M.H.7    Lee, H.J.8    Paik, Y.K.9    Yoo, J.S.10
  • 54
    • 77957265728 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2 and lysophospholipids in tumor angiogenesis
    • Linkous AG, Yazlovitskaya EM, Hallahan DE (2010) Cytosolic phospholipase A2 and lysophospholipids in tumor angiogenesis. J Natl Cancer Inst 102: 1398-1412.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 1398-1412
    • Linkous, A.G.1    Yazlovitskaya, E.M.2    Hallahan, D.E.3
  • 55
    • 38649141497 scopus 로고    scopus 로고
    • Sustained complete response and complications rates after radiofrequency ablation of very early hepatocellular carcinoma in cirrhosis: Is resection still the treatment of choice?
    • Livraghi T, Meloni F, Di Stasi M, Rolle E, Solbiati L, Tinelli C, Rossi S (2008) Sustained complete response and complications rates after radiofrequency ablation of very early hepatocellular carcinoma in cirrhosis: is resection still the treatment of choice? Hepatology 47: 82-89.
    • (2008) Hepatology , vol.47 , pp. 82-89
    • Livraghi, T.1    Meloni, F.2    Di Stasi, M.3    Rolle, E.4    Solbiati, L.5    Tinelli, C.6    Rossi, S.7
  • 56
    • 0037308133 scopus 로고    scopus 로고
    • Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival
    • Llovet JM, Bruix J (2003) Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival. Hepatology 37: 429-442.
    • (2003) Hepatology , vol.37 , pp. 429-442
    • Llovet, J.M.1    Bruix, J.2
  • 57
    • 77957725789 scopus 로고    scopus 로고
    • Peroxiredoxin 2: A potential biomarker for early diagnosis of hepatitis B virus related liver fibrosis identified by proteomic analysis of the plasma
    • Lu Y, Liu J, Lin C, Wang H, Jiang Y, Wang J, Yang P, He F (2010) Peroxiredoxin 2: a potential biomarker for early diagnosis of hepatitis B virus related liver fibrosis identified by proteomic analysis of the plasma. BMC Gastroenterol 10: 115.
    • (2010) BMC Gastroenterol , vol.10 , pp. 115
    • Lu, Y.1    Liu, J.2    Lin, C.3    Wang, H.4    Jiang, Y.5    Wang, J.6    Yang, P.7    He, F.8
  • 59
    • 84858077778 scopus 로고    scopus 로고
    • Carnitine derivatives: Clinical usefulness
    • Malaguarnera M (2012) Carnitine derivatives: clinical usefulness. Curr Opin Gastroenterol 28: 166-176.
    • (2012) Curr Opin Gastroenterol , vol.28 , pp. 166-176
    • Malaguarnera, M.1
  • 61
    • 84864438094 scopus 로고    scopus 로고
    • New serum markers of hepatocellular carcinoma
    • Masuzaki R, Karp SJ, Omata M (2012) New serum markers of hepatocellular carcinoma. Semin Oncol 39: 434-439.
    • (2012) Semin Oncol , vol.39 , pp. 434-439
    • Masuzaki, R.1    Karp, S.J.2    Omata, M.3
  • 62
    • 67650945240 scopus 로고    scopus 로고
    • A pilot study of proteomic profiles of human hepatocellular carcinoma in the United States
    • Matos JM, Witzmann FA, Cummings OW, Schmidt CM (2009) A pilot study of proteomic profiles of human hepatocellular carcinoma in the United States. J Surg Res 155: 237-243.
    • (2009) J Surg Res , vol.155 , pp. 237-243
    • Matos, J.M.1    Witzmann, F.A.2    Cummings, O.W.3    Schmidt, C.M.4
  • 70
    • 77950839180 scopus 로고    scopus 로고
    • Identification of b2-microgloblin as a candidate for early diagnosis of imaging-invisible hepatocellular carcinoma in patient with liver cirrhosis
    • Saito Y, Oba N, Nishinakagawa S, Mizuguchi Y, Kojima T, Nomura K, Nakatsura T (2010) Identification of b2-microgloblin as a candidate for early diagnosis of imaging-invisible hepatocellular carcinoma in patient with liver cirrhosis. Oncol Rep 23: 1325-1330.
