Novel antitumor strategy utilizing a plasmid expressing a Mycobacterium tuberculosis antigen as a “danger signal” to block immune escape of tumor cells

Pharmaceutics

Volumn 7, Issue 3, 2015, Pages 165-174

  Koyama, Yoshiyuki ^a,b   Yoshihara, Chieko ^c   Ito, Tomoko ^a,b  

^a FUKUJUJI HOSPITAL   (Japan)

^b Osaka Prefecture University   (Japan)

^c OTSUMA WOMEN'S UNIVERSITY   (Japan)

Author keywords

Cytokine; Danger signal; Early secretory antigenic target 6; Immune escape; Immuno gene therapy; Mycobacterium tuberculosis; Nanoparticle; Non viral; Plasmid; Transfection

Indexed keywords

BACTERIAL DNA; CHONDROITIN SULFATE; EARLY SECRETORY ANTIGENIC TARGET 6; INTERLEUKIN 12; INTERLEUKIN 2; POLYETHYLENEIMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GENE THERAPY; CANCER INHIBITION; CONTROLLED STUDY; DRUG POTENTIATION; ESAT 6 GENE; GENE VECTOR; IL 12 GENE; IL 2 GENE; IMMUNE RESPONSE; IN VIVO STUDY; MALE; MELANOMA B16; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PARTICLE SIZE; PHARMACOLOGICAL BLOCKING; PLASMID; PROTEIN EXPRESSION; SURVIVAL RATE; TUMOR CELL; TUMOR ESCAPE; TUMOR REGRESSION; TUMOR VOLUME;

EID: 84938404355     PISSN: None     EISSN: 19994923     Source Type: Journal    
DOI: 10.3390/pharmaceutics7030165     Document Type: Article

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