Cardiovascular control after spinal cord injury

Current Vascular Pharmacology

Volumn 2, Issue 1, 2004, Pages 71-79

  Gondim, F A A ^a,b   Lopes Jr , A C A ^a   Oliveira, G R ^c   Rodrigues, C L ^a   Leal, P R L ^a   Santos, A A ^a   Rola, F H ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autonomic hyperreflexia; Autonomic nervous system; Blood pressure; Heart rate; Spinal cord injury

Indexed keywords

ADRENALIN; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; ANESTHETIC AGENT; ATROPINE; CAPTOPRIL; CATECHOLAMINE; CHLORALOSE; CLONIDINE; DIAZOXIDE; GLYCERYL TRINITRATE; HYDRALAZINE; IMIDAZOLINE; KETAMINE; METHOXYFLURANE; MIDODRINE; N METHYL DEXTRO ASPARTIC ACID; N(G) NITROARGININE METHYL ESTER; NIFEDIPINE; NORADRENALIN; PENTOBARBITAL; PHENOXYBENZAMINE; PHENTOLAMINE; PRAZOSIN; XYLAZINE;

ADRENALIN BLOOD LEVEL; ADRENERGIC STIMULATION; AUTONOMIC HYPERREFLEXIA; AUTONOMIC NERVOUS SYSTEM; BRADYCARDIA; CARDIOVASCULAR SYSTEM; CENTRAL VENOUS PRESSURE; DRUG MECHANISM; HEART ARRHYTHMIA; HEART OUTPUT; HEMODYNAMICS; HUMAN; HYPOTENSION; LUMBAR SPINAL CORD; NONHUMAN; NORADRENALIN BLOOD LEVEL; ORTHOSTATIC HYPOTENSION; PARAPLEGIA; QUADRIPLEGIA; REVIEW; SPINAL CORD INJURY; SYMPATHETIC NERVE CELL; SYMPATHETIC TONE; THORACIC SPINAL CORD; VASCULAR RESISTANCE;

ANIMALS; AUTONOMIC DYSREFLEXIA; AUTONOMIC NERVOUS SYSTEM DISEASES; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; HEART RATE; HUMANS; SPINAL CORD INJURIES;

EID: 3042702804     PISSN: 15701611     EISSN: None     Source Type: Journal    
DOI: 10.2174/1570161043476474     Document Type: Review

References (99)

