CD44-SLC1A2 Fusion Transcripts in Primary Colorectal Cancer

Pathology and Oncology Research

Volumn 21, Issue 3, 2015, Pages 759-764

  Shinmura, Kazuya ^a   Kato, Hisami ^a   Igarashi, Hisaki ^a   Inoue, Yusuke ^a   Nakamura, Satoki ^a   Du, Chunping ^a   Kurachi, Kiyotaka ^a   Nakamura, Toshio ^a   Ogawa, Hiroshi ^b   Tanahashi, Masayuki ^b   Niwa, Hiroshi ^b   Sugimura, Haruhiko ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SEIREI MIKATAHARA GENERAL HOSPITAL   (Japan)

Author keywords

CD44 SLC1A2; Colorectal cancer; Fusion transcript

Indexed keywords

APC PROTEIN; APIP SLC1A2 FUSION PROTEIN; CD44 SLC1A2 FUSION PROTEIN; EXCITATORY AMINO ACID TRANSPORTER 2; GENOMIC DNA; HERMES ANTIGEN; HYBRID PROTEIN; K RAS PROTEIN; MESSENGER RNA; PROTEIN MSH2; UNCLASSIFIED DRUG; APIP PROTEIN, HUMAN; APOPTOSIS REGULATORY PROTEIN; CD44 PROTEIN, HUMAN; GLUTAMATE TRANSPORTER; SLC1A2 PROTEIN, HUMAN;

ADULT; APC GENE; ARTICLE; CANCER LOCALIZATION; CANCER TISSUE; CD44 GENE; COLLOID CARCINOMA; COLORECTAL CANCER; CONTROLLED STUDY; DOWN REGULATION; EXON; FEMALE; FUSION GENE; GENE EXPRESSION REGULATION; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MISMATCH REPAIR; MUTATIONAL ANALYSIS; NON SMALL CELL LUNG CANCER; ONCOGENE K RAS; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; UPREGULATION; AGED; CANCER STAGING; COLORECTAL TUMOR; ENZYME IMMUNOASSAY; FOLLOW UP; GENE FUSION; GENETICS; LUNG TUMOR; LYMPH NODE METASTASIS; METABOLISM; MIDDLE AGED; PATHOLOGY; PROGNOSIS; REAL TIME POLYMERASE CHAIN REACTION; SECONDARY;

ADENOCARCINOMA, MUCINOUS; AGED; ANTIGENS, CD44; APOPTOSIS REGULATORY PROTEINS; CARCINOMA, NON-SMALL-CELL LUNG; COLORECTAL NEOPLASMS; FEMALE; FOLLOW-UP STUDIES; GENE FUSION; GLUTAMATE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; IMMUNOENZYME TECHNIQUES; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84938070276     PISSN: 12194956     EISSN: 15322807     Source Type: Journal    
DOI: 10.1007/s12253-014-9887-2     Document Type: Article

References (21)

1. Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara S, Watanabe H, Kurashina K, Hatanaka H, Bando M, Ohno S, Ishikawa Y, Aburatani H, Niki T, Sohara Y, Sugiyama Y, Mano H (2007) Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 448:561–566
2. Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ (2007) Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131:1190–1203
3. Shinmura K, Kageyama S, Tao H, Bunai T, Suzuki M, Kamo T, Takamochi K, Suzuki K, Tanahashi M, Niwa H, Ogawa H, Sugimura H (2008) EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas. Lung Cancer 61:163–169
4. Matsuura S, Shinmura K, Kamo T, Igarashi H, Maruyama K, Tajima M, Ogawa H, Tanahashi M, Niwa H, Funai K, Kohno T, Suda T, Sugimura H (2013) CD74-ROS1 fusion transcripts in resected non-small cell lung carcinoma. Oncol Rep 30:1675–1680
5. Zheng J (2013) Oncogenic chromosomal translocations and human cancer. Oncol Rep 30:2011–2019
6. Bittner N, Ostoros G, Géczi L (2014) New treatment options for lung adenocarcinoma–in view of molecular background. Pathol Oncol Res 20:11–25
7. Mitsudomi T, Suda K, Yatabe Y (2013) Surgery for NSCLC in the era of personalized medicine. Nat Rev Clin Oncol 10:235–244
8. Tao J, Deng NT, Ramnarayanan K, Huang B, Oh HK, Leong SH, Lim SS, Tan IB, Ooi CH, Wu J, Lee M, Zhang S, Rha SY, Chung HC, Smoot DT, Ashktorab H, Kon OL, Cacheux V, Yap C, Palanisamy N, Tan P (2011) CD44-SLC1A2 gene fusions in gastric cancer. Sci Transl Med 3:77ra30
9. Giacomini CP, Sun S, Varma S, Shain AH, Giacomini MM, Balagtas J, Sweeney RT, Lai E, Del Vecchio CA, Forster AD, Clarke N, Montgomery KD, Zhu S, Wong AJ, van de Rijn M, West RB, Pollack JR (2013) Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types. PLoS Genet 9:e1003464
10. Shinmura K, Goto M, Suzuki M, Tao H, Yamada H, Igarashi H, Matsuura S, Maeda M, Konno H, Matsuda T, Sugimura H (2011) Reduced expression of MUTYH with suppressive activity against mutations caused by 8-hydroxyguanine is a novel predictor of a poor prognosis in human gastric cancer. J Pathol 225:414–423
11. Tao H, Shinmura K, Yamada H, Maekawa M, Osawa S, Takayanagi Y, Okamoto K, Terai T, Mori H, Nakamura T, Sugimura H (2010) Identification of 5 novel germline APC mutations and characterization of clinical phenotypes in Japanese patients with classical and attenuated familial adenomatous polyposis. BMC Res Notes 3:305
12. Fujisaki T, Tanaka Y, Fujii K, Mine S, Saito K, Yamada S, Yamashita U, Irimura T, Eto S (1999) CD44 stimulation induces integrin-mediated adhesion of colon cancer cell lines to endothelial cells by up-regulation of integrins and c-Met and activation of integrins. Cancer Res 59:4427–4434
13. Lugli A, Tzankov A, Zlobec I, Terracciano LM (2008) Differential diagnostic and functional role of the multi-marker phenotype CDX2/CK20/CK7 in colorectal cancer stratified by mismatch repair status. Mod Pathol 21:1403–1412
14. Marcus VA, Madlensky L, Gryfe R, Kim H, So K, Millar A, Temple LK, Hsieh E, Hiruki T, Narod S, Bapat BV, Gallinger S, Redston M (1999) Immunohistochemistry for hMLH1 and hMSH2: a practical test for DNA mismatch repair-deficient tumors. Am J Surg Pathol 23:1248–1255
15. Hampel H, Frankel WL, Martin E, Arnold M, Khanduja K, Kuebler P, Nakagawa H, Sotamaa K, Prior TW, Westman J, Panescu J, Fix D, Lockman J, Comeras I, de la Chapelle A (2005) Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer). N Engl J Med 352:1851–1860
16. Kelleher FC, McDermott R (2010) The emerging pathogenic and therapeutic importance of the anaplastic lymphoma kinase gene. Eur J Cancer 46:2357–2368
17. Takeuchi K, Soda M, Togashi Y, Suzuki R, Sakata S, Hatano S, Asaka R, Hamanaka W, Ninomiya H, Uehara H, Lim Choi Y, Satoh Y, Okumura S, Nakagawa K, Mano H, Ishikawa Y (2012) RET, ROS1 and ALK fusions in lung cancer. Nat Med 18:378–381
18. Dang CV (2010) Rethinking the Warburg effect with Myc micromanaging glutamine metabolism. Cancer Res 70:859–862
19. Willard SS, Koochekpour S (2013) Glutamate signaling in benign and malignant disorders: current status, future perspectives, and therapeutic implications. Int J Biol Sci 9:728–742
20. Kakar S, Aksoy S, Burgart LJ, Smyrk TC (2004) Mucinous carcinoma of the colon: correlation of loss of mismatch repair enzymes with clinicopathologic features and survival. Mod Pathol 17:696–700
21. Terui H, Tachikawa T, Kakuta M, Nishimura Y, Yatsuoka T, Yamaguchi K, Yura K, Akagi K (2013) Molecular and clinical characteristics of MSH6 germline variants detected in colorectal cancer patients. Oncol Rep 30:2909–2916