Accuracy of lipoarabinomannan and xpert MTB/RIF testing in cerebrospinal fluid to diagnose tuberculous meningitis in an autopsy cohort of HIV-infected adults

Journal of Clinical Microbiology

Volumn 53, Issue 8, 2015, Pages 2667-2673

  Cox, Janneke A ^a,b   Lukande, Robert L ^b   Kalungi, Sam ^b,c   Van Marck, Eric ^d   Lammens, Martin ^d   Van De Vijver, Koen ^e   Kambugu, Andrew ^b   Nelson, Ann M ^f   Colebunders, Robert ^a,g   Manabe, Yukari C ^b,h  

^a INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^b MAKERERE UNIVERSITY   (Uganda)

^c MULAGO HOSPITAL   (Uganda)

^d ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^e NETHERLANDS CANCER INSTITUTE   (Netherlands)

^f JOINT PATHOLOGY CENTER   (United States)

^g UNIVERSITY OF ANTWERP   (Belgium)

^h JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; AUTOPSY; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID ANALYSIS; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN TISSUE; LIPOARABINOMANNAN ENZYME LINKED IMMUNOSORBENT ASSAY; LIPOARABINOMANNAN LATERAL FLOW ASSAY; MAJOR CLINICAL STUDY; MALE; POINT OF CARE TESTING; PREDICTIVE VALUE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; TUBERCULOUS MENINGITIS; UGANDAN; XPERT M. TUBERCULOSIS/RIF ASSAY; CHEMISTRY; COMPARATIVE STUDY; COMPLICATION; EVALUATION STUDY; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOASSAY; MOLECULAR DIAGNOSIS; POINT OF CARE SYSTEM; PROCEDURES; TUBERCULOSIS, MENINGEAL; UGANDA;

BACTERIAL DNA; LIPOARABINOMANNAN; LIPOPOLYSACCHARIDE;

ADULT; AUTOPSY; CEREBROSPINAL FLUID; COHORT STUDIES; DIAGNOSTIC TESTS, ROUTINE; DNA, BACTERIAL; FEMALE; HIV INFECTIONS; HUMANS; IMMUNOASSAY; LIPOPOLYSACCHARIDES; MALE; MOLECULAR DIAGNOSTIC TECHNIQUES; POINT-OF-CARE SYSTEMS; SENSITIVITY AND SPECIFICITY; TUBERCULOSIS, MENINGEAL; UGANDA;

EID: 84938152044     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.00624-15     Document Type: Article

References (30)