    • (2010) Oncol Rep , vol.23 , pp. 1325-1330
    • Saito, Y.1    Oba, N.2    Nishinakagawa, S.3    Mizuguchi, Y.4    Kojima, T.5    Nomura, K.6    Nakatsura, T.7
  • 72
    • 39049175370 scopus 로고    scopus 로고
    • Protein identification by tandem mass spectrometry and sequence database searching
    • Nesvizhskii AI (2007) Protein identification by tandem mass spectrometry and sequence database searching. Methods Mol Biol 367: 87-119.
    • (2007) Methods Mol Biol , vol.367 , pp. 87-119
    • Nesvizhskii, A.I.1
  • 73
    • 70450225591 scopus 로고    scopus 로고
    • Urinary creatinine excretion, an indirect measure of muscle mass, is an independent predictor of cardiovascular disease and mortality in the general population
    • Oterdoom LH, Gansevoort RT, Schouten JP, de Jong PE, Gans RO, Bakker SJ (2009) Urinary creatinine excretion, an indirect measure of muscle mass, is an independent predictor of cardiovascular disease and mortality in the general population. Atherosclerosis 207: 534-540.
    • (2009) Atherosclerosis , vol.207 , pp. 534-540
    • Oterdoom, L.H.1    Gansevoort, R.T.2    Schouten, J.P.3    De Jong, P.E.4    Gans, R.O.5    Bakker, S.J.6
  • 76
    • 0017801514 scopus 로고
    • Physiological factors influencing serum bile acid levels
    • Ponz De Leon M, Murphy GM, Dowling RH (1978) Physiological factors influencing serum bile acid levels. Gut 19: 32-39.
    • (1978) Gut , vol.19 , pp. 32-39
    • Ponz De Leon, M.1    Murphy, G.M.2    Dowling, R.H.3
  • 82
    • 1242316198 scopus 로고    scopus 로고
    • Ultra-high-efficiency strong cation exchange LC/RPLC/MS/MS for high dynamic range characterization of the human plasma proteome
    • Shen Y, Jacobs JM, Camp 2nd DG, Fang R, Moore RJ, Smith RD, Xiao W, Davis RW, Tompkins RG (2004) Ultra-high-efficiency strong cation exchange LC/RPLC/MS/MS for high dynamic range characterization of the human plasma proteome. Anal Chem 76: 1134-1144.
    • (2004) Anal Chem , vol.76 , pp. 1134-1144
    • Shen, Y.1    Jacobs, J.M.2    Camp, D.G.3    Fang, R.4    Moore, R.J.5    Smith, R.D.6    Xiao, W.7    Davis, R.W.8    Tompkins, R.G.9
  • 83
    • 0038555469 scopus 로고    scopus 로고
    • A strategy for the comparative analysis of serum proteomes for the discovery of biomarkers for hepatocellular carcinoma
    • Steel LF, Shumpert D, Trotter M, Seeholzer SH, Evans AA, London WT, Dwek R, Block TM (2003) A strategy for the comparative analysis of serum proteomes for the discovery of biomarkers for hepatocellular carcinoma. Proteomics 3: 601-609.
    • (2003) Proteomics , vol.3 , pp. 601-609
    • Steel, L.F.1    Shumpert, D.2    Trotter, M.3    Seeholzer, S.H.4    Evans, A.A.5    London, W.T.6    Dwek, R.7    Block, T.M.8
  • 84
    • 77950647292 scopus 로고    scopus 로고
    • Proteomics of hepatocellular carcinoma: Serum vimentin as a surrogate marker for small tumors (oor = 2 cm)
    • Sun S, Poon RT, Lee NP, Yeung C, Chan KL, Ng IO, Day PJ, Luk JM (2010a) Proteomics of hepatocellular carcinoma: serum vimentin as a surrogate marker for small tumors (oor = 2 cm). J Proteome Res 9: 1923-1930.
