Sequential use of aminophylline and theophylline for the treatment of atropine-resistant bradycardia after spinal cord injury: A case report

Journal of Cardiology

Volumn 49, Issue 2, 2007, Pages 91-96

  Sakamoto, Tomohiro ^b   Sadanaga, Tsuneaki ^a   Okazaki, Tomoki ^a  

^a Yatsushiro Health Insurance General Hospital   (Japan)

^b SAISEIKAI KUMAMOTO HOSPITAL   (Japan)

Author keywords

Antiarrliytlimia (atropine); Bradycardia (aminophylline, theophylline)

Indexed keywords

AMINOPHYLLINE; ATROPINE; THEOPHYLLINE; CARDIOTONIC AGENT;

AGED; ARTICLE; CASE REPORT; CERVICAL SPINAL CORD INJURY; CONTINUOUS INFUSION; DRUG BLOOD LEVEL; DRUG SUBSTITUTION; DRUG TREATMENT FAILURE; DRUG WITHDRAWAL; ELECTROCARDIOGRAPHY; EMERGENCY WARD; HEART RATE; HUMAN; JAPANESE; LOADING DRUG DOSE; MALE; PHYSICAL EXAMINATION; SINUS BRADYCARDIA; THORACIC SPINE; BRADYCARDIA; DRUG ADMINISTRATION; DRUG COMBINATION; DRUG RESISTANCE; INTRAVENOUS DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; SPINAL CORD INJURY; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; AGED; AMINOPHYLLINE; ATROPINE; BRADYCARDIA; CARDIOTONIC AGENTS; DRUG ADMINISTRATION SCHEDULE; DRUG RESISTANCE; DRUG THERAPY, COMBINATION; HEART RATE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; SPINAL CORD INJURIES; THEOPHYLLINE; TREATMENT OUTCOME;

EID: 34247197102     PISSN: 09145087     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Lehmann KG, Lane JG, Piepmeier JM, Batsford VP: Cardiovascular abnormalities accompanying acute spinal cord injury in humans: Incidence, time course and severity. J Am Coll Cardiol 1987; 10: 46-52
2. Vallbona C, Cardus D, Spencer WA, Hoff HE: Patterns of sinus arrhythmia in patients with lesions of the central nervous system. Am J Cardiol 1965; 16: 379-389
3. Winslow EB, Lesch M, Talano JV, Meyer PR: Spinal cord injuries associated with cardiopulmonary complications. Spine 1986; 11: 809-812
4. Silbert PL, Davis JM: Late asystole in high cervical spinal cord injury: Case report. Paraplegia 1990; 28: 137-140
5. Gilgoff IS, Ward SL, Hohn AR: Cardiac pacemaker in high spinal cord injury. Arch Phys Med Rehabil 1991; 72: 601-603
6. Saito D, Matsubara K, Yamanari H, Obayashi N, Uchida S. Maekawa K. Sato T, Mizuo K, Kobayashi H, Haraoka S: Effects of oral theophylline on sick sinus syndrome. J Am Coll Cardiol 1993; 21: 1199-1204
7. Pasnoori R, Leesar MA: Use of aminophylline in the treatment of severe symptomatic bradycardia resistant to atropine. Cardiol Rev 2004; 12: 65-68
8. Schulz-Stubner S: The use of small-dose theophylline for the treatment of bradycardia in patients with spinal cord injury. Anesth Analg 2005; 101: 1809-1811
9. Marino RJ, Barros T, Biering-Sorensen F, Burns SP, Donovan VH, Graves DE, Haak M, Hudson EM, Priebe MM; ASIA Neurological Standards Committee 2002: International standards for neurological classification of spinal cord injury. J Spinal Cord Med 2003 ; 26 (Suppl 1) S50-S56
10. Anonymous: 2005 American heart association guidelines for cardiopulmonary resuscitation and emergency cardio vascular care: Part 7.3: Management of symptomatic bradycardia and tachycardia. Circulation 2005; 112: IV 67-IV 77
11. Belardinelli L, Fenton RA, Vest A, L.inden J, Aithaus JS, Berne RM: Extracellular action of adenosine and the antagonism by aminophylline on the atrioventricular conduction of isolated perfused guinea pig and rat hearts. Circ Res 1982; 51: 569-579
12. WestfalI DP, Fleming WW: Sensitivity changes in the dog heart to norepinephrine, calcium and aminophyline resulting from pretreatment with reserpine. J Pharmacol Exp Ther 1968; 159: 98-106
13. Rall TW: Role of adenosine 3', 5'-monophosphate(cyclic AMP) in actions of catecholamines. Pharmacol Rev 1972; 24: 399-409
14. Ellenbogen KA, Szentpetery S, Katz MR: Reversibility of prolonged chronotropic dysfunction with theophylline following orthotopic cardiac transplantation. Am Heart J 1988; 116: 202-206
15. Strasberg B, Bassevich R, Mager A, Kusniec J, Sagie A, Sclarovsky S: Effects of aminophylline on atrioventricular conduction in patients with late atrioventricular block during inferior wall acute myocardial infarction. Am J Cardiol 1991; 67: 527-528
16. Altun A, Kirdar C, Ozbay G: Effect of aminophylline in patients with atropine-resistant late advanced atrioventricuiar block during acute inferior myocardial infarction. Clin Cardiol 1998; 21: 759-762