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Volumn 78, Issue , 2015, Pages 87-93

Multiple roles of tumor necrosis factor-alpha in fracture healing

Author keywords

Bone healing; Metabolic bone disease; TNF

Indexed keywords

INTERLEUKIN 1BETA; LYMPHOTOXIN; TUMOR NECROSIS FACTOR ALPHA; TNF PROTEIN, HUMAN; TUMOR NECROSIS FACTOR;

EID: 84938503765     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2015.05.001     Document Type: Review
Times cited : (60)

References (87)
  • 1
    • 22544481349 scopus 로고    scopus 로고
    • The course of bone healing is influenced by the initial shear fixation stability
    • Schell H., et al. The course of bone healing is influenced by the initial shear fixation stability. J Orthop Res 2005, 23(5):1022-1028.
    • (2005) J Orthop Res , vol.23 , Issue.5 , pp. 1022-1028
    • Schell, H.1
  • 2
    • 0037869486 scopus 로고    scopus 로고
    • The initial phase of fracture healing is specifically sensitive to mechanical conditions
    • Klein P., et al. The initial phase of fracture healing is specifically sensitive to mechanical conditions. J Orthop Res 2003, 21(4):662-669.
    • (2003) J Orthop Res , vol.21 , Issue.4 , pp. 662-669
    • Klein, P.1
  • 3
    • 18244379581 scopus 로고    scopus 로고
    • Initial vascularization and tissue differentiation are influenced by fixation stability
    • Lienau J., et al. Initial vascularization and tissue differentiation are influenced by fixation stability. J Orthop Res 2005, 23(3):639-645.
    • (2005) J Orthop Res , vol.23 , Issue.3 , pp. 639-645
    • Lienau, J.1
  • 4
    • 0031296497 scopus 로고    scopus 로고
    • Wound healing in sepsis and trauma
    • Thornton F.J., Schaffer M.R., Barbul A. Wound healing in sepsis and trauma. Shock 1997, 8(6):391-401.
    • (1997) Shock , vol.8 , Issue.6 , pp. 391-401
    • Thornton, F.J.1    Schaffer, M.R.2    Barbul, A.3
  • 5
    • 79957809134 scopus 로고    scopus 로고
    • The biology of fracture healing
    • Marsell R., Einhorn T.A. The biology of fracture healing. Injury 2011, 42(6):551-555.
    • (2011) Injury , vol.42 , Issue.6 , pp. 551-555
    • Marsell, R.1    Einhorn, T.A.2
  • 6
    • 0034999587 scopus 로고    scopus 로고
    • Expression of osteoprotegerin, receptor activator of NF-kappaB ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing
    • Kon T., et al. Expression of osteoprotegerin, receptor activator of NF-kappaB ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing. J Bone Miner Res 2001, 16(6):1004-1014.
    • (2001) J Bone Miner Res , vol.16 , Issue.6 , pp. 1004-1014
    • Kon, T.1
  • 7
    • 77953402288 scopus 로고    scopus 로고
    • Restoration of regenerative osteoblastogenesis in aged mice: modulation of TNF
    • Wahl E.C., et al. Restoration of regenerative osteoblastogenesis in aged mice: modulation of TNF. J Bone Miner Res 2010, 25(1):114-123.
    • (2010) J Bone Miner Res , vol.25 , Issue.1 , pp. 114-123
    • Wahl, E.C.1
  • 8
    • 0042978778 scopus 로고    scopus 로고
    • Impaired fracture healing in the absence of TNF-alpha signaling: the role of TNF-alpha in endochondral cartilage resorption
    • Gerstenfeld L.C., et al. Impaired fracture healing in the absence of TNF-alpha signaling: the role of TNF-alpha in endochondral cartilage resorption. J Bone Miner Res 2003, 18(9):1584-1592.
    • (2003) J Bone Miner Res , vol.18 , Issue.9 , pp. 1584-1592
    • Gerstenfeld, L.C.1
  • 10
    • 0029102852 scopus 로고
    • The expression of cytokine activity by fracture callus
    • Einhorn T.A., et al. The expression of cytokine activity by fracture callus. J Bone Miner Res 1995, 10(8):1272-1281.
    • (1995) J Bone Miner Res , vol.10 , Issue.8 , pp. 1272-1281
    • Einhorn, T.A.1
  • 11
    • 0033860607 scopus 로고    scopus 로고
    • Is human fracture hematoma inherently angiogenic?
    • Street J., et al. Is human fracture hematoma inherently angiogenic?. Clin Orthop Relat Res 2000, 378:224-237.
    • (2000) Clin Orthop Relat Res , vol.378 , pp. 224-237
    • Street, J.1
  • 12
    • 0027301947 scopus 로고
    • The importance of the hematoma for fracture healing in rats
    • Grundnes O., Reikeras O. The importance of the hematoma for fracture healing in rats. Acta Orthop Scand 1993, 64(3):340-342.