1. World Health Organization. 2013. Global tuberculosis report 2013. World Health Organization, Geneva, Switzerland. http://apps.who.int/iris/bitstream/10665/91355/1/9789241564656-eng.pdf.
2. Wilkinson D, Moore DA. 1996. HIV-related tuberculosis in South Africa-clinical features and outcome. S Afr Med J 86:64-67.
3. Yang Z, Kong Y, Wilson F, Foxman B, Fowler AH, Marrs CF, Cave MD, Bates JH. 2004. Identification of risk factors for extrapulmonary tuberculosis. Clin Infect Dis 38:199-205. http://dx.doi.org/10.1086/380644.
4. Azuaje C, Fernandez Hidalgo N, Almirante B, Martin-Casabona N, Ribera E, Diaz M, Prats G, Pahissa A. 2006. Tuberculous meningitis: a comparative study in relation to concurrent human immunodeficiency virus infection. Enferm Infecc Microbiol Clin 24:245-250. (In Spanish.) http://dx.doi.org/10.1016/S0213-005X(06)73770-3.
5. Marais S, Pepper DJ, Marais BJ, Török ME. 2010. HIV-associated tuberculous meningitis-diagnostic and therapeutic challenges. Tuberculosis (Edinb) 90:367-374. http://dx.doi.org/10.1016/j.tube.2010.08.006.
6. Verdon R, Chevret S, Laissy JP, Wolff M. 1996. Tuberculous meningitis in adults: review of 48 cases. Clin Infect Dis 22:982-988. http://dx.doi.org/10.1093/clinids/22.6.982.
7. Marais S, Thwaites G, Schoeman JF, Török ME, Misra UK, Prasad K, Donald PR, Wilkinson RJ, Marais BJ. 2010. Tuberculous meningitis: a uniform case definition for use in clinical research. Lancet Infect Dis 10: 803-812. http://dx.doi.org/10.1016/S1473-3099(10)70138-9.
8. Ho J, Marais BJ, Gilbert GL, Ralph AP. 2013. Diagnosing tuberculous meningitis-have we made any progress? Trop Med Int Health 18:783-793. http://dx.doi.org/10.1111/tmi.12099.
9. Mishra AK, Driessen NN, Appelmelk BJ, Besra GS. 2011. Lipoarabinomannan and related glycoconjugates: structure, biogenesis and role in Mycobacterium tuberculosis physiology and host-pathogen interaction. FEMS Microbiol Rev 35:1126-1157. http://dx.doi.org/10.1111/j.1574-6976.2011.00276.x.
10. Sada E, Aguilar D, Torres M, Herrera T. 1992. Detection of lipoarabinomannan as a diagnostic test for tuberculosis. J Clin Microbiol 30:2415-2418.
11. Patel VB, Bhigjee AI, Paruk HF, Singh R, Meldau R, Connolly C, Ndung?u T, Dheda K. 2009. Utility of a novel lipoarabinomannan assay for the diagnosis of tuberculous meningitis in a resource-poor high-HIV prevalence setting. Cerebrospinal Fluid Res 6:13. http://dx.doi.org/10.1186/1743-8454-6-13.
12. Dheda K, Davids V, Lenders L, Roberts T, Meldau R, Ling D, Brunet L, van Zyl Smit R, Peter J, Green C, Badri M, Sechi L, Sharma S, Hoelscher M, Dawson R, Whitelaw A, Blackburn J, Pai M, Zumla A. 2010. Clinical utility of a commercial LAM-ELISA assay for TB diagnosis in HIVinfected patients using urine and sputum samples. PLoS One 5:e9848. http://dx.doi.org/10.1371/journal.pone.0009848.
13. Patel VB, Singh R, Connolly C, Kasprowicz V, Zumla A, Ndungu T, Dheda K. 2010. Comparison of a clinical prediction rule and a LAM antigen-detection assay for the rapid diagnosis of TBM in a high HIV prevalence setting. PLoS One 5:e15664. http://dx.doi.org/10.1371/journal.pone.0015664.
14. Nakiyingi L, Moodley VM, Manabe YC, Nicol MP, Holshouser M, Armstrong DT, Zemanay W, Sikhondze W, Mbabazi O, Nonyane BA, Shah M, Joloba ML, Alland D, Ellner JJ, Dorman SE. 2014. Diagnostic accuracy of a rapid urine lipoarabinomannan test for tuberculosis in HIVinfected adults. J Acquir Immune Defic Syndr 66:270-279. http://dx.doi.org/10.1097/QAI.0000000000000151.
15. World Health Organization. 2013. Xpert MTB/RIF assay for the diagnosis of pulmonary and extrapulmonary TB in adults and children. Policy update. World Health Organization, Geneva, Switzerland. http://apps.who.int/iris/bitstream/10665/112472/1/9789241506335-eng.pdf.
