Porous hydroxyapatite and gelatin/hydroxyapatite microspheres obtained by calcium phosphate cement emulsion

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 97 B, Issue 1, 2011, Pages 156-166

  Perez, Roman A ^a,b   Del Valle, Sergio ^a   Altankov, George ^c,d   Ginebra, Maria Pau ^a,b  

^a UNIVERSITAT POLITÈCNICA DE CATALUNYA   (Spain)

^b BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

^c INSTITUTE FOR BIOENGINEERING OF CATALONIA IBEC   (Spain)

^d INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

bone graft; calcium phosphate(s); composite hard tissue; hydroxy(1)lapatite; microspheres

Indexed keywords

BONE GRAFT; CALCIUM PHOSPHATE CEMENT; COMPOSITE/HARD TISSUE; ENTANGLED NETWORKS; FLUORESCENT STAINING; HIGH POROSITY; HYDROPHOBIC PHASE; HYDROXY(1)LAPATITE; HYDROXYAPATITE CRYSTALS; MICROCARRIERS; POROUS HYDROXYAPATITE; POWDER SIZE; ROTATION SPEED; SAOS-2 CELLS; SEM STUDY; SETTING REACTIONS; SIZE DISPERSION; TRI-CALCIUM PHOSPHATES; WATER IN OIL EMULSIONS;

ADHESION; APATITE; BIOMATERIALS; BONE; CALCIUM; CELL ADHESION; CEMENTS; EMULSIFICATION; EMULSIONS; GRAFTS; GROWTH KINETICS; HYDROXYAPATITE; MICROSPHERES;

CALCIUM PHOSPHATE;

CALCIUM PHOSPHATE; CALCIUM PHOSPHATE CEMENT; CEMENT; FLUORESCENT DYE; GELATIN; GELATIN HYDROXYAPATITE MICROSPHERE; HYDROXYAPATITE; LACTATE DEHYDROGENASE; LIQUID PARAFFIN; MICROSPHERE; OLIVE OIL; SUNFLOWER OIL; UNCLASSIFIED DRUG; WATER;

ARTICLE; CELL ADHESION; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN; CELL STRAIN SAOS 2; CELL STRUCTURE; DISPERSION; EMULSION; HUMAN; HUMAN CELL; HYDROLYSIS; MICROCARRIER CULTURE; PARTICLE SIZE; POROSITY; SCANNING ELECTRON MICROSCOPY; VISCOSITY; X RAY DIFFRACTION;

BONE CEMENTS; CALCIUM PHOSPHATES; CELL ADHESION; CELL LINE; DURAPATITE; EMULSIONS; GELATIN; HUMANS; MICROSPHERES; OSTEOBLASTS; POROSITY;

EID: 79952374437     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.31798     Document Type: Article

References (40)