    • (1993) Acta Orthop Scand , vol.64 , Issue.3 , pp. 340-342
    • Grundnes, O.1    Reikeras, O.2
  • 13
    • 0025087997 scopus 로고
    • The osteogenetic potential of fracture haematoma. Subperiosteal and intramuscular transplantation of the haematoma
    • Mizuno K., et al. The osteogenetic potential of fracture haematoma. Subperiosteal and intramuscular transplantation of the haematoma. J Bone Joint Surg (Br) 1990, 72(5):822-829.
    • (1990) J Bone Joint Surg (Br) , vol.72 , Issue.5 , pp. 822-829
    • Mizuno, K.1
  • 14
    • 79951820514 scopus 로고    scopus 로고
    • Upregulation of inflammatory genes and downregulation of sclerostin gene expression are key elements in the early phase of fragility fracture healing
    • [e16947]
    • Caetano-Lopes J., et al. Upregulation of inflammatory genes and downregulation of sclerostin gene expression are key elements in the early phase of fragility fracture healing. PLoS ONE 2011, 6(2). [e16947].
    • (2011) PLoS ONE , vol.6 , Issue.2
    • Caetano-Lopes, J.1
  • 15
    • 84894672814 scopus 로고    scopus 로고
    • Spatial cytokine distribution following traumatic injury
    • Currie H.N., et al. Spatial cytokine distribution following traumatic injury. Cytokine 2014, 66(2):112-118.
    • (2014) Cytokine , vol.66 , Issue.2 , pp. 112-118
    • Currie, H.N.1
  • 16
    • 0037376627 scopus 로고    scopus 로고
    • Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation
    • Gerstenfeld L.C., et al. Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation. J Cell Biochem 2003, 88(5):873-884.
    • (2003) J Cell Biochem , vol.88 , Issue.5 , pp. 873-884
    • Gerstenfeld, L.C.1
  • 17
    • 84865760183 scopus 로고    scopus 로고
    • Short-term exposure to tumor necrosis factor-alpha enables human osteoblasts to direct adipose tissue-derived mesenchymal stem cells into osteogenic differentiation
    • Lu Z., et al. Short-term exposure to tumor necrosis factor-alpha enables human osteoblasts to direct adipose tissue-derived mesenchymal stem cells into osteogenic differentiation. Stem Cells Dev 2012, 21(13):2420-2429.
    • (2012) Stem Cells Dev , vol.21 , Issue.13 , pp. 2420-2429
    • Lu, Z.1
  • 18
    • 0024954184 scopus 로고
    • The biology of fracture healing. An overview for clinicians. Part I
    • Frost H.M. The biology of fracture healing. An overview for clinicians. Part I. Clin Orthop Relat Res 1989, 248:283-293.
    • (1989) Clin Orthop Relat Res , vol.248 , pp. 283-293
    • Frost, H.M.1
  • 19
    • 0031734171 scopus 로고    scopus 로고
    • The cell and molecular biology of fracture healing
    • [Suppl.]
    • Einhorn T.A. The cell and molecular biology of fracture healing. Clin Orthop Relat Res 1998, 355:S7-S21. [Suppl.].
    • (1998) Clin Orthop Relat Res , vol.355 , pp. S7-S21
    • Einhorn, T.A.1
  • 20
    • 33745507931 scopus 로고    scopus 로고
    • TNF-alpha mediates p38 MAP kinase activation and negatively regulates bone formation at the injured growth plate in rats
    • Zhou F.H., et al. TNF-alpha mediates p38 MAP kinase activation and negatively regulates bone formation at the injured growth plate in rats. J Bone Miner Res 2006, 21(7):1075-1088.
    • (2006) J Bone Miner Res , vol.21 , Issue.7 , pp. 1075-1088
    • Zhou, F.H.1
  • 21
    • 73249114253 scopus 로고    scopus 로고
    • Dose effect of tumor necrosis factor-alpha on in vitro osteogenic differentiation of mesenchymal stem cells on biodegradable polymeric microfiber scaffolds
    • Mountziaris P.M., Tzouanas S.N., Mikos A.G. Dose effect of tumor necrosis factor-alpha on in vitro osteogenic differentiation of mesenchymal stem cells on biodegradable polymeric microfiber scaffolds. Biomaterials 2010, 31(7):1666-1675.
    • (2010) Biomaterials , vol.31 , Issue.7 , pp. 1666-1675
    • Mountziaris, P.M.1    Tzouanas, S.N.2    Mikos, A.G.3
  • 22
    • 49149115009 scopus 로고    scopus 로고
    • Comparison of the healing of open tibial fractures covered with either muscle or fasciocutaneous tissue in a murine model
    • Harry L.E., et al. Comparison of the healing of open tibial fractures covered with either muscle or fasciocutaneous tissue in a murine model. J Orthop Res 2008, 26(9):1238-1244.
