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Volumn 20, Issue 1, 2014, Pages 11-25

New treatment options for lung adenocarcinoma - In view of molecular background

Author keywords

Adenocarcinoma; EGFR mutation; EML 4 ALK; KRAS; Monoclonal antibodies; Non Small Cell Lung Cancer (NSCLC); Signal transduction pathway; Targeted therapies; Tyrosine kinase inhibitors; VEGFR

Indexed keywords

AFATINIB; AFLIBERCEPT; ANAPLASTIC LYMPHOMA KINASE; AXITINIB; BEVACIZUMAB; CABOZANTINIB; CANERTINIB; CEDIRANIB; CETUXIMAB; CRIZOTINIB; DACOMITINIB; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; IMMUNOMODULATING AGENT; LINIFANIB; METMAB; MOTESANIB; NERATINIB; NINTEDANIB; ONARTUZUMAB; PAZOPANIB; PELITINIB; PF 0299804; PROTEIN RET; RAMUCIRUMAB; SCATTER FACTOR RECEPTOR; SORAFENIB; SUNITINIB; TIVANTINIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB;

EID: 84896052573     PISSN: 12194956     EISSN: 15322807     Source Type: Journal    
DOI: 10.1007/s12253-013-9719-9     Document Type: Review
Times cited : (41)

