메뉴 건너뛰기




Volumn 43, Issue 4, 2015, Pages 731-742

Alpha-Pinene Exhibits Anti-Inflammatory Activity Through the Suppression of MAPKs and the NF-κB Pathway in Mouse Peritoneal Macrophages

Author keywords

Inflammation; Macrophage; Mitogen Activated Protein Kinase; Nuclear factor kappa B; Pinene

Indexed keywords

CYCLOOXYGENASE 2; ESSENTIAL OIL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; NITRITE; PINENE; RECOMBINANT INTERLEUKIN 6; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA; ALPHA-PINENE; ANTIINFLAMMATORY AGENT; LIPOPOLYSACCHARIDE; PTGS2 PROTEIN, MOUSE; TERPENE;

EID: 84938416779     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X15500457     Document Type: Article
Times cited : (218)

References (34)
  • 1
    • 0032925361 scopus 로고    scopus 로고
    • Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathway block inducible nitric oxide syn-thase and tumor necrosis factor accumulation in murine macrophages stimulated with lipo-polysaccharide and interferon-gamma
    • Ajizian, S.J., B.K. English and E.A. Meals. Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathway block inducible nitric oxide syn-thase and tumor necrosis factor accumulation in murine macrophages stimulated with lipo-polysaccharide and interferon-gamma. J. Infect. Dis. 179: 939-944, 1999.
    • (1999) J. Infect. Dis. , vol.179 , pp. 939-944
    • Ajizian, S.J.1    English, B.K.2    Meals, E.A.3
  • 3
    • 0030271387 scopus 로고    scopus 로고
    • NF-kappa B: Ten years after
    • Baeuerle, P.A. and D. Baltimore. NF-kappa B: Ten years after. Cell 87: 13-20, 1996.
    • (1996) Cell , vol.87 , pp. 13-20
    • Baeuerle, P.A.1    Baltimore, D.2
  • 5
    • 0035019373 scopus 로고    scopus 로고
    • IFN-gamma LPS induction of iNOS is modulated by ERK JNK/SAPK and p38(MAPK) in a mouse macrophage cell line
    • Chan, E.D. and D.W. Riches. IFN-gamma LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38(MAPK) in a mouse macrophage cell line. Am. J. Physiol.-Cell Physiol. 280: C441-C450, 2001.
    • (2001) Am. J. Physiol.-Cell Physiol. , vol.280 , pp. C441-C450
    • Chan, E.D.1    Riches, D.W.2
  • 6
    • 0037810249 scopus 로고    scopus 로고
    • Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: Potential targeting for therapeutic intervention
    • Chang, F., L.S. Steelman, J.T. Lee, J.G. Shelton, P.M. Navolani, W.L. Blalock, R.A. Franklin and J.A. McCubrey. Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: Potential targeting for therapeutic intervention. Leukemia 17: 1263-1293, 2003.
    • (2003) Leukemia , vol.17 , pp. 1263-1293
    • Chang, F.1    Steelman, L.S.2    Lee, J.T.3    Shelton, J.G.4    Navolani, P.M.5    Blalock, W.L.6    Franklin, R.A.7    McCubrey, J.A.8
  • 8
    • 84886088387 scopus 로고    scopus 로고
    • Variations of the chemical composition and bioactivity of essential oils from leaves and stems of Liquid-ambar styraciflua (Altingiaceae)
    • El-Readi, M.Z., H.H. Eid, M.L. Ashour, S.Y. Eid, R.M. Labib, F. Sporer and M. Wink. Variations of the chemical composition and bioactivity of essential oils from leaves and stems of Liquid-ambar styraciflua (Altingiaceae). J. Pharm. Pharmacol. 65: 1653-1663, 2013.
    • (2013) J. Pharm. Pharmacol. , vol.65 , pp. 1653-1663