1. McKinley WO, Tewksbury MA, Godbout CJ. Comparison of medical complications following nontraumatic and traumatic spinal cord injury. J Spinal Cord Med 2002; 25: 88-93.
2. Ditunno JF Jr, Formal CS. Chronic spinal cord injury. N Engl J Med 1994; 330: 550-556.
3. McDonald JW, Sadowsky C. Spinal-cord injury. Lancet 2002; 359: 417-25.
4. O'Connor P. Incidence and patterns of spinal cord injury in Australia. Accid Anal Prev 2002; 34: 405-15.
5. No authors. Spinal cord injury: facts and figures at a glance. J Spinal Cord Med 2001; 24: 212-3.
6. Sugarman B. Medical complications of spinal cord injury. Q J Med 1985; 54: 3-18.
7. Saper CB. The central autonomic nervous system: conscious visceral perception and autonomic pattern generation. Ann Rev Neurosci 2002; 25: 433-69.
8. Atkinson PP, Atkinson JL. Spinal shock. Mayo Clin Proc 1996; 71: 384-9.
9. Llewellyn-Smith IJ, Weaver LC. Changes in synaptic inputs to sympathetic preganglionic neurons after spinal cord injury. J Comp Neurol 2001; 435: 226-40.
10. Wilson RH, Whiteshed MC, Moorehead RJ. Problems in diagnosis and management of hypovolaemia in spinal injury. Br J Clin Pract 1993; 47: 224-5.
11. Mathias CJ, Christensen NJ, Frankel HL, Spalding JM. Cardiovascular control in recently injured tetraplegics in spinal shock. Q J Med 1979; 48: 273-87.
12. Dolan EJ, Tator CH. The treatment of hypotension due to acute experimental spinal cord compression injury. Surg Neurol 1980; 13: 380-84.
13. Levi L, Wolf A, Belzberg H. Hemodynamic parameters in patients with acute cervical cord trauma: description, intervention and prediction of outcome. Neurosurgery 1993; 33: 1007-16.
14. Groat RA, Peele TL. Blood pressure response to acutely increased pressure upon the spinal cord. Am J Physiol 1945; 144: 578-587.
15. Eidelberg EE. Cardiovascular response to experimental spinal cord compression. J Neurosurg 1973; 38: 326-31.
16. Tibbs PA, Young B, McAllister RG, Brooks Wh, Tackett L. Studies of experimental cervical spinal cord transection Part I. J Neurosurg 1978; 49: 558-62.
17. Tibbs PA, Young B, Todd EP, Ziegler MG, McAllister RG. Studies of experimental cervical spinal cord transection Part II. J Neurosurg 1979; 50: 629-32.
18. Tibbs PA, Young B, McAllister RG, Todd PT. Studies of experimental cervical spinal cord transection Part III. J Neurosurg 1979; 50: 633-38.
19. Tibbs PA, Young B, Todd EP, McAllister RG, Hubbard S. Studies of experimental cervical spinal cord transection Part IV. J Neurosurg 1980; 52: 197-202.
20. Guha Ab, Tator CH. Acute cardiovascular effects of experimental spinal cord injury. J Trauma 1988; 28: 481-90.
21. Bravo G, Rojas-Martinez R, Larios F, Hong E, Castaneda-Hernandez G, Rojas G. Mechanisms involved in the cardiovascular alterations immediately after spinal cord injury. Life Sciences 2001; 68: 1527-34.
22. Bravo G, Hong E, Rojas G, Guizar-Sahagun G. Sympathetic blockade significantly improves cardiovascular alterations immediately after spinal cord injury in rats. Neurosci Lett 2002; 319: 95-8.
23. Greenhot JH, Mauck Jr HP. The effect of cervical cord injury on cardiac rhythm and conduction. Am Heart J 1972; 83: 659-62.
24. Greenhoot JG, Shiel FO'M, Mauck Jr HP. Experimental spinal cord injury: electrocardiographic and fucsinophilic myocardial degeneration. Arch Neurol 1972; 83: 524-29.
25. Leal PRL, Gondim FAA, Graca JRV, Lopes Jr AC deA, Ferreira de Queiroz DA, Rodrigues CL, et al. Alteracões hemodinâmicas póstranseccão medular cervical aguda em ratos anestesiados. Federacão de Sociedades de Biologia Experimental 2002; 105 resumo 10.046.
26. Maignan E, Dong WX, Legrand M, Safar M, Cuche JL. Sympathetic activity in the rat: effects of anaesthesia on noradrenaline kinetics. J Auton Nerv Syst 2000; 80: 46-51.
27. Claus-Walker J, Vallbona C, Carter RE, Lipscomb HS. Resting and stimulated endocrine function in human subjects with cervical spinal cord transection. J Chronic Dis 1971; 24: 193-207.
