메뉴 건너뛰기




Volumn 50, Issue 1-2, 2015, Pages 11-17

The Origin, Expression, Function and Future Research Focus of a G Protein-coupled Receptor, Mas-related Gene X2 (MrgX2)

Author keywords

Dorsal root ganglion (DRG); Immunity; Mas related gene X2 (MrgX2); Mast cell; Nociception

Indexed keywords

BETA DEFENSIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CORTISTATIN; G PROTEIN COUPLED RECEPTOR; MAS RELATED GENE X2 PROTEIN; PEPTIDE; PMX 53 PEPTIDE; PROADRENOMEDULLIN N TERMINAL PEPTIDE; SUBSTANCE P; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE; ADRENOMEDULLIN; DEXTRORPHAN; ISOPROTEIN; MRGPRX2 PROTEIN, HUMAN; NERVE PROTEIN; NEUROPEPTIDE; NEUROPEPTIDE RECEPTOR;

EID: 84938289976     PISSN: 00796336     EISSN: 18732186     Source Type: Journal    
DOI: 10.1016/j.proghi.2015.06.001     Document Type: Review
Times cited : (15)

References (38)
  • 1
    • 85069351930 scopus 로고    scopus 로고
    • Mp-02.03: The lhrh receptor antagonist cetrorelix exhibits agonistic activity against the orphan gpcr mrgx2: A novel mode of action?
    • Aicher B., Schmidt P., Engel J., Guenther E. Mp-02.03: The lhrh receptor antagonist cetrorelix exhibits agonistic activity against the orphan gpcr mrgx2: A novel mode of action?. Urology 2009, 74:S45.
    • (2009) Urology , vol.74 , pp. S45
    • Aicher, B.1    Schmidt, P.2    Engel, J.3    Guenther, E.4
  • 2
    • 77954937675 scopus 로고    scopus 로고
    • Morphine is an exogenous ligand for mrgx2, a g protein-coupled receptor for cortistatin
    • Akuzawa N., Obinata H., Izumi T., Takeda S. Morphine is an exogenous ligand for mrgx2, a g protein-coupled receptor for cortistatin. Journal of Cell and Animal Biology 2009, 3:216-221.
    • (2009) Journal of Cell and Animal Biology , vol.3 , pp. 216-221
    • Akuzawa, N.1    Obinata, H.2    Izumi, T.3    Takeda, S.4
  • 3
    • 27644531496 scopus 로고    scopus 로고
    • Expression of cortistatin and mrgx2, a specific cortistatin receptor, in human neuroendocrine tissues and related tumours
    • Allia E., Tarabra E., Volante M., Cerrato M., Ghigo E., Muccioli G., Papotti M. Expression of cortistatin and mrgx2, a specific cortistatin receptor, in human neuroendocrine tissues and related tumours. J Pathol 2005, 207:336-345.
    • (2005) J Pathol , vol.207 , pp. 336-345
    • Allia, E.1    Tarabra, E.2    Volante, M.3    Cerrato, M.4    Ghigo, E.5    Muccioli, G.6    Papotti, M.7
  • 7
    • 30344480231 scopus 로고    scopus 로고
    • Characterization of the mas-related gene family: Structural and functional conservation of human and rhesus mrgx receptors
    • Burstein E.S., Ott T.R., Feddock M., Ma J.N., Fuhs S., Wong S., Schiffer H.H., Brann M.R., Nash N.R. Characterization of the mas-related gene family: Structural and functional conservation of human and rhesus mrgx receptors. Br J Pharmacol 2006, 147:73-82.
    • (2006) Br J Pharmacol , vol.147 , pp. 73-82
    • Burstein, E.S.1    Ott, T.R.2    Feddock, M.3    Ma, J.N.4    Fuhs, S.5    Wong, S.6    Schiffer, H.H.7    Brann, M.R.8    Nash, N.R.9
  • 9
    • 0142092547 scopus 로고    scopus 로고
    • Adaptive evolution of mrg, a neuron-specific gene family implicated in nociception
    • Choi S.S., Lahn B.T. Adaptive evolution of mrg, a neuron-specific gene family implicated in nociception. Genome research 2003, 13:2252-2259.
    • (2003) Genome research , vol.13 , pp. 2252-2259
    • Choi, S.S.1    Lahn, B.T.2
  • 10
    • 1542564787 scopus 로고    scopus 로고
    • The cationic antimicrobial peptide ll-37 modulates dendritic cell differentiation and dendritic cell-induced t cell polarization
    • Davidson D.J., Currie A.J., Reid G.S., Bowdish D.M., MacDonald K.L., Ma R.C., Hancock R.E., Speert D.P. The cationic antimicrobial peptide ll-37 modulates dendritic cell differentiation and dendritic cell-induced t cell polarization. J Immunol 2004, 172:1146-1156.
    • (2004) J Immunol , vol.172 , pp. 1146-1156
    • Davidson, D.J.1    Currie, A.J.2    Reid, G.S.3    Bowdish, D.M.4    MacDonald, K.L.5    Ma, R.C.6    Hancock, R.E.7    Speert, D.P.8
  • 11
