Cardiovascular and autonomic dysfunctions after spinal cord injury

Spinal Cord Medicine: Second Edition

Volumn , Issue , 2011, Pages

  Garstang, Susan V ^a,b   Walker, Heather ^c  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84938201008     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (177)

1. Mohrman D, Heller L. Chapter 9: Regulation of arterial pressure. Lange cardiovascular physiology. New York: McGraw-Hill Companies, 2006.
2. Downey J, Myers, SJ, Gonzalez, EG, et al. The physiological basis of rehabilitation medicine. 2nd ed. Boston: Butterworth-Heinemann, 1994.
3. Appenzeller O, Oribe E. Autonomic anatomy, histology and neurotransmission. The autonomic nervous system: an introduction to basic and clinical concepts. 5th ed. New York: Elsevier, 1997:2-8.
4. Bonica JJ. Autonomic innervation of the viscera in relation to nerve block. Anesthesiology 1968;29(4):793-813.
5. Loewy AD, Spyer KM. Central regulation of autonomic functions. New York: Oxford University Press, 1990.
6. Janes RD, Brandys JC, Hopkins DA, et al. Anatomy of human extrinsic cardiac nerves and ganglia. Am J Cardiol 1986;57(4):299-309.
7. Glenn MB, Bergman SB. Cardiovascular changes following spinal cord injury. Top Spinal Cord Inj Rehabil 1997;2(4):47-53.
8. Collins HL, Rodenbaugh DW, DiCarlo SE. Spinal cord injury alters cardiac electrophysiology and increases the susceptibility to ventricular arrhythmias. Prog Brain Res 2006;152:275-288.
9. Mohrman D, Heller L. Chapter 7: Vascular control. Lange cardiovascular physiology. New York: McGraw-Hill Companies, 2006.
10. Krassioukov AV, Fehlings MG. Effect of graded spinal cord compression on cardiovascular neurons in the rostro-ventro-lateral medulla. Neuroscience 1999;88(3):959-973.
11. Krassioukov A. Which pathways must be spared in the injured human spinal cord to retain cardiovascular control? Prog Brain Res 2006;152:39-47.
12. Furlan JC, Fehlings MG, Shannon P, et al. Descending vasomotor pathways in humans: correlation between axonal preservation and cardiovascular dysfunction after spinal cord injury. J Neurotrauma 2003;20(12):1351-1363.
13. Quinton P. Sweating and its disorders. Annu Rev Med 1983;34:429-452.
14. Krassioukov A, Claydon VE. The clinical problems in cardiovascular control following spinal cord injury: an overview. Prog Brain Res 2006;152:223-229.
15. Schramm LP. Spinal sympathetic interneurons: their identification and roles after spinal cord injury. Prog Brain Res 2006;152:27-37.
16. Grimm DR, De Meersman RE, Almenoff PL, et al. Sympathovagal balance of the heart in subjects with spinal cord injury. Am J Physiol 1997;272(2 Pt 2):H835-H842.
17. Teasell RW, Arnold JM, Krassioukov A, et al. Cardiovascular consequences of loss of supraspinal control of the sympathetic nervous system after spinal cord injury. Arch Phys Med Rehabil 2000;81(4):506-516.
18. Legramante JM, Raimondi G, Massaro M, et al. Positive and negative feedback mechanisms in the neural regulation of cardiovascular function in healthy and spinal cord-injured humans. Circulation 6 2001;103(9):1250-1255.
19. Bilello JF, Davis JW, Cunningham MA, et al. Cervical spinal cord injury and the need for cardiovascular intervention. Arch Surg 2003;138(10):1127-1129.
20. Tibbs PA, Young B, McAllister RG, et al. Studies of experimental cervical spinal cord transection. Part I: Hemodynamic changes after acute cervical spinal cord transection. J Neurosurg 1978;49(4):558-562.
21. Tibbs PA, Young B, McAllister RG Jr, et al. Studies of experimental cervical spinal cord transection. Part III: Effects of acute cervical spinal cord transection on cerebral blood flow. J Neurosurg 1979;50(5):633-638.
22. Tibbs PA, Young B, Todd EP, et al. Studies of experimental cervical spinal cord transection. Part IV: Effects of cervical spinal cord transection on myocardial blood flow in anesthetized dogs. J Neurosurg 1980;52(2):197-202.
