Cortistatin - A new neuroendocrine hormone?

Pediatric Endocrinology Reviews

Volumn 4, Issue 2, 2006, Pages 106-110

  Rubinfeld, Hadara ^a   Shimon, Ilan ^a,b  

^a TEL AVIV UNIVERSITY   (Israel)

^b RABIN MEDICAL CENTER   (Israel)

Author keywords

Cortistatin; GH secretagogue receptor; Growth hormone; Somatostatin; Somatostatin receptor

Indexed keywords

COMPLEMENTARY DNA; CORTISTATIN; G PROTEIN COUPLED RECEPTOR; HORMONE; NEUROPEPTIDE; SOMATOSTATIN; UNCLASSIFIED DRUG;

HORMONE ACTION; HORMONE RELEASE; HUMAN; IMMUNE SYSTEM; NEUROBIOLOGY; RECEPTOR BINDING; REVIEW; TISSUE DISTRIBUTION;

AMINO ACID SEQUENCE; ANIMALS; HUMANS; MOLECULAR SEQUENCE DATA; NEUROPEPTIDES; NEUROSECRETORY SYSTEMS;

EID: 33847717931     PISSN: 15654753     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (43)

1. de Lecea L, Criado JR, Prospero-Garcia O, Gautvik KM, Schweitzer P, Danielson PE, Dunlop CL, Siggins GR, Henriksen SJ, Sutcliffe JG. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature 1996;381:242-245
2. de Lecea L, Ruiz-Lozano P, Danielson PE, Peelle-Kirley J, Foye PE, Frankel WN, Sutcliffe JG. Cloning, mRNA expression and chromosomal mapping of mouse and human preprocortistatin. Genomics 1997;42:499-506
3. Dalm VA, Van Hagen PM, de Krijger RR, Kros JM, Van Koetsveld PM, Van Der Lely AJ, Lamberts SW, Hofland LJ. Distribution pattern of somatostatin and cortistatin mRNA in human central and peripheral tissues. Clin Endocrinol 2004;60:625-629
4. Allia E, Tarabra E, Volante M, Cerrato M, Ghigo E, Muccioli G, Papotti M. Expression of cortistatin and MrgX2, a specific cortistatin receptor, in human neuroendocrine tissues and related tumours. J Pathol 2005;207:336-345
5. Puebla L, Mouchantaf R, Sasi R, Khare S, Bennett HP, James S, Patel YC. Processing of rat preprocortistatin in mouse AtT-20 cells. J Neurochem 1999;73:1273-1277
6. Fukusumi S, Kitada C, Takekawa S, Kizawa H, Sakamoto J, Miyamoto M, Hinuma S, Kitano K, Fujino M. Identification and characterization of a novel human cortistatin-like peptide. Biochem Biophys Res Commun 1997;232:157-163
7. Siehler S, Seuwen K, Hoyer D. [125I]Tyr10-cortistatin14 labels all five somatostatin receptors. Naunyn Schmiedebergs Arch Pharmacol 1998;357:483-489
8. Deghenghi R, Papotti M, Ghigo E, Muccioli G. Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland. J Endocrinol Invest 2001;24:RC1-RC3
9. Robas N, Mead E, Fidock M. MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion. J Biol Chem 2003;278:44400-44404
10. Spier AD, de Lecea L. Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res Rev 2000;33:228-241
11. Vasilaki A, Lanneau C, Dournaud P, De Lecea L, Gardette R, Epelbaum J. Cortistatin affects glutamate sensitivity in mouse hypothalamic neurons through activation of sst2 somatostatin receptor subtype. Neuroscience 1999;88:359-364
12. Sanchez-Alavez M, Gomez-Chavarin M, Navarro L, Jimenez-Anguiano A, Murillo-Rodriguez E, Prado-Alcala RA, Drucker-Colin R, Prospero-Garcia O. Cortistatin modulates memory processes in rats. Brain Res 2000;858:78-83
