pH-Sensitive Polymeric Nanoparticles with Gold(I) Compound Payloads Synergistically Induce Cancer Cell Death through Modulation of Autophagy

Molecular Pharmaceutics

Volumn 12, Issue 8, 2015, Pages 2869-2878

  Lin, Yao Xin ^a,b   Gao, Yu Juan ^a   Wang, Yi ^a,b   Qiao, Zeng Ying ^a   Fan, Gang ^a   Qiao, Sheng Lin ^a,b   Zhang, Ruo Xin ^a   Wang, Lei ^a   Wang, Hao ^a  

^a NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

autophagy; cancer; nanoparticles; pH sensitive; polymer; ROS

Indexed keywords

BETA AMINO ACID; ESTER; GOLD NANOPARTICLE; POLYMER; REACTIVE OXYGEN METABOLITE; TERTIARY AMINE; THIOREDOXIN REDUCTASE; DRUG CARRIER; GOLD; METAL NANOPARTICLE; MICELLE;

ALKALINIZATION; APOPTOSIS; ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; CANCER CELL; CELL DEATH; CELL KILLING; CELL PH; CELL STRUCTURE; CONTROLLED STUDY; DISSOCIATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; LYSOSOME; MCF 7 CELL LINE; MICELLE; MODULATION; NANOENCAPSULATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTON TRANSPORT; UPREGULATION; CHEMICAL PHENOMENA; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; METABOLISM; PH; PHAGOSOME; TUMOR CELL LINE;

APOPTOSIS; AUTOPHAGY; CELL LINE, TUMOR; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GOLD; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LYSOSOMES; MCF-7 CELLS; METAL NANOPARTICLES; MICELLES; PHAGOSOMES; POLYMERS; REACTIVE OXYGEN SPECIES;

EID: 84938328579     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.5b00060     Document Type: Article

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