High-capacity glycolytic and mitochondrial oxidative metabolisms mediate the growth ability of glioblastoma

International Journal of Oncology

Volumn 47, Issue 3, 2015, Pages 1009-1016

  Kim, Jungim ^a   Han, Jeongsu ^a   Jang, Yunseon ^a   Kim, Soo Jeong ^a   Lee, Min Joung ^a   Ryu, Min Jeong ^a   Kweon, Gi Ryang ^a   Heo, Jun Young ^a  

^a Chungnam National University College of Medicine   (South Korea)

Author keywords

Astrocyte; Extracellular acidification rate; Glioblastoma multiforme; Lactate dehydrogenase; Oxygen consumption rate

Indexed keywords

CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; GLYCOGEN; LACTATE DEHYDROGENASE; LACTIC ACID; MESSENGER RNA; OLIGOMYCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PYRUVATE CARBOXYLASE; ROTENONE; SUCCINATE DEHYDROGENASE;

ACIDIFICATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CELL; CANCER GROWTH; CELL GROWTH; CITRIC ACID CYCLE; CONTROLLED STUDY; GLIOBLASTOMA; GLIOBLASTOMA CELL LINE; GLYCOLYSIS; GROWTH RATE; HUMAN; HUMAN CELL; METABOLIC CAPACITY; MITOCHONDRIAL RESPIRATION; MOUSE; NEUROBLASTOMA; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; BRAIN TUMOR; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MITOCHONDRION; OXIDATIVE STRESS; PATHOLOGY; TUMOR CELL LINE;

ASTROCYTES; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CELLS, CULTURED; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; GLYCOLYSIS; HUMANS; MITOCHONDRIA; NEUROBLASTOMA; OXIDATIVE STRESS;

EID: 84938097988     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2015.3101     Document Type: Article

References (35)