28. Osborn JW, Taylor RB, Schramm LP. Chronic cervical spinal cord injury and autonomic hyperreflexia in rats. Am J Physiol 1990; 258: R169-74.
29. Krassioukov AV, Weaver LC. Episodic hypertension due to autonomic dysreflexia in acute and chronic spinal cord-injured rats. Am J Physiol 1995; 268: H2077-83.
30. Maiorov DN, Weaver LC, Krassioukov AV. Relationship between sympathetic activity and arterial pressure in conscious spinal rats. Am J Physiol 1997; 272: H625-31.
31. Goodim Fde A, Alencar HM, Rodrigues CL, da Graca JR, dos Santos AA, Rola FH. Complete cervical or thoracic spinal cord transections delay gastric emptying and gastrointestinal transit of liquid in awake rats. Spinal Cord 1999; 37: 793-9.
32. Rodrigues CL, Gondim Fde A, Leal PR, Camurca FD, Freire CC, dos Santos AA, et al. Gastric emptying and gastrointestinal transit of liquid throughout the first month after thoracic spinal cord transection in awake rats. Dig Dis Sci 2001; 46: 1604-9.
33. Miller CO, Johns DG, Schramm LP. Spinal interneurons play a minor role in generating ongoing renal sympathetic nerve activity in spinally intact rats. Brain Res 2001; 918(1-2): 101-6.
34. Taylor RF, Schramm LP. Differential effects of spinal transection on sympathetic nerve activities in rats. Am J Physiol 1987; 253: R611-618.
35. Taylor RB, Weaver LC. Dorsal root afferent influences on tonic firing of renal and mesenteric sympathetic nerves in rats. Am J Physiol 1993; 264: R1193-1199.
36. Weaver LC, Stein RD. Effects of spinal cord transection on sympathetic discharge in decerebrate-unanesthetized cats. Am J Physiol 1989; 257: R1506-11.
37. Yardley CP, Fitzsimons CL, Weaver LC. Cardiac and peripheral vascular contributions to hypotension in spinal cats. Am J Physiol 1989; 257: H1347-53
38. Osborn JW Jr, Livingstone RH, Schramm LP. Elevated renal nerve activity after spinal transection: effects on renal function. Am J Physiol 1987; 253: R619-25.
39. Trostel KA, Katz SA, Osborn JW. Functional evidence for sympathetic nerve activity in councious cervical spinal rats. Am J Physiol 1991; 261: R434-441.
40. Trostel KA, Osborn JW. Does the spinal cord generate functionally significant sympathetic activity in the awake rat. Am J Physiol 1994; 266: R1102-10.
41. Hong Y, Cechetto DF, Weaver LC. Spinal cord regulation of sympathetic activity in intact and spinal rats. Am J Physiol 1994; 266: H1485-93.
42. Wallin BG, Stjernberg L. Sympathetic activity in man after spinal cord injury. Brain 1984; 107: 183-98.
43. Stjernberg L, Blumberg H, Wallin BG. Sympathetic activity in man after spinal cord injury. Outflow to muscle below the lesion. Brain 1986; 109: 695-715.
44. Mathias CJ, Frankel HL. Cardiovascular control in spinal man. Annu Rev Physiol 1988; 50: 577-92.
45. Arnold JM, Feng QP, Delaney GA, Teasell RW. Autonomic dysreflexia in tetraplegic patients: evidence for alpha-adrenoceptor hyper-responsiveness. Clin Auton Res 1995; 5: 267-70.
46. Innes IR, Kosterlitz HW. The effects of preganglionic and postganglionic denervation on the responses of the incitating membrane to sympathomimetic substances. J Physiol (London) 1954; 124: 25-43.
47. Mathias CJ, Frankel HL, Christensen NJ, Spalding JM. Enhanced pressor response to noradrenaline in patients with cervical spinal cord transection. Brain 1976; 99: 757-70.
48. Mathias CJ, Christensen NJ, Corbett JL, Frankel HL, Spalding JM. Plasma catecholamines during paroxysmal neurogenic hypertension in quadriplegic man. Circ Res 1976; 39: 204-8.
49. Krum H, Brown DJ, Rowe PR, Louis WJ, Howes LG. Steady state plasma [3H]-noradrenaline kinetics in quadriplegic chronic spinal cord injury patients. J Auton Pharmacol 1990; 10: 221-6.
50. Rodriguez GP, Claus-Walker J, Kent MC, Stal S. Adrenergic receptors in insensitive skin of spinal cord injured patients. Arch Phys Med Rehabil 1986; 67: 177-80.
