Dynamic cell culture on calcium phosphate microcarriers for bone tissue engineering applications

Journal of Tissue Engineering

Volumn 5, Issue , 2014, Pages

  Perez, Roman A ^a,b,c   Riccardi, Kiara ^a,b   Altankov, George ^d,e   Ginebra, Maria Pau ^a,b  

^a UNIVERSITAT POLITÈCNICA DE CATALUNYA   (Spain)

^b BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

^c Dankook University   (South Korea)

^d INSTITUTE FOR BIOENGINEERING OF CATALONIA IBEC   (Spain)

^e INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

bone tissue engineering; Calcium phosphate microcarrier; gelatin; hydroxyapatite microcarrier; spinner flask

Indexed keywords

BONE; BOTTLES; CALCIUM PHOSPHATE; CELL CULTURE; CELL ENGINEERING; CELLS; EMULSIFICATION; PROTEINS; SCAFFOLDS (BIOLOGY);

BONE TISSUE ENGINEERING; CALCIUM PHOSPHATE MICROCARRIER; DYNAMIC CELL CULTURES; GELATIN; HYDROXYAPATITE MICROCARRIER; MICROCARRIERS; SPINNER FLASKS; TISSUE ENGINEERING APPLICATIONS; TRI-CALCIUM PHOSPHATES;

HYDROXYAPATITE;

CALCIUM PHOSPHATE; DRUG CARRIER; MICROCARRIER; UNCLASSIFIED DRUG;

ANALYTICAL PARAMETERS; ARTICLE; BONE TISSUE; CELL COUNT; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; PARTICLE SIZE; PRIORITY JOURNAL; ROTATION; SCANNING ELECTRON MICROSCOPY; SPECTROPHOTOMETRY; TISSUE ENGINEERING;

EID: 84938369263     PISSN: None     EISSN: 20417314     Source Type: Journal    
DOI: 10.1177/2041731414543965     Document Type: Article

References (35)