    • (2008) J Orthop Res , vol.26 , Issue.9 , pp. 1238-1244
    • Harry, L.E.1
  • 23
    • 0029955184 scopus 로고    scopus 로고
    • Repair of calvarial defects with flap tissue: role of bone morphogenetic proteins and competent responding tissues
    • Khouri R.K., et al. Repair of calvarial defects with flap tissue: role of bone morphogenetic proteins and competent responding tissues. Plast Reconstr Surg 1996, 98(1):103-109.
    • (1996) Plast Reconstr Surg , vol.98 , Issue.1 , pp. 103-109
    • Khouri, R.K.1
  • 24
    • 62449127652 scopus 로고    scopus 로고
    • Migration of bone marrow-derived mesenchymal stem cells induced by tumor necrosis factor-alpha and its possible role in wound healing
    • Fu X., et al. Migration of bone marrow-derived mesenchymal stem cells induced by tumor necrosis factor-alpha and its possible role in wound healing. Wound Repair Regen 2009, 17(2):185-191.
    • (2009) Wound Repair Regen , vol.17 , Issue.2 , pp. 185-191
    • Fu, X.1
  • 25
    • 54049116347 scopus 로고    scopus 로고
    • Immunoregulatory role of mesenchymal stem cells in bone reparation processes
    • Zubov D.O. Immunoregulatory role of mesenchymal stem cells in bone reparation processes. Fiziol Zh 2008, 54(4):30-36.
    • (2008) Fiziol Zh , vol.54 , Issue.4 , pp. 30-36
    • Zubov, D.O.1
  • 26
    • 0346964738 scopus 로고    scopus 로고
    • Induced membranes secrete growth factors including vascular and osteoinductive factors and could stimulate bone regeneration
    • Pelissier P., et al. Induced membranes secrete growth factors including vascular and osteoinductive factors and could stimulate bone regeneration. J Orthop Res 2004, 22(1):73-79.
    • (2004) J Orthop Res , vol.22 , Issue.1 , pp. 73-79
    • Pelissier, P.1
  • 27
    • 77952529848 scopus 로고    scopus 로고
    • Antitumor necrotic factor agent promotes BMP-2-induced ectopic bone formation
    • Eguchi Y., et al. Antitumor necrotic factor agent promotes BMP-2-induced ectopic bone formation. J Bone Miner Metab 2010, 28(2):157-164.
    • (2010) J Bone Miner Metab , vol.28 , Issue.2 , pp. 157-164
    • Eguchi, Y.1
  • 28
    • 84879084602 scopus 로고    scopus 로고
    • The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling
    • Zhao Y.P., et al. The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling. Biomaterials 2013, 34(27):6412-6421.
    • (2013) Biomaterials , vol.34 , Issue.27 , pp. 6412-6421
    • Zhao, Y.P.1
  • 29
    • 0034953367 scopus 로고    scopus 로고
    • Impaired intramembranous bone formation during bone repair in the absence of tumor necrosis factor-alpha signaling
    • Gerstenfeld L.C., et al. Impaired intramembranous bone formation during bone repair in the absence of tumor necrosis factor-alpha signaling. Cells Tissues Organs 2001, 169(3):285-294.
    • (2001) Cells Tissues Organs , vol.169 , Issue.3 , pp. 285-294
    • Gerstenfeld, L.C.1
  • 30
    • 0024957026 scopus 로고
    • The biology of fracture healing. An overview for clinicians. Part II
    • Frost H.M. The biology of fracture healing. An overview for clinicians. Part II. Clin Orthop Relat Res 1989, 248:294-309.
    • (1989) Clin Orthop Relat Res , vol.248 , pp. 294-309
    • Frost, H.M.1
  • 31
    • 45249115763 scopus 로고    scopus 로고
    • Modulation of the inflammatory response for enhanced bone tissue regeneration
    • Mountziaris P.M., Mikos A.G. Modulation of the inflammatory response for enhanced bone tissue regeneration. Tissue Eng. Part B Rev. 2008, 14(2):179-186.
    • (2008) Tissue Eng. Part B Rev. , vol.14 , Issue.2 , pp. 179-186
    • Mountziaris, P.M.1    Mikos, A.G.2
  • 32
    • 0025061136 scopus 로고
    • Role of transforming growth factor-beta in bone remodeling
    • Bonewald L.F., Mundy G.R. Role of transforming growth factor-beta in bone remodeling. Clin Orthop Relat Res 1990, 250:261-276.
    • (1990) Clin Orthop Relat Res , vol.250 , pp. 261-276
    • Bonewald, L.F.1    Mundy, G.R.2
  • 33
    • 0027445123 scopus 로고
    • Transforming growth factor-beta enhances fracture healing in rabbit tibiae
    • Lind M., et al. Transforming growth factor-beta enhances fracture healing in rabbit tibiae. Acta Orthop Scand 1993, 64(5):553-556.
