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Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 17, 2015, Pages 3535-3540

Novel hybrids of 3-n-butylphthalide and edaravone: Design, synthesis and evaluations as potential anti-ischemic stroke agents

(8) Sheng, Xiao a,b Hua, Kai a Yang, Chunyu a Wang, Xiaoli a Ji, Hui a Xu, Jinyi a Huang, Zhangjian a Zhang, Yihua a

a CHINA PHARMACEUTICAL UNIVERSITY (China)

b FUDAN UNIVERSITY (China)

Author keywords

3 n Butylphthalide (NBP); Anti ischemic stroke; Anti platelet aggregation; Antioxidant activity; Edaravone (Eda)

Indexed keywords

ACETYLSALICYLIC ACID; ANTIOXIDANT; ANTITHROMBOCYTIC AGENT; BUTYLPHTHALIDE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; NORPHENAZONE; SUPEROXIDE; TICLOPIDINE; 3-N-BUTYLPHTHALIDE; BENZOFURAN DERIVATIVE; NEUROPROTECTIVE AGENT; PHENAZONE; PHENYLMETHYLPYRAZOLONE; SCAVENGER;

ACIDIFICATION; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ESTERIFICATION; IN VITRO STUDY; NERVE CELL NECROSIS; PC12 CELL LINE; RING OPENING; TAUTOMER; THROMBOCYTE AGGREGATION; ANALOGS AND DERIVATIVES; ANIMAL; CELL LINE; CHEMISTRY; DRUG EFFECTS; HUMAN; METABOLISM; NERVE CELL; PATHOLOGY; RAT; STROKE;

ANIMALS; ANTIPYRINE; BENZOFURANS; CELL LINE; DRUG DESIGN; FREE RADICAL SCAVENGERS; HUMANS; HYDROGEN PEROXIDE; NEURONS; NEUROPROTECTIVE AGENTS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RATS; STROKE;

EID: 84938379655 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2015.06.090 Document Type: Article

Times cited : (46)

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