1. J.H.ParkR.A.PerezG.Z.Jin. Microcarriers designed for cell culture and tissue engineering of bone. Tissue Eng Part B Rev2013; 19(2): 172–190.
2. R.A.PerezJ.E.WonJ.C.Knowles. Naturally and synthetic smart composite biomaterials for tissue regeneration. Adv Drug Deliv Rev2013; 65(4): 471–496.
3. M.P.GinebraM.EspanolE.B.Montufar. New processing approaches in calcium phosphate cements and their applications in regenerative medicine. Acta Biomater2010; 6(8): 2863–2873.
4. S.C.Wu. Influence of hydrodynamic shear stress on microcarrier-attached cell growth: cell line dependency and surfactant protection. Bioprocess Eng1999; 21(3): 201–206.
5. G.EibesF.Dos SantosP.Z.Andrade. Maximizing the ex vivo expansion of human mesenchymal stem cells using a microcarrier-based stirred culture system. J Biotechnol2010; 146(4): 194–197.
6. S.FrauenschuhE.ReichmannY.Ibold. A microcarrier-based cultivation system for expansion of primary mesenchymal stem cells. Biotechnol Prog2007; 23(1): 187–193.
7. L.BooL.SelvaratnamC.C.Tai. Expansion and preservation of multipotentiality of rabbit bone-marrow derived mesenchymal stem cells in dextran-based microcarrier spin culture. J Mater Sci Mater Med2011; 22(5): 1343–1356.
8. Y.YangF.M.RossiE.E.Putnins. Ex vivo expansion of rat bone marrow mesenchymal stromal cells on microcarrier beads in spin culture. Biomaterials2007; 28(20): 3110–3120.
9. H.J.ChungI.K.KimT.G.Kim. Highly open porous biodegradable microcarriers: in vitro cultivation of chondrocytes for injectable delivery. Tissue Eng Part A2008; 14(5): 607–615.
10. L.E.FreedC.Vunjak-NovakovicR.Langer. Cultivation of cell-polymer cartilage implants in bioreactors. J Cell Biochem1993; 51(3): 257–264.
11. H.H.LeeS.J.HongC.H.Kim. Preparation of hydroxyapatite spheres with an internal cavity as a scaffold for hard tissue regeneration. J Mater Sci Mater Med2008; 19(9): 3029–3034.
12. J.S.ParkS.J.HongH.Y.Kim. Evacuated calcium phosphate spherical microcarriers for bone regeneration. Tissue Eng Part A2010; 16(5): 1681–1691.
13. R.A.PerezS.Del ValleG.Altankov. Porous hydroxyapatite and gelatin/hydroxyapatite microspheres obtained by calcium phosphate cement emulsion. J Biomed Mater Res B Appl Biomater2011; 97(1): 156–166.
14. R.A.PerezG.AltankovE.Jorge-Herrero. Micro- and nanostructured hydroxyapatite-collagen microcarriers for bone tissue-engineering applications. J Tissue Eng Regen Med2013; 7(5): 353–361.
15. W.PaulS.T.Sharma. Development of porous spherical hydroxyapatite granules: application towards protein delivery. J Mater Sci Mater Med1999; 10(7): 383–388.
16. V.S.KomlevS.M.BarinovE.V.Koplik. A method to fabricate porous spherical hydroxyapatite granules intended for time-controlled drug release. Biomaterials2002; 23(16): 3449–3454.
17. J.MaldaE.KreijveldJ.S.Temenoff. Expansion of human nasal chondrocytes on macroporous microcarriers enhances redifferentiation. Biomaterials2003; 24(28): 5153–5161.
18. J.M.Melero-MartinM.A.DowlingM.Smith. Expansion of chondroprogenitor cells on macroporous microcarriers as an alternative to conventional monolayer systems. Biomaterials2006; 27(15): 2970–2979.
19. D.SchopR.van Dijkhuizen-RadersmaE.Bogart. Expansion of human mesenchymal stromal cells on microcarriers: growth and metabolism. J Tissue Eng Regen Med2010; 4(2): 131–140.
20. S.C.WuW.C.HsiehM.Y.Liau. Comparisons of microcarrier cell culture processes in one hundred mini-liter spinner flask and fifteen-liter bioreactor cultures. Bioproc Biosyst Eng1998; 19(6): 431–434.
21. C.HewittK.LeeA.Nienow. Expansion of human mesenchymal stem cells on microcarriers. Biotechnol Lett2011; 33(11): 2325–2335.
22. R.S.CherryE.T.Papoutsakis. Hydrodynamic effects on cells in agitated tissue culture reactors. Bioprocess Eng1986; 1(1): 29–41.
23. H.S.YangO.JeonS.H.Bhang. Suspension culture of mammalian cells using thermosensitive microcarrier that allows cell detachment without proteolytic enzyme treatment. Cell Transplant2010; 19(9): 1123–1132.
24. F.D.SantosP.Z.AndradeM.M.Abecasis. Toward a clinical-grade expansion of mesenchymal stem cells from human sources: a microcarrier-based culture system under xeno-free conditions. Tissue Eng Part C Methods2011; 17(12): 1201–1210.
25. A.N.El-Moghaz. Factors effects the growth of Chinese hamster ovary (CHO) cell on microcarriers culture. Adv Biores2010; 1(1): 182–188.
26. M.C.SouzaM.S.FreireL.R.Castilho. Influence of culture conditions on Vero cell propagation on non-porous microcarriers. Braz Arch Biol Technol2005; 48: 71–77.
27. S.LakhotiaE.T.Papoutsakis. Agitation induced cell injury in microcarrier cultures. Protective effect of viscosity is agitation intensity dependent: experiments and modeling. Biotechnol Bioeng1992; 39(1): 95–107.
28. W.ZhangX.F.WalboomersG.Van Osch. Hard tissue formation in a porous HA/TCP ceramic scaffold loaded with stromal cells derived from dental pulp and bone marrow. Tissue Eng Part A2008; 14(2): 285–294.
29. L.BjerreC.BüngerA.Baatrup. Flow perfusion culture of human mesenchymal stem cells on coralline hydroxyapatite scaffolds with various pore sizes. J Biomed Mater Res A2011; 97(3): 251–263.
30. E.EngelS.Del ValleC.Aparicio. Discerning the role of topography and ion exchange in cell response of bioactive tissue engineering scaffolds. Tissue Eng Part A2008; 14(8): 1341–1351.
31. R.A.PerezH.W.KimM.P.Ginebra. Polymeric additives to enhance the functional properties of calcium phosphate cements. J Tissue Eng2013; 3(1): 2041731412439555.
32. C.FrondozaA.SohrabiD.Hungerford. Human chondrocytes proliferate and produce matrix components in microcarrier suspension culture. Biomaterials1996; 17(9): 879–888.
33. A.H.ShikaniD.J.FinkSohrabi. Propagation of human nasal chondrocytes in microcarrier spinner culture. Am J Rhinol2004; 18(2): 105–112.
34. J.MaldaP.van den BrinkP.Meeuwse. Effect of oxygen tension on adult articular chondrocytes in microcarrier bioreactor culture. Tissue Eng2004; 10(7–8): 987–994.
35. H.TanJ.WuD.Huang. The design of biodegradable microcarriers for induced cell aggregation. Macromol Biosci2010; 10(2): 156–163.