13. Dalm VA, van Hagen PM, van Koetsveld PM, Langerak AW, van der Lely AJ, Lamberts SW, Hofland LJ. Cortistatin rather than somatostatin as a potential endogenous ligand for somatostatin receptors in the human immune system. J Clin Endocrinol Metab 2003;88:270-276
14. Veber DF, Holly FW, Nutt RF, Bergstrand SJ, Brady SF, Hirschmann R, Glitzer MS, Saperstein R. Highly active cyclic and bicyclic somatostatin analogues of reduced ring size. Nature 1979;280:512-514
15. de Lecea L, del Rio JA, Criado JR, Alcantara S, Morales M, Danielson PE, Henriksen SJ, Soriano E, Sutcliffe JG. Cortistatin is expressed in a distinct subset of cortical interneurons. J Neurosci 1997;17:5868-5880
16. Papotti M, Tarabra E, Allia E, Bozzalla-Cassione F, Broglio F, Deghenghi R, Ghigo E, Muccioli G. Presence of cortistatin in the human pancreas. J Endocrinol Invest 2003;26:RC15-RC18
17. Ejeskar K, Abel F, Sjoberg R, Backstrom J, Kogner P, Martinsson T. Fine mapping of the human preprocortistatin gene (CORT) to neuroblastoma consensus deletion region 1p36.3→p36.2, but absence of mutations in primary tumors. Cytogenet Cell Genet 2000;89:62-66
18. Notas G, Kolios G, Mastrodimou N, Kampa M, Vasilaki A, Xidakis C, Castanas E, Thermos K, Kouroumalis E. Cortistatin production by HepG2 human hepatocellular carcinoma cell line and distribution of somatostatin receptors. J Hepatol 2004;40:792-798
19. Yan S, Li M, Chai H, Yang H, Lin PH, Yao Q, Chen C. TNF-alpha decreases expression of somatostatin, somatostatin receptors and cortistatin in human coronary endothelial cells. J Surg Res 2005;123:294-301
20. 1a Receptors in Ghrelin Inhibition of Gastric Acid Secretion in the Rat. Journal of Neuroendocrinology 2006;18:122-128
21. Cassoni P, Muccioli G, Marrocco T, Volante M, Allia E, Ghigo E, Deghenghi R, Papotti M. Cortistatin-14 inhibits cell proliferation of human thyroid carcinoma cell lines of both follicular and parafollicular origin. J Endocrinol Invest 2002;25:362-368
22. Nothacker HP, Wang Z, Zeng H, Mahata SK, O'Connor DT, Civelli O. Proadrenomedullin N-terminal peptide and cortistatin activation of MrgX2 receptor is based on a common structural motif. Eur J Pharmacol 2005;519:191-193
23. Breder CD, Yamada Y, Yasuda K, Seino S, Saper CB, Bell GI. Differential expression of somatostatin receptor subtypes in brain. J Neurosci 1992;12:3920-3934
24. Kaupmann K, Bruns C, Hoyer D, Seuwen K, Lubbert H. Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain. FEBS Lett 1993;331:53-59
25. O'Carroll AM, Krempels K. Widespread distribution of somatostatin receptor messenger ribonucleic acids in rat pituitary. Endocrinology 1995;136:5224-5227
26. Day R, Dong W, Panetta R, Kraicer J, Greenwood MT, Patel YC. Expression of mRNA for somatostatin receptor (sstr) types 2 and 5 in individual rat pituitary cells. A double labeling in situ hybridization analysis. Endocrinology 1995;136:5232-5235
27. Bruno JF, Xu Y, Song J, Berelowitz M. Tissue distribution of somatostatin receptor subtype messenger ribonucleic acid in the rat. Endocrinology 1993;133:2561-2567
28. Spier AD, Fabre V, de Lecea L. Cortistatin radioligand binding in wildtype and somatostatin receptor-deficient mouse brain. Regul Pept 2005;124:179-186
