Rsu1 regulates ethanol consumption in Drosophila and humans

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 30, 2015, Pages E4085-E4093

  Ojelade, Shamsideen A ^a   Jia, Tianye ^b,c   Rodan, Aylin R ^a,z   Chenyang, Tao ^d,e   Kadrmas, Julie L ^f   Cattrell, Anna ^b,c   Ruggeri, Barbara ^b,c   Charoen, Pimphen ^g,h   Lemaitre, Hervé ^i,j   Banaschewski, Tobias ^k   Büchel, Christian ^l   Bokde, Arun L W ^m   Carvalho, Fabiana ^b,c   Conrod, Patricia J ^b,n   Flor, Herta ^k   Frouin, Vincent ^o   Gallinat, Jürgen ^p   Garavan, Hugh ^m,q   Gowland, Penny A ^r   Heinz, Andreas ^p   Ittermann, Bernd ^r   Lathrop, Mark ^o   Lubbe, Steven ^b,c   Martinot, Jean Luc ^i,j   Pausu, Tomás ^r,s,t   Smolka, Michael N ^u   Spanagel, Rainer ^k   O'Reilly, Paul F ^b,c   Laitinen, Jaana ^v   Veijola, Juha M ^w   Feng, Jianfeng ^d,e   Desrivières, Sylvane ^b,c   Jarvelin, Marjo Riitta ^g,w,x,y   Schumann, Gunter ^b,c   Rothenfluh, Adrian ^a   more..

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d FUDAN UNIVERSITY   (China)

^e UNIVERSITY OF WARWICK   (United Kingdom)

^f UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^g Imperial College London   (United Kingdom)

^h MAHIDOL UNIVERSITY   (Thailand)

ⁱ INSERM   (France)

^j ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^k UNIVERSITY OF HEIDELBERG   (Germany)

^l UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^m TRINITY COLLEGE DUBLIN   (Ireland)

ⁿ CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^o DIF   (France)

^p CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^q UNIVERSITY OF VERMONT   (United States)

^r UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^s UNIVERSITY OF TORONTO   (Canada)

^t MCGILL UNIVERSITY   (Canada)

^u DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^v FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

^w UNIVERSITY OF OULU   (Finland)

^x OULU UNIVERSITY HOSPITAL   (Finland)

^y NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^z UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

more..

Author keywords

Actin; Addiction; Alcohol; Genetics

Indexed keywords

ACTIN; ALCOHOL; CELL ADHESION MOLECULE; PROTEIN; RAC1 PROTEIN; RAS SUPPRESSOR 1 PROTEIN; UNCLASSIFIED DRUG; DROSOPHILA PROTEIN; GUANOSINE TRIPHOSPHATASE; INTEGRIN; RSU1 PROTEIN, DROSOPHILA; RSU1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ACTIN FILAMENT; ADULT; ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; FEMALE; GENOTYPE; HUMAN; MALE; NERVOUS SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; SIGNAL TRANSDUCTION; VENTRAL STRIATUM; ADOLESCENT; ANIMAL; BRAIN; CHEMISTRY; CHILD; COHORT ANALYSIS; CYTOSKELETON; DOMINANT GENE; DRINKING BEHAVIOR; GENETIC POLYMORPHISM; GENETICS; METABOLISM; MUTATION; NERVE CELL; PHYSIOLOGY; QUESTIONNAIRE;

BASIDIOMYCOTA;

ACTINS; ADOLESCENT; ADULT; ALCOHOL DRINKING; ANIMALS; BRAIN; CELL ADHESION MOLECULES; CHILD; COHORT STUDIES; CYTOSKELETON; DROSOPHILA PROTEINS; ETHANOL; FEMALE; GENES, DOMINANT; GTP PHOSPHOHYDROLASES; HUMANS; INTEGRINS; MALE; MUTATION; NEURONS; POLYMORPHISM, GENETIC; SURVEYS AND QUESTIONNAIRES; TRANSCRIPTION FACTORS;

EID: 84938150145     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1417222112     Document Type: Article

References (51)