23. Tibbs PA, Young B, Ziegler MG, et al. Studies of experimental cervical spinal cord transection. Part II: Plasma norepinephrine levels after acute cervical spinal cord transection. J Neurosurg 1979;50(5):629-632.
24. Guha A, Tator CH. Acute cardiovascular effects of experimental spinal cord injury. J Trauma 1988;28(4):481-490.
25. Bravo G, Guizar-Sahagun G, Ibarra A, et al. Cardiovascular alterations after spinal cord injury: an overview. Curr Med Chem Cardiovasc Hematol Agents 2004;2(2):133-148.
26. Claus-Walker J, Halstead LS. Metabolic and endocrine changes in spinal cord injury: II (section 1). Consequences of partial decentralization of the autonomic nervous system. Arch Phys Med Rehabil 1982;63(11):569-575.
27. Ditunno JF, Little JW, Tessler A, et al. Spinal shock revisited: a four-phase model.[see comment]. Spinal Cord 2004;42(7):383-395.
28. Yardley CP, Fitzsimons CL, Weaver LC. Cardiac and peripheral vascular contributions to hypotension in spinal cats. Am J Physiol 1989;257(5 Pt 2):H1347-H1353.
29. Hall ED, Wolf DL. Post-traumatic spinal cord ischemia: relationship to injury severity and physiological parameters. Cent Nerv Syst Trauma 1987;4(1):15-25.
30. Castro-Moure F, Kupsky W, Goshgarian HG. Pathophysiological classification of human spinal cord ischemia. J Spinal Cord Med 1997;20(1):74-87.
31. Blood pressure management after acute spinal cord injury. Neurosurgery 2002;50(3 Suppl):S58-S62.
32. Lehmann KG, Lane JG, Piepmeier JM, et al. Cardiovascular abnormalities accompanying acute spinal cord injury in humans: incidence, time course and severity. J Am Coll Cardiol 1987;10(1):46-52.
33. Mathias CJ, Christensen NJ, Frankel HL, et al. Cardiovascular control in recently injured tetraplegics in spinal shock. QJM 1979;48(190):273-287.
34. Management of acute spinal cord injuries in an intensive care unit or other monitored setting. Neurosurgery 2002;50(3 Suppl):S51-S57.
35. Tator CH, Rowed DW, Schwartz ML, et al. Management of acute spinal cord injuries. Can J Surg 1984;27(3):289-293.
36. Levi L, Wolf A, Belzberg H. Hemodynamic parameters in patients with acute cervical cord trauma: description, intervention, and prediction of outcome. Neurosurgery 1993;33(6):1007-1016; discussion 1016-1007.
37. Vale FL, Burns J, Jackson AB, et al. Combined medical and surgical treatment after acute spinal cord injury: results of a prospective pilot study to assess the merits of aggressive medical resuscitation and blood pressure management. J Neurosurg 1997;87(2):239-246.
38. Ball PA. Critical care of spinal cord injury. Spine 15 2001;26(24 Suppl):S27-S30.
39. Zach GA, Seiler W, Dollfus P. Treatment results of spinal cord injuries in the Swiss Parplegic Centre of Basle. Paraplegia 1976;14(1):58-65.
40. Wolf A, Levi L, Mirvis S, et al. Operative management of bilateral facet dislocation. J Neurosurg 1991;75(6):883-890.
41. Ploumis A, Yadlapalli N, Fehlings MG, et al. A systematic review of the evidence supporting a role for vasopressor support in acute SCI. Spinal Cord. 2010;48(5):356-362.
42. Gilgoff IS, Ward SL, Hohn AR. Cardiac pacemaker in high spinal cord injury. Arch Phys Med Rehabil 1991;72(8):601-603.
43. Mathias CJ. Bradycardia and cardiac arrest during tracheal suction-mechanisms in tetraplegic patients. Eur J Intensive Care Med 1976;2(4):147-156.
44. Zipnick RI, Scalea TM, Trooskin SZ, et al. Hemodynamic responses to penetrating spinal cord injuries [see comment]. J Trauma 1993;35(4):578-582; discussion 582-573.
45. Frankel HL, Mathias CJ, Spalding JM. Mechanisms of reflex cardiac arrest in tetraplegic patients. Lancet 1975;2(7946):1183-1185.
