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Volumn 5, Issue , 2015, Pages

A TLR9 agonist enhances the anti-tumor immunity of peptide and lipopeptide vaccines via different mechanisms

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE; TLR9 PROTEIN, HUMAN; TOLL LIKE RECEPTOR 9; VACCINE;

EID: 84938226194     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep12578     Document Type: Article
Times cited : (22)

References (55)
  • 1
    • 0032869689 scopus 로고    scopus 로고
    • Approaches to improve engineered vaccines for human immunodeficiency virus and other viruses that cause chronic infections
    • Berzofsky, J. A. et al. Approaches to improve engineered vaccines for human immunodeficiency virus and other viruses that cause chronic infections. Immunol Rev 170, 151-172 (1999).
    • (1999) Immunol Rev , vol.170 , pp. 151-172
    • Berzofsky, J.A.1
  • 2
    • 0033868504 scopus 로고    scopus 로고
    • Vaccine development for hepatitis C
    • Lechmann, M. & Liang, T. J. Vaccine development for hepatitis C. Semin Liver Dis 20, 211-226, doi: 10.1055/s-2000-9947 (2000).
    • (2000) Semin Liver Dis , vol.20 , pp. 211-226
    • Lechmann, M.1    Liang, T.J.2
  • 3
    • 0029148848 scopus 로고
    • Can the immune response control HIV infection?
    • Paul, W. E. Can the immune response control HIV infection? Cell 82, 177-182 (1995).
    • (1995) Cell , vol.82 , pp. 177-182
    • Paul, W.E.1
  • 4
  • 5
    • 33750980717 scopus 로고    scopus 로고
    • Current status of short synthetic peptides as vaccines
    • Hans, D., Young, P. R. & Fairlie, D. P. Current status of short synthetic peptides as vaccines. Med Chem 2, 627-646 (2006).
    • (2006) Med Chem , vol.2 , pp. 627-646
    • Hans, D.1    Young, P.R.2    Fairlie, D.P.3
  • 6
    • 79961077781 scopus 로고    scopus 로고
    • Presentation of lipopeptide by dendritic cells induces anti-tumor responses via an endocytosis-independent pathway in vivo
    • Song, Y. C. et al. Presentation of lipopeptide by dendritic cells induces anti-tumor responses via an endocytosis-independent pathway in vivo. J Leukoc Biol 90, 323-332 (2011).
    • (2011) J Leukoc Biol , vol.90 , pp. 323-332
    • Song, Y.C.1
  • 7
    • 0029200883 scopus 로고
    • A compendium of vaccine adjuvants and excipients
    • Vogel, F. R. & Powell, M. F. A compendium of vaccine adjuvants and excipients. Pharm Biotechnol 6, 141-228 (1995).
    • (1995) Pharm Biotechnol , vol.6 , pp. 141-228
    • Vogel, F.R.1    Powell, M.F.2
  • 8
    • 0029199540 scopus 로고
    • Adjuvant properties of aluminum and calcium compounds
    • Gupta, R. K., Rost, B. E., Relyveld, E. & Siber, G. R. Adjuvant properties of aluminum and calcium compounds. Pharm Biotechnol 6, 229-248 (1995).
    • (1995) Pharm Biotechnol , vol.6 , pp. 229-248
    • Gupta, R.K.1    Rost, B.E.2    Relyveld, E.3    Siber, G.R.4
  • 9
    • 1842631153 scopus 로고    scopus 로고
    • Immunotherapeutic uses of CpG oligodeoxynucleotides
    • Klinman, D. M. Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat Rev Immunol 4, 249-258 (2004).
    • (2004) Nat Rev Immunol , vol.4 , pp. 249-258
    • Klinman, D.M.1
  • 10
    • 3142602923 scopus 로고    scopus 로고
    • CpG oligonucleotides improve the protective immune response induced by the anthrax vaccination of rhesus macaques
    • Klinman, D. M., Xie, H., Little, S. F., Currie, D. & Ivins, B. E. CpG oligonucleotides improve the protective immune response induced by the anthrax vaccination of rhesus macaques. Vaccine 22, 2881-2886 (2004).
    • (2004) Vaccine , vol.22 , pp. 2881-2886
    • Klinman, D.M.1    Xie, H.2    Little, S.F.3    Currie, D.4    Ivins, B.E.5
  • 11
    • 33750961667 scopus 로고    scopus 로고
    • Enhancement of infectious disease vaccines through TLR9-dependent recognition of CpG DNA
    • McCluskie, M. J. & Krieg, A. M. Enhancement of infectious disease vaccines through TLR9-dependent recognition of CpG DNA. Curr Top Microbiol Immunol 311, 155-178 (2006).