51. Osborn JW, Taylor RF, Schramm LP. Determinants of arterial pressure after chronic spinal transection in rats. Am J Physiol 1989; 256: R666-73.
52. Krassioukov AV, Weaver LC. Morphological changes in sympathetic preganglionic neurons after spinal cord injury in rats. Neuroscience 1996; 70: 211-25.
53. Weaver LC, Verghese P, Bruce JC, Fehlings MG, Krenz NR, Marsh DR. Autonomic dysreflexia and primary afferent sprouting after clip-compression injury of the rat spinal cord. J Neurotrauma 2001; 18: 1107-19.
54. Teasell RW, Arnold MO, Krassioukov A, Delaney GA. Cardiovascular consequences of loss of supraspinal control of the sympathetic nervous system after spinal cord injur. Arch Phys Med Rehabil 2000; 81: 506-16.
55. Krenz NR, Weaver LC. Sprouting of primary afferent fibers after spinal cord transection in the rat. Neuroscience 1998; 85: 443-58.
56. Krenz NR, Weaver LC. Effect of spinal cord transection on N-methyl-D-aspartate receptors in the cord. J Neurotrauma 1998; 15: 1027-36.
57. Maiorov DN, Krenz NR, Krassioukov AV, Weaver LC. Role of spinal NMDA and AMPA receptors in episodic hypertension in conscious spinal rats. Am J Physiol 1997; 273: H1266-74.
58. Hilton J. A course of lectures on pain and the therapeutic influence of mechanical and physiological rest in accidents and surgical diseases. Lancet 1860; 2: 401-404.
59. Bolwby AA. On conditions of reflexes in cases of injury to spinal cord; with special reference to indications for operative interference. Med Chir Ter 1890; 73: 317-25.
60. Head H, Riddoch G. Autonomic bladder, excessive sweating and some reflex conditions in gross injuries of spinal cord. Brain 1917; 46: 188-263.
61. Silver JR. The history of Guttmann's and Whitteridge's discovery of autonomic dysreflexia. Spinal Cord 2000; 38: 581-96.
62. Guttmann L, Whitteridge D. Effects of bladder distension on autonomic mechanism after sinal cord injuries. Brain 1947; 70: 361-404.
63. Bateman AM, Goldish GD. Autonomic dysreflexia in multiple sclerosis. J Spinal Cord Med 2002; 25: 40-2.
64. Gimovski ML, Ojeda A, Ozaki R, Zerne S. Management of autonomic hyperreflexia associated with a low thoracic spinal cord lesion. Am J Obstet Gynecol 1985; 153: 223-4.
65. Roche WJ, Nwofia C, Gittler M, Patel R, Yarkony G. Catecholamine-induced hypertension in lumbosacral paraplegia: five case reports. Arch Phys Med Rehabil 2000; 81: 222-5.
66. Brown BT, Carrion HM, Politano VA. Guanethidine sulfate in the prevention of autonomic hyperreflexia. J Urol 1979; 122: 55-7.
67. Abouleish E. Hypertension in a paraplegic parturient. Anesthesiology 1980; 53: 348.
68. Kursh ED, Freehafer A, Persky L. Complications of autonomic dysreflexia. J Urol 1977; 118: 70-2.
69. Guttman L, Frankel HL, Paeslack V. Cardiac irregularities during labor in paraplegic women. Paraplegia 1965; 3: 141-151.
70. Yarkony GM, Katz RT, Wu YC. Seizures secondary to autonomic dysreflexia. Arch Phys Med Rehabil 1986; 67: 834-5.
71. Colachis SC, Fugate LP. Autonomic dysreflexia associated with transient aphasia. Spinal Cord 2002; 40: 142-4.
72. Colachis SC 3rd, Clinchot DM. Autonomic hyperreflexia associated with recurrent cardiac arrest: case report. Spinal Cord 1997; 35: 256-7.
73. Colachis SC 3rd. Autonomic hyperreflexia with spinal cord injury. J Am Paraplegia Soc 1992; 15: 171-86.
74. Karlsson AK. Autonomic dysreflexia. Spinal Cord 1999; 37: 383-91.
75. McKinley WO, Gittler MS, Kirshblum SC, Stiens SA, Groah SL. Spinal cord injury medicine. 2. Medical complications after spinal cord injury: Identification and management. Arch Phys Med Rehabil 2002; 83(3 Suppl 1): S58-64, S90-8
76. Kewalramani LS. Autonomic dysreflexia in traumatic myelopathy. Am J Phys Med 1980; 59: 1-21.
77. Young W, DeCrescito V, Tomasula JJ, Ho V. The role of the sympathetic nervous system in pressor responses induced by spinal injury. J Neurosurg 1980; 52: 473-81.