1. Cancedda R, Giannoni P, Mastrogiacomo M,. A tissue engineering approach to bone repair in large animal models and in clinical practice. Biomaterials 2007; 28: 4240-4250. (Pubitemid 47212405)
2. Fischer EM, Layrolle P, Van Blitterswijk CA, De Bruijn JD,. Bone formation by mesenchymal progenitor cells cultured on dense and microporous hydroxyapatite particles. Tissue Eng 2003; 9: 1179-1188. (Pubitemid 37467665)
3. Mankani MH, Kuznetsov SA, Fowler B, Kingman A, Robey PG,. In vivo bone formation by human bone marrow stromal cells: Effect of carrier particle size and shape. Biotechnol Bioeng 2001; 72: 96-107. (Pubitemid 32085898)
4. Bohner M, Baumgart F,. Theoretical model to determine the effects of geometrical factors on the resorption of calcium phosphate bone substitutes. Biomaterials 2004; 25: 3569-3582. (Pubitemid 38331991)
5. Malda J, Frondoza CG,. Microcarriers in the engineering of cartilage and bone. Trends Biotechnol 2006; 24: 299-304. (Pubitemid 43977904)
6. Paul W, Sharma ST,. Development of porous spherical hydroxyapatite granules: Application towards protein delivery. J Mater Sci Mater Med 1999; 10: 383-388. (Pubitemid 29371645)
7. Komlev VS, Barinov SM, Koplik EV,. A method to fabricate porous spherical hydroxyapatite granules intended for time-controlled drug release. Biomaterials 2002; 23: 3449-3454. (Pubitemid 34615651)
8. Komlev VS, Barinov SM, Girardin E, Oscarsson S, Rosengren A, Rustichelli F, Orlovskii VP,. Porous spherical hydroxyapatite and fluorhydroxyapaite granules: Processing and characterization. Sci Technol Adv Mater 2003; 4: 503-508.
9. Qiu Q, Ducheyne P, Ayyaswamy PS,. Fabrication, characterization and evaluation of bioceramic hollow microspheres used as microcarriers for 3-D bone tissue formation in rotating bioreactors. Biomaterials 1999; 20: 989-1001. (Pubitemid 29229467)
10. Wu C, Chang J,. Bonelike apatite formation on carbon microspheres. Mater Lett 2007; 61: 2502-2505. (Pubitemid 46560124)
11. Barrias CC, Ribeiro CC, Barbosa MA,. Adhesion and proliferation of human osteoblastic cells seeded on injectable hydroxyapatite microspheres. Key Eng Mater 2004; 254/256: 877-880.
12. Kim HW, Yoon BH, Kim HE,. Microsphere of apatite-gelatin nanocomposite as bone regenerative filler. J Mater Sci Mater Med 2005; 16: 1105-1109.
13. Wu T, Huang H, Lan C, Lin C, Hsu F, Wang Y,. Studies on the microspheres comprised of reconstituded collagen and hydroxyapatite. Biomaterials 2004; 25: 651-658. (Pubitemid 37357279)
14. Bohner M,. Implant comprising calcium cement and hydrophobic liquid. US Patent 6,642,285 B1, 2003.
15. Ginebra MP, Espanol M, Montufar EB, Perez RA, Mestres G,. New processing approaches in calcium phosphate cements and their applications in regenerative medicine. Acta Biomater 2010; 6: 2863-2873.
16. Bohner M, van Lenthe GH, Grünenfelder S, Hirsiger W, Evison R, Müller R,. Synthesis and characterization of porous β-tricalcium phosphate blocks. Biomaterials 2005; 26: 6099-6105. (Pubitemid 40834284)
17. Ginebra MP,. Calcium phosphate bone cements. In:, Deb S, editor. Orthopaedic Bone Cements. Cambridge: Woodhead Publishing Limited; 2008. pp 206-230.
18. Espanol M, Perez RA, Montufar EB, Marichal A, Sacco A, Ginebra MP,. Intrinsic porosity of calcium phosphate cements and its significance for drug delivery and tissue engineering applications. Acta Biomater 2009; 5: 2752-2762.
19. Ginebra MP, Traykova T, Planell JA,. Calcium phosphate cements as bone drug delivery systems: A review. J Controlled Release 2006; 113: 102-110. (Pubitemid 44202359)
20. Emsley J, Knight CG, Farndale RW, Barnes MJ, Liddington RC,. Structural basis of collagen recognition by integrin α2β1. Cell 2000; 101: 47-56.
21. Ginebra MP, Fernandez E, De Maeyer EAP, Verbeeck RMH, Boltong MG, Ginebra J, Driessens FCM, Planell JA,. Setting reaction and hardening of an apatitic calcium phosphate cement. J Dent Res 1997; 76: 905-912. (Pubitemid 127732682)