46. Pasnoori VR, Leesar MA. Use of aminophylline in the treatment of severe symptomatic bradycardia resistant to atropine. Cardiology in review. 2004;12(2):65-68.
47. Sakamoto T, Sadanaga T, Okazaki T. Sequential use of aminophylline and theophylline for the treatment of atropine-resistant bradycardia after spinal cord injury: a case report. J Cardiol 2007;49(2):91-96.
48. Weant KA, Kilpatrick M, Jaikumar S. Aminophylline for the treatment of symptomatic bradycardia and asystole secondary to cervical spine injury. Neurocrit Care 2007;7(3):250-252.
49. Whitman CB, Schroeder WS, Ploch PJ, et al. Efficacy of aminophylline for treatment of recurrent symptomatic bradycardia after spinal cord injury. Pharmacotherapy 2008;28(1):131-135.
50. Ruiz-Arango AF, Robinson VJB, Sharma GK. Characteristics of patients with cervical spinal injury requiring permanent pacemaker implantation. Cardiol Rev 2006;14(4):e8-e11.
51. Theodore J, Robin ED. Speculations on neurogenic pulmonary edema (NPE). Am Rev Respir Dis 1976;113(4):405-411.
52. Karlsson AK. Autonomic dysfunction in spinal cord injury: clinical presentation of symptoms and signs. Prog Brain Res 2006;152:1-8.
53. Phanthumchinda K, Khaoroptham S, Kongratananan N, et al. Neurogenic pulmonary edema associated with spinal cord infarction from arteriovenous malformation. J Med Assoc Thai 1988;71(3):150-153.
54. Kiker JD, Woodside JR, Jelinek GE. Neurogenic pulmonary edema associated with autonomic dysreflexia. J Urol 1982;128(5):1038-1039.
55. Gondim FAA, Lopes ACA Jr, Oliveira GR, et al. Cardiovascular control after spinal cord injury. Curr Vasc Pharmacol 2004;2(1):71-79.
56. Krassioukov AV, Weaver LC. Reflex and morphological changes in spinal preganglionic neurons after cord injury in rats. Clin Exp Hypertens 1995;17(1-2):361-373.
57. Maiorov DN, Weaver LC, Krassioukov AV. Relationship between sympathetic activity and arterial pressure in conscious spinal rats. Am J Physiol 1997;272(2 Pt 2):H625-H631.
58. Mathias CJ. Orthostatic hypotension: causes, mechanisms, and influencing factors. Neurology 1995;45(Suppl 5):S6-S11.
59. Nitsche B, Perschak H, Curt A, et al. Loss of circadian blood pressure variability in complete tetraplegia. J Hum Hypertens1996;10(5):311-317.
60. Krum H, Louis WJ, Brown DJ, et al. Diurnal blood pressure variation in quadriplegic chronic spinal cord injury patients. Clin Sci (Colch) 1991;80(3):271-276.
61. Jacobs PL, Mahoney ET, Robbins A, et al. Hypokinetic circulation in persons with paraplegia. Med Sci Sports Exerc 2002;34(9):1401-1407.
62. de Groot PC, Bleeker MW, van Kuppevelt DH, et al. Rapid and extensive arterial adaptations after spinal cord injury. Arch Phys Med Rehabil 2006;87(5):688-696.
63. de Groot PC, van Dijk A, Dijk E, et al. Preserved cardiac function after chronic spinal cord injury. Arch Phys Med Rehabil 2006;87(9):1195-1200.
64. Nash MS, Bilsker S, Marcillo AE, et al. Reversal of adaptive left ventricular atrophy following electrically-stimulated exercise training in human tetraplegics. Paraplegia 1991;29(9):590-599.
65. Peronnet F, Beliveau L, Boudreau G, et al. Regional plasma catecholamine removal and release at rest and exercise in dogs. Am J Physiol 1988;254(4 Pt 2):R663-R672.
66. Jensen-Urstad M, Svedenhag J, Sahlin K. Effect of muscle mass on lactate formation during exercise in humans. Eur J Appl Physiol Occup Physiol 1994;69(3):189-195.
67. Schmid A, Huonker M, Stahl F, et al. Free plasma catecholamines in spinal cord injured persons with different injury levels at rest and during exercise. J Auton Nerv Syst 1998;68(1-2):96-100.
