P-glycoprotein confers acquired resistance to 17-DMAG in lung cancers with an ALK rearrangement

BMC Cancer

Volumn 15, Issue 1, 2015, Pages

  Kim, Hee Joung ^a   Lee, Kye Young ^a   Kim, Young Whan ^b   Choi, Yun Jung ^c   Lee, Jung Eun ^c   Choi, Chang Min ^c   Baek, In Jeoung ^c   Rho, Jin Kyung ^c   Lee, Jae Cheol ^c  

^a Konkuk University Hospital   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c University of Ulsan   (South Korea)

Author keywords

ALK; Heat shock protein 90; Lung cancer; P glycoprotein; Resistance

Indexed keywords

ALVESPIMYCIN; ANAPLASTIC LYMPHOMA KINASE; ANAPLASTIC LYMPHOMA KINASE INHIBITOR; DICOUMAROL; LUMINESPIB; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; PACLITAXEL; PHOSPHOTRANSFERASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RHODAMINE 123; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VERAPAMIL; 17-(DIMETHYLAMINOETHYLAMINO)-17-DEMETHOXYGELDANAMYCIN; ABCB1 PROTEIN, HUMAN; BENZOQUINONE DERIVATIVE; MACROCYCLIC LACTAM; NQO1 PROTEIN, HUMAN; PROTEIN TYROSINE KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

A549 PR CELL LINE; ALK GENE; ARTICLE; CANCER INHIBITION; CANCER RESISTANCE; CELL PROLIFERATION; CELL SURVIVAL; CHEMOSENSITIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS RESISTANCE; ENZYME INHIBITION; GENE REARRANGEMENT; GENETIC TRANSFECTION; H2228 DR CELL LINE; H3122 DR 1 CELL LINE; H3122 DR 2 CELL LINE; H460 PR CELL LINE; HUMAN; HUMAN CELL; LUNG CANCER CELL LINE; MTT ASSAY; NON SMALL CELL LUNG CANCER; P GP GENE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENETICS; LUNG TUMOR; METABOLISM; TUMOR CELL LINE;

BENZOQUINONES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DICUMAROL; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LACTAMS, MACROCYCLIC; LUNG NEOPLASMS; NAD(P)H DEHYDROGENASE (QUINONE); P-GLYCOPROTEINS; PACLITAXEL; RECEPTOR PROTEIN-TYROSINE KINASES;

EID: 84938212571     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/s12885-015-1543-z     Document Type: Article

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