    • (2006) Curr Top Microbiol Immunol , vol.311 , pp. 155-178
    • McCluskie, M.J.1    Krieg, A.M.2
  • 12
    • 11344257404 scopus 로고    scopus 로고
    • CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: A double-blind phase I/II study
    • Cooper, C. L. et al. CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: a double-blind phase I/II study. J Clin Immunol 24, 693-701, doi: 10.1007/s10875-004-6244-3 (2004).
    • (2004) J Clin Immunol , vol.24 , pp. 693-701
    • Cooper, C.L.1
  • 13
    • 0037726807 scopus 로고    scopus 로고
    • A phase i study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant
    • Halperin, S. A. et al. A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant. Vaccine 21, 2461-2467 (2003).
    • (2003) Vaccine , vol.21 , pp. 2461-2467
    • Halperin, S.A.1
  • 14
    • 0004582004 scopus 로고    scopus 로고
    • CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice
    • Brazolot Millan, C. L., Weeratna, R., Krieg, A. M., Siegrist, C. A. & Davis, H. L. CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice. Proc Natl Acad Sci USA 95, 15553-15558 (1998).
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 15553-15558
    • Brazolot Millan, C.L.1    Weeratna, R.2    Krieg, A.M.3    Siegrist, C.A.4    Davis, H.L.5
  • 15
    • 0030900680 scopus 로고    scopus 로고
    • Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma
    • Wooldridge, J. E., Ballas, Z., Krieg, A. M. & Weiner, G. J. Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma. Blood 89, 2994-2998 (1997).
    • (1997) Blood , vol.89 , pp. 2994-2998
    • Wooldridge, J.E.1    Ballas, Z.2    Krieg, A.M.3    Weiner, G.J.4
  • 16
    • 76649093262 scopus 로고    scopus 로고
    • Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice
    • Zhu, Q. et al. Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice. J Clin Invest 120, 607-616 (2010).
    • (2010) J Clin Invest , vol.120 , pp. 607-616
    • Zhu, Q.1
  • 17
    • 61749088168 scopus 로고    scopus 로고
    • Innovative strategies for co-delivering antigens and CpG oligonucleotides
    • Krishnamachari, Y. & Salem, A. K. Innovative strategies for co-delivering antigens and CpG oligonucleotides. Adv Drug Deliv Rev 61, 205-217 (2009).
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 205-217
    • Krishnamachari, Y.1    Salem, A.K.2
  • 18
    • 2442471894 scopus 로고    scopus 로고
    • Strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides
    • Mutwiri, G. K., Nichani, A. K., Babiuk, S. & Babiuk, L. A. Strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides. J Control Release 97, 1-17 (2004).
    • (2004) J Control Release , vol.97 , pp. 1-17
    • Mutwiri, G.K.1    Nichani, A.K.2    Babiuk, S.3    Babiuk, L.A.4
  • 19
    • 0035838984 scopus 로고    scopus 로고
    • Dendritic cells: Specialized and regulated antigen processing machines
    • Mellman, I. & Steinman, R. M. Dendritic cells: specialized and regulated antigen processing machines. Cell 106, 255-258 (2001).
    • (2001) Cell , vol.106 , pp. 255-258
    • Mellman, I.1    Steinman, R.M.2
  • 20
    • 17144383586 scopus 로고    scopus 로고
    • Novel conjugates of epitope fusion peptides with CpG-ODN display enhanced immunogenicity and HIV recognition
    • Daftarian, P. et al. Novel conjugates of epitope fusion peptides with CpG-ODN display enhanced immunogenicity and HIV recognition. Vaccine 23, 3453-3468 (2005).
    • (2005) Vaccine , vol.23 , pp. 3453-3468
    • Daftarian, P.1
  • 21
    • 78649871196 scopus 로고    scopus 로고
    • Peptide vaccine induces enhanced tumor growth associated with apoptosis induction in CD8+ T cells
    • Muraoka, D. et al. Peptide vaccine induces enhanced tumor growth associated with apoptosis induction in CD8+ T cells. J Immunol 185, 3768-3776 (2010).
    • (2010) J Immunol , vol.185 , pp. 3768-3776
    • Muraoka, D.1
  • 22
    • 0031867535 scopus 로고    scopus 로고
    • Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
    • Sparwasser, T. et al. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur J Immunol 28, 2045-2054 (1998).
    • (1998) Eur J Immunol , vol.28 , pp. 2045-2054
    • Sparwasser, T.1
  • 24
    • 33748762545 scopus 로고    scopus 로고
    • Pathogen recognition and development of particulate vaccines: Does size matter?