68. Levin BE, Martin BF, Natelson BH. Basal sympatho-adrenal function in quadriplegic man. J Auton Nerv Syst 1980;2(4):327-336.
69. Schmid A, Halle M, Stutzle C, et al. Lipoproteins and free plasma catecholamines in spinal cord injured men with different injury levels. Clin Physiol 2000;20(4):304-310.
70. Schmid A, Huonker M, Barturen JM, et al. Catecholamines, heart rate, and oxygen uptake during exercise in persons with spinal cord injury. J Appl Physiol 1998;85(2):635-641.
71. Frisbie JH, Steele DJ. Postural hypotension and abnormalities of salt and water metabolism in myelopathy patients. Spinal Cord 1997;35(5):303-307.
72. Sclater A, Alagiakrishnan K. Orthostatic hypotension. A primary care primer for assessment and treatment. Geriatrics 2004;59(8):22-27.
73. Illman A, Stiller K, Williams M. The prevalence of orthostatic hypotension during physiotherapy treatment in patients with an acute spinal cord injury. Spinal Cord 2000;38(12):741-747.
74. Mathias CJ, Frankel HL. Autonomic disturbance in spinal cord lesions. Oxford, UK: Oxford Medical Publications, 1992.
75. Faghri PD, Yount JP, Pesce WJ, et al. Circulatory hypokinesis and functional electric stimulation during standing in persons with spinal cord injury. Arch Phys Med Rehabil 2001;82(11):1587-1595.
76. Ten Harkel AD, van Lieshout JJ, Wieling W. Effects of leg muscle pumping and tensing on orthostatic arterial pressure: a study in normal subjects and patients with autonomic failure. Clin Sci (Colch) 1994;87(5):553-558.
77. Jacobsen TN, Nielsen HV, Kassis E, et al. Subcutaneous and skeletal muscle vascular responses in human limbs to lower body negative pressure. Acta Physiol Scand 1992;144(3):247-252.
78. Houtman S, Colier WN, Oeseburg B, et al. Systemic circulation and cerebral oxygenation during head-up tilt in spinal cord injured individuals. Spinal Cord 2000;38(3):158-163.
79. Gonzales F, Chang JY, Banovac K, et al. Autoregulation of cerebral blood flow in patients with orthostatic hypotension after spinal cord injury. Paraplegia 1991;29:1-7.
80. Mathias CJ. Orthostatic hypotension and paroxysmal hypertension in humans with high spinal cord injury. Prog Brain Res 2006;152:231-243.
81. Schmitt JK, Koch KS, Midha M. Profound hypotension in a tetraplegic patient following angiotensin-converting enzyme inhibitor lisinopril. Case report. Paraplegia 1994;32(12):871-874.
82. Claydon VE, Steeves JD, Krassioukov A. Orthostatic hypotension following spinal cord injury: understanding clinical pathophysiology. Spinal Cord 2006;44(6):341-351.
83. Mukand J, Karlin L, Barrs K, et al. Midodrine for the management of orthostatic hypotension in patients with spinal cord injury: a case report. Arch Phys Med Rehabil 2001;82(5):694-696.
84. Barber DB, Rogers SJ, Fredrickson MD, et al. Midodrine hydrochloride and the treatment of orthostatic hypotension in tetraplegia: two cases and a review of the literature. Spinal Cord 2000;38(2):109-111.
85. Groomes TE, Huang CT. Orthostatic hypotension after spinal cord injury: treatment with fludrocortisone and ergotamine. Arch Phys Med Rehabil 1991;72(1):56-58.
86. Gimovsky ML, Ojeda A, Ozaki R, et al. Management of autonomic hyperreflexia associated with a low thoracic spinal cord lesion. Am J Obstet Gynecol 1985;153(2):223-224.
87. Thompson CE, Witham AC. Paroxysmal hypertension in spinal cord injuries. N Engl J Med 1948;239(8):291-294.
88. Mathias CJ, Christensen NJ, Corbett JL, et al. Plasma catecholamines during paroxysmal neurogenic hypertension in quadriplegic man. Circ Res 1976;39(2):204-208.
89. McGuire TJ, Kumar VN. Autonomic dysreflexia in the spinal cord-injured. What the physician should know about this medical emergency. Postgrad Med 1986;80(2):81-84, 89.
