Manipulation of health span and function by dietary caloric restriction mimetics

Annals of the New York Academy of Sciences

Volumn 1363, Issue 1, 2016, Pages 5-10

  Roth, George S ^a   Ingram, Donald K ^b  

^a GeroScience Inc   (United States)

^b PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

Calories; Dietary restriction; Health span; Mimetics

Indexed keywords

METFORMIN; NUTRACEUTICAL; OXALOACETIC ACID; RAPAMYCIN; RESVERATROL; ANTIDIABETIC AGENT; SIRTUIN;

ARTICLE; BIOMIMETICS; CALORIC RESTRICTION; DRUG MECHANISM; FOOD INTAKE; HUMAN; INTERVENTION STUDY; LIFESPAN; ANIMAL; DIET; DRUG EFFECTS; GLYCOLYSIS; HEALTH; LONGEVITY; PROCEDURES;

ANIMALS; BIOMIMETICS; CALORIC RESTRICTION; DIET; GLYCOLYSIS; HEALTH; HUMANS; HYPOGLYCEMIC AGENTS; LONGEVITY; OXALOACETIC ACID; SIROLIMUS; SIRTUINS;

EID: 84938149781     PISSN: 00778923     EISSN: 17496632     Source Type: Journal    
DOI: 10.1111/nyas.12834     Document Type: Article

References (35)

1. Weindruch, R. & R.L. Walford. 1988. The Retardation of Aging and Disease by Dietary Restriction. Springfield, IL: Charles C. Thomas.
2. Fontana, L., L Partridge & V.D. Longo. 2010. Extending healthy lifespan: from yeast to humans. Science 328: 321-326.
3. Ingram, D.K., R.G. Cutler, R. Weindruch, et al. 1990. Dietary restriction and aging: the initiation of a primate study. J. Gerontology 45: B148-B163.
4. Kemnitz, J.W., R. Weindruch, E.B. Roecker, et al. 1993. Dietary restriction of adult male rhesus monkeys: design, methodology, and preliminary findings from the first year of study. J. Gerontology 48: B17-B26.
5. Colman, R.J., R.M. Anderson, S.C. Johnson, et al. 2009. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 325: 201-204.
6. Colman, R.J., T.M. Beasley, J.W. Kemnitz, et al. 2014. Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. Nat. Commun. 1: 3557.
7. Mattison, J.A., G.S. Roth, T.M. Beasley, et al. 2012. Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 489: 318-321.
8. Lane, M.A., D.K. Ingram, G.S. Roth, et al. 1998. 2-Deoxy-d-glucose feeding in rats mimics physiological effects of calorie restriction. J. Anti-Aging Med. 1: 327-337.
9. Lane, M.A., D.K. Ingram & G.S. Roth. 2002. The serious search for an anti-aging pill. Sci. Am. 287: 24-29.
10. Stipp, D. 2010. The anti-aging revolution. Fortune 14: 124-130.
11. Ingram, D.K. & G.S. Roth. 2015. Calorie restriction mimetics: can you have your cake and eat it, too? Aging Res. Rev. 20: 46-52.
12. Roth, G.S. & D.K. Ingram. 2015. "Calorie restriction mimetics: progress and potential." In Nutrition, Exercise and Epigenetics: Ageing Interventions. B.P. Yu, Ed.: 211-244. New York: Springer.
13. Selman, C. 2014. Dietary restriction and the pursuit of effective mimetics. Proc. Nutr. Soc. 10: 1-11.
14. Roth, G.S., M.A. Lane, D.K. Ingram, et al. 2002. Physiological markers of dietary caloric restriction in animals predict longevity in humans. Science 297: 811.
15. Roth, G., M. Hayek, S. Massimino, et al. 2009. Mannoheptulose: glycolytic inhibitor and novel caloric restriction mimetic. FASEB J. 23: Meeting Abstract 553.1.
16. Davenport, G., S. Massimino, M. Hayek, et al. 2010. Biological activity of avocado-derived mannoheptulose in dogs. FASEB J. 24: Meeting Abstract 725.4.
17. Pitha, J., G.S. Roth, M.G. Hayek, et al. 2013. Inventors: the Iams Co. and GeroScience Inc., assignees. U.S. Patent 8563522 B2. [date of application] Oct.22.
18. Strong, R, R.A. Miller, C. M.Astle, et al. 2013. Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. J. Gerontol. A Biol. Sci. Med. Sci. 68: 6-16.
19. Dhahbi, J.M., P.L. Mote, G.M. Fahy, et al. 2005. Identification of potential caloric restriction mimetics by microarray profiling. Physiol. Genomics 23: 343-350.
20. Hay, N. & N. Sonenberg. 2004. Upstream and downstream of mTOR. Genes Dev. 18: 1926-1945.
21. Tokunaga, C., K. Yoshino & K. Yonezawa. 2004. mTOR integrates amino acid- and energy-sensing pathways. Biochem. Biophys. Res. Commun. 313: 443-446.
22. Hands, S.L., C.G. Proud & A. Wyttenbach. 2006. mTOR's role in ageing: protein synthesis or autophagy? Aging (Milano) 20: 586-597.
23. Harrison, D.E., R. Strong, Z.D. Sharp, et al. 2009. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460: 392-395.
24. Miller R.A., D.E. Harrison, C.M. Astle, et al. 2014. Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell 13: 468-477.
25. Halloran, J., S.A. Hussong, R. Burbank, et al. 2012. Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice. Neuroscience 223: 102-113.
26. Flynn, J.M., M.N. O'Leary, C.A. Zambataro, et al. 2013. Late-life rapamycin treatment reverses age-related heart dysfunction. Aging Cell 12: 851-862.
27. Ciuffreda, L., C. Di Sanza, U.C. Incani, et al. 2010. The mTOR pathway: a new target in cancer therapy. Curr. Cancer Drug Targets 10: 484-495.
28. Houde, V.P., S. Brûlé, W.T. Festuccia, et al. 2010. Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue. Diabetes 59: 1338-1348.
29. Chang, G.R., Y.Y. Wu, Y.S. Chiu, et al. 2009. Long-term administration of rapamycin reduces adiposity, but impairs glucose tolerance in high-fat diet-fed KK/HlJ mice. Basic Clin. Pharmacol. Toxicol. 105: 188-198.
30. Fraenkel, M., M. Ketzinel-Gilad, Y. Ariav, et al. 2008. mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes. Diabetes 57: 945-957.
31. Wilkinson, J.E., L. Burmeister, S.V. Brooks, et al. 2012. Rapamycin slows aging in mice. Aging Cell 11: 675-682.
32. Neff, F., D. Flores-Dominguez, D.P. Ryan, et al. 2013. Rapamycin extends murine lifespan but has limited effects on aging. J. Clin. Invest. 123: 3272-3291.
33. Cash, A., 2009. Oxaloacetic acid supplementation as a mimic of calorie restriction. Open Longev. Sci. 3: 22-27.
34. Yoshikawa, K., 1968. Studies on anti-diabetic effect of sodium oxaloacetate. Tohoku J. Exp. Med. 96: 127-141.
35. Williams, D.S., A. Cash, L. Hamadani, et al. 2009. Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. Aging Cell 8: 765-768.