Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1852, Issue 10, 2015, Pages 2056-2065

  Douris, Nicholas ^a   Melman, Tamar ^a   Pecherer, Jordan M ^a   Pissios, Pavlos ^a   Flier, Jeffrey S ^a   Cantley, Lewis C ^a,b   Locasale, Jason W ^a,c   Maratos Flier, Eleftheria ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c Department of Obstetrics Gynecology   (United States)

Author keywords

Free fatty acid metabolism; Hepatic steatosis; Ketogenesis; Ketogenic diet; Liver; Mass spectrometry; Metabolomics

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACYL COENZYME A DESATURASE; AMINO ACID; FIBROBLAST GROWTH FACTOR 21; TRIACYLGLYCEROL;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CATABOLISM; CIRCADIAN RHYTHM; CONTROLLED STUDY; DOWN REGULATION; ENERGY EXPENDITURE; FATTY LIVER; GENE EXPRESSION; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; INFLAMMATION; INSULIN SENSITIVITY; KETOGENIC DIET; LIFESPAN; LONGEVITY; METABOLOMICS; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTAKE; WEIGHT REDUCTION;

MUS;

EID: 84938268460     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2015.07.009     Document Type: Article

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