    • (1993) Acta Orthop Scand , vol.64 , Issue.5 , pp. 553-556
    • Lind, M.1
  • 34
    • 0028205108 scopus 로고
    • Local injection of TGF-beta increases the strength of tibial fractures in the rat
    • Nielsen H.M., et al. Local injection of TGF-beta increases the strength of tibial fractures in the rat. Acta Orthop Scand 1994, 65(1):37-41.
    • (1994) Acta Orthop Scand , vol.65 , Issue.1 , pp. 37-41
    • Nielsen, H.M.1
  • 35
    • 0028918872 scopus 로고
    • Regulation of proliferation and osteochondrogenic differentiation of periosteum-derived cells by transforming growth factor-beta and basic fibroblast growth factor
    • Iwasaki M., et al. Regulation of proliferation and osteochondrogenic differentiation of periosteum-derived cells by transforming growth factor-beta and basic fibroblast growth factor. J Bone Joint Surg Am 1995, 77(4):543-554.
    • (1995) J Bone Joint Surg Am , vol.77 , Issue.4 , pp. 543-554
    • Iwasaki, M.1
  • 36
    • 0142026448 scopus 로고    scopus 로고
    • Controlling mesenchymal stem cell differentiation by TGFBeta family members
    • Roelen B.A., Dijke P. Controlling mesenchymal stem cell differentiation by TGFBeta family members. J Orthop Sci 2003, 8(5):740-748.
    • (2003) J Orthop Sci , vol.8 , Issue.5 , pp. 740-748
    • Roelen, B.A.1    Dijke, P.2
  • 37
    • 1842864941 scopus 로고    scopus 로고
    • Recruitment of mesenchymal stem cells and expression of TGF-beta 1 and VEGF in the early stage of shock wave-promoted bone regeneration of segmental defect in rats
    • Chen Y.J., et al. Recruitment of mesenchymal stem cells and expression of TGF-beta 1 and VEGF in the early stage of shock wave-promoted bone regeneration of segmental defect in rats. J Orthop Res 2004, 22(3):526-534.
    • (2004) J Orthop Res , vol.22 , Issue.3 , pp. 526-534
    • Chen, Y.J.1
  • 38
    • 0033845083 scopus 로고    scopus 로고
    • Systemic corticosteroids inhibit bone healing in a rabbit ulnar osteotomy model
    • Waters R.V., et al. Systemic corticosteroids inhibit bone healing in a rabbit ulnar osteotomy model. Acta Orthop Scand 2000, 71(3):316-321.
    • (2000) Acta Orthop Scand , vol.71 , Issue.3 , pp. 316-321
    • Waters, R.V.1
  • 39
    • 68049117091 scopus 로고    scopus 로고
    • The effect of newer anti-rheumatic drugs on osteogenic cell proliferation: an in-vitro study
    • Malviya A., et al. The effect of newer anti-rheumatic drugs on osteogenic cell proliferation: an in-vitro study. J Orthop Surg Res 2009, 4:17.
    • (2009) J Orthop Surg Res , vol.4 , pp. 17
    • Malviya, A.1
  • 40
    • 79952122953 scopus 로고    scopus 로고
    • TNF-alpha promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells
    • Glass G.E., et al. TNF-alpha promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells. Proc Natl Acad Sci U S A 2011, 108(4):1585-1590.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.4 , pp. 1585-1590
    • Glass, G.E.1
  • 41
    • 84858021975 scopus 로고    scopus 로고
    • Activation of NF-kappaB/p65 facilitates early chondrogenic differentiation during endochondral ossification
    • [e33467]
    • Caron M.M., et al. Activation of NF-kappaB/p65 facilitates early chondrogenic differentiation during endochondral ossification. PLoS ONE 2012, 7(3). [e33467].
    • (2012) PLoS ONE , vol.7 , Issue.3
    • Caron, M.M.1
  • 42
    • 0036181393 scopus 로고    scopus 로고
    • Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing
    • Cho T.J., Gerstenfeld L.C., Einhorn T.A. Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing. J Bone Miner Res 2002, 17(3):513-520.
    • (2002) J Bone Miner Res , vol.17 , Issue.3 , pp. 513-520
    • Cho, T.J.1    Gerstenfeld, L.C.2    Einhorn, T.A.3
  • 43
    • 14244262341 scopus 로고    scopus 로고
    • Interleukin-1beta and TNF-alpha act in synergy to inhibit longitudinal growth in fetal rat metatarsal bones
    • Martensson K., Chrysis D., Savendahl L. Interleukin-1beta and TNF-alpha act in synergy to inhibit longitudinal growth in fetal rat metatarsal bones. J Bone Miner Res 2004, 19(11):1805-1812.