    • El-Readi, M.Z.1    Eid, H.H.2    Ashour, M.L.3    Eid, S.Y.4    Labib, R.M.5    Sporer, F.6    Wink, M.7
  • 9
    • 0030740981 scopus 로고    scopus 로고
    • Excretory/secretory products from plerocercoids of Spirometraerinacei reduce iNOS and chemokine mRNA levels in peritoneal macrophages stimulated with cytokines and/or LPS
    • Fukumoto, S., K. Hirai, T. Tanihata, Y. Ohmori, D.J. Stuehr and T.A. Hamilton. Excretory/secretory products from plerocercoids of Spirometraerinacei reduce iNOS and chemokine mRNA levels in peritoneal macrophages stimulated with cytokines and/or LPS. Parasite Immunol. 19: 325-332, 1997.
    • (1997) Parasite Immunol. , vol.19 , pp. 325-332
    • Fukumoto, S.1    Hirai, K.2    Tanihata, T.3    Ohmori, Y.4    Stuehr, D.J.5    Hamilton, T.A.6
  • 10
    • 16644367561 scopus 로고    scopus 로고
    • Antibacterial and antifungal effects of essential oils from coniferous trees
    • Hong, E.J., K.J. Na, I.G. Choi, K.C. Choi and E.B. Jeung. Antibacterial and antifungal effects of essential oils from coniferous trees. Biol. Pharm. Bull. 27: 863-866, 2004.
    • (2004) Biol. Pharm. Bull. , vol.27 , pp. 863-866
    • Hong, E.J.1    Na, K.J.2    Choi, I.G.3    Choi, K.C.4    Jeung, E.B.5
  • 11
    • 29144511607 scopus 로고    scopus 로고
    • MAPK signalling pathways as molecular targets for anti-inflammatory therapy from molecular mechanisms to therapeutic benefits
    • Kaminska, B. MAPK signalling pathways as molecular targets for anti-inflammatory therapy from molecular mechanisms to therapeutic benefits. Biochim. Biophys. Acta 1754: 253-262, 2005.
    • (2005) Biochim. Biophys. Acta , vol.1754 , pp. 253-262
    • Kaminska, B.1
  • 13
    • 36849072564 scopus 로고    scopus 로고
    • Inhibition of LPS-induced iNOS, COX-2 and cytokines expression by Poncirin through the NF-kappaB inacti-vation in RAW 264.7 macrophage cells
    • Kim, J.B., A.R. Han, E.Y. Park, J.Y. Kim, W. Cho, J. Lee, E.K. Seo and K.T. Lee. Inhibition of LPS-induced iNOS, COX-2 and cytokines expression by Poncirin through the NF-kappaB inacti-vation in RAW 264.7 macrophage cells. Biol. Pharm. Bull. 30: 2345-2351, 2007.
    • (2007) Biol. Pharm. Bull. , vol.30 , pp. 2345-2351
    • Kim, J.B.1    Han, A.R.2    Park, E.Y.3    Kim, J.Y.4    Cho, W.5    Lee, J.6    Seo, E.K.7    Lee, K.T.8
  • 15
    • 78751486553 scopus 로고    scopus 로고
    • Anti-inflammatory activity of hyperoside through the suppression of nuclear factor-B activation in mouse peritoneal macrophages
    • Kim, S.J., J.Y. Um and J.Y. Lee. Anti-inflammatory activity of hyperoside through the suppression of nuclear factor-B activation in mouse peritoneal macrophages. Am. J. Chin. Med. 39: 171-181, 2011.
    • (2011) Am. J. Chin. Med. , vol.39 , pp. 171-181
    • Kim, S.J.1    Um, J.Y.2    Lee, J.Y.3
  • 16
    • 67649382201 scopus 로고    scopus 로고
    • Comparison of chemical compositions and antimicrobial activities of essential oils from three conifer trees; Pinus densiflora Cryptomeria japonica and Chamaecyparis obusa
    • Lee, J.H., B.K. Lee, J.H. Kim, S.H. Lee and S.K. Hong. Comparison of chemical compositions and antimicrobial activities of essential oils from three conifer trees; Pinus densiflora, Cryptomeria japonica, and Chamaecyparis obusa. J. Microbiol. Biotechnol. 19: 391-396, 2009.