16. Causse M, Ruiz P, Gutierrez-Aroca JB, Casal M. 2011. Comparison of two molecular methods for rapid diagnosis of extrapulmonary tuberculosis. J Clin Microbiol 49:3065-3067. http://dx.doi.org/10.1128/JCM.00491-11.
17. Patel VB, Theron G, Lenders L, Matinyena B, Connolly C, Singh R, Coovadia Y, Ndung?u T, Dheda K. 2013. Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous meningitis in a high burden setting: a prospective study. PLoS Med 10:e1001536. http://dx.doi.org/10.1371/journal.pmed.1001536.
18. Tortoli E, Russo C, Piersimoni C, Mazzola E, Dal Monte P, Pascarella M, Borroni E, Mondo A, Piana F, Scarparo C, Coltella L, Lombardi G, Cirillo DM. 2012. Clinical validation of Xpert MTB/RIF for the diagnosis of extrapulmonary tuberculosis. Eur Respir J 40:442-447. http://dx.doi.org/10.1183/09031936.00176311.
19. Zeka AN, Tasbakan S, Cavusoglu C. 2011. Evaluation of the GeneXpert MTB/RIF assay for rapid diagnosis of tuberculosis and detection of rifampin resistance in pulmonary and extrapulmonary specimens. J Clin Microbiol 49:4138-4141. http://dx.doi.org/10.1128/JCM.05434-11.
20. Cox JA, Lukande RL, Kalungi S, Van Marck E, Van de Vijver K, Kambugu A, Nelson AM, Manabe YC, Colebunders R. 2014. Needle autopsy to establish the cause of death in HIV-infected hospitalized adults in Uganda: a comparison to complete autopsy. J Acquir Immune Defic Syndr 67:169-176. http://dx.doi.org/10.1097/QAI.0000000000000290.
21. Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig LM, Moher D, Rennie D, de Vet HC, Lijmer JG. 2003. The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration. Ann Intern Med 138:W1-W12. http://dx.doi.org/10.7326/0003-4819-138-1-200301070-00012-w1.
22. Thwaites G, Chau TT, Mai NT, Drobniewski F, McAdam K, Farrar J. 2000. Tuberculous meningitis. J Neurol Neurosurg Psychiatry 68:289-299. http://dx.doi.org/10.1136/jnnp.68.3.289.
23. Thwaites GE, Chau TT, Farrar JJ. 2004. Improving the bacteriological diagnosis of tuberculous meningitis. J Clin Microbiol 42:378-379. http://dx.doi.org/10.1128/JCM.42.1.378-379.2004.
24. World Health Organization. 2014. WHO monitoring of Xpert MTB/RIF roll-out. World Health Organization, Geneva, Switzerland. http://who.int/tb/laboratory/mtbrifrollout/en/.
25. Kroidl I, Clowes P, Mwakyelu J, Maboko L, Kiangi A, Rachow A, Reither K, Jung J, Nsojo A, Saathoff E, Hoelscher M. 2014. Reasons for false-positive lipoarabinomannan ELISA results in a Tanzanian population. Scand J Infect Dis 46:144-148. http://dx.doi.org/10.3109/00365548.2013.853133.
26. Boehme C, Molokova E, Minja F, Geis S, Loscher T, Maboko L, Koulchin V, Hoelscher M. 2005. Detection of mycobacterial lipoarabinomannan with an antigen-capture ELISA in unprocessed urine of Tanzanian patients with suspected tuberculosis. Trans R Soc Trop Med Hyg 99:893-900. http://dx.doi.org/10.1016/j.trstmh.2005.04.014.
27. Nhu NT, Heemskerk D, Thu do DA, Chau TT, Mai NT, Nghia HD, Loc PP, Ha DT, Merson L, Thinh TT, Day J, Chau N, Wolbers M, Farrar J, Caws M. 2014. Evaluation of GeneXpert MTB/RIF for diagnosis of tuberculous meningitis. J Clin Microbiol 52:226-233. http://dx.doi.org/10.1128/JCM.01834-13.
28. Scott LE, Beylis N, Nicol M, Nkuna G, Molapo S, Berrie L, Duse A, Stevens WS. 2014. Diagnostic accuracy of Xpert MTB/RIF for extrapulmonary tuberculosis specimens: establishing a laboratory testing algorithm for South Africa. J Clin Microbiol 52:1818-1823. http://dx.doi.org/10.1128/JCM.03553-13.
29. Denkinger CM, Pai M. 2014. Using cerebrospinal fluid for the diagnosis of tuberculous meningitis with GeneXpert. Eur Respir J 44:1095-1096. http://dx.doi.org/10.1183/09031936.00106914.
30. Dastur DK, Lalitha VS, Udani PM, Parekh U. 1970. The brain and meninges in tuberculous meningitis-gross pathology in 100 cases and pathogenesis. Neurol India 18:86-100.