22. Hayashi A, Oh SC,. Gelation of gelatin solution. Agric Biol Chem 1983; 47: 1711-1716.
23. Teng S, Chen L, Guo Y, Shi J,. Formation of nano-hydroxyapatite in gelatin droplets and the resulting porous composite microspheres. J Inorg Biochem 2007; 101: 686-691. (Pubitemid 46349225)
24. Johnston JH, Peard GT,. The surface tension of gelatin solutions. Biochem J 1925; 19: 281-289.
25. McClements DJ,. Food Emulsions: Principles, Practices, and Techniques. Boca Ratõn: CRC Press; 2004.
26. Liu C, Shao H, Chen F, Zheng H,. Effects of the granularity of raw materials on the hydration and hardening process of calcium phosphate cement. Biomaterials 2003; 24: 4103-4113. (Pubitemid 36809012)
27. Ginebra MP, Driessens FCM, Planell JA,. Effect of the particle size on the micro and nanostructural features of a calcium phosphate cement: A kinetic analysis. Biomaterials 2004; 25: 3453-3462. (Pubitemid 38331989)
28. Zhang Y, Xu HHK, Tagaki S, Chow LC,. In-situ hardening hydroxyapatite-based scaffold for bone repair. J Mater Sci Mater Med 2006; 17: 437-445. (Pubitemid 43827973)
29. Yuasa T, Miyamoto Y, Ishikawa K, Takechia M, Momota Y, Tatehara S, Nagayama M,. Effects of apatite cements on proliferation and differentiation of human osteoblasts in vitro. Biomaterials 2004; 25: 1159-1166. (Pubitemid 37476193)
30. Zhao L, Burguera EF, Xu HHK, Amin N, Ryou H, Arola DD,. Fatigue and human umbilical cord stem cell seeding characteristics of calcium phosphate-chitosan-biodegradable fiber scaffold. Biomaterials 2010; 31: 840-847.
31. Bigi A, Torricelli P, Fini M, Bracci B, Panzaavolta S, Sturba L, Giardino R,. A biomimetic gelatin-calcium phosphate bone cement. Int J Artif Organs 2004; 27: 664-673. (Pubitemid 39369010)
32. Bigi A, Panzavolta S, Sturba L, Torricelli P, Fini M, Giardino R,. Normal and osteopenic bone-derived osteoblast response to a biomimetic gelatin-calcium phosphate bone cement. J Biomed Mater Res A 2006; 78: 739-745. (Pubitemid 44300027)
33. Kim HW, Kim HE, Salih V,. Stimulation of osteoblast responses to biomimetic nanocomposites of gelatin-hydroxyapatite for tissue engineering scaffolds. Biomaterials 2005; 26: 5221-5230. (Pubitemid 40387844)
34. Zhang WM, Kapyla J, Puranen JS, Knight CG, Tiger CF, Pentikainen OT, Johnson MS, Farndale RW, Heino J, Gullberg D,. Alpha 11beta 1 integrin recognizes the GFOGER sequence in interstitial collagens. J Biol Chem 2003; 278: 7270-7277. (Pubitemid 36800729)
35. Knight CG, Morton LF, Onley DJ, Peachey AR, Messent AJ, Smethurst PA, Tuckwell DS, Farndale RW, Barnes MJ,. Identification in collagen type I of an integrin alpha2 beta1-binding site containing an essential GER sequence. J Biol Chem 1998; 273: 33287-33294.
36. Pioletti DP, Takei H, Lin T, Van Landuyt P, Ma QJ, Kwon SY, Sung KP,. The effects of calcium phosphate cement particles on osteoblast functions. Biomaterials 2000; 21: 1103-1114. (Pubitemid 30173148)
37. Misiek DJ, Kent JN, Carr RF,. Soft tissue responses to hydroxylapatite particles of different shapes. J Oral Maxillofac Surg 1984; 42: 150-160. (Pubitemid 14159412)
38. Engel E, del Valle S, Aparicio C, Altankov G, Asin L, Planell JA, Ginebra MP,. Discerning the role of topography and ion exchange in cell response of bioactive tissue engineering scaffolds. Tissue Eng 2008; 14: 1341-1351.
39. Shelton RM, Liu Y, Cooper PR, Gbureck U, German MJ, Barralet JE,. Bone marrow cell gene expression and tissue construct assembly using octacalcium phosphate microscaffolds. Biomaterials 2006; 27: 2874-2881. (Pubitemid 43165756)
40. Kuijpers AJ, van Wachem PB, van Luyn MJA, Platinga JA, Engbers GHM, Krijgsveld J, Zaat SAJ, Dankert J, Feijen J,. In vivo compatibility and degradation of crosslinked gelatin gels incorporated in knitted Dacron. J Biomed Mat Res 2000; 51: 136-145. (Pubitemid 30331992)