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Volumn 42, Issue 6, 2011, Pages 551-555

The biology of fracture healing

Author keywords

Angiogenesis; Bone healing; Bone injury; Bone trauma; Callus; Cartilaginous; Endochondral; Intramembranous; Periosteal; Revascularisation

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN 2; INTERLEUKIN 1; INTERLEUKIN 11; INTERLEUKIN 18; INTERLEUKIN 6; STROMAL CELL DERIVED FACTOR 1; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

EID: 79957809134     PISSN: 00201383     EISSN: 18790267     Source Type: Journal    
DOI: 10.1016/j.injury.2011.03.031     Document Type: Article
Times cited : (1295)

References (47)
  • 1
    • 39149143035 scopus 로고    scopus 로고
    • Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis
    • Ai-Aql ZS, Alagl AS, Graves DT. Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis. J Dent Res 2008;87(2):107-18.
    • (2008) J Dent Res , vol.87 , Issue.2 , pp. 107-118
    • Ai-Aql, Z.S.1    Alagl, A.S.2    Graves, D.T.3
  • 2
    • 67649444317 scopus 로고    scopus 로고
    • BMP2 is essential for post natal osteogenesis but not for recruitment of osteogenic stem cells
    • Bais MV,Wigner N, Young M, et al. BMP2 is essential for post natal osteogenesis but not for recruitment of osteogenic stem cells. Bone 2009;45(2):254-66.
    • (2009) Bone , vol.45 , Issue.2 , pp. 254-266
    • Bais, M.V.1    Wigner, N.2    Young, M.3
  • 3
    • 33744936801 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha: Alternative role as an inhibitor of osteoclast formation in vitro
    • DOI 10.1016/j.bone.2006.02.056, PII S8756328206003206
    • Balga R, Wetterwald A, Portenier J, et al. Tumor necrosis factor-alpha: alternative role as an inhibitor of osteoclast formation in vitro. Bone 2006;39(2):325-35. (Pubitemid 43851380)
    • (2006) Bone , vol.39 , Issue.2 , pp. 325-335
    • Balga, R.1    Wetterwald, A.2    Portenier, J.3    Dolder, S.4    Mueller, C.5    Hofstetter, W.6
  • 5
    • 0001997726 scopus 로고
    • Biophysical principles affecting bone structure
    • Bourne GH, editor. 2nd ed. New York: Academic Press
    • Bassett CAL. Biophysical principles affecting bone structure. In: Bourne GH, editor. Biochemistry and physiology of bone. 2nd ed. New York: Academic Press; 1971. p. 341-76.
    • (1971) Biochemistry and Physiology of Bone , pp. 341-376
    • Bassett, C.A.L.1
  • 6
    • 0021612066 scopus 로고
    • Production of a standard closed fracture in laboratory animal bone
    • Bonnarens F, Einhorn TA. Production of a standard closed fracture in laboratory animal bone. J Orthop Res 1984;2(1):97-101. (Pubitemid 14034681)
    • (1984) Journal of Orthopaedic Research , vol.2 , Issue.1 , pp. 97-101
    • Bonnarens, F.1    Einhorn, T.A.2
  • 7
    • 0026153593 scopus 로고
    • Linear relationship between the volume of hypertrophic chondrocytes and the rate of longitudinal bone growth in growth plates
    • Breur GJ, VanEnkevort BA, Farnum CE, et al. Linear relationship between the volume of hypertrophic chondrocytes and the rate of longitudinal bone growth in growth plates. J Orthop Res 1991;9(3):348-59.
    • (1991) J Orthop Res , vol.9 , Issue.3 , pp. 348-359
    • Breur, G.J.1    VanEnkevort, B.A.2    Farnum, C.E.3
  • 8
    • 0345305374 scopus 로고    scopus 로고
    • Angiogenesis and bone repair
    • DOI 10.1016/S1359-6446(03)02866-6, PII S1359644603028666
    • Carano RA, Filvaroff EH. Angiogenesis and bone repair. Drug Discovery Today 2003;8(21):980-9. (Pubitemid 37474243)
    • (2003) Drug Discovery Today , vol.8 , Issue.21 , pp. 980-989
    • Carano, R.A.D.1    Filvaroff, E.H.2
  • 9
    • 4043184065 scopus 로고    scopus 로고
    • Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
    • Ceradini DJ, Kulkarni AR, CallaghanMJ. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 2004;10(8):858-64.
