Intravitreal clearance and volume of distribution of compounds in rabbits: In silico prediction and pharmacokinetic simulations for drug development

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 95, Issue , 2015, Pages 215-226

  Del Amo, Eva M ^a,b   Vellonen, Kati Sisko ^b   Kidron, Heidi ^a   Urtti, Arto ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Clearance; Intravitreal injection; Ocular drug delivery; Pharmacokinetic simulation; QSPR; Volume of distribution

Indexed keywords

AMIKACIN; HEPTANOL; DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL STRUCTURE; COMPARTMENT MODEL; COMPUTER MODEL; CURVE FITTING; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DEVELOPMENT; DRUG DISTRIBUTION; DRUG STRUCTURE; HYDROGEN BOND; INTRAVITREAL DRUG ADMINISTRATION; MACROMOLECULE; MOLECULAR WEIGHT; NONHUMAN; PREDICTION; QUANTITATIVE STRUCTURE PROPERTY RELATION; VOLUME OF DISTRIBUTION; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; DRUG DATABASE; DRUG DESIGN; METABOLISM; PHARMACOKINETICS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RABBIT; TISSUE DISTRIBUTION;

ANIMALS; COMPUTER SIMULATION; DATABASES, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; DRUG DESIGN; HYDROGEN BONDING; INTRAVITREAL INJECTIONS; MODELS, BIOLOGICAL; MOLECULAR WEIGHT; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RABBITS; TISSUE DISTRIBUTION;

EID: 84938214323     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2015.01.003     Document Type: Article

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