References (79)
  • 1
    • 79551563284 scopus 로고    scopus 로고
    • International association for the study of lung cancer/American thoracic society/European respiratory society international multidisciplinary classification of lung adenocarcinoma
    • Travis WD, Brambilla E et al (2011) International association for the study of lung cancer/American thoracic society/European respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thoracic Oncol 6:2244-2285
    • (2011) J Thoracic Oncol , vol.6 , pp. 2244-2285
    • Travis, W.D.1    Brambilla, E.2
  • 2
    • 77649091118 scopus 로고    scopus 로고
    • A novel, high sensitive antibody allows for the routine detection of ALK - Rearranged lung adenocarcinomas by standard immunohistochemistry
    • Mino-Kenudson M et al (2010) A novel, high sensitive antibody allows for the routine detection of ALK - rearranged lung adenocarcinomas by standard immunohistochemistry. Clin Cancer Res 16:1561-1571
    • (2010) Clin Cancer Res , vol.16 , pp. 1561-1571
    • Mino-Kenudson, M.1
  • 3
    • 0037050352 scopus 로고    scopus 로고
    • Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
    • Shiller JH (2002) Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 2:92-98
    • (2002) N Engl J Med , vol.2 , pp. 92-98
    • Shiller, J.H.1
  • 4
    • 53749097825 scopus 로고    scopus 로고
    • Chemotherapy in addition to supportive care improves survival in advanced non-small-cell lung cancer: A systematic review and meta-analysis of individual patient data from 16 randomised controlled trials
    • NSCLC Meta-Analysis Collaborative Group
    • NSCLC Meta-Analysis Collaborative Group (2008) Chemotherapy in addition to supportive care improves survival in advanced non-small-cell lung cancer: a systematic review and meta-analysis of individual patient data from 16 randomised controlled trials. J Clin Oncol 28:4617-4625
    • (2008) J Clin Oncol , vol.28 , pp. 4617-4625
  • 5
    • 74949133978 scopus 로고    scopus 로고
    • American society of clinical oncology clinical practice guideline update on chemotherapy for stage IV non-small-cell lung cancer
    • Azolli CG (2009) American society of clinical oncology clinical practice guideline update on chemotherapy for stage IV non-small-cell lung cancer. J Clin Oncol 36:6251-6266
    • (2009) J Clin Oncol , vol.36 , pp. 6251-6266
    • Azolli, C.G.1
  • 6
  • 7
    • 84857507055 scopus 로고    scopus 로고
    • Maintenance therapy with pemetrexed plus best supportive care versus placebo plus best supportive care after induction therapy with pemetrexed plus cisplatin for advanced nonsquamosus non-small cell lung cancer (PARAMOUNT): A double - Blind, phase 3, randomised controlled trial
    • Paz-Ares L (2012) Maintenance therapy with pemetrexed plus best supportive care versus placebo plus best supportive care after induction therapy with pemetrexed plus cisplatin for advanced nonsquamosus non-small cell lung cancer (PARAMOUNT): a double - blind, phase 3, randomised controlled trial. Lancet Oncol 3:247-255
    • (2012) Lancet Oncol , vol.3 , pp. 247-255
    • Paz-Ares, L.1
  • 8
    • 84867566940 scopus 로고    scopus 로고
    • Final overall survival (OS) result of the phase III study of maintenance pemetrexed (pem) plus best supportive care (BSC) versus placebo (plb) plus BSC immediatly following induction treatment with pem plus cisplatin (cis) for advanced nonsquamosus (NS) non-small cell lung cancer (NSCLC)
    • PPARAMOUNT abstr LBA7507
    • Paz-Ares L, PPARAMOUNT (2012) Final overall survival (OS) result of the phase III study of maintenance pemetrexed (pem) plus best supportive care (BSC) versus placebo (plb) plus BSC immediatly following induction treatment with pem plus cisplatin (cis) for advanced nonsquamosus (NS) non-small cell lung cancer (NSCLC). J Clin Oncol 30:(Suppl; abstr LBA7507)
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Paz-Ares, L.1
  • 9
    • 66249135629 scopus 로고    scopus 로고
    • Combined inhibition of the VEGFR and EGFR signalling pathways in the treatment of NSCLC
    • Pennel NA (2009) Combined inhibition of the VEGFR and EGFR signalling pathways in the treatment of NSCLC. Oncologist 14:399-411
    • (2009) Oncologist , vol.14 , pp. 399-411
    • Pennel, N.A.1
  • 10
    • 84875947292 scopus 로고    scopus 로고
    • New targetable oncogenes in Non-small-cell lung cancer
    • Oxanard GR, Binder A (2013) New targetable oncogenes in Non-small-cell lung cancer. J Clin Oncol 31:1097-1104
    • (2013) J Clin Oncol , vol.31 , pp. 1097-1104