    • 0035822998 scopus 로고    scopus 로고
    • A diverse family of gpcrs expressed in specific subsets of nociceptive sensory neurons
    • Dong X., Han S., Zylka M.J., Simon M.I., Anderson D.J. A diverse family of gpcrs expressed in specific subsets of nociceptive sensory neurons. Cell 2001, 106:619-632.
    • (2001) Cell , vol.106 , pp. 619-632
    • Dong, X.1    Han, S.2    Zylka, M.J.3    Simon, M.I.4    Anderson, D.J.5
  • 15
    • 79960727577 scopus 로고    scopus 로고
    • G protein coupled receptor specificity for c3a and compound 48/80-induced degranulation in human mast cells: Roles of mas-related genes mrgx1 and mrgx2
    • Kashem S.W., Subramanian H., Collington S.J., Magotti P., Lambris J.D., Ali H. G protein coupled receptor specificity for c3a and compound 48/80-induced degranulation in human mast cells: Roles of mas-related genes mrgx1 and mrgx2. Eur J Pharmacol 2011, 668:299-304.
    • (2011) Eur J Pharmacol , vol.668 , pp. 299-304
    • Kashem, S.W.1    Subramanian, H.2    Collington, S.J.3    Magotti, P.4    Lambris, J.D.5    Ali, H.6
  • 17
    • 11144348648 scopus 로고    scopus 로고
    • Interaction and cellular localization of the human host defense peptide ll-37 with lung epithelial cells
    • Lau Y.E., Rozek A., Scott M.G., Goosney D.L., Davidson D.J., Hancock R.E. Interaction and cellular localization of the human host defense peptide ll-37 with lung epithelial cells. Infection and immunity 2005, 73:583-591.
    • (2005) Infection and immunity , vol.73 , pp. 583-591
    • Lau, Y.E.1    Rozek, A.2    Scott, M.G.3    Goosney, D.L.4    Davidson, D.J.5    Hancock, R.E.6
  • 18
    • 84899547166 scopus 로고    scopus 로고
    • Prevention of anti-microbial peptide ll-37-induced apoptosis and atp release in the urinary bladder by a modified glycosaminoglycan
    • Lee W.Y., Savage J.R., Zhang J., Jia W., Oottamasathien S., Prestwich G.D. Prevention of anti-microbial peptide ll-37-induced apoptosis and atp release in the urinary bladder by a modified glycosaminoglycan. PloS one 2013, 8:e77854.
    • (2013) PloS one , vol.8 , pp. e77854
    • Lee, W.Y.1    Savage, J.R.2    Zhang, J.3    Jia, W.4    Oottamasathien, S.5    Prestwich, G.D.6
  • 19
    • 0142200897 scopus 로고    scopus 로고
    • Epithelial cell-derived antibacterial peptides human beta-defensins and cathelicidin: Multifunctional activities on mast cells
    • Niyonsaba F., Hirata M., Ogawa H., Nagaoka I. Epithelial cell-derived antibacterial peptides human beta-defensins and cathelicidin: Multifunctional activities on mast cells. Current drug targets Inflammation and allergy 2003, 2:224-231.
    • (2003) Current drug targets Inflammation and allergy , vol.2 , pp. 224-231
    • Niyonsaba, F.1    Hirata, M.2    Ogawa, H.3    Nagaoka, I.4
  • 20
    • 0035058454 scopus 로고    scopus 로고
    • Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and ll-37 on histamine release and prostaglandin d(2) production from mast cells
    • Niyonsaba F., Someya A., Hirata M., Ogawa H., Nagaoka I. Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and ll-37 on histamine release and prostaglandin d(2) production from mast cells. European journal of immunology 2001, 31:1066-1075.
    • (2001) European journal of immunology , vol.31 , pp. 1066-1075
    • Niyonsaba, F.1    Someya, A.2    Hirata, M.3    Ogawa, H.4    Nagaoka, I.5
  • 22
    • 53749086028 scopus 로고    scopus 로고
    • Targeting human mast cells expressing g-protein-coupled receptors in allergic diseases
    • Okayama Y., Saito H., Ra C. Targeting human mast cells expressing g-protein-coupled receptors in allergic diseases. Allergol Int 2008, 57:197-203.
    • (2008) Allergol Int , vol.57 , pp. 197-203
    • Okayama, Y.1    Saito, H.2    Ra, C.3
  • 23
    • 0242666360 scopus 로고    scopus 로고
    • Mrgx2 is a high potency cortistatin receptor expressed in dorsal root ganglion
    • Robas N., Mead E., Fidock M. Mrgx2 is a high potency cortistatin receptor expressed in dorsal root ganglion. The Journal of biological chemistry 2003, 278:44400-44404.