    • (2010) J Proteome Res , vol.9 , pp. 1923-1930
    • Sun, S.1    Poon, R.T.2    Lee, N.P.3    Yeung, C.4    Chan, K.L.5    Ng, I.O.6    Day, P.J.7    Luk, J.M.8
  • 85
    • 55249094350 scopus 로고    scopus 로고
    • Quantitative proteomic signature of liver cancer cells: Tissue transglutaminase 2 could be a novel protein candidate of human hepatocellular carcinoma
    • Sun Y, Mi W, Cai J, Ying W, Liu F, Lu H, Qiao Y, Jia W, Bi X, Lu N, Liu S, Qian X, Zhao X (2008) Quantitative proteomic signature of liver cancer cells: tissue transglutaminase 2 could be a novel protein candidate of human hepatocellular carcinoma. J Proteome Res 7: 3847-3859.
    • (2008) J Proteome Res , vol.7 , pp. 3847-3859
    • Sun, Y.1    Mi, W.2    Cai, J.3    Ying, W.4    Liu, F.5    Lu, H.6    Qiao, Y.7    Jia, W.8    Bi, X.9    Lu, N.10    Liu, S.11    Qian, X.12    Zhao, X.13
  • 86
    • 77951905695 scopus 로고    scopus 로고
    • Differential proteomics identification of HSP90 as potential serum biomarker in hepatocellular carcinoma by two-dimensional electrophoresis and mass spectrometry
    • Sun Y, Zang Z, Xu X, Zhang Z, Zhong L, Zan W, Zhao Y, Sun L (2010b) Differential proteomics identification of HSP90 as potential serum biomarker in hepatocellular carcinoma by two-dimensional electrophoresis and mass spectrometry. Int J Mol Sci 11: 1423-1433.
    • (2010) Int J Mol Sci , vol.11 , pp. 1423-1433
    • Sun, Y.1    Zang, Z.2    Xu, X.3    Zhang, Z.4    Zhong, L.5    Zan, W.6    Zhao, Y.7    Sun, L.8
  • 87
    • 34547740606 scopus 로고    scopus 로고
    • Plasma lyso-phosphatidylcholine concentration is decreased in cancer patients with weight loss and activated inflammatory status
    • Taylor LA, Arends J, Hodina AK, Unger C, Massing U (2007) Plasma lyso-phosphatidylcholine concentration is decreased in cancer patients with weight loss and activated inflammatory status. Lipids Health Dis 6: 17.
    • (2007) Lipids Health Dis , vol.6 , pp. 17
    • Taylor, L.A.1    Arends, J.2    Hodina, A.K.3    Unger, C.4    Massing, U.5
  • 90
    • 84863042105 scopus 로고    scopus 로고
    • Metabonomic profiles discriminate hepatocellular carcinoma from liver cirrhosis by ultraperformance liquid chromatography-mass spectrometry
    • Wang B, Chen D, Chen Y, Hu Z, Cao M, Xie Q, Chen Y, Xu J, Zheng S, Li L (2012) Metabonomic profiles discriminate hepatocellular carcinoma from liver cirrhosis by ultraperformance liquid chromatography-mass spectrometry. J Proteome Res 11: 1217-1227.
    • (2012) J Proteome Res , vol.11 , pp. 1217-1227
    • Wang, B.1    Chen, D.2    Chen, Y.3    Hu, Z.4    Cao, M.5    Xie, Q.6    Chen, Y.7    Xu, J.8    Zheng, S.9    Li, L.10
  • 92
    • 84886752754 scopus 로고    scopus 로고
    • Differentiating hepatocellular carcinoma from hepatitis C using metabolite profiling
    • Wei S, Suryani Y, Gowda GA, Skill N, Maluccio M, Raftery D (2012) Differentiating hepatocellular carcinoma from hepatitis C using metabolite profiling. Metabolites 2: 701-716.