    • Oxanard, G.R.1    Binder, A.2
  • 11
    • 79960218807 scopus 로고    scopus 로고
    • Genotype-driven therapies for non-small cell lung cancer: Focus on EGFR, KRAS and ALK gene abnormalities
    • Gaughan EM (2011) Genotype-driven therapies for non-small cell lung cancer: focus on EGFR, KRAS and ALK gene abnormalities. Ther Adv Med Oncol 3:113-125
    • (2011) Ther Adv Med Oncol , vol.3 , pp. 113-125
    • Gaughan, E.M.1
  • 12
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • DOI 10.1038/nrc1609
    • Hynes NE, Lane H (2005) ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 5:341-354 (Pubitemid 40637826)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 13
    • 68949201629 scopus 로고    scopus 로고
    • Acitvating and resistance mutations of EGFR in non-small-cell lung cancer: Role in clinical responses to EGFR tyrosine kinase inhibitors
    • Gazdar AF (2009) Acitvating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical responses to EGFR tyrosine kinase inhibitors. Oncogene 28:24-31
    • (2009) Oncogene , vol.28 , pp. 24-31
    • Gazdar, A.F.1
  • 14
    • 79952191279 scopus 로고    scopus 로고
    • Lung cancer in never smokers: Change of a mindset in the molecular era
    • Lee YJ et al (2011) Lung cancer in never smokers: change of a mindset in the molecular era. Lung Cancer 72:9-15
    • (2011) Lung Cancer , vol.72 , pp. 9-15
    • Lee, Y.J.1
  • 15
    • 78651087933 scopus 로고    scopus 로고
    • Frequency of EGFR and KRAS mutations in lung adenocarcinoma in African Americans
    • Reinersman JM et al (2011) Frequency of EGFR and KRAS mutations in lung adenocarcinoma in African Americans. J Thorac Oncol 6:28-31
    • (2011) J Thorac Oncol , vol.6 , pp. 28-31
    • Reinersman, J.M.1
  • 16
    • 84875943507 scopus 로고    scopus 로고
    • KRAS mutation: Should We test for it, and does it matter?
    • Patrick JR, Thomas ES (2013) KRAS mutation: should We test for it, and does it matter? J Clin Oncol 31:1112-1121
    • (2013) J Clin Oncol , vol.31 , pp. 1112-1121
    • Patrick, J.R.1    Thomas, E.S.2
  • 17
    • 84875211965 scopus 로고    scopus 로고
    • KRAS mutation in patients with lung cancer: A predictor for poor prognosis but Not for EGFR-TKIs or chemotherapy
    • Guan JL et al (2013) KRAS mutation in patients with lung cancer: a predictor for poor prognosis but Not for EGFR-TKIs or chemotherapy. Ann Surg Oncol 4:1381-11388
    • (2013) Ann Surg Oncol , vol.4 , pp. 1381-11388
    • Guan, J.L.1
  • 18
    • 70349720358 scopus 로고    scopus 로고
    • Biomarker analyses from a phase III, randomised, open-label, first-line study of gefitinib(G) versus carboplatin/paclitaxel(C/P) in clinically selected patients with advanced non-small cell lung cancer (NSCLC) in Asia (IPASS)
    • Fukuoka M (2009) Biomarker analyses from a phase III, randomised, open-label, first-line study of gefitinib(G) versus carboplatin/paclitaxel(C/P) in clinically selected patients with advanced non-small cell lung cancer (NSCLC) in Asia (IPASS) J Clin Oncol 27:(suppl 15)
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. 15
    • Fukuoka, M.1
  • 19
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small cell lung cancer
    • Shepherd FA (2005) Erlotinib in previously treated non-small cell lung cancer. N Eng Med 353:123-132
    • (2005) N Eng Med , vol.353 , pp. 123-132
    • Shepherd, F.A.1
  • 20
    • 77953541527 scopus 로고    scopus 로고
    • Erlotinib as maintenance treatment in advanced non-small cell lung cancer: A multicentre, randomised, placebo - Controlled phase III study
    • Capuzzo F (2010) Erlotinib as maintenance treatment in advanced non-small cell lung cancer: a multicentre, randomised, placebo - controlled phase III study. Lancet Oncol 6:521-529
    • (2010) Lancet Oncol , vol.6 , pp. 521-529
    • Capuzzo, F.1
  • 21
    • 79954606282 scopus 로고    scopus 로고
    • Efficacy results from the randomised phase III OPTIMAL (CTONG 0802) study comparing first-line Erlotinib versus carboplatin (CBDCA) plus gemcitabine (GEM) in Chinese advanced non small cell lung cancer (NSCLC) patients (PTS) with EGFR activating mutations
    • LBA 13
    • Zhou C, Wu YL (2010) Efficacy results from the randomised phase III OPTIMAL (CTONG 0802) study comparing first-line Erlotinib versus carboplatin (CBDCA) plus gemcitabine (GEM) in Chinese advanced non small cell lung cancer (NSCLC) patients (PTS) with EGFR activating mutations. Ann Oncol 21(supp.8):LBA 13
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 8
    • Zhou, C.1    Wu, Y.L.2
  • 22
