Compromised immune response in infants at risk for type 1 diabetes born by Caesarean Section

Clinical Immunology

Volumn 160, Issue 2, 2015, Pages 282-285

  Puff, R ^a   D'Orlando, O ^a   Heninger, A K ^b   Kuhn D ^b   Krause, S ^a   Winkler, C ^a,c   Beyerlein, A ^a   Bonifacio, E ^b   Ziegler, A G ^a,c  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Caesarean section; Cytokine; Immune responsiveness; Tetanus response; Type 1 diabetes

Indexed keywords

CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G4; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; TETANUS ANTIBODY; TETANUS TOXOID; TUMOR NECROSIS FACTOR ALPHA; BACTERIUM ANTIBODY; IL10 PROTEIN, HUMAN; IL1B PROTEIN, HUMAN; IL2 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; IL8 PROTEIN, HUMAN; IMMUNOGLOBULIN G; INTERLEUKIN 12; TETANUS TOXIN;

ADAPTIVE IMMUNITY; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CESAREAN SECTION; CHILD; CONTROLLED STUDY; HIGH RISK INFANT; HUMAN; IMMUNE RESPONSE; IMMUNE STATUS; IMMUNOCOMPROMISED PATIENT; INFANT; INFLAMMATION; INNATE IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MEMORY T LYMPHOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; TETANUS PROPHYLAXIS; VAGINAL DELIVERY; CASE CONTROL STUDY; DELIVERY; DIABETES MELLITUS, TYPE 1; FEMALE; GENETICS; IMMUNOLOGY; MALE; PROSPECTIVE STUDY;

ADAPTIVE IMMUNITY; ANTIBODIES, BACTERIAL; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CESAREAN SECTION; DELIVERY, OBSTETRIC; DIABETES MELLITUS, TYPE 1; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; IMMUNOGLOBULIN G; INFANT; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-1BETA; INTERLEUKIN-2; INTERLEUKIN-6; INTERLEUKIN-8; MALE; PROSPECTIVE STUDIES; TETANUS TOXIN; TETANUS TOXOID; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84938071267     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2015.06.008     Document Type: Article

References (18)

1. Patah L.E., Malik A.M. Models of childbirth care and cesarean rates in different countries. Rev. Saude Publica 2011, 45:185-194.
2. Cho C.E., Norman M. Cesarean section and development of the immune system in the offspring. Am. J. Obstet. Gynecol. 2013, 208:249-254.
3. Sparrow R.L., Cauchi J.A., Ramadi L.T., Waugh C.M., Kirkland M.A. Influence of mode of birth and collection on WBC yields of umbilical cord blood units. Transfusion 2002, 42:210-215.
4. Samelson R., Larkey D.M., Amankwah K.S., McConnachie P. Effect of labor on lymphocyte subsets in full-term neonates. Am. J. Reprod. Immunol. 1992, 28:71-73.
5. Yildiran A., Yurdakul E., Guloglu D., Dogu F., Arsan S., Arikan M., Cengiz L., Tezcan S., Ikinciogullari A. The effect of mode of delivery on T regulatory (Treg) cells of cord blood. Indian J. Pediatr. 2011, 78:1234-1238.
6. Malamitsi-Puchner A., Protonotariou E., Boutsikou T., Makrakis E., Sarandakou A., Creatsas G. The influence of the mode of delivery on circulating cytokine concentrations in the perinatal period. Early Hum. Dev. 2005, 81:387-392.
7. Bonifacio E., Warncke K., Winkler C., Wallner M., Ziegler A.G. Cesarean section and interferon-induced helicase gene polymorphisms combine to increase childhood type 1 diabetes risk. Diabetes 2011, 60:3300-3306.
8. Almqvist C., Cnattingius S., Lichtenstein P., Lundholm C. The impact of birth mode of delivery on childhood asthma and allergic diseases-a sibling study. Clin. Exp. Allergy 2012, 42:1369-1376.
9. Marild K., Stephansson O., Montgomery S., Murray J.A., Ludvigsson J.F. Pregnancy outcome and risk of celiac disease in offspring: a nationwide case-control study. Gastroenterology 2012, 142:39-45. (e33).
10. Cardwell C.R., Stene L.C., Joner G., Cinek O., Svensson J., Goldacre M.J., Parslow R.C., Pozzilli P., Brigis G., Stoyanov D., Urbonaite B., Sipetić S., Schober E., Ionescu-Tirgoviste C., Devoti G., de Beaufort C.E., Buschard K., Patterson C.C. Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a metaanalysis of observational studies. Diabetologia 2008, 51:726-735.
11. Ziegler A.G., Bonifacio E., Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes. Diabetologia 2012, 55:1937-1943.
12. Krischer J.P., Lynch K.F., Schatz D.A., Ilonen J., Lernmark A., Hagopian W.A., Rewers M.J., She J.X., Simell O.G., Toppari J., Ziegler A.G., Akolkar B., Bonifacio E., The 6year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study. Diabetologia 2015, 58:5980-5987.
13. Hummel S., Pflüger M., Hummel M., Bonifacio E., Ziegler A.G. Primary dietary intervention study to reduce the risk of islet autoimmunity in children at increased risk for type 1 diabetes: the BABYDIET study. Diabetes Care 2011, 34:1301-1305.
14. Heninger A.K., Monti P., Wilhelm C., Schwaiger P., Kuehn D., Ziegler A.G., Bonifacio E. Activation of islet autoreactive naive T cells in infants is influenced by homeostatic mechanisms and antigen-presenting capacity. Diabetes 2013, 62:2059-2066.
15. Schmid S., Molteni A., Fuchtenbusch M., Naserke H.E., Ziegler A.G., Bonifacio E. Reduced IL-4 associated antibody responses to vaccine in early pre-diabetes. Diabetologia 2002, 45:677-685.
16. Yektaei-Karin E., Moshfegh A., Lundahl J., Berggren V., Hansson L.O., Marchini G. The stress of birth enhances in vitro spontaneous and IL-8-induced neutrophil chemotaxis in the human newborn. Pediatr. Allergy Immunol. 2007, 18:643-651.
17. Keelan J.A., Blumenstein M., Helliwell R.J., Sato T.A., Marvin K.W., Mitchell M.D. Cytokines, prostaglandins and parturition-a review. Placenta 2003, 24(Suppl. A):S33-S46.
18. Endesfelder D., zu Castell W., Ardissone A., Davis-Richardson A.G., Achenbach P., Hagen M., Pflueger M., Gano K.A., Fagen J.R., Drew J.C., Brown C.T., Kolaczkowski B., Atkinson M., Schatz D., Bonifacio E., Triplett E.W., Ziegler A.G. Compromised gut microbiota networks in children with anti-islet cell autoimmunity. Diabetes 2014, 63:2006-2014.