    • (2004) J Bone Miner Res , vol.19 , Issue.11 , pp. 1805-1812
    • Martensson, K.1    Chrysis, D.2    Savendahl, L.3
  • 44
    • 0026153593 scopus 로고
    • Linear relationship between the volume of hypertrophic chondrocytes and the rate of longitudinal bone growth in growth plates
    • Breur G.J., et al. Linear relationship between the volume of hypertrophic chondrocytes and the rate of longitudinal bone growth in growth plates. J Orthop Res 1991, 9(3):348-359.
    • (1991) J Orthop Res , vol.9 , Issue.3 , pp. 348-359
    • Breur, G.J.1
  • 45
    • 73549115418 scopus 로고    scopus 로고
    • High levels of tumor necrosis factor-alpha contribute to accelerated loss of cartilage in diabetic fracture healing
    • Alblowi J., et al. High levels of tumor necrosis factor-alpha contribute to accelerated loss of cartilage in diabetic fracture healing. Am J Pathol 2009, 175(4):1574-1585.
    • (2009) Am J Pathol , vol.175 , Issue.4 , pp. 1574-1585
    • Alblowi, J.1
  • 46
    • 20044375180 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha (TNF-alpha) coordinately regulates the expression of specific matrix metalloproteinases (MMPS) and angiogenic factors during fracture healing
    • Lehmann W., et al. Tumor necrosis factor alpha (TNF-alpha) coordinately regulates the expression of specific matrix metalloproteinases (MMPS) and angiogenic factors during fracture healing. Bone 2005, 36(2):300-310.
    • (2005) Bone , vol.36 , Issue.2 , pp. 300-310
    • Lehmann, W.1
  • 47
    • 77954693022 scopus 로고    scopus 로고
    • TNF-alpha mediates diabetes-enhanced chondrocyte apoptosis during fracture healing and stimulates chondrocyte apoptosis through FOXO1
    • Kayal R.A., et al. TNF-alpha mediates diabetes-enhanced chondrocyte apoptosis during fracture healing and stimulates chondrocyte apoptosis through FOXO1. J Bone Miner Res 2010, 25(7):1604-1615.
    • (2010) J Bone Miner Res , vol.25 , Issue.7 , pp. 1604-1615
    • Kayal, R.A.1
  • 48
    • 0034858555 scopus 로고    scopus 로고
    • Induction of apoptosis in chondrocytes by tumor necrosis factor-alpha
    • Aizawa T., et al. Induction of apoptosis in chondrocytes by tumor necrosis factor-alpha. J Orthop Res 2001, 19(5):785-796.
    • (2001) J Orthop Res , vol.19 , Issue.5 , pp. 785-796
    • Aizawa, T.1
  • 49
    • 39149143035 scopus 로고    scopus 로고
    • Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis
    • Ai-Aql Z.S., et al. Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis. J Dent Res 2008, 87(2):107-118.
    • (2008) J Dent Res , vol.87 , Issue.2 , pp. 107-118
    • Ai-Aql, Z.S.1
  • 50
    • 0030910126 scopus 로고    scopus 로고
    • Inflammatory cytokines regulate proliferation of cultured human osteoblasts
    • Frost A., et al. Inflammatory cytokines regulate proliferation of cultured human osteoblasts. Acta Orthop Scand 1997, 68(2):91-96.
    • (1997) Acta Orthop Scand , vol.68 , Issue.2 , pp. 91-96
    • Frost, A.1
  • 51
    • 33144480718 scopus 로고    scopus 로고
    • Human microvascular endothelial cell activation by IL-1 and TNF-alpha stimulates the adhesion and transendothelial migration of circulating human CD14+ monocytes that develop with RANKL into functional osteoclasts
    • Kindle L., et al. Human microvascular endothelial cell activation by IL-1 and TNF-alpha stimulates the adhesion and transendothelial migration of circulating human CD14+ monocytes that develop with RANKL into functional osteoclasts. J Bone Miner Res 2006, 21(2):193-206.
    • (2006) J Bone Miner Res , vol.21 , Issue.2 , pp. 193-206
    • Kindle, L.1
  • 52
    • 59449108478 scopus 로고    scopus 로고
    • Human hypertrophic nonunion tissue contains mesenchymal progenitor cells with multilineage capacity in vitro
    • Iwakura T., et al. Human hypertrophic nonunion tissue contains mesenchymal progenitor cells with multilineage capacity in vitro. J Orthop Res 2009, 27(2):208-215.
    • (2009) J Orthop Res , vol.27 , Issue.2 , pp. 208-215
    • Iwakura, T.1
  • 53
    • 0016164585 scopus 로고
    • Tibial blood supply in relation to fracture healing
    • Rhinelander F.W. Tibial blood supply in relation to fracture healing. Clin Orthop Relat Res 1974, 105:34-81.
