Tanshinone IIA attenuates chronic pancreatitis- induced pain in rats via downregulation of HMGB1 and TRL4 expression in the spinal cord

Pain Physician

Volumn 18, Issue 4, 2015, Pages E615-E628

  Wang, Ye Song ^a   Li, Yuan Yuan ^a   Wang, Li Hua ^b   Kang, Ying ^b   Zhang, Jie ^b   Liu, Zi Quan ^c   Wang, Kun ^b   Kaye, Alan David ^d   Chen, Lei ^e  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c Affiliated Hospital of Logistics University of CAPF   (China)

^d LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Department of Internal Medicine   (China)

Author keywords

Astrocyte; Chronic pancreatitis; HMGB1; Proinflammatory cytokine; Spinal cord; Tanshinone IIA; TLR4

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; NEUTRALIZING ANTIBODY; PLACEBO; TANSHINONE IIA; TOLL LIKE RECEPTOR 4; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR ALPHA; BENZOFURAN DERIVATIVE; BLOCKING ANTIBODY; CYTOKINE; HBP1 PROTEIN, RAT; TASHINONE IIA; TLR4 PROTEIN, RAT;

ABDOMINAL PAIN; ADULT; ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; CHINESE MEDICINE; CHRONIC PANCREATITIS; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATORY INFILTRATE; MALE; MECHANICAL STIMULATION; NEUROPATHIC PAIN; NONHUMAN; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD; TREATMENT RESPONSE; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED; COMPLICATION; DRUG EFFECTS; GENETICS; HYPERALGESIA; INTRAPERITONEAL DRUG ADMINISTRATION; INTRASPINAL DRUG ADMINISTRATION; METABOLISM; NEURALGIA; PAIN; PAIN MEASUREMENT; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIBODIES, BLOCKING; BENZOFURANS; CYTOKINES; DOWN-REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; HMGB1 PROTEIN; HYPERALGESIA; INJECTIONS, INTRAPERITONEAL; INJECTIONS, SPINAL; NEURALGIA; PAIN; PAIN MEASUREMENT; PANCREATITIS, CHRONIC; RATS; RATS, SPRAGUE-DAWLEY; TOLL-LIKE RECEPTOR 4; TRINITROBENZENESULFONIC ACID;

EID: 84938088762     PISSN: 15333159     EISSN: 21501149     Source Type: Journal    
DOI: None     Document Type: Article

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