90. Young JS. Use of guanethidine in control of sympathetic hyperreflexia in persons with cervical and thoracic cord lesions. Arch Phys Med Rehabil 1963;44:204-207.
91. Lindan R, Joiner E, Freehafer AA, et al. Incidence and clinical features of autonomic dysreflexia in patients with spinal cord injury. Paraplegia 1980;18(5):285-292.
92. Erickson RP. Autonomic hyperreflexia: pathophysiology and medical management. Arch Phys Med Rehabil 1980;61(10):431-440.
93. Kurnick NB. Autonomic hyperreflexia and its control in patients with spinal cord lesions. Ann Intern Med 1956;44(4):678-686.
94. Ragnarsson K, Hall K, Wilmot C, et al. Pulmonary, cardiovascular, and metabolic conditions. In: spinal cord injury: Clinical Outcomes from the Model system. pages 79-99. Stover S, DeLisa JA, Witeneck G, eds. Gaithersburg, MD: Aspen Publishers, Inc., 1995.
95. Krassioukov AV, Furlan JC, Fehlings MG. Autonomic dysreflexia in acute spinal cord injury: an under-recognized clinical entity. J Neurotrauma 2003;20(8):707-716.
96. Helkowski WM, Ditunno JF Jr, Boninger M. Autonomic dysreflexia: incidence in persons with neurologically complete and incomplete tetraplegia. J Spinal Cord Med 2003;26(3):244-247.
97. Trop CS, Bennett CJ. The evaluation of autonomic dysreflexia. Semin Urol 1992;10(2):95-101.
98. Eade MN. Paroxysmal hypertension in spinal cord injuries (autonomic hyperreflexia). N Z Med J 1964;63:574-580.
99. Bloch RF. Autonomic dysfuntion In: Management of Spinal Cord Injuries. Baltimore Williams & Wilkins, 1986.
100. Kewalramani LS. Autonomic dysreflexia in traumatic myelopathy. Am J Phys Med 1980;59(1):1-21.
101. Pfitzner J. Poiseuille and his law. Anaesthesia 1976;31(2):273-275.
102. Karlsson AK. Autonomic dysreflexia. Spinal Cord 1999;37(6):383-391.
103. Yarkony GM, Katz RT, Wu YC. Seizures secondary to autonomic dysreflexia. Arch Phys Med Rehabil 1986;67(11):834-835.
104. Kursh ED, Freehafer A, Persky L. Complications of autonomic dysreflexia. J Urol 1977;118(1 Pt 1):70-72.
105. Eltorai I, Kim R, Vulpe M, et al. Fatal cerebral hemorrhage due to autonomic dysreflexia in a tetraplegic patient: case report and review. Paraplegia 1992;30(5):355-360.
106. Dolinak D, Balraj E. Autonomic dysreflexia and sudden death in people with traumatic spinal cord injury. Am J Forensic Med Pathol 2007;28(2):95-98.
107. Colachis SC III. Hypothermia associated with autonomic dysreflexia after traumatic spinal cord injury. Am J Phys Med Rehabil 2002;81(3):232-235.
108. Chaves CJ, Lee G. Reversible posterior leukoencephalopathy in a patient with autonomic dysreflexia: a case report. Spinal Cord 2008;46(11):760-761.
109. Bhambhani Y. Physiology of wheelchair racing in athletes with spinal cord injury. Sports Med 2002;32(1):23-51.
110. Cole TM, Kottke FJ, Olson M, et al. Alterations of cardiovascular control in high spinal myelomalacia. Arch Phys Med Rehabil 1967;48(7):359-368.
111. Hall PA, Young JV. Autonomic hyperreflexia in spinal cord injured patients: trigger mechanism-dressing changes of pressure sores. J Trauma 1983;23(12):1074-1075.
112. Sheel AW, Krassioukov AV, Inglis JT, et al. Autonomic dysreflexia during sperm retrieval in spinal cord injury: influence of lesion level and sildenafil citrate. J Appl Physiol 2005;99(1):53-58.
113. Ekland MB, Krassioukov AV, McBride KE, et al. Incidence of autonomic dysreflexia and silent autonomic dysreflexia in men with spinal cord injury undergoing sperm retrieval: implications for clinical practice. J Spinal Cord Med2008;31(1):33-39.