    • (2004) Nat Med , vol.10 , Issue.8 , pp. 858-864
    • Ceradini, D.J.1    Kulkarni, A.R.2    Callaghan, M.J.3
  • 10
    • 62649138786 scopus 로고    scopus 로고
    • Wnt pathway, an essential role in bone regeneration
    • Chen Y, Alman BA. Wnt pathway, an essential role in bone regeneration,. J Cell Biochem 2009;106(3):353-62.
    • (2009) J Cell Biochem , vol.106 , Issue.3 , pp. 353-362
    • Chen, Y.1    Alman, B.A.2
  • 11
    • 33846425331 scopus 로고    scopus 로고
    • Overexpression of CXCR4 increases migration and proliferation of human adipose tissue stromal cells
    • DOI 10.1089/scd.2006.15.853
    • Cho HH, Kyoung KM, Seo MJ, et al. Overexpression of CXCR4 increases migration and proliferation of human adipose tissue stromal cells. Stem Cell Dev 2006;15(6):853-64. (Pubitemid 46147857)
    • (2006) Stem Cells and Development , vol.15 , Issue.6 , pp. 853-864
    • Cho, H.H.1    Kyoung, K.M.2    Seo, M.J.3    Kim, Y.J.4    Bae, Y.C.5    Jung, J.S.6
  • 12
    • 0036181393 scopus 로고    scopus 로고
    • Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing
    • Cho TJ, Gerstenfeld LC, Einhorn TA. Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing. J Bone Miner Res 2002;17(3):513-20. (Pubitemid 34171766)
    • (2002) Journal of Bone and Mineral Research , vol.17 , Issue.3 , pp. 513-520
    • Cho, T.-J.1    Gerstenfeld, L.C.2    Einhorn, T.A.3
  • 13
    • 0041827114 scopus 로고    scopus 로고
    • Altered fracture repair in the abscence of MMP9
    • DOI 10.1242/dev.00559
    • Colnot C, Thompson Z, Miclau T, et al. Altered fracture repair in the absence of MMP9. Development 2003;130(17):4123-33. (Pubitemid 37063429)
    • (2003) Development , vol.130 , Issue.17 , pp. 4123-4133
    • Colnot, C.1    Thompson, Z.2    Miclau, T.3    Werb, Z.4    Helms, J.A.5
  • 14
    • 27744607999 scopus 로고    scopus 로고
    • Current concepts of molecular aspects of bone healing
    • DOI 10.1016/j.injury.2005.07.019, PII S0020138305002767
    • Dimitriou R, Tsiridis E, Giannoudis PV. Current concepts of molecular aspects of bone healing. Injury 2005;36(12):1392-404. (Pubitemid 41618169)
    • (2005) Injury , vol.36 , Issue.12 , pp. 1392-1404
    • Dimitriou, R.1    Tsiridis, E.2    Giannoudis, P.V.3
  • 15
    • 0031734171 scopus 로고    scopus 로고
    • The cell and molecular biology of fracture healing
    • Einhorn TA. The cell and molecular biology of fracture healing. Clin Orthop Relat Res 1998;(355 Suppl.):S7-21.
    • (1998) Clin Orthop Relat Res , Issue.355 SUPPL.
    • Einhorn, T.A.1
  • 16
    • 33646201771 scopus 로고    scopus 로고
    • The science of fracture healing
    • Einhorn TA. The science of fracture healing. J Orthop Trauma 2005;19(10):S4-6.