    • Xiang, S. D. et al. Pathogen recognition and development of particulate vaccines: does size matter? Methods 40, 1-9 (2006).
    • (2006) Methods , vol.40 , pp. 1-9
    • Xiang, S.D.1
  • 25
    • 84864146395 scopus 로고    scopus 로고
    • Development of antigen cross-presentation capacity in dendritic cells
    • Dresch, C., Leverrier, Y., Marvel, J. & Shortman, K. Development of antigen cross-presentation capacity in dendritic cells. Trends Immunol 33, 381-388 (2012).
    • (2012) Trends Immunol , vol.33 , pp. 381-388
    • Dresch, C.1    Leverrier, Y.2    Marvel, J.3    Shortman, K.4
  • 26
    • 78650522411 scopus 로고    scopus 로고
    • Adjuvating the adjuvant: Facilitated delivery of an immunomodulatory oligonucleotide to TLR9 by a cationic antimicrobial peptide in dendritic cells
    • Aichinger, M. C. et al. Adjuvating the adjuvant: facilitated delivery of an immunomodulatory oligonucleotide to TLR9 by a cationic antimicrobial peptide in dendritic cells. Vaccine 29, 426-436 (2011).
    • (2011) Vaccine , vol.29 , pp. 426-436
    • Aichinger, M.C.1
  • 27
    • 64049103406 scopus 로고    scopus 로고
    • Treatment with LL-37 peptide enhances antitumor effects induced by CpG oligodeoxynucleotides against ovarian cancer
    • Chuang, C. M., Monie, A., Wu, A., Mao, C. P. & Hung, C. F. Treatment with LL-37 peptide enhances antitumor effects induced by CpG oligodeoxynucleotides against ovarian cancer. Hum Gene Ther 20, 303-313, doi: 10.1089/hum.2008.124 (2009).
    • (2009) Hum Gene Ther , vol.20 , pp. 303-313
    • Chuang, C.M.1    Monie, A.2    Wu, A.3    Mao, C.P.4    Hung, C.F.5
  • 28
    • 0029127063 scopus 로고
    • The endocytic activity of dendritic cells
    • Steinman, R. M. & Swanson, J. The endocytic activity of dendritic cells. J Exp Med 182, 283-288 (1995).
    • (1995) J Exp Med , vol.182 , pp. 283-288
    • Steinman, R.M.1    Swanson, J.2
  • 29
    • 0036318851 scopus 로고    scopus 로고
    • Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments
    • Ahmad-Nejad, P. et al. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur J Immunol 32, 1958-1968 (2002).
    • (2002) Eur J Immunol , vol.32 , pp. 1958-1968
    • Ahmad-Nejad, P.1
  • 30
    • 84867086654 scopus 로고    scopus 로고
    • DEC-205 is a cell surface receptor for CpG oligonucleotides
    • Lahoud, M. H. et al. DEC-205 is a cell surface receptor for CpG oligonucleotides. Proc Natl Acad Sci USA 109, 16270-16275 (2012).
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 16270-16275
    • Lahoud, M.H.1
  • 31
    • 79954570242 scopus 로고    scopus 로고
    • Granulin is a soluble cofactor for toll-like receptor 9 signaling
    • Park, B. et al. Granulin is a soluble cofactor for toll-like receptor 9 signaling. Immunity 34, 505-513 (2011).
    • (2011) Immunity , vol.34 , pp. 505-513
    • Park, B.1
  • 32
    • 0028179056 scopus 로고
    • Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens
    • Huang, A. Y. et al. Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. Science 264, 961-965 (1994).
    • (1994) Science , vol.264 , pp. 961-965
    • Huang, A.Y.1
  • 33
    • 0033522179 scopus 로고    scopus 로고
    • Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen
    • Sigal, L. J., Crotty, S., Andino, R. & Rock, K. L. Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen. Nature 398, 77-80, doi: 10.1038/18038 (1999).
    • (1999) Nature , vol.398 , pp. 77-80
    • Sigal, L.J.1    Crotty, S.2    Andino, R.3    Rock, K.L.4
  • 34
    • 0037446752 scopus 로고    scopus 로고
    • A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells
    • Datta, S. K. et al. A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells. J Immunol 170, 4102-4110 (2003).
    • (2003) J Immunol , vol.170 , pp. 4102-4110
    • Datta, S.K.1
  • 35
    • 0036686398 scopus 로고    scopus 로고
    • CpG-DNA aided cross-presentation of soluble antigens by dendritic cells
    • Maurer, T. et al. CpG-DNA aided cross-presentation of soluble antigens by dendritic cells. Eur J Immunol 32, 2356-2364 (2002).
