Establishment of animal model of a human lung adenocarcinoma drug-resistant cell line Anip973/NVB and investigation on mechanism of drug resistance

Chinese Journal of Lung Cancer

Volumn 15, Issue 3, 2012, Pages 146-151

  Wang, Meng ^a   Hong, Xuan ^a   Sun, Qinwen ^b   Li, Ruilin ^c   Yang, Zhaoyang ^a   Chen, Gongyan ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b Harbin Thoracic Hospital   (China)

^c Chinese medical hospital of Weihai city   (China)

Author keywords

Bcl 2; Lung neoplasms; MRP3; Multidrug resistance; Navelbine

Indexed keywords

MULTIDRUG RESISTANCE PROTEIN 3; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER RESISTANCE; CELL STRUCTURE; CELL TRANSPLANTATION; CONTROLLED STUDY; DRUG RESISTANCE; ELECTRON MICROSCOPE; GROWTH CURVE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TUMOR XENOGRAFT;

EID: 84922686102     PISSN: 10093419     EISSN: 19996187     Source Type: Journal    
DOI: 10.3779/j.issn.1009-3419.2012.03.03     Document Type: Article

References (16)

1. Tsang TY, Tang WY, Chan JY, et al. P-glycoprotein enhances radiationinduced apoptotic cell death through the regulation of miR-16 and Bcl-2 expressions in hepatocellular carcinoma cells. Apoptosis, 2011, 16(5): 524-535.
2. Wang G, Rong J, Zhou Z, et al. Novel gene P28GANK confers multidrug resistance by modulating the expression of MDR-1, Bcl-2 and Bax in osteosarcoma cells. Mol Biol, 2010, 44(6): 1010-1017.
3. Wang YL, Yan YL, Zhou NJ, et al. Mechanism of multidrug resistance of human small cell lung cancer cell line H446/VP. Chin Med J, 2010, 123(22): 3299-3303.
4. Young LC, Campling BG, Cole SP, et al. Multidrug resistance proteins MRP3, MRP1, and MRP2 in lung cancer: correlation of protein levels with drug response and messenger RNA levels. Clin Cancer Res, 2001, 7(6): 1798-1804.
5. Hirose M. The process behind the expression of mdr-1/P-gp and mrp/MRP in human leukemia/lymphoma. Anticancer Res, 2009, 29(4): 1073-1077.
6. Breuninger LM, Paul S, Gaughan K, et al. Expression of multi-drug resistance-associated protein in NIH/3T3 cells confers multi-drug resistance associated with increased drug efflux and altered intracelluiar drug distribution. Cancer Res, 1995, 55(22): 5342-5347.
7. Reed JC. Bcl-2-family proteins and hematologic malignancies: history and future prospects. Blood, 2008, 111(7): 3322-3330.
8. Tothova E, Fricova M, Stecova N, et al. High expression of Bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy. Neoplasma, 2002, 49(3): 141-144.
9. Galante JM, Mortenson MM, Bowles TL, et al. ERK/BCL-2 pathway in the resistance of pancreatic cancer to anoikis. J Surg Res, 2009, 152(1): 18-25.
10. Young LC, Campling BG, Voskoglou-Nomikos T, et al. Expression of multidrug resistance protein-related genes in lung cancer: correlation with drug response. Clin Cancer Res, 1999, 5(3): 673-680.
11. Oguri T, Isobe T, Fujitaka K, et al. Association between expression of the MRP3 gene and exposure to platinum drugs in lung cancer. Int J Cancer, 2001, 93(4): 584-589.
12. Hagmann W, Jesnowski R, Faissner R, et al. ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Up-regulation in 5-fluorouracil-resistant cells. Pancreatology, 2009, 9(1-2): 136-144.
13. Wang XB, Wang SS, Zhang QF, et al. Inhibition of tetramethylpyrazine on P-gp, MRP2, MRP3 and MRP5 in multidrug resistant human hepatocellular carcinoma cells. Oncol Rep, 2010, 23(1): 211-215.
14. Chen GY, Yang ZY, Hong X, et al. Establishment of a multi drug-resistant human lung adenocarcinoma cell line and biological characteristics. Zhonghua Yi Xue Za Zhi, 2007, 87(13): 924-926.
15. Chen GY, Guo SY, Liu JJ. Expression of hTERT mRNA in Anip973 and Anip973/NVB cell detected by quantitative real-time PCR. Zhongguo Fei Ai Za Zhi, 2010, 13(4): 297-300.
16. Khodadadian M, Leroux ME, Auzenne E, et al. MRP- and BCL-2-mediated drug resistance in human SCLC: effects of apoptotic sphingolipids in vitro. Lung Cancer, 2009, 66(1): 48-57.