78. Wallin G. Abnormalities of sympathetic regulation after cervical cord lesions. Acta Neurochir Suppl (Wien) 1986; 36: 123-4.
79. Weaver LC, Marsh DR, Gris D, Meakin SO, Dekaban GA. Central mechanisms for autonomic dysreflexia after spinal cord injury. Prog Brain Res 2002; 137: 83-95.
80. Sansone GR, Bianca R, Cueva-Rolón R, Gómez LE, Komisaruk. Cardiovascular responses to vaginocervical stimulation in the spinal cord-transected rat. Am J Physiol 1997; 273: R1361-66.
81. Jacob JE, Pniak A, Weaver LC, Brown A. Autonomic dysreflexia in a mouse model of spinal cord injury. Neuroscience 2001; 108: 687-93.
82. Collins HL, Dicarlo SE. Acute exercise reduces the response to colon distension in T(5) spinal rats. Am J Physiol Heart Circ Physiol 2002; 282: H1566-70.
83. Krassioukov AV, Jonson DG, Schramm LP. Spinal interneurons are hyperresponsive to somatic and visceral stimuli after chronic spinal cord transaction in the rat. Neurosci Abstr 2000; 26: 1191.
84. Krenz NR, Meakin SO, Krassioukov AV, Weaver LC. Neutralizing intraspinal nerve growth factor blocks autonomic dysreflexia caused by spinal cord injury. J Neurosci 1999; 19: 7405-14.
85. No authors. Acute management of autonomic dysreflexia: adults with spinal cord injury presenting to health-care facilities. Consortium for spinal cord. J Spinal Cord Med 1997; 20: 284-308.
86. Esmail Z, Shalansky KF, Sunderji R, Anton H, Chambers K, Fish W. Evaluation of captopril for the management of hypertension in autonomic dysreflexia: a pilot study. Arch Phys Med Rehabil 2002; 83: 604-8.
87. Frankel HL, Michaelis LS, Golding DR, Beral V. The blood pressure in paraplegia. I. Paraplegia 1972; 10: 193-200.
88. Figoni SF. Exercise responses and quadriplegia. Med Sci Sports Exerc 1993; 25: 433-41.
89. Corbett JL, Frankel HL, Harris PJ. Cardiovascular responses to tilting in tetraplegic man. J Physiol (London) 1971; 215: 411-31.
90. Faghri PD, Yount JP, Pesce WJ, Seetharama S, Votto JJ. Circulatory hypokinesis and functional electric stimulation during standing in persons with spinal cord injury. Arch Phys Med Rehabil 2001; 82: 1587-95.
91. Illman A, Stiller K, Williams M. The prevalence of orthostatic hypotension during physiotherapy treatment in patients with an acute spinal cord injury. Spinal Cord 2000; 38: 741-7.
92. Cariga P, Ahmed S, Mathias CJ, Gardner BP. The prevalence and association of neck (coat-hanger) pain and orthostatic (postural) hypotension in human spinal cord injury. Spinal Cord 2002; 40: 77-82.
93. Baliga RR, Catz AB, Watson LD, Short DJ, Frankel HL, Mathias CJ. Cardiovascular and hormonal responses to food ingestion in humans with spinal cord transection. Clin Auton Res 1997; 7: 137-41.
94. Mukand J, Karlin L, Barrs K, Lublin P. Midodrine for the management of orthostatic hypotension in patients with spinal cord injury: A case report. Arch Phys Med Rehabil 2001; 82: 694-6.
95. Elokda AS, Nielsen DH, Shields RK. Effect of functional neuromuscular stimulation on postural related orthostatic stress in individuals with acute spinal cord injury. J Rehabil Res Dev 2000; 37: 535-42.
96. Grimm DR, Meersman RE, Almenoff PL, Spungen AM, Bauman WL. Sympathovagal balance of the heart in sujects with spinal cord injury. Am J Physiol 1997; 272: H835-42.
97. Baldridge BR, Burgess DE, Zimmerman EE, Carroll JJ, Sprinkle AG, Speakman RO, et al. Heart rate-arterial blood pressure relationship in conscious rat before vs. after spinal cord transection. Am J Physiol Regul Integr Comp Physiol 2002; 283: R748-56.
98. Legramante JM, Raimondi G, Massaro M, Iellamo F. Positive and negative feedback mechanisms in the neural regulation of cardiovascular function in healthy and spinal cord-injured humans. Circulation 2001; 103: 1250-5.
99. Krum H, Louis WJ, Brown DJ, Jackman GP, Howes LG. Diurnal blood pressure variation in quadriplegic chronic spinal cord injury patients. Clin Science 1991; 80: 271-6.