IL-1 and TNF antagonists prevent inhibition of fracture healing by ethanol in rats

Toxicological Sciences

Volumn 82, Issue 2, 2004, Pages 656-660

  Perrien, Daniel S ^a,b   Wahl, Elizabeth C ^a   Hogue, William R ^b   Feige, Ulrich ^c   Aronson, James ^a,b   Ronis, Martin J J ^b,d   Badger, Thomas M ^d   Lumpkin Jr , Charles K ^a,b  

^a ARKANSAS CHILDREN S HOSPITAL RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c AMGEN INC   (United States)

^d U S DEPARTMENT OF AGRICULTURE   (United States)

Author keywords

Alcohol; Interleukin 1; Interleukin 1 recombinant antagonist; Repair; Total enternal nutrition; Tumor necrosis factor

Indexed keywords

ALCOHOL; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; TUMOR NECROSIS FACTOR RECEPTOR;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MINERAL; BONE RADIOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIETARY INTAKE; DRUG DOSE REGIMEN; FRACTURE EXTERNAL FIXATION; FRACTURE HEALING; LONG TERM EXPOSURE; MALE; NONHUMAN; PROTECTION; QUANTITATIVE ANALYSIS; RAT; SCORING SYSTEM; STATISTICAL SIGNIFICANCE; TIBIA FRACTURE; TUBE FEEDING;

ANIMALS; BONY CALLUS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ETHANOL; FRACTURE HEALING; INTERLEUKIN-1; MALE; OSTEOGENESIS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SIGNAL TRANSDUCTION; TOMOGRAPHY, X-RAY COMPUTED; TUMOR NECROSIS FACTOR-ALPHA; WEIGHT GAIN;

ANIMALIA;

EID: 10044241572     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfi002     Document Type: Article

References (20)

1. Aronson, J., Gao, G. G., Shen, X. C., McLaren, S. G., Skinner, R. A., Badger,T. M., and Lumpkin, C. K., Jr. (2001). The effect of aging on distraction osteogenesis in the rat. J. Orthop. Res. 19, 421-427.
2. Atkins, G. J., Haynes, D. R., Geary, S. M., Loric, M., Crotti, T. N., and Findlay, D. M. (2000). Coordinated cytokine expression by stromal and hematopoietic cells during human osteoclast formation. Bone 26, 653-661.
3. Badger, T. M., Ronis, M. J., Lumpkin, C. K., Valentine, C. R., Shahare, M., Irby, D., Huang, J., Mercado, C., Thomas, P., and Ingelman-Sundberg, M. (1993). Effects of chronic ethanol on growth hormone secretion and hepatic cytochrome P450 isozymes of the rat. J. Pharmacol. Exp. Ther. 264, 438-447.
4. Bikle, D. D. (1993). Alcohol-induced bone disease. World Rev. Nutr. Diet. 73, 53-79.
5. Brown, E. C., Perrien, D. S., Fletcher, T. W., Irby, D. J., Aronson, J., Gao, G. G., Hogue, W.J., Skinner, R. A., Suva, L. J., Ronis, M. J., Hakkak, R., Badger, T.M., and Lumpkin, C. K., Jr. (2002). Skeletal toxicity associated with chronic ethanol exposure in a rat model using total enteral nutrition. J. Pharmacol. Exp. Ther. 301, 1132-1138.
6. Chakkalakal, D. A., Novak, J. R., Fritz, E. D., Mollner, T. J., McVicker, D. L., Lybarger, D. L., McGuire, M. H., and Donohue, T. M., Jr. (2002). Chronic ethanol consumption results in deficient bone repair in rats. Alcohol Alcohol 37, 13-20.
7. Crilly, R. G., Anderson, C., Hogan, D., and Delaquerriere-Richardson, L. (1988). Bone histomorphometry, bone mass, and related parameters in alcoholic males. Calcif. Tissue Int. 43, 269-276.
8. Dai, J., Lin, D., Zhang, J., Habib, P., Smith, P., Murtha, J., Fu, Z., Yao, Z., Qi, Y., and Keller, E. T. (2000). Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice. J. Clin. Invest. 106, 887-895.
9. Dyer, S. A., Buckendahl, P., and Sampson, H. W. (1998). Alcohol consumption inhibits osteoblastic cell proliferation and activity in vivo. Alcohol 16, 337-341.
10. Elmali, N., Ertem, K., Ozen, S., Inan, M., Baysal, T., Guner, G., and Bora, A. (2002). Fracture healing and bone mass in rats fed on liquid diet containing ethanol. Alcohol Clin. Exp. Res. 26, 509-513.
11. Ke, H. Z., Qi, H., Chidsey-Frink, K. L., Crawford, D. T., and Thompson, D. D. (2001). Lasofoxifene (CP-336,156) protects against the age-related changes in bone mass, bone strength, and total serum cholesterol in intact aged male rats. J. Bone Miner. Res. 16, 765-773.
12. Nanes, M. S. (2003). Tumor necrosis factor-alpha: Molecular and cellular mechanisms in skeletal pathology. Gene 321, 1-15.
13. Nyquist, F., Berglund, M., Nilsson, B. E., and Obrant, K. J. (1997). Nature and healing of tibial shaft fractures in alcohol abusers. Alcohol Alcohol 32, 91-95.
14. Nyquist, F., Halvorsen, V., Madsen, J. E., Nordsletten, L., and Obrant, K. J. (1999). Ethanol and its effects on fracture healing and bone mass in male rats. Acta Orthop. Scand. 70, 212-216.
15. Perrien, D. S., Brown, E. C., Fletcher, T. W., Irby, D. J., Aronson, J., Gao, G. G., Skinner, R. A., Hogue, W. R., Feige, U., Suva, L. J., Ronis, M. J., Badger, T. M., and Lumpkin, C. K., Jr. (2002). Interleukin-1 and tumor necrosis factor antagonists attenuate ethanol-induced inhibition of bone formation in a rat model of distraction osteogenesis. J. Pharmacol. Exp. Ther. 303, 904-908.
16. Perrien, D. S., Liu, Z., Wahl, E. C., Bunn, R. C., Skinner, R. A., Aronson, J., Fowlkes, J., Badger, T. M., and Lumpkin, C. K., Jr. (2003). Chronic ethanol exposure is associated with a local increase in TNF-alpha and decreased proliferation in the rat distraction gap. Cytokine 23, 179-189.
17. Purohit, V. (1997). Introduction to the alcohol and osteoporosis symposium. Alcohol Clin. Exp. Res. 21, 383-384.
18. Turner, R. T. (2000). Skeletal response to alcohol. Alcohol Clin. Exp. Res. 24, 1693-1701.
19. Turner, R. T., Greene, V. S., and Bell, N. H. (1987). Demonstration that ethanol inhibits bone matrix synthesis and mineralization in the rat. J. Bone Miner. Res. 2, 61-66.
20. Turner, R. T., Wronski, T. J., Zhang, M., Kidder, L. S., Bloomfield, S. A., and Sibonga, J. D. (1998). Effects of ethanol on gene expression in rat bone: Transient dose-dependent changes in mRNA levels for matrix proteins, skeletal growth factors, and cytokines are followed by reductions in bone formation. Alcohol Clin. Exp. Res. 22, 1591-1599.