    • (2002) Eur J Immunol , vol.32 , pp. 2356-2364
    • Maurer, T.1
  • 36
    • 54049103221 scopus 로고    scopus 로고
    • Cutting edge: TLR ligands increase TCR triggering by slowing peptide-MHC class i decay rates
    • Rudd, B. D., Brien, J. D., Davenport, M. P. & Nikolich-Zugich, J. Cutting edge: TLR ligands increase TCR triggering by slowing peptide-MHC class I decay rates. J Immunol 181, 5199-5203 (2008).
    • (2008) J Immunol , vol.181 , pp. 5199-5203
    • Rudd, B.D.1    Brien, J.D.2    Davenport, M.P.3    Nikolich-Zugich, J.4
  • 37
    • 79951840612 scopus 로고    scopus 로고
    • Presentation of soluble antigens to CD8+ T cells by CpG oligodeoxynucleotide-primed human naive B cells
    • Jiang, W., Lederman, M. M., Harding, C. V. & Sieg, S. F. Presentation of soluble antigens to CD8+ T cells by CpG oligodeoxynucleotide-primed human naive B cells. J Immunol 186, 2080-2086 (2011).
    • (2011) J Immunol , vol.186 , pp. 2080-2086
    • Jiang, W.1    Lederman, M.M.2    Harding, C.V.3    Sieg, S.F.4
  • 38
    • 33645079137 scopus 로고    scopus 로고
    • The synthetic analogue of mycoplasmal lipoprotein FSL-1 induces dendritic cell maturation through Toll-like receptor 2
    • Kiura, K. et al. The synthetic analogue of mycoplasmal lipoprotein FSL-1 induces dendritic cell maturation through Toll-like receptor 2. FEMS Immunol Med Microbiol 46, 78-84 (2006).
    • (2006) FEMS Immunol Med Microbiol , vol.46 , pp. 78-84
    • Kiura, K.1
  • 39
    • 84899567400 scopus 로고    scopus 로고
    • Molecular mechanisms of TLR2-mediated antigen cross-presentation in dendritic cells
    • Shen, K. Y. et al. Molecular mechanisms of TLR2-mediated antigen cross-presentation in dendritic cells. J Immunol 192, 4233-4241 (2014).
    • (2014) J Immunol , vol.192 , pp. 4233-4241
    • Shen, K.Y.1
  • 40
    • 1642353588 scopus 로고    scopus 로고
    • Control of cross-presentation during dendritic cell maturation
    • Gil-Torregrosa, B. C. et al. Control of cross-presentation during dendritic cell maturation. Eur J Immunol 34, 398-407, doi: 10.1002/eji.200324508 (2004).
    • (2004) Eur J Immunol , vol.34 , pp. 398-407
    • Gil-Torregrosa, B.C.1
  • 41
    • 0035500862 scopus 로고    scopus 로고
    • Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo
    • Pulendran, B. et al. Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo. J Immunol 167, 5067-5076 (2001).
    • (2001) J Immunol , vol.167 , pp. 5067-5076
    • Pulendran, B.1
  • 42
    • 20044382430 scopus 로고    scopus 로고
    • Toll-like receptor 3 promotes cross-priming to virus-infected cells
    • Schulz, O. et al. Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature 433, 887-892 (2005).
    • (2005) Nature , vol.433 , pp. 887-892
    • Schulz, O.1
  • 43
    • 33947607799 scopus 로고    scopus 로고
    • Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response
    • Bourquin, C. et al. Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response. Blood 109, 2953-2960 (2007).
    • (2007) Blood , vol.109 , pp. 2953-2960
    • Bourquin, C.1
  • 44
    • 84872696776 scopus 로고    scopus 로고
    • TLR7 triggering with polyuridylic acid promotes cross-presentation in CD8alpha+ conventional dendritic cells by enhancing antigen preservation and MHC class i antigen permanence on the dendritic cell surface
    • Crespo, M. I. et al. TLR7 triggering with polyuridylic acid promotes cross-presentation in CD8alpha+ conventional dendritic cells by enhancing antigen preservation and MHC class I antigen permanence on the dendritic cell surface. J Immunol 190, 948-960 (2013).
    • (2013) J Immunol , vol.190 , pp. 948-960
    • Crespo, M.I.1
  • 45
    • 55749092126 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells efficiently cross-prime naive T cells in vivo after TLR activation
    • Mouries, J. et al. Plasmacytoid dendritic cells efficiently cross-prime naive T cells in vivo after TLR activation. Blood 112, 3713-3722 (2008).