1. World Health Organization (2004) Global Status Report on Alcohol (World Health Organization, Geneva), pp 65-66.
2. Lim SS, et al. (2012) A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet 380(9859):2224-2260.
3. Gelernter J, Kranzler HR (2009) Genetics of alcohol dependence. Hum Genet 126(1):91-99.
4. Dick DM, et al. (2006) Endophenotypes successfully lead to gene identification: Results from the collaborative study on the genetics of alcoholism. Behav Genet 36(1):112-126.
5. Schumann G, et al. (2011) Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proc Natl Acad Sci USA 108(17):7119-7124.
6. Joslyn G, et al. (2011) Glypican gene GPC5 participates in the behavioral response to ethanol: Evidence from humans, mice, and fruit flies. G3(Bethesda) 1(7):627-635.
7. Rodan AR, Rothenfluh A (2010) The genetics of behavioral alcohol responses in Drosophila. Int Rev Neurobiol 91:25-51.
8. Kaun KR, Devineni AV, Heberlein U (2012) Drosophila melanogaster as a model to study drug addiction. Hum Genet 131(6):959-975.
9. Lee H-G, Kim Y-C, Dunning JS, Han K-A (2008) Recurring ethanol exposure induces disinhibited courtship in Drosophila. PLoS ONE 3(1):e1391.
10. Wolf FW, Rodan AR, Tsai LT-Y, Heberlein U (2002) High-resolution analysis of ethanolinduced locomotor stimulation in Drosophila. J Neurosci 22(24):11035-11044.
11. Ja WW, et al. (2007) Prandiology of Drosophila and the CAFE assay. Proc Natl Acad Sci USA 104(20):8253-8256.
12. Devineni AV, Heberlein U (2009) Preferential ethanol consumption in Drosophila models features of addiction. Curr Biol 19(24):2126-2132.
13. Rothenfluh A, Cowan CW (2013) Emerging roles of actin cytoskeleton regulating enzymes in drug addiction: Actin or reactin'? Curr Opin Neurobiol 23(4):507-512.
14. Offenhäuser N, et al. (2006) Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics. Cell 127(1):213-226.
15. Eddison M, et al. (2011) arouser reveals a role for synapse number in the regulation of ethanol sensitivity. Neuron 70(5):979-990.
16. Rothenfluh A, et al. (2006) Distinct behavioral responses to ethanol are regulated by alternate RhoGAP18B isoforms. Cell 127(1):199-211.
17. Kadrmas JL, et al. (2004) The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1. J Cell Biol 167(6):1019-1024.
18. Brand AH, Perrimon N (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118(2):401-415.
19. Yang C-H, et al. (2009) Control of the postmating behavioral switch in Drosophila females by internal sensory neurons. Neuron 61(4):519-526.
20. McGuire SE, Le PT, Osborn AJ, Matsumoto K, Davis RL (2003) Spatiotemporal rescue of memory dysfunction in Drosophila. Science 302(5651):1765-1768.
21. Bhandari P, Kendler KS, Bettinger JC, Davies AG, Grotewiel M (2009) An assay for evoked locomotor behavior in Drosophila reveals a role for integrins in ethanol sensitivity and rapid ethanol tolerance. Alcohol Clin Exp Res 33(10):1794-1805.
22. Corl AB, et al. (2009) Happyhour, a Ste20 family kinase, implicates EGFR signaling in ethanol-induced behaviors. Cell 137(5):949-960.
23. Kapfhamer D, et al. (2012) JNK pathway activation is controlled by Tao/TAOK3 to modulate ethanol sensitivity. PLoS ONE 7(12):e50594.
24. Dougherty GW, Jose C, Gimona M, Cutler ML (2008) The Rsu-1-PINCH1-ILK complex is regulated by Ras activation in tumor cells. Eur J Cell Biol 87(8-9):721-734.
25. Pitman JL, et al. (2009) There are many ways to train a fly. Fly (Austin) 3(1):3-9.
26. Kaun KR, Azanchi R, Maung Z, Hirsh J, Heberlein U (2011) A Drosophila model for alcohol reward. Nat Neurosci 14(5):612-619.
27. Krashes MJ, Keene AC, Leung B, Armstrong JD, Waddell S (2007) Sequential use of mushroom body neuron subsets during drosophila odor memory processing. Neuron 53(1):103-115.
28. Mao Z, Roman G, Zong L, Davis RL (2004) Pharmacogenetic rescue in time and space of the rutabaga memory impairment by using Gene-Switch. Proc Natl Acad Sci USA 101(1):198-203.
