The Acute Extracellular Flux (XF) assay to assess compound effects on mitochondrial function

Journal of Biomolecular Screening

Volumn 20, Issue 3, 2015, Pages 422-429

  Wang, Ruolan ^a   Novick, Steven J ^a   Mangum, James B ^a   Queen, Kennedy ^a   Ferrick, David A ^b   Rogers, George W ^b   Stimmel, Julie B ^a  

^a GLAXOSMITHKLINE   (United States)

^b Seahorse Bioscience   (United States)

Author keywords

acute; mitochondrial dysfunction; screening assay; toxicities

Indexed keywords

BIOTIN; BUSPIRONE; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; CLOTRIMAZOLE; EFAVIRENZ; FLUINDOSTATIN; FLUOXETINE; IMATINIB; NEFAZODONE; NIMESULIDE; PHENFORMIN; RISPERIDONE; ROTENONE; TOLCAPONE; TROGLITAZONE; MOLECULAR LIBRARY;

ACIDIFICATION; ACUTE EXTRACELLULAR FLUX ASSAY; ARTICLE; CONTROLLED STUDY; CURVE FITTING; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HEPG2 CELL LINE; HIGH THROUGHPUT SCREENING; OXYGEN CONSUMPTION; PRIORITY JOURNAL; TOXICITY TESTING; WHOLE CELL; AUTOMATION; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HUMAN; METABOLISM; MITOCHONDRION; MOLECULAR LIBRARY; PROCEDURES; REPRODUCIBILITY;

AUTOMATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HEP G2 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MITOCHONDRIA; REPRODUCIBILITY OF RESULTS; SMALL MOLECULE LIBRARIES;

EID: 84923359936     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057114557621     Document Type: Article

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