    • (2005) J Orthop Trauma , vol.19 , Issue.10
    • Einhorn, T.A.1
  • 18
    • 0037376627 scopus 로고    scopus 로고
    • Fracture healing as a post-natal developmental process: Molecular, spatial, and temporal aspects of its regulation
    • DOI 10.1002/jcb.10435
    • Gerstenfeld LC, Cullinane DM, Barnes GL. Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation,. J Cell Biochem 2003;88(5):873-84. (Pubitemid 36337032)
    • (2003) Journal of Cellular Biochemistry , vol.88 , Issue.5 , pp. 873-884
    • Gerstenfeld, L.C.1    Cullinane, D.M.2    Barnes, G.L.3    Graves, D.T.4    Einhorn, T.A.5
  • 19
    • 69249162221 scopus 로고    scopus 로고
    • Regenerative effects of transplanted mesenchymal stem cells in fracture healing
    • Granero-Molto F, Weis JA, Miga MI. Regenerative effects of transplanted mesenchymal stem cells in fracture healing. Stem Cell 2009;27(8):1887-98.
    • (2009) Stem Cell , vol.27 , Issue.8 , pp. 1887-1898
    • Granero-Molto, F.1    Weis, J.A.2    Miga, M.I.3
  • 20
    • 32944462633 scopus 로고    scopus 로고
    • Risk factors, treatment, and outcomes associated with nonunion of the midshaft humerus fracture
    • Green E, Lubahn JD, Evans J. Risk factors, treatment, and outcomes associated with nonunion of the midshaft humerus fracture. J Surg Orthop Adv 2005;14(2):64-72.
    • (2005) J Surg Orthop Adv , vol.14 , Issue.2 , pp. 64-72
    • Green, E.1    Lubahn, J.D.2    Evans, J.3
  • 21
    • 0027571103 scopus 로고
    • Current concepts in bone healing. Review of the literature
    • Greenbaum MA, Kanat IO. Current concepts in bone healing. Review of the literature. J Am Podiatr Med Assoc 1993;83(3):123-9.
    • (1993) J Am Podiatr Med Assoc , vol.83 , Issue.3 , pp. 123-129
    • Greenbaum, M.A.1    Kanat, I.O.2
  • 22
    • 0001789767 scopus 로고
    • Fracture biology and biomechanics
    • Slatter D, editor. Philadelphia: WB Saunders
    • Hulse D, Hyman B. Fracture biology and biomechanics. In: Slatter D, editor. Textbook of small animal surgery. Philadelphia: WB Saunders; 1993 . p. 1595-603.
    • (1993) Textbook of Small Animal Surgery , pp. 1595-1603
    • Hulse, D.1    Hyman, B.2
  • 24
    • 45549085001 scopus 로고    scopus 로고
    • Osteogenesis and angiogenesis: The potential for engineering bone
    • Kanczler JM, Oreffo RO. Osteogenesis and angiogenesis: the potential for engineering bone. Eur Cell Mater 2008;15:100-14. (Pubitemid 351955734)
    • (2008) European Cells and Materials , vol.15 , pp. 100-114
    • Kanczler, J.M.1    Oreffo, R.O.C.2
  • 25
    • 51849093548 scopus 로고    scopus 로고
    • Fracture vascularity and bone healing: A systematic review of the role of VEGF
    • Keramaris NC, Calori GM, Nikolaou VS. Fracture vascularity and bone healing: a systematic review of the role of VEGF. Injury 2008;39(2):S45-57.
    • (2008) Injury , vol.39 , Issue.2
    • Keramaris, N.C.1    Calori, G.M.2    Nikolaou, V.S.3
  • 26
    • 0016800156 scopus 로고
    • Morphological and biochemical studies during differentiation and calcification of fracture callus cartilage
    • Ketenjian AY, Arsenis C. Morphological and biochemical studies during differentiation and calcification of fracture callus cartilage. Clin Orthop Relat Res 1975;107:266-73.
    • (1975) Clin Orthop Relat Res , vol.107 , pp. 266-273
    • Ketenjian, A.Y.1    Arsenis, C.2
  • 27
    • 61649090805 scopus 로고    scopus 로고
    • Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model
    • Kitaori T, Ito H, Schwarz EM, et al. Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model. Arthritis Rheum 2009;60(3):813-23.