1. Ohgaki H and Kleihues P: Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J Neuropathol Exp Neurol 64: 479-489, 2005.
2. Campbell AM, Rennie JS, Moos KF and Patton D: Neuroblastoma presenting as mandibular swelling in a two-year-old girl - a short case report. Br J Oral Maxillofac Surg 25: 422-426, 1987.
3. Diehn M, Nardini C, Wang DS, McGovern S, Jayaraman M, Liang Y, Aldape K, Cha S and Kuo MD: Identification of noninvasive imaging surrogates for brain tumor gene-expression modules. Proc Natl Acad Sci USA 105: 5213-5218, 2008.
4. Buckner JC: Factors influencing survival in high-grade gliomas. Semin Oncol 30 (Suppl 19): S10-S14, 2003.
5. Bouzier-Sore AK and Pellerin L: Unraveling the complex metabolic nature of astrocytes. Front Cell Neurosci 7: 179, 2013.
6. Bélanger M, Allaman I and Magistretti PJ: Brain energy metabolism: Focus on astrocyte-neuron metabolic cooperation. Cell Metab 14: 724-738, 2011.
7. Suzuki A, Stern SA, Bozdagi O, Huntley GW, Walker RH, Magistretti PJ and Alberini CM: Astrocyte-neuron lactate transport is required for long-term memory formation. Cell 144: 810-823, 2011.
8. Walz W and Mukerji S: Lactate production and release in cultured astrocytes. Neurosci Lett 86: 296-300, 1988.
9. Dringen R, Wiesinger H and Hamprecht B: Uptake of L-lactate by cultured rat brain neurons. Neurosci Lett 163: 5-7, 1993.
10. Bagley PR, Tucker SP, Nolan C, Lindsay JG, Davies A, Baldwin SA, Cremer JE and Cunningham VJ: Anatomical mapping of glucose transporter protein and pyruvate dehydrogenase in rat brain: An immunogold study. Brain Res 499: 214-224, 1989.
11. Cahn RD, Zwilling E, Kaplan NO and Levine L: Nature and Development of Lactic Dehydrogenases: The two major types of this enzyme form molecular hybrids which change in makeup during development. Science 136: 962-969, 1962.
12. Bittar PG, Charnay Y, Pellerin L, Bouras C and Magistretti PJ: Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain. J Cereb Blood Flow Metab 16: 1079-1089, 1996.
13. Crane CA, Austgen K, Haberthur K, Hofmann C, Moyes KW, Avanesyan L, Fong L, Campbell MJ, Cooper S, Oakes SA, et al: Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients. Proc Natl Acad Sci USA 111: 12823-12828, 2014.
14. Nieder C, Marienhagen K, Dalhaug A, Aandahl G, Haukland E and Pawinski A: Prognostic models predicting survival of patients with brain metastases: Integration of lactate dehydrogenase, albumin and extracranial organ involvement. Clin Oncol (R Coll Radiol) 26: 447-452, 2014.
15. Woo DH, Han KS, Shim JW, Yoon BE, Kim E, Bae JY, Oh SJ, Hwang EM, Marmorstein AD, Bae YC, et al: TREK-1 and Best1 channels mediate fast and slow glutamate release in astrocytes upon GPCR activation. Cell 151: 25-40, 2012.
16. Biedler JL, Helson L and Spengler BA: Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture. Cancer Res 33: 2643-2652, 1973.
17. Warburg O: On respiratory impairment in cancer cells. Science 124: 269-270, 1956.
18. Vander Heiden MG, Cantley LC and Thompson CB: Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 324: 1029-1033, 2009.
19. Wang R, Novick SJ, Mangum JB, Queen K, Ferrick DA, Rogers GW and Stimmel JB: The acute extracellular flux (XF) assay to assess compound effects on mitochondrial function. J Biomol Screen 20: 422-429 2015.
20. Park JW, Lee SY, Yang JY, Rho HW, Park BH, Lim SN, Kim JS and Kim HR: Effect of carbonyl cyanide m-chlorophenylhydrazone (CCCP) on the dimerization of lipoprotein lipase. Biochim Biophys Acta 1344: 132-138, 1997.
21. Xie J, Wu H, Dai C, Pan Q, Ding Z, Hu D, Ji B, Luo Y and Hu X: Beyond Warburg effect - dual metabolic nature of cancer cells. Sci Rep 4: 4927, 2014.
22. Chiarugi A, Dölle C, Felici R and Ziegler M: The NAD metabolome - a key determinant of cancer cell biology. Nat Rev Cancer 12: 741-752, 2012.
23. Jitrapakdee S, St Maurice M, Rayment I, Cleland WW, Wallace JC and Attwood PV: Structure, mechanism and regulation of pyruvate carboxylase. Biochem J 413: 369-387, 2008.
24. Brown AM and Ransom BR: Astrocyte glycogen and brain energy metabolism. Glia 55: 1263-1271, 2007.
25. Gatenby RA and Gillies RJ: Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4: 891-899, 2004.
26. Fischer K, Hoffmann P, Voelkl S, Meidenbauer N, Ammer J, Edinger M, Gottfried E, Schwarz S, Rothe G, Hoves S, et al: Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood 109: 3812-3819, 2007.
27. Hirschhaeuser F, Sattler UG and Mueller-Klieser W: Lactate: A metabolic key player in cancer. Cancer Res 71: 6921-6925, 2011.
28. Van Meir EG, Hadjipanayis CG, Norden AD, Shu HK, Wen PY and Olson JJ: Exciting new advances in neuro-oncology: The avenue to a cure for malignant glioma. CA Cancer J Clin 60: 166-193, 2010.
29. Stickland LH: The Pasteur effect in normal yeast and its inhibition by various agents. Biochem J 64: 503-515, 1956.
30. Lovatt D, Sonnewald U, Waagepetersen HS, Schousboe A, He W, Lin JH, Han X, Takano T, Wang S, Sim FJ, et al: The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex. J Neurosci 27: 12255-12266, 2007.
31. Kim HM, Kim H, Jung WH and Koo JS: Metabolic phenotypes in primary unknown metastatic carcinoma. J Transl Med 12: 2, 2014.
32. Nakajima A, Tomimoto A, Fujita K, Sugiyama M, Takahashi H, Ikeda I, Hosono K, Endo H, Yoneda K, Iida H, et al: Inhibition of peroxisome proliferator-activated receptor gamma activity suppresses pancreatic cancer cell motility. Cancer Sci 99: 1892-1900, 2008.
33. Omar HA, Berman-Booty L, Kulp SK and Chen CS: Energy restriction as an antitumor target. Future Oncol 6: 1675-1679, 2010.
34. Le A, Cooper CR, Gouw AM, Dinavahi R, Maitra A, Deck LM, Royer RE, Vander Jagt DL, Semenza GL and Dang CV: Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci USA 107: 2037-2042, 2010.
35. Fantin VR, St-Pierre J and Leder P: Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 9: 425-434, 2006.