114. Elliott S, Krassioukov A. Malignant autonomic dysreflexia in spinal cord injured men. Spinal Cord 2006;44(6):386-392.
115. Linsenmeyer TA, Campagnolo DI, Chou IH. Silent autonomic dysreflexia during voiding in men with spinal cord injuries. J Urol 1996;155(2):519-522.
116. Giannantoni A, Di Stasi SM, Scivoletto G, et al. Autonomic dysreflexia during urodynamics. Spinal Cord 1998;36(11):756-760.
117. Kirshblum SC, House JG, O'Connor KC. Silent autonomic dysreflexia during a routine bowel program in persons with traumatic spinal cord injury: a preliminary study. Arch Phys Med Rehabil 2002;83(12):1774-1776.
118. Furusawa K, Sugiyama H, Ikeda A, et al. Autonomic dysreflexia during a bowel program in patients with cervical spinal cord injury. Acta Med Okayama 2007;61(4):221-227.
119. Furusawa K, Sugiyama H, Tokuhiro A, et al. Topical anesthesia blunts the pressor response induced by bowel manipulation in subjects with cervical spinal cord injury. Spinal Cord 2009;47(2):144-148.
120. Lisenmeyer TA. Acute management of autonomic dysreflexia: individuals with spinal cord injury presenting to health-care facilities. Clinical practice guidelines. Consortium for spinal cord medicine. Washington, DC: Paralyzed Veterans Association, 2001:1-25.
121. Braddom RL, Rocco JF. Autonomic dysreflexia. A survey of current treatment. Am J Phys Med Rehabil 1991;70(5):234-241.
122. Acute management of autonomic dysreflexia: adults with spinal cord injury presenting to health-care facilities. Consortium for spinal cord. J Spinal Cord Med. 1997;20(3):284-308.
123. Watson N. Anti-coagulant therapy in the prevention of venous thrombosis and pulmonary embolism in the spinal cord injury. Paraplegia 1978;16(3):265-269.
124. Waring WP, Karunas RS. Acute spinal cord injuries and the incidence of clinically occurring thromboembolic disease. Paraplegia 1991;29(1):8-16.
125. Myllynen P, Kammonen M, Rokkanen P, et al. Deep venous thrombosis and pulmonary embolism in patients with acute spinal cord injury: a comparison with nonparalyzed patients immobilized due to spinal fractures. J Trauma1985;25(6):541-543.
126. Merli GJ, Herbison GJ, Ditunno JF, et al. Deep vein thrombosis: prophylaxis in acute spinal cord injured patients. Arch Phys Med Rehabil 1988;69(9):661-664.
127. Geerts WH, Code KI, Jay RM, et al. A prospective study of venous thromboembolism after major trauma. N Engl J Med 1994;331(24):1601-1606.
128. Clagett GP, Anderson FA Jr, Heit J, et al. Prevention of venous thromboembolism. Chest 1995;108(4 Suppl):312S-334S.
129. Green D, Lee MY, Lim AC, et al. Prevention of thromboembolism after spinal cord injury using low-molecular-weight heparin. Ann Intern Med 1990;113(8):571-574.
130. Rossi EC, Green D, Rosen JS, et al. Sequential changes in factor VIII and platelets preceding deep vein thrombosis in patients with spinal cord injury. Br J Haematol 1980;45(1):143-151.
131. Merli GJ, Crabbe S, Paluzzi RG, et al. Etiology, incidence, and prevention of deep vein thrombosis in acute spinal cord injury. Arch Phys Med Rehabil 1993;74(11):1199-1205.
132. Mattos MA, Londrey GL, Leutz DW, et al. Color-flow duplex scanning for the surveillance and diagnosis of acute deep venous thrombosis. J Vasc Surg 1992;15(2):366-375; discussion 375-366.
133. Persson AV, Jones C, Zide R, et al. Use of the triplex scanner in diagnosis of deep venous thrombosis. Arch Surg 1989;124(5):593-596.
134. Powell M, Kirshblum S, O'Connor KC. Duplex ultrasound screening for deep vein thrombosis in spinal cord injured patients at rehabilitation admission. Arch Phys Med Rehabil 1999;80(9):1044-1046.