    • (2009) Arthritis Rheum , vol.60 , Issue.3 , pp. 813-823
    • Kitaori, T.1    Ito, H.2    Schwarz, E.M.3
  • 29
    • 33748068793 scopus 로고    scopus 로고
    • Cytokines regulating osteoclast formation and function
    • DOI 10.1889/1.2196518, PII 0000228120060700000015
    • Lee SK, Lorenzo J. Cytokines regulating osteoclast formation and function. Curr Opin Rheumatol 2006;18(4):411-8. (Pubitemid 44297288)
    • (2006) Current Opinion in Rheumatology , vol.18 , Issue.4 , pp. 411-418
    • Lee, S.-K.1    Lorenzo, J.2
  • 30
    • 20044375180 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha (TNF-alpha) coordinately regulates the expression of specific matrix metalloproteinases (MMPS) and angiogenic factors during fracture healing
    • DOI 10.1016/j.bone.2004.10.010
    • Lehmann W, Edgar CM, Wang K. Tumor necrosis factor alpha (TNF-alpha) coordinately regulates the expression of specific matrix metalloproteinases (MMPS) and angiogenic factors during fracture healing. Bone 2005;36(2):300-10. (Pubitemid 40283587)
    • (2005) Bone , vol.36 , Issue.2 , pp. 300-310
    • Lehmann, W.1    Edgar, C.M.2    Wang, K.3    Cho, T.-J.4    Barnes, G.L.5    Kakar, S.6    Graves, D.T.7    Rueger, J.M.8    Gerstenfeld, L.C.9    Einhorn, T.A.10
  • 31
    • 25144491290 scopus 로고    scopus 로고
    • Time course of myocardial stromal cell-derived factor 1 expression and beneficial effects of intravenously administered bone marrow stem cells in rats with experimental myocardial infarction
    • DOI 10.1007/s00395-005-0521-z
    • Ma J, Ge J, Zhang S, et al. Time course of myocardial stromal cell-derived factor 1 expression and beneficial effects of intravenously administered bone marrow stem cells in rats with experimental myocardial infarction. Basic Res Cardiol 2005;100(3):217-23. (Pubitemid 41348812)
    • (2005) Basic Research in Cardiology , vol.100 , Issue.3 , pp. 217-223
    • Ma, J.1    Ge, J.2    Zhang, S..3    Sun, A.4    Shen, J.5    Chen, L.6    Wang, K.7    Zou, Y.8
  • 32
    • 77649143538 scopus 로고    scopus 로고
    • Emerging bone healing therapies
    • Marsell R, Einhorn TA. Emerging bone healing therapies. J Orthop Trauma 2010;24(1):S4-8.
    • (2010) J Orthop Trauma , vol.24 , Issue.1
    • Marsell, R.1    Einhorn, T.A.2
  • 33
    • 77956023094 scopus 로고    scopus 로고
    • The role of endogenous bone morphogenetic proteins in normal skeletal repair
    • Marsell R, Einhorn TA. The role of endogenous bone morphogenetic proteins in normal skeletal repair. Injury 2009;40(3):S4-7.
    • (2009) Injury , vol.40 , Issue.3
    • Marsell, R.1    Einhorn, T.A.2
  • 34
    • 45249115763 scopus 로고    scopus 로고
    • Modulation of the inflammatory response for enhanced bone tissue regeneration
    • DOI 10.1089/ten.teb.2008.0038
    • Mountziaris PM, Mikos AG. Modulation of the inflammatory response for enhanced bone tissue regeneration. Tissue Eng B Rev 2008;14(2):179-86. (Pubitemid 351839215)
    • (2008) Tissue Engineering - Part B: Reviews , vol.14 , Issue.2 , pp. 179-186
    • Mountziaris, P.M.1    Mikos, A.G.2
  • 35
    • 0036780632 scopus 로고    scopus 로고
    • Effects of intramedullary femoral fracture fixation: What is the impact of experimental studies in regards to the clinical knowledge?
    • Pape HC, Giannoudis PV, Grimme K, et al. Effects of intramedullary femoral fracture fixation: what is the impact of experimental studies in regards to the clinical knowledge? Shock 2002;18(4):291-300.
    • (2002) Shock , vol.18 , Issue.4 , pp. 291-300
    • Pape, H.C.1    Giannoudis, P.V.2    Grimme, K.3
  • 36
    • 0036854433 scopus 로고    scopus 로고
    • Evolution of the internal fixation of long bone fractures. The scientific basis of biological internal fixation: Choosing a new balance between stability and biology
    • Perren SM. Evolution of the internal fixation of long bone fractures. The scientific basis of biological internal fixation: choosing a new balance between stability and biology. J Bone Joint Surg Br 2002;84(8):1093-110.