    • (2009) J. Microbiol. Biotechnol. , vol.19 , pp. 391-396
    • Lee, J.H.1    Lee, B.K.2    Kim, J.H.3    Lee, S.H.4    Hong, S.K.5
  • 17
    • 0036781052 scopus 로고    scopus 로고
    • NF-kappaB regulation in the immune system
    • Li, Q. and I.M. Verma. NF-kappaB regulation in the immune system. Nat. Rev. Immunol. 2: 725-734, 2002.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 19
    • 0030666222 scopus 로고    scopus 로고
    • Innate immunity: The virtues of a nonclonal system of recognition
    • Medzhitov, R. and C.A. Janeway Jr. Innate immunity: The virtues of a nonclonal system of recognition. Cell 9: 295-298, 1997.
    • (1997) Cell , vol.9 , pp. 295-298
    • Medzhitov, R.1    Janeway, C.A.2
  • 20
    • 77749267767 scopus 로고    scopus 로고
    • The essential oil of turpentine and its major volatile fraction (alpha-and beta-pinenes): A review
    • Mercier, B., J. Prost and M. Prost. The essential oil of turpentine and its major volatile fraction (alpha-and beta-pinenes): A review. Int. J. Occup. Med. Environ. Health 22: 331-342, 2009.
    • (2009) Int. J. Occup. Med. Environ. Health , vol.22 , pp. 331-342
    • Mercier, B.1    Prost, J.2    Prost, M.3
  • 22
    • 0036669379 scopus 로고    scopus 로고
    • Distinct functions of COX-1 and COX-2
    • Morita, I. Distinct functions of COX-1 and COX-2. Prostaglandins Other Lipid Mediat. 68-69: 165-175, 2002.
    • (2002) Prostaglandins Other Lipid Mediat. , vol.68-69 , pp. 165-175
    • Morita, I.1
  • 23
    • 34548190038 scopus 로고    scopus 로고
    • IL-6 signaling in inflammatory bowel disease: Pathophysiological role and clinical relevance
    • Mudter, J. and M.F. Neurath. IL-6 signaling in inflammatory bowel disease: Pathophysiological role and clinical relevance. Inflamm. Bowel Dis. 13: 1016-1023, 2007.
    • (2007) Inflamm. Bowel Dis. , vol.13 , pp. 1016-1023
    • Mudter, J.1    Neurath, M.F.2
  • 24
    • 0037385031 scopus 로고    scopus 로고
    • Common herbs, essential oils, and monoterpenes potently modulate bone metabolism
    • Mühlbauer, R.C., A. Lozano, S. Palacio, A. Reinli and R. Felix. Common herbs, essential oils, and monoterpenes potently modulate bone metabolism. Bone 32: 372-380, 2003.
    • (2003) Bone , vol.32 , pp. 372-380
    • Mühlbauer, R.C.1    Lozano, A.2    Palacio, S.3    Reinli, A.4    Felix, R.5
  • 25
    • 84907897623 scopus 로고    scopus 로고
    • The therapeutic efficacy of a-pinene in an experimental mouse model of allergic rhinitis
    • Nam, S.Y., C.K. Chung, J.H. Seo, S.Y. Rah, H.M. Kim and H.J. Jeong. The therapeutic efficacy of a-pinene in an experimental mouse model of allergic rhinitis. Int. Immunopharmacol. 23: 273-282, 2014.
    • (2014) Int. Immunopharmacol. , vol.23 , pp. 273-282
    • Nam, S.Y.1    Chung, C.K.2    Seo, J.H.3    Rah, S.Y.4    Kim, H.M.5    Jeong, H.J.6
  • 26
    • 0025232329 scopus 로고
    • Interferon gamma and interleukin 2 synergize to induce selective monokine expression in murine peritoneal macrophages
    • Narumi, S., J.H. Finke and T.A. Hamilton. Interferon gamma and interleukin 2 synergize to induce selective monokine expression in murine peritoneal macrophages. J. Biol. Chem. 265: 7036-7041, 1990.