    • (2008) Blood , vol.112 , pp. 3713-3722
    • Mouries, J.1
  • 46
    • 10744219675 scopus 로고    scopus 로고
    • TLR9 signals after translocating from the ER to CpG DNA in the lysosome
    • Latz, E. et al. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat Immunol 5, 190-198 (2004).
    • (2004) Nat Immunol , vol.5 , pp. 190-198
    • Latz, E.1
  • 47
    • 84888364668 scopus 로고    scopus 로고
    • Mannose receptor 1 mediates cellular uptake and endosomal delivery of CpG-motif containing oligodeoxynucleotides
    • Moseman, A. P. et al. Mannose receptor 1 mediates cellular uptake and endosomal delivery of CpG-motif containing oligodeoxynucleotides. J Immunol 191, 5615-5624 (2013).
    • (2013) J Immunol , vol.191 , pp. 5615-5624
    • Moseman, A.P.1
  • 48
    • 33746884630 scopus 로고    scopus 로고
    • Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation
    • Guiducci, C. et al. Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation. J Exp Med 203, 1999-2008 (2006).
    • (2006) J Exp Med , vol.203 , pp. 1999-2008
    • Guiducci, C.1
  • 49
    • 42449125194 scopus 로고    scopus 로고
    • Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class i
    • Di Pucchio, T. et al. Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I. Nat Immunol 9, 551-557 (2008).
    • (2008) Nat Immunol , vol.9 , pp. 551-557
    • Di Pucchio, T.1
  • 50
    • 14844340568 scopus 로고    scopus 로고
    • Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate
    • Delamarre, L., Pack, M., Chang, H., Mellman, I. & Trombetta, E. S. Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate. Science 307, 1630-1634 (2005).
    • (2005) Science , vol.307 , pp. 1630-1634
    • Delamarre, L.1    Pack, M.2    Chang, H.3    Mellman, I.4    Trombetta, E.S.5
  • 51
    • 4143146210 scopus 로고    scopus 로고
    • Important role of cathepsin S in generating peptides for TAP-independent MHC class i crosspresentation in vivo
    • Shen, L., Sigal, L. J., Boes, M. & Rock, K. L. Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo. Immunity 21, 155-165 (2004).
    • (2004) Immunity , vol.21 , pp. 155-165
    • Shen, L.1    Sigal, L.J.2    Boes, M.3    Rock, K.L.4
  • 52
    • 42449157557 scopus 로고    scopus 로고
    • Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation
    • Burgdorf, S., Scholz, C., Kautz, A., Tampe, R. & Kurts, C. Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation. Nat Immunol 9, 558-566 (2008).
    • (2008) Nat Immunol , vol.9 , pp. 558-566
    • Burgdorf, S.1    Scholz, C.2    Kautz, A.3    Tampe, R.4    Kurts, C.5
  • 53
    • 84856884584 scopus 로고    scopus 로고
    • IFN-alpha enhances cross-presentation in human dendritic cells by modulating antigen survival, endocytic routing, and processing
    • Spadaro, F. et al. IFN-alpha enhances cross-presentation in human dendritic cells by modulating antigen survival, endocytic routing, and processing. Blood 119, 1407-1417 (2012).
    • (2012) Blood , vol.119 , pp. 1407-1417
    • Spadaro, F.1
  • 54
    • 59649116879 scopus 로고    scopus 로고
    • A novel technology for the production of a heterologous lipoprotein immunogen in high yield has implications for the field of vaccine design
    • Chen, H. W. et al. A novel technology for the production of a heterologous lipoprotein immunogen in high yield has implications for the field of vaccine design. Vaccine 27, 1400-1409 (2009).
    • (2009) Vaccine , vol.27 , pp. 1400-1409
    • Chen, H.W.1
  • 55
    • 1942470018 scopus 로고    scopus 로고
    • A single-step, sensitive flow cytofluorometric assay for the simultaneous assessment of membrane-bound and ingested Candida albicans in phagocytosing neutrophils
    • Busetto, S., Trevisan, E., Patriarca, P. & Menegazzi, R. A single-step, sensitive flow cytofluorometric assay for the simultaneous assessment of membrane-bound and ingested Candida albicans in phagocytosing neutrophils. Cytometry A 58, 201-206, doi: 10.1002/cyto.a.20014 (2004).
    • (2004) Cytometry A , vol.58 , pp. 201-206
    • Busetto, S.1    Trevisan, E.2    Patriarca, P.3    Menegazzi, R.4


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