    • (1974) Clin Orthop Relat Res , vol.105 , pp. 34-81
    • Rhinelander, F.W.1
  • 54
    • 0019289398 scopus 로고
    • Arteriographic studies in delayed-union and non-union of fractures
    • Arany L., et al. Arteriographic studies in delayed-union and non-union of fractures. Radiol Diagn (Berl) 1980, 21(5):673-681.
    • (1980) Radiol Diagn (Berl) , vol.21 , Issue.5 , pp. 673-681
    • Arany, L.1
  • 55
    • 0028297686 scopus 로고
    • Delayed unions and nonunions of open tibial fractures. Correlation with arteriography results
    • Dickson K., et al. Delayed unions and nonunions of open tibial fractures. Correlation with arteriography results. Clin Orthop Relat Res 1994, 302:189-193.
    • (1994) Clin Orthop Relat Res , vol.302 , pp. 189-193
    • Dickson, K.1
  • 56
    • 0038779423 scopus 로고    scopus 로고
    • Vascularity in a new model of atrophic nonunion
    • Reed A.A., et al. Vascularity in a new model of atrophic nonunion. J Bone Joint Surg (Br) 2003, 85(4):604-610.
    • (2003) J Bone Joint Surg (Br) , vol.85 , Issue.4 , pp. 604-610
    • Reed, A.A.1
  • 57
    • 0036239197 scopus 로고    scopus 로고
    • Human atrophic fracture non-unions are not avascular
    • Reed A.A., et al. Human atrophic fracture non-unions are not avascular. J Orthop Res 2002, 20(3):593-599.
    • (2002) J Orthop Res , vol.20 , Issue.3 , pp. 593-599
    • Reed, A.A.1
  • 58
    • 84938491515 scopus 로고    scopus 로고
    • Do atrophic non-unions have lower levels of growth factors than hypertrophic non-unions and healing fractures
    • (British Volume)
    • Reed A.A.C., et al. Do atrophic non-unions have lower levels of growth factors than hypertrophic non-unions and healing fractures. J Bone Joint Surg 2002, 84-B(Suppl. I):19. (British Volume).
    • (2002) J Bone Joint Surg , pp. 19
    • Reed, A.A.C.1
  • 59
    • 0030798903 scopus 로고    scopus 로고
    • Local expression of tumor necrosis factor alpha in an experimental model of acute osteomyelitis in rats
    • Littlewood-Evans A.J., et al. Local expression of tumor necrosis factor alpha in an experimental model of acute osteomyelitis in rats. Infect Immun 1997, 65(8):3438-3443.
    • (1997) Infect Immun , vol.65 , Issue.8 , pp. 3438-3443
    • Littlewood-Evans, A.J.1
  • 60
    • 0029917279 scopus 로고    scopus 로고
    • Local and systemic inflammatory mediator release in patients with acute and chronic posttraumatic osteomyelitis
    • Klosterhalfen B., et al. Local and systemic inflammatory mediator release in patients with acute and chronic posttraumatic osteomyelitis. J Trauma 1996, 40(3):372-378.
    • (1996) J Trauma , vol.40 , Issue.3 , pp. 372-378
    • Klosterhalfen, B.1
  • 61
    • 0029828759 scopus 로고    scopus 로고
    • Roles of the bacterial cell wall and capsule in induction of tumor necrosis factor alpha by type III group B streptococci
    • Vallejo J.G., Baker C.J., Edwards M.S. Roles of the bacterial cell wall and capsule in induction of tumor necrosis factor alpha by type III group B streptococci. Infect Immun 1996, 64(12):5042-5046.
    • (1996) Infect Immun , vol.64 , Issue.12 , pp. 5042-5046
    • Vallejo, J.G.1    Baker, C.J.2    Edwards, M.S.3
  • 62
    • 0031727182 scopus 로고    scopus 로고
    • Surface-associated protein from Staphylococcus aureus stimulates osteoclastogenesis: possible role in S. aureus-induced bone pathology
    • Meghji S., et al. Surface-associated protein from Staphylococcus aureus stimulates osteoclastogenesis: possible role in S. aureus-induced bone pathology. Br J Rheumatol 1998, 37(10):1095-1101.
    • (1998) Br J Rheumatol , vol.37 , Issue.10 , pp. 1095-1101
    • Meghji, S.1
  • 63
    • 0024889943 scopus 로고
    • Inhibitory effects of tumor necrosis factor alpha on fracture healing in rats
    • Hashimoto J., et al. Inhibitory effects of tumor necrosis factor alpha on fracture healing in rats. Bone 1989, 10(6):453-457.