    • 84866927445 scopus 로고    scopus 로고
    • TAILOR: A phase III trial comparing erlotinib with docetaxel as the second-line treatment of NSCLC patients with wild -type (wt) EGFR
    • abstr LBA7501
    • Garassino MC (2012) TAILOR: A phase III trial comparing erlotinib with docetaxel as the second-line treatment of NSCLC patients with wild -type (wt) EGFR. J Clin Oncol 30:(abstr LBA7501)
    • (2012) J Clin Oncol , vol.30
    • Garassino, M.C.1
  • 23
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
    • Rosell R, Carcereny E et al (2013) Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 3:239-246
    • (2013) Lancet Oncol , vol.3 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2
  • 24
    • 56249109644 scopus 로고    scopus 로고
    • Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST) a randomised phase III trial
    • Kim ES, Hirsh V et al (2008) Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST) a randomised phase III trial. The Lancet 372:1809-1818
    • (2008) The Lancet , vol.372 , pp. 1809-1818
    • Kim, E.S.1    Hirsh, V.2
  • 25
    • 79960702788 scopus 로고    scopus 로고
    • Biomarker analyses and final overall survival results from a phase III, randomised, open -label, first-line study of Gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced Non-small-cell lung cancer in Asia (IPASS)
    • Fukuoka M, Wu Y (2011) Biomarker analyses and final overall survival results from a phase III, randomised, open -label, first-line study of Gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced Non-small-cell lung cancer in Asia (IPASS). J Clin Oncol 29:2866-2874
    • (2011) J Clin Oncol , vol.29 , pp. 2866-2874
    • Fukuoka, M.1    Wu, Y.2
  • 26
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS (2009) Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Eng J Med 361:947-957
    • (2009) N Eng J Med , vol.361 , pp. 947-957
    • Mok, T.S.1
  • 27
    • 84857650666 scopus 로고    scopus 로고
    • Final results of a phase II study of first- line gefitinib for elderly patients (PTS) with advanced non-small cell lung cancer (NSCLC) harbour epidermal growth factor receptor (EGFR) mutations. NEJ 003 study
    • Abstract:3559
    • Inoue A, Minegishi M, Maemondo M (2010) Final results of a phase II study of first- line gefitinib for elderly patients (PTS) with advanced non-small cell lung cancer (NSCLC) harbour epidermal growth factor receptor (EGFR) mutations. NEJ 003 study. Ann Oncol 21:(Suppl 8) Abstract:3559
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 8
    • Inoue, A.1    Minegishi, M.2    Maemondo, M.3
  • 28
    • 84855311144 scopus 로고    scopus 로고
    • EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: Analysis of data from the phase 3 FLEX study
    • The
    • The Pirker R, Pereira JR (2012) EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: analysis of data from the phase 3 FLEX study. Lancet Oncol 1:33-42
    • (2012) Lancet Oncol , vol.1 , pp. 33-42
    • Pirker, R.1    Pereira, J.R.2
  • 29
    • 84883179862 scopus 로고    scopus 로고
    • Targeting the ERBB family in cancer: Couples therapy
    • Teblutt N, Pedersen MW (2013) Targeting the ERBB family in cancer: couples therapy. Nat Rev Cancer 13:663-673
    • (2013) Nat Rev Cancer , vol.13 , pp. 663-673
    • Teblutt, N.1    Pedersen, M.W.2
  • 30
    • 84867667464 scopus 로고    scopus 로고
    • Phase IIB/III double-blind randomised trial of afatinib (BIBW 2992, an irreversibile inhibitor of EGFR/HER1 and HER2)+best supportive care (BSC) versus placebo+BSC in patients with NSCLC failing 1-2 lines of chemotehrapy and erlotinib or gefitinib (LUX-LUNG 1)
    • LBA1
    • Miller VA (2012) Phase IIB/III double-blind randomised trial of afatinib (BIBW 2992, an irreversibile inhibitor of EGFR/HER1 and HER2)+best supportive care (BSC) versus placebo+BSC in patients with NSCLC failing 1-2 lines of chemotehrapy and erlotinib or gefitinib (LUX-LUNG 1) Ann Oncol 21:(Suppl 8,LBA1)
    • (2012) Ann Oncol , vol.21 , Issue.SUPPL. 8
    • Miller, V.A.1
  • 31
    • 84896053832 scopus 로고    scopus 로고
    • LUX-Lung 3: A randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin as first-line treatment for patients with advanced adenocarcinoma of the lung harboring EGFR-activating mutations
    • LBA 7500
    • Chi YJ (2012) LUX-Lung 3: A randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin as first-line treatment for patients with advanced adenocarcinoma of the lung harboring EGFR-activating mutations. J Clinic Oncol 30:18(Suppl. LBA 7500)