    • (2003) The Journal of biological chemistry , vol.278 , pp. 44400-44404
    • Robas, N.1    Mead, E.2    Fidock, M.3
  • 24
    • 33847717931 scopus 로고    scopus 로고
    • Cortistatin - a new neuroendocrine hormone?
    • Rubinfeld H., Shimon I. Cortistatin - a new neuroendocrine hormone?. Pediatr Endocrinol Rev 2006, 4:106-110.
    • (2006) Pediatr Endocrinol Rev , vol.4 , pp. 106-110
    • Rubinfeld, H.1    Shimon, I.2
  • 26
    • 84455172954 scopus 로고    scopus 로고
    • Mas-related gene x2 (mrgx2) is a novel g protein-coupled receptor for the antimicrobial peptide ll-37 in human mast cells: Resistance to receptor phosphorylation, desensitization, and internalization
    • Subramanian H., Gupta K., Guo Q., Price R., Ali H. Mas-related gene x2 (mrgx2) is a novel g protein-coupled receptor for the antimicrobial peptide ll-37 in human mast cells: Resistance to receptor phosphorylation, desensitization, and internalization. The Journal of biological chemistry 2011, 286:44739-44749.
    • (2011) The Journal of biological chemistry , vol.286 , pp. 44739-44749
    • Subramanian, H.1    Gupta, K.2    Guo, Q.3    Price, R.4    Ali, H.5
  • 27
    • 84879623977 scopus 로고    scopus 로고
    • Beta-defensins activate human mast cells via mas-related gene x2
    • Subramanian H., Gupta K., Lee D., Bayir A.K., Ahn H., Ali H. Beta-defensins activate human mast cells via mas-related gene x2. J Immunol 2013, 191:345-352.
    • (2013) J Immunol , vol.191 , pp. 345-352
    • Subramanian, H.1    Gupta, K.2    Lee, D.3    Bayir, A.K.4    Ahn, H.5    Ali, H.6
  • 28
    • 79956312553 scopus 로고    scopus 로고
    • Pmx-53 as a dual cd88 antagonist and an agonist for mas-related gene 2 (mrgx2) in human mast cells
    • Subramanian H., Kashem S.W., Collington S.J., Qu H., Lambris J.D., Ali H. Pmx-53 as a dual cd88 antagonist and an agonist for mas-related gene 2 (mrgx2) in human mast cells. Molecular pharmacology 2011, 79:1005-1013.
    • (2011) Molecular pharmacology , vol.79 , pp. 1005-1013
    • Subramanian, H.1    Kashem, S.W.2    Collington, S.J.3    Qu, H.4    Lambris, J.D.5    Ali, H.6
  • 31
    • 1542782281 scopus 로고    scopus 로고
    • Mrgx is a novel transcriptional regulator that exhibits activation or repression of the b-myb promoter in a cell type-dependent manner
    • Tominaga K., Leung J.K., Rookard P., Echigo J., Smith J.R., Pereira-Smith O.M. Mrgx is a novel transcriptional regulator that exhibits activation or repression of the b-myb promoter in a cell type-dependent manner. The Journal of biological chemistry 2003, 278:49618-49624.
    • (2003) The Journal of biological chemistry , vol.278 , pp. 49618-49624
    • Tominaga, K.1    Leung, J.K.2    Rookard, P.3    Echigo, J.4    Smith, J.R.5    Pereira-Smith, O.M.6
  • 32
    • 20344397687 scopus 로고    scopus 로고
    • Mrgx is not essential for cell growth and development in the mouse
    • Tominaga K., Matzuk M.M., Pereira-Smith O.M. Mrgx is not essential for cell growth and development in the mouse. Mol Cell Biol 2005, 25:4873-4880.
    • (2005) Mol Cell Biol , vol.25 , pp. 4873-4880
    • Tominaga, K.1    Matzuk, M.M.2    Pereira-Smith, O.M.3
  • 34
    • 84871027267 scopus 로고    scopus 로고
    • A comprehensive summary of ll-37, the factotum human cathelicidin peptide
    • Vandamme D., Landuyt B., Luyten W., Schoofs L. A comprehensive summary of ll-37, the factotum human cathelicidin peptide. Cellular immunology 2012, 280:22-35.
    • (2012) Cellular immunology , vol.280 , pp. 22-35
    • Vandamme, D.1    Landuyt, B.2    Luyten, W.3    Schoofs, L.4
  • 37
    • 20444396169 scopus 로고    scopus 로고
    • Adaptive evolution of mrgx2, a human sensory neuron specific gene involved in nociception
    • Yang S., Liu Y., Lin A.A., Cavalli-Sforza L.L., Zhao Z., Su B. Adaptive evolution of mrgx2, a human sensory neuron specific gene involved in nociception. Gene 2005, 352:30-35.
    • (2005) Gene , vol.352 , pp. 30-35
    • Yang, S.1    Liu, Y.2    Lin, A.A.3    Cavalli-Sforza, L.L.4    Zhao, Z.5    Su, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.