    • (1989) Bone , vol.10 , Issue.6 , pp. 453-457
    • Hashimoto, J.1
  • 64
    • 80054903998 scopus 로고    scopus 로고
    • The biologics anakinra and etanercept prevent cytokine-induced growth retardation in cultured fetal rat metatarsal bones
    • Fernandez-Vojvodich P., Karimian E., Savendahl L. The biologics anakinra and etanercept prevent cytokine-induced growth retardation in cultured fetal rat metatarsal bones. Horm Res Paediatr 2011, 76(4):278-285.
    • (2011) Horm Res Paediatr , vol.76 , Issue.4 , pp. 278-285
    • Fernandez-Vojvodich, P.1    Karimian, E.2    Savendahl, L.3
  • 65
    • 12944262423 scopus 로고    scopus 로고
    • RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism
    • Li J., et al. RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci U S A 2000, 97(4):1566-1571.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , Issue.4 , pp. 1566-1571
    • Li, J.1
  • 66
    • 85047685623 scopus 로고    scopus 로고
    • TNFalpha potently activates osteoclasts, through a direct action independent of and strongly synergistic with RANKL
    • Fuller K., et al. TNFalpha potently activates osteoclasts, through a direct action independent of and strongly synergistic with RANKL. Endocrinology 2002, 143(3):1108-1118.
    • (2002) Endocrinology , vol.143 , Issue.3 , pp. 1108-1118
    • Fuller, K.1
  • 67
    • 0034523328 scopus 로고    scopus 로고
    • TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand
    • Lam J., et al. TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest 2000, 106(12):1481-1488.
    • (2000) J Clin Invest , vol.106 , Issue.12 , pp. 1481-1488
    • Lam, J.1
  • 68
    • 3042594155 scopus 로고    scopus 로고
    • Role of TNF-alpha producing T-cells in bone loss induced by estrogen deficiency
    • Roggia C., et al. Role of TNF-alpha producing T-cells in bone loss induced by estrogen deficiency. Minerva Med 2004, 95(2):125-132.
    • (2004) Minerva Med , vol.95 , Issue.2 , pp. 125-132
    • Roggia, C.1
  • 69
    • 0027135964 scopus 로고
    • Peripheral monocyte culture supernatants of menopausal women can induce bone resorption: involvement of cytokines
    • Cohen-Solal M.E., et al. Peripheral monocyte culture supernatants of menopausal women can induce bone resorption: involvement of cytokines. J Clin Endocrinol Metab 1993, 77(6):1648-1653.
    • (1993) J Clin Endocrinol Metab , vol.77 , Issue.6 , pp. 1648-1653
    • Cohen-Solal, M.E.1
  • 70
    • 34447303828 scopus 로고    scopus 로고
    • Effect of blockade of TNF-alpha and interleukin-1 action on bone resorption in early postmenopausal women
    • Charatcharoenwitthaya N., et al. Effect of blockade of TNF-alpha and interleukin-1 action on bone resorption in early postmenopausal women. J Bone Miner Res 2007, 22(5):724-729.
    • (2007) J Bone Miner Res , vol.22 , Issue.5 , pp. 724-729
    • Charatcharoenwitthaya, N.1
  • 71
    • 77954498935 scopus 로고    scopus 로고
    • Estradiol suppresses NF-kappa B activation through coordinated regulation of let-7a and miR-125b in primary human macrophages
    • Murphy A.J., Guyre P.M., Pioli P.A. Estradiol suppresses NF-kappa B activation through coordinated regulation of let-7a and miR-125b in primary human macrophages. J Immunol 2010, 184(9):5029-5037.
    • (2010) J Immunol , vol.184 , Issue.9 , pp. 5029-5037
    • Murphy, A.J.1    Guyre, P.M.2    Pioli, P.A.3
  • 72
    • 0033592892 scopus 로고    scopus 로고
    • Estradiol repression of tumor necrosis factor-alpha transcription requires estrogen receptor activation function-2 and is enhanced by coactivators
    • An J., et al. Estradiol repression of tumor necrosis factor-alpha transcription requires estrogen receptor activation function-2 and is enhanced by coactivators. Proc Natl Acad Sci U S A 1999, 96(26):15161-15166.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.26 , pp. 15161-15166
    • An, J.1
  • 73
  • 74
    • 24644502237 scopus 로고    scopus 로고
    • Healing of fractures in osteoporotic rat mandible shown by the expression of bone morphogenetic protein-2 and tumour necrosis factor-alpha
    • Islam A.A., et al. Healing of fractures in osteoporotic rat mandible shown by the expression of bone morphogenetic protein-2 and tumour necrosis factor-alpha. Br J Oral Maxillofac Surg 2005, 43(5):383-391.
    • (2005) Br J Oral Maxillofac Surg , vol.43 , Issue.5 , pp. 383-391
    • Islam, A.A.1
  • 75
    • 79958772684 scopus 로고    scopus 로고
    • Effects of obesity on bone metabolism
    • Cao J.J. Effects of obesity on bone metabolism. J Orthop Surg Res 2011, 6:30.