135. Kadyan V, Clinchot DM, Mitchell GL, et al. Surveillance with duplex ultrasound in traumatic spinal cord injury on initial admission to rehabilitation. J Spinal Cord Med 2003;26(3):231-235.
136. Kadyan V, Clinchot DM, Colachis SC. Cost-effectiveness of duplex ultrasound surveillance in spinal cord injury. Am J Phys Med Rehabil 2004;83(3):191-197.
137. Virchow R. Thrombose und Embolie. Matzdorff ea, transCanton, MA, 1998.
138. Frieden RA, Ahn JH, Pineda HD, et al. Venous plethysmography values in patients with spinal cord injury. Arch Phys Med Rehabil 1987;68(7):427-429.
139. Rouleau P, Guertin PA. Early changes in deep vein diameter and biochemical markers associated with thrombi formation after spinal cord injury in mice. J Neurotrauma 2007;24(8):1406-1414.
140. Frisbie JH. Fibrinogen metabolism in patients with spinal cord injury. J Spinal Cord Med 2006;29(5):507-510.
141. Ersoz G, Ficicilar H, Pasin M, et al. Platelet aggregation in traumatic spinal cord injury. Spinal Cord 1999;37(9):644-647.
142. Boudaoud L, Roussi J, Lortat-Jacob S, et al. Endothelial fibrinolytic reactivity and the risk of deep venous thrombosis after spinal cord injury. Spinal Cord 1997;35(3):151-157.
143. Winther K, Gleerup G, Snorrason K, et al. Platelet function and fibrinolytic activity in cervical spinal cord injured patients. Thromb Res 1992;65(3):469-474.
144. Rowbotham BJ, Carroll P, Whitaker AN, et al. Measurement of crosslinked fibrin derivatives-use in the diagnosis of venous thrombosis. Thromb Haemost 1987;57(1):59-61.
145. Bounameaux H. Low molecular weight heparins and prevention of postoperative thrombosis. Br J Surg 1989;76(5):524.
146. Roussi J, Bentolila S, Boudaoud L, et al. Contribution of D-Dimer determination in the exclusion of deep venous thrombosis in spinal cord injury patients. Spinal Cord 1999;37(8):548-552.
147. Furlan JC, Fehlings MG. Role of screening tests for deep venous thrombosis in asymptomatic adults with acute spinal cord injury: an evidence-based analysis. Spine 2007;32(17):1908-1916.
148. Meythaler JM, DeVivo MJ, Hayne JB. Cost-effectiveness of routine screening for proximal deep venous thrombosis in acquired brain injury patients admitted to rehabilitation. Arch Phys Med Rehabil 1996;77(1):1-5.
149. Green D, Rossi EC, Yao JS, et al. Deep vein thrombosis in spinal cord injury: effect of prophylaxis with calf compression, aspirin, and dipyridamole. Paraplegia 1982;20(4):227-234.
150. Green D, Lee MY, Ito VY, et al. Fixed- vs adjusted-dose heparin in the prophylaxis of thromboembolism in spinal cord injury. JAMA 1988;260(9):1255-1258.
151. Winemiller MH, Stolp-Smith KA, Silverstein MD, et al. Prevention of venous thromboembolism in patients with spinal cord injury: effects of sequential pneumatic compression and heparin. J Spinal Cord Med 1999;22(3):182-191.
152. Merli GJ, Crabbe S, Doyle L, et al. Mechanical plus pharmacological prophylaxis for deep vein thrombosis in acute spinal cord injury. Paraplegia 1992;30(8):558-562.
153. Aito S, Pieri A, D'Andrea M, et al. Primary prevention of deep venous thrombosis and pulmonary embolism in acute spinal cord injured patients. Spinal Cord 2002;40(6):300-303.
154. Deep K, Jigajinni MV, McLean AN, et al. Prophylaxis of thromboembolism in spinal injuries-results of enoxaparin used in 276 patients. Spinal Cord 2001;39(2):88-91.
155. Thumbikat P, Poonnoose PM, Balasubrahmaniam P, et al. A comparison of heparin/warfarin and enoxaparin thromboprophylaxis in spinal cord injury: the Sheffield experience. Spinal Cord 2002;40(8):416-420.
