Prediction of the vitreal half-life of small molecular drug-like compounds

Pharmaceutical Research

Volumn 29, Issue 12, 2012, Pages 3302-3311

  Kidron, Heidi ^a   Del Amo, Eva M ^a   Vellonen, Kati Sisko ^a,b   Urtti, Arto ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Blood retinal barrier; Intravitreal injection; Multivariate analysis; Ocular drug delivery; QSPR

Indexed keywords

ACICLOVIR; AMIKACIN; AMPICILLIN; AZTREONAM; CANDESARTAN; CARBENICILLIN; CEFALEXIN; CEFALOTIN; CEFAZOLIN; CEFEPIME; CEFTAZIDIME; CEFTIZOXIME; CEFTRIAXONE; CIDOFOVIR; CIPROFLOXACIN; CLARITHROMYCIN; CLINDAMYCIN; CYCLOSPORIN A; DEXAMETHASONE; FLUCONAZOLE; GANCICLOVIR; GENTAMICIN; GREPAFLOXACIN; KANAMYCIN; LATAMOXEF; LINCOMYCIN; METHOTREXATE; NETILMICIN; QUINIDINE; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG ELIMINATION; DRUG HALF LIFE; HYDROGEN BOND; LIPOPHILICITY; MATHEMATICAL MODEL; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RABBIT; RELIABILITY; VITREOUS BODY;

ANIMALS; BLOOD-RETINAL BARRIER; COMPUTER SIMULATION; HALF-LIFE; HYDROGEN BONDING; INTRAVITREAL INJECTIONS; MODELS, BIOLOGICAL; MULTIVARIATE ANALYSIS; PHARMACEUTICAL PREPARATIONS; RABBITS; VITREOUS BODY;

EID: 84872073026     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0822-5     Document Type: Article

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