    • (2011) J Orthop Surg Res , vol.6 , pp. 30
    • Cao, J.J.1
  • 76
    • 0037397789 scopus 로고    scopus 로고
    • Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes
    • Pedersen M., et al. Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes. Mech Ageing Dev 2003, 124(4):495-502.
    • (2003) Mech Ageing Dev , vol.124 , Issue.4 , pp. 495-502
    • Pedersen, M.1
  • 77
    • 33745896155 scopus 로고    scopus 로고
    • Recent advances in the relationship between obesity, inflammation, and insulin resistance
    • Bastard J.P., et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 2006, 17(1):4-12.
    • (2006) Eur Cytokine Netw , vol.17 , Issue.1 , pp. 4-12
    • Bastard, J.P.1
  • 78
    • 27644586335 scopus 로고    scopus 로고
    • Cellular basis for age-related changes in fracture repair
    • Lu C., et al. Cellular basis for age-related changes in fracture repair. J Orthop Res 2005, 23(6):1300-1307.
    • (2005) J Orthop Res , vol.23 , Issue.6 , pp. 1300-1307
    • Lu, C.1
  • 79
    • 0035067737 scopus 로고    scopus 로고
    • The chondrogenic potential of periosteum decreases with age
    • O'Driscoll S.W., et al. The chondrogenic potential of periosteum decreases with age. J Orthop Res 2001, 19(1):95-103.
    • (2001) J Orthop Res , vol.19 , Issue.1 , pp. 95-103
    • O'Driscoll, S.W.1
  • 80
    • 77955981693 scopus 로고    scopus 로고
    • Influences of age and mechanical stability on volume, microstructure, and mineralization of the fracture callus during bone healing: is osteoclast activity the key to age-related impaired healing?
    • Mehta M., et al. Influences of age and mechanical stability on volume, microstructure, and mineralization of the fracture callus during bone healing: is osteoclast activity the key to age-related impaired healing?. Bone 2010, 47(2):219-228.
    • (2010) Bone , vol.47 , Issue.2 , pp. 219-228
    • Mehta, M.1
  • 81
    • 0023721856 scopus 로고
    • The influence of diabetes mellitus on the healing of closed fractures
    • Loder R.T. The influence of diabetes mellitus on the healing of closed fractures. Clin Orthop Relat Res 1988, 232:210-216.
    • (1988) Clin Orthop Relat Res , vol.232 , pp. 210-216
    • Loder, R.T.1
  • 82
    • 0024383874 scopus 로고
    • Defects of early fracture-healing in experimental diabetes
    • Macey L.R., et al. Defects of early fracture-healing in experimental diabetes. J Bone Joint Surg Am 1989, 71(5):722-733.
    • (1989) J Bone Joint Surg Am , vol.71 , Issue.5 , pp. 722-733
    • Macey, L.R.1
  • 83
    • 10044241572 scopus 로고    scopus 로고
    • IL-1 and TNF antagonists prevent inhibition of fracture healing by ethanol in rats
    • Perrien D.S., et al. IL-1 and TNF antagonists prevent inhibition of fracture healing by ethanol in rats. Toxicol Sci 2004, 82(2):656-660.
    • (2004) Toxicol Sci , vol.82 , Issue.2 , pp. 656-660
    • Perrien, D.S.1
  • 84
    • 0034190257 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis
    • Schwarz E.M., et al. Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis. J Orthop Res 2000, 18(3):472-480.
    • (2000) J Orthop Res , vol.18 , Issue.3 , pp. 472-480
    • Schwarz, E.M.1
  • 85
    • 0032893277 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha mediates orthopedic implant osteolysis
    • Merkel K.D., et al. Tumor necrosis factor-alpha mediates orthopedic implant osteolysis. Am J Pathol 1999, 154(1):203-210.
    • (1999) Am J Pathol , vol.154 , Issue.1 , pp. 203-210
    • Merkel, K.D.1
  • 86
    • 0029880417 scopus 로고    scopus 로고
    • Role of tumor necrosis factor alpha in particulate-induced bone resorption
    • Algan S.M., Purdon M., Horowitz S.M. Role of tumor necrosis factor alpha in particulate-induced bone resorption. J Orthop Res 1996, 14(1):30-35.
    • (1996) J Orthop Res , vol.14 , Issue.1 , pp. 30-35
    • Algan, S.M.1    Purdon, M.2    Horowitz, S.M.3
  • 87
    • 0035143798 scopus 로고    scopus 로고
    • Efficacy of etanercept for wear debris-induced osteolysis
    • Childs L.M., et al. Efficacy of etanercept for wear debris-induced osteolysis. J Bone Miner Res 2001, 16(2):338-347.
    • (2001) J Bone Miner Res , vol.16 , Issue.2 , pp. 338-347
    • Childs, L.M.1


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