29. Stacey D, et al.; IMAGEN Consortium (2012) RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release. Proc Natl Acad Sci USA 109(51):21128-21133.
30. Nees F, et al.; IMAGEN Consortium (2012) Determinants of early alcohol use in healthy adolescents: The differential contribution of neuroimaging and psychological factors. Neuropsychopharmacology 37(4):986-995.
31. Andrews MM, et al. (2011) Individuals family history positive for alcoholism show functional magnetic resonance imaging differences in reward sensitivity that are related to impulsivity factors. Biol Psychiatry 69(7):675-683.
32. Beck A, et al. (2009) Ventral striatal activation during reward anticipation correlates with impulsivity in alcoholics. Biol Psychiatry 66(8):734-742.
33. Villafuerte S, et al. (2012) Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism. Mol Psychiatry 17(5):511-519.
34. Wrase J, et al. (2007) Dysfunction of reward processing correlates with alcohol craving in detoxified alcoholics. Neuroimage 35(2):787-794.
35. Yau W-YW, et al. (2012) Nucleus accumbens response to incentive stimuli anticipation in children of alcoholics: Relationships with precursive behavioral risk and lifetime alcohol use. J Neurosci 32(7):2544-2551.
36. Knutson B, Westdorp A, Kaiser E, Hommer D (2000) FMRI visualization of brain activity during a monetary incentive delay task. Neuroimage 12(1):20-27.
37. Der-Avakian A, Markou A (2012) The neurobiology of anhedonia and other rewardrelated deficits. Trends Neurosci 35(1):68-77.
38. Bach FR, Jordan MI (2002) Kernel independent component analysis. J Mach Learn Res 3(1):1-48.
39. Yang J, et al. (2010) Common SNPs explain a large proportion of the heritability for human height. Nat Genet 42(7):565-569.
40. Bierut LJ, et al.; Gene, Environment Association Studies Consortium (2010) A genomewide association study of alcohol dependence. Proc Natl Acad Sci USA 107(11):5082-5087.
41. Jones PB, Rantakallio P, Hartikainen AL, Isohanni M, Sipila P (1998) Schizophrenia as a long-term outcome of pregnancy, delivery, and perinatal complications: A 28-year follow-up of the 1966 north Finland general population birth cohort. Am J Psychiatry 155(3):355-364.
42. Torregrossa MM, Corlett PR, Taylor JR (2011) Aberrant learning and memory in addiction. Neurobiol Learn Mem 96(4):609-623.
43. Cingolani LA, Goda Y (2008) Actin in action: The interplay between the actin cytoskeleton and synaptic efficacy. Nat Rev Neurosci 9(5):344-356.
44. Dietz DM, et al. (2012) Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons. Nat Neurosci 15(6):891-896.
45. Kiraly DD, et al. (2010) Behavioral and morphological responses to cocaine require kalirin7. Biol Psychiatry 68(3):249-255.
46. Schumann G, et al.; IMAGEN consortium (2010) The IMAGEN study: Reinforcementrelated behaviour in normal brain function and psychopathology. Mol Psychiatry 15(12):1128-1139.
47. Gil AG, Wagner EF, Tubman JG (2004) Associations between early-adolescent substance use and subsequent young-adult substance use disorders and psychiatric disorders among a multiethnic male sample in South Florida. Am J Public Health 94(9):1603-1609.
48. Dougherty GW, Chopp T, Qi SM, Cutler ML (2005) The Ras suppressor Rsu-1 binds to the LIM 5 domain of the adaptor protein PINCH1 and participates in adhesion-related functions. Exp Cell Res 306(1):168-179.
49. Chunduru S, et al. (2002) Identification of an alternatively spliced RNA for the Ras suppressor RSU-1 in human gliomas. J Neurooncol 60(3):201-211.
50. Kramár EA, Lin B, Rex CS, Gall CM, Lynch G (2006) Integrin-driven actin polymerization consolidates long-term potentiation. Proc Natl Acad Sci USA 103(14):5579-5584.
51. Peru y Colón de Portugal RL, et al. (2012) Adult neuronal Arf6 controls ethanolinduced behavior with Arfaptin downstream of Rac1 and RhoGAP18B. J Neurosci 32(49):17706-17713.