    • (2012) Metabolites , vol.2 , pp. 701-716
    • Wei, S.1    Suryani, Y.2    Gowda, G.A.3    Skill, N.4    Maluccio, M.5    Raftery, D.6
  • 93
    • 67650388695 scopus 로고    scopus 로고
    • Metabolomic profiling of human urine in hepatocellular carcinoma patients using gas chromatography/mass spectrometry
    • Wu H, Xue R, Dong L, Liu T, Deng C, Zeng H, Shen X (2009) Metabolomic profiling of human urine in hepatocellular carcinoma patients using gas chromatography/mass spectrometry. Anal Chim Acta 648: 98-104.
    • (2009) Anal Chim Acta , vol.648 , pp. 98-104
    • Wu, H.1    Xue, R.2    Dong, L.3    Liu, T.4    Deng, C.5    Zeng, H.6    Shen, X.7
  • 94
    • 84863016061 scopus 로고    scopus 로고
    • Comparative proteomic studies of serum from patients with hepatocellular carcinoma
    • Wu W, Li J, Liu Y, Zhang C, Meng X, Zhou Z (2012) Comparative proteomic studies of serum from patients with hepatocellular carcinoma. J Invest Surg 25: 37-42.
    • (2012) J Invest Surg , vol.25 , pp. 37-42
    • Wu, W.1    Li, J.2    Liu, Y.3    Zhang, C.4    Meng, X.5    Zhou, Z.6
  • 96
    • 56149092963 scopus 로고    scopus 로고
    • A serum metabolomic investigation on hepatocellular carcinoma patients by chemical derivatization followed by gas chromatography/mass spectrometry
    • Xue R, Lin Z, Deng C, Dong L, Liu T, Wang J, Shen X (2008) A serum metabolomic investigation on hepatocellular carcinoma patients by chemical derivatization followed by gas chromatography/mass spectrometry. Rapid communications in mass spectrometry: RCM 22: 3061-3068.
    • (2008) Rapid Communications in Mass Spectrometry: RCM , vol.22 , pp. 3061-3068
    • Xue, R.1    Lin, Z.2    Deng, C.3    Dong, L.4    Liu, T.5    Wang, J.6    Shen, X.7
  • 97
    • 34248230200 scopus 로고    scopus 로고
    • Identification of human hepatocellular carcinoma-related proteins by proteomic approaches
    • Yang MH, Tyan YC, Jong SB, Huang YF, Liao PC, Wang MC (2007a) Identification of human hepatocellular carcinoma-related proteins by proteomic approaches. Anal Bioanal Chem 388: 637-643.
    • (2007) Anal Bioanal Chem , vol.388 , pp. 637-643
    • Yang, M.H.1    Tyan, Y.C.2    Jong, S.B.3    Huang, Y.F.4    Liao, P.C.5    Wang, M.C.6
  • 98
    • 34547171180 scopus 로고    scopus 로고
    • Metabonomic studies of human hepatocellular carcinoma using high-resolution magic-angle spinning 1H NMR spectroscopy in conjunction with multivariate data analysis
    • Yang Y, Li C, Nie X, Feng X, Chen W, Yue Y, Tang H, Deng F (2007b) Metabonomic studies of human hepatocellular carcinoma using high-resolution magic-angle spinning 1H NMR spectroscopy in conjunction with multivariate data analysis. J Proteome Res 6: 2605-2614.