    • (2002) J Bone Joint Surg Br , vol.84 , Issue.8 , pp. 1093-1110
    • Perren, S.M.1
  • 37
    • 24344488119 scopus 로고    scopus 로고
    • Bone healing: Histologic and physiologic concepts
    • Fackelman GE, editor. Stuttgart, NY: Thieme
    • Rahn BA. Bone healing: histologic and physiologic concepts. In: Fackelman GE, editor. Bone in clinical orthopedics. Stuttgart, NY: Thieme; 2002 . p. 287-326.
    • (2002) Bone in Clinical Orthopedics , pp. 287-326
    • Rahn, B.A.1
  • 39
    • 0001902639 scopus 로고
    • Histologic and ultrastructural features of fracture healing
    • Brighton CT, Friedlander GE, Lane JM, editors. Rosemont: American Academy of Orthopedic Surgeons
    • Schenk RK, Hunziker EB. Histologic and ultrastructural features of fracture healing. In: Brighton CT, Friedlander GE, Lane JM, editors. Bone formation and repair. Rosemont: American Academy of Orthopedic Surgeons; 1994 . p. 117-45.
    • (1994) Bone Formation and Repair , pp. 117-145
    • Schenk, R.K.1    Hunziker, E.B.2
  • 41
    • 0023681306 scopus 로고
    • Cortical bone repair. The relationship of the lacunar-canalicular system and intercellular gap junctions to the repair process
    • Shapiro F. Cortical bone repair. The relationship of the lacunar-canalicular system and intercellular gap junctions to the repair process. J Bone Joint Surg Am Vol 1988;70(7):1067-81.
    • (1988) J Bone Joint Surg Am Vol , vol.70 , Issue.7 , pp. 1067-1081
    • Shapiro, F.1
  • 42
    • 33947305450 scopus 로고    scopus 로고
    • Molecular aspects of fracture healing: Which are the important molecules?
    • Tsiridis E, Upadhyay N, Giannoudis P. Molecular aspects of fracture healing: which are the important molecules? Injury 2007;38(1):S11-25.
    • (2007) Injury , vol.38 , Issue.1
    • Tsiridis, E.1    Upadhyay, N.2    Giannoudis, P.3
  • 45
    • 84961030442 scopus 로고
    • Mineral metabolism of fractures of the tibia in man studied with external counting of Sr85
    • Wendeberg B. Mineral metabolism of fractures of the tibia in man studied with external counting of Sr85. Acta Orthop 1961;(52):1-79.
    • (1961) Acta Orthop , Issue.52 , pp. 1-79
    • Wendeberg, B.1
  • 46
    • 77953429870 scopus 로고    scopus 로고
    • Acute phosphate restriction leads to impaired fracture healing and resistance to BMP-2
    • April
    • Wigner NA, Luderer HF, Cox MK, et al. Acute phosphate restriction leads to impaired fracture healing and resistance to BMP-2. J Bone Miner Res 2010;(April 25(4)):724-33.
    • (2010) J Bone Miner Res , vol.25 , Issue.4 , pp. 724-733
    • Wigner, N.A.1    Luderer, H.F.2    Cox, M.K.3
  • 47
    • 36148989585 scopus 로고    scopus 로고
    • Callus mineralization and maturation are delayed during fracture healing in interleukin-6 knockout mice
    • DOI 10.1016/j.bone.2007.07.022, PII S8756328207005546
    • Yang X, Ricciardi BF, Hernandez-Soria A, et al. Callus mineralization and maturation are delayed during fracture healing in interleukin-6 knockout mice. Bone 2007;41(6):928-36. (Pubitemid 350116738)
    • (2007) Bone , vol.41 , Issue.6 , pp. 928-936
    • Yang, X.1    Ricciardi, B.F.2    Hernandez-Soria, A.3    Shi, Y.4    Pleshko, C.N.5    Bostrom, M.P.G.6


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