29. Rezek M, Havlicek V, Hughes KR, Friesen H. Cortical administration of somatostatin (SRIF): effect on sleep and motor behavior. Pharmacol Biochem Behav 1976;5:73-77
30. Vecsei L, Kiraly C, Bollok I, Nagy A, Varga J, Penke B, Telegdy G. Comparative studies with somatostatin and cysteamine in different behavioral tests on rats. Pharmacol Biochem Behav 1984;21:833-837
31. Connor M, Ingram SL, Christie MJ. Cortistatin increase of a potassium conductance in rat locus coeruleus in vitro. Br J Pharmacol 1997;122:1567-1572
32. Gardette R, Faivre-Bauman A, Loudes C, Kordon C, Epelbaum J. Modulation by somatostatin of glutamate sensitivity during development of mouse hypothalamic neurons in vitro. Brain Res Dev Brain Res 1995;86:123-133
33. Dalm VA, van Hagen PM, van Koetsveld PM, Achilefu S, Houtsmuller AB, Pols DH, van der Lely AJ, Lamberts SW, Hofland LJ. Expression of somatostatin, cortistatin and somatostatin receptors in human monocytes, macrophages and dendritic cells. Am J Physiol Endocrinol Metab 2003; 285:E344-E353
34. Gonzalez-Rey E, Varela N, Sheibanie AF, Chorny A, Ganea D, Delgado M. Cortistatin, an antiinflammatory peptide with therapeutic action in inflammatory bowel disease. Proc Natl Acad Sci USA 2006;103:4228-4233
35. Gonzalez-Rey E, Chorny A, Robledo G, Delgado M. Cortistatin, a new antiinflammatory peptide with therapeutic effect on lethal endotoxemia. J Exp Med 2006;203:563-571
36. Deghenghi R, Avallone R, Torsello A, Muccioli G, Ghigo E, Locatelli V. Growth hormone-inhibiting activity of cortistatin in the rat. J Endocrinol Invest 2001;24:RC31-RC33
37. Broglio F, Arvat E, Benso A, Gottero C, Prodam F, Grottoli S, Papotti M, Muccioli G, van der Lely AJ, Deghenghi R, Ghigo E. Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans. J Clin Endocrinol Metab 2002;87:3783-3790
38. Gottero C, Prodam F, Destefanis S, Benso A, Gauna C, Me E, Filtri L, Riganti F, van Der Lely AJ, Ghigo E, Broglio F. Cortistatin-17 and -14 exert the same endocrine activities as somatostatin in humans. Growth Horm IGF Res 2004;14:382-387
39. Grottoli S, Gasco V, Broglio F, Baldelli R, Ragazzoni F, Gallenca F, Mainolfi A, Prodam F, Muccioli G, Ghigo E. Cortistatin-17 and somatostatin-14 display the same effects on GH, PRL and insulin secretion in patients with acromegaly or prolactinoma. J Clin Endocrinol Metab 2006;91:1595-1599
40. Rubinfeld H, Hadani M, Barkai G, Taylor JE, Culler MD, Shimon I. Cortistatin inhibits Growth hormone release from human fetal and adenoma pituitary cells and prolactin secretion from cultured prolactinomas. J Clin Endocrinol Metab 2006 In press
41. Baranowska B, Chmielowska M, Wolinska-Witort E, Bik W, Baranowska-Bik A, Martynska L. Direct effect of cortistatin on GH release from cultured pituitary cells in the rat. Neuro Endocrinol Lett 2006;27:1-2
42. Luque RM, Peinado JR, Gracia-Navarro F, Broglio F, Ghigo E, Kineman RD, Malagon MM, Castano JP. Cortistatin mimics somatostatin by inducing a dual, dose-dependent stimulatory and inhibitory effect on growth hormone secretion in somatotropes. J Mol Endocrinol 2006;36:547-556
43. Shimon I, Yan X, Taylor JE, Weiss MH, Culler MD, Melmed S. Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumors. J Clin Invest 1997;100:2386-2392