    • (1990) J. Biol. Chem. , vol.265 , pp. 7036-7041
    • Narumi, S.1    Finke, J.H.2    Hamilton, T.A.3
  • 27
    • 35748979444 scopus 로고    scopus 로고
    • Interleukin-6 in the pathogenesis of rheumatoid arthritis
    • Park, J.Y. and M.H. Pillinger. Interleukin-6 in the pathogenesis of rheumatoid arthritis. Bull. NYU. Hosp. Jt. Dis. 65(Suppl 1): S4-S10, 2007.
    • (2007) Bull. NYU. Hosp. Jt. Dis. , vol.65 , pp. S4-S10
    • Park, J.Y.1    Pillinger, M.H.2
  • 28
    • 80855141627 scopus 로고    scopus 로고
    • Biological evaluation of isoegomaketone isolated from Perilla frutescens and its synthetic derivatives as anti-inflammatory agents
    • Park, Y.D., C.H. Ji, D.S. Choi, M.W. Byun and I.Y. Jeong. Biological evaluation of isoegomaketone isolated from Perilla frutescens and its synthetic derivatives as anti-inflammatory agents. Arch. Pharm. Res. 34: 1277-1282, 2011.
    • (2011) Arch. Pharm. Res. , vol.34 , pp. 1277-1282
    • Park, Y.D.1    Ji, C.H.2    Choi, D.S.3    Byun, M.W.4    Jeong, I.Y.5
  • 30
    • 0034913364 scopus 로고    scopus 로고
    • Anti-tumor necrosis factor therapy in sepsis: Update on clinical trials and lessons learned
    • Reinhart, K. and W. Karzai. Anti-tumor necrosis factor therapy in sepsis: Update on clinical trials and lessons learned. Crit. Care. Med. 29(Suppl 7): S121-S125, 2001.
    • (2001) Crit. Care. Med. , vol.29 , pp. S121-S125
    • Reinhart, K.1    Karzai, W.2
  • 31
    • 84869834766 scopus 로고    scopus 로고
    • Role of IL-6 in asthma and other inflammatory pulmonary diseases
    • Rincon, M. and C.G. Irvin. Role of IL-6 in asthma and other inflammatory pulmonary diseases. Int. J. Biol. Sci. 8: 1281-1290, 2012.
    • (2012) Int. J. Biol. Sci. , vol.8 , pp. 1281-1290
    • Rincon, M.1    Irvin, C.G.2
  • 32
    • 78449265591 scopus 로고    scopus 로고
    • TNF inhibitors-new and old agents for rheumatoid arthritis
    • Simsek, I. TNF inhibitors-new and old agents for rheumatoid arthritis. Bull. NYU. Hosp. Jt. Dis. 68: 204-210, 2010.
    • (2010) Bull. NYU. Hosp. Jt. Dis. , vol.68 , pp. 204-210
    • Simsek, I.1
  • 33
    • 0029553831 scopus 로고
    • Tumor necrosis factor (TNF) in inflammatory bowel disease: Gene polymorphisms, animal models, and potential for anti-TNF therapy
    • Stokkers, P.C., L. Camoglio and S.J. van Deventer. Tumor necrosis factor (TNF) in inflammatory bowel disease: Gene polymorphisms, animal models, and potential for anti-TNF therapy. J. Inflamm. 47: 97-103, 1995.
    • (1995) J. Inflamm. , vol.47 , pp. 97-103
    • Stokkers, P.C.1    Camoglio, L.2    Van Deventer, S.J.3
  • 34
    • 0025969117 scopus 로고
    • Systemic TNF administration in psoriatic patients: A promising therapeutic modality for severe psoriasis
    • Takematsu, H., H. Ozawa, T. Yoshimura, M. Hara, A. Sakakibara, J. Oyama and H. Tagami. Systemic TNF administration in psoriatic patients: A promising therapeutic modality for severe psoriasis. Br. J. Dermatol. 124: 209-210, 1991.
    • (1991) Br. J. Dermatol. , vol.124 , pp. 209-210
    • Takematsu, H.1    Ozawa, H.2    Yoshimura, T.3    Hara, M.4    Sakakibara, A.5    Oyama, J.6    Tagami, H.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.