Prediction of vitreal half-life based on drug physicochemical properties: Quantitative structure-pharmacokinetic relationships (QSPKR)

Pharmaceutical Research

Volumn 26, Issue 5, 2009, Pages 1236-1260

  Durairaj, Chandrasekar ^a   Shah, Jaymin C ^b   Senapati, Shruti ^c   Kompella, Uday B ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Half life; Intravitreal; Pharmacokinetics; Quantitative structure pharmacokinetic relationship (QSPKR); Rabbits

Indexed keywords

ACICLOVIR; AMIKACIN; AMPHOTERICIN B; AMPICILLIN; CARBENICILLIN; CEFALEXIN; CEFALOTIN; CEFAZOLIN; CEFTAZIDIME; CEFTRIAXONE; CHLORAMPHENICOL; CIDOFOVIR; CIPROFLOXACIN; CLINDAMYCIN PHOSPHATE; CYCLOSPORIN A; ERYTHROMYCIN GLUCOHEPTONATE; FLEROXACIN; FLUCONAZOLE; FOSCARNET; GANCICLOVIR; GENTAMICIN; GREPAFLOXACIN; KANAMYCIN; LATAMOXEF; LINCOMYCIN; METHOTREXATE; METICILLIN; OFLOXACIN; OXACILLIN; UNINDEXED DRUG;

ALBINISM; ARTICLE; DRUG HALF LIFE; DRUG SOLUBILITY; LIPOPHILICITY; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ANIMALS; EYE; HALF-LIFE; LINEAR MODELS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PREDICTIVE VALUE OF TESTS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RABBITS; SOLUBILITY;

EID: 63949084933     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-008-9728-7     Document Type: Article

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