    • (2007) J Proteome Res , vol.6 , pp. 2605-2614
    • Yang, Y.1    Li, C.2    Nie, X.3    Feng, X.4    Chen, W.5    Yue, Y.6    Tang, H.7    Deng, F.8
  • 99
    • 70349321699 scopus 로고    scopus 로고
    • A metabonomic study of hepatitis B-induced liver cirrhosis and hepatocellular carcinoma by using RP-LC and HILIC coupled with mass spectrometry
    • Yin P, Wan D, Zhao C, Chen J, Zhao X, Wang W, Lu X, Yang S, Gu J, Xu G (2009) A metabonomic study of hepatitis B-induced liver cirrhosis and hepatocellular carcinoma by using RP-LC and HILIC coupled with mass spectrometry. Mol Biosyst 5: 868-876.
    • (2009) Mol Biosyst , vol.5 , pp. 868-876
    • Yin, P.1    Wan, D.2    Zhao, C.3    Chen, J.4    Zhao, X.5    Wang, W.6    Lu, X.7    Yang, S.8    Gu, J.9    Xu, G.10
  • 100
    • 84873269399 scopus 로고    scopus 로고
    • Urinary metabolic profiling identifies a key role for glycocholic acid in human liver cancer by ultra-performance liquid-chromatography coupled with high-definition mass spectrometry
    • Zhang A, Sun H, Yan G, Han Y, Ye Y, Wang X (2013) Urinary metabolic profiling identifies a key role for glycocholic acid in human liver cancer by ultra-performance liquid-chromatography coupled with high-definition mass spectrometry. Clin Chim Acta 418: 86-90.
    • (2013) Clin Chim Acta , vol.418 , pp. 86-90
    • Zhang, A.1    Sun, H.2    Yan, G.3    Han, Y.4    Ye, Y.5    Wang, X.6
  • 101
    • 77954573328 scopus 로고    scopus 로고
    • Combination of improved (18)O incorporation and multiple reaction monitoring: A universal strategy for absolute quantitative verification of serum candidate biomarkers of liver cancer
    • Zhao Y, Jia W, Sun W, Jin W, Guo L, Wei J, Ying W, Zhang Y, Xie Y, Jiang Y, He F, Qian X (2010) Combination of improved (18)O incorporation and multiple reaction monitoring: a universal strategy for absolute quantitative verification of serum candidate biomarkers of liver cancer. J Proteome Res 9: 3319-3327.
    • (2010) J Proteome Res , vol.9 , pp. 3319-3327
    • Zhao, Y.1    Jia, W.2    Sun, W.3    Jin, W.4    Guo, L.5    Wei, J.6    Ying, W.7    Zhang, Y.8    Xie, Y.9    Jiang, Y.10    He, F.11    Qian, X.12
  • 102
    • 84868323261 scopus 로고    scopus 로고
    • Serum metabolic profiling study of hepatocellular carcinoma infected with hepatitis B or hepatitis C virus by using liquid chromatography-mass spectrometry
    • Zhou L, Ding L, Yin P, Lu X, Wang X, Niu J, Gao P, Xu G (2012a) Serum metabolic profiling study of hepatocellular carcinoma infected with hepatitis B or hepatitis C virus by using liquid chromatography-mass spectrometry. J Proteome Res 11: 5433-5442.
    • (2012) J Proteome Res , vol.11 , pp. 5433-5442
    • Zhou, L.1    Ding, L.2    Yin, P.3    Lu, X.4    Wang, X.5    Niu, J.6    Gao, P.7    Xu, G.8
  • 103
    • 84862786784 scopus 로고    scopus 로고
    • Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases
    • Zhou L, Wang Q, Yin P, Xing W, Wu Z, Chen S, Lu X, Zhang Y, Lin X, Xu G (2012b) Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases. Anal Bioanal Chem 403: 203-213.
    • (2012) Anal Bioanal Chem , vol.403 , pp. 203-213
    • Zhou, L.1    Wang, Q.2    Yin, P.3    Xing, W.4    Wu, Z.5    Chen, S.6    Lu, X.7    Zhang, Y.8    Lin, X.9    Xu, G.10


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