156. Prevention of venous thromboembolism in the acute treatment phase after spinal cord injury: a randomized, multicenter trial comparing low-dose heparin plus intermittent pneumatic compression with enoxaparin. J Trauma2003;54(6):1116-1124; discussion 1125-1116.
157. Prevention of venous thromboembolism in the rehabilitation phase after spinal cord injury: prophylaxis with low-dose heparin or enoxaparin. J Trauma 2003;54(6):1111-1115.
158. Hebbeler SL, Marciniak CM, Crandall S, et al. Daily vs twice daily enoxaparin in the prevention of venous thromboembolic disorders during rehabilitation following acute spinal cord injury. J Spinal Cord Med 2004;27(3):236-240.
159. Chiou-Tan FY, Garza H, Chan KT, et al. Comparison of dalteparin and enoxaparin for deep venous thrombosis prophylaxis in patients with spinal cord injury. Am J Phys Med Rehabil 2003;82(9):678-685.
160. Slavik RS, Chan E, Gorman SK, et al. Dalteparin versus enoxaparin for venous thromboembolism prophylaxis in acute spinal cord injury and major orthopedic trauma patients: 'DETECT' trial. J Trauma 2007;62(5):1075-1081; discussion 1081.
161. Prevention of thromboembolism in spinal cord injury. Consortium for spinal cord medicine. J Spinal Cord Med 1997;20(3):259-283.
162. Wysowski DK, Talarico L, Bacsanyi J, Botstein P. Spinal and epidural hematoma and low-molecular-weight heparin. N Engl J Med 1998;338(24):1774-1775.
163. Khansarinia S, Dennis JW, Veldenz HC, Butcher JL, Hartland L. Prophylactic Greenfield filter placement in selected high-risk trauma patients. J Vasc Surg 1995;22(3):231-235; discussion 235-236.
164. Wojcik R, Cipolle MD, Fearen I, et al. Long-term follow-up of trauma patients with a vena caval filter. J Trauma 2000;49(5):839-843.
165. Giannoudis PV, Pountos I, Pape HC, et al. Safety and efficacy of vena cava filters in trauma patients. Injury 2007;38(1):7-18.
166. Balshi JD, Cantelmo NL, Menzoian JO. Complications of caval interruption by Greenfield filter in quadriplegics. J Vasc Surg 1989;9(4):558-562.
167. Maxwell RA, Chavarria-Aguilar M, Cockerham WT, et al. Routine prophylactic vena cava filtration is not indicated after acute spinal cord injury. J Trauma 2002;52(5):902-906.
168. Johns JS, Nguyen C, Sing RF. Vena cava filters in spinal cord injuries: evolving technology. J Spinal Cord Med 2006;29(3):183-190.
169. Gorman PH, Qadri SF, Rao-Patel A. Prophylactic inferior vena cava (IVC) filter placement may increase the relative risk of deep venous thrombosis after acute spinal cord injury. J Trauma 2009;66(3):707-712.
170. Snow V, Qaseem A, Barry P, et al. Management of venous thromboembolism: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians. Ann Intern Med 2007;146(3):204-210.
171. Segal JB, Streiff MB, Hofmann LV, et al. Management of venous thromboembolism: a systematic review for a practice guideline. Ann Intern Med 2007;146(3):211-222.
172. McKinley WO, Jackson AB, Cardenas DD, et al. Long-term medical complications after traumatic spinal cord injury: a regional model systems analysis. Arch Phys Med Rehabil 1999;80(11):1402-1410.
173. Qureshi MM, Cudkowicz ME, Zhang H, et al. Increased incidence of deep venous thrombosis in ALS. Neurology 2007;68(1):76-77.
174. Kim SW, Charallel JT, Park KW, et al. Prevalence of deep venous thrombosis in patients with chronic spinal cord injury. Arch Phys Med Rehabil 1994;75(9):965-968.
175. Sawka MN, Latzka WA, Pandolf KB. Temperature regulation during upper body exercise: able-bodied and spinal cord injured. Med Sci Sports Exerc 1989;21(5 Suppl):S132-S140.
176. Wallin BG, Stjernberg L. Sympathetic activity in man after spinal cord injury. Outflow to skin below the lesion. Brain 1984;107(Pt 1):183-198.
177. Downey JA, Chiodi HP, Darling RC. Central temperature regulation in the spinal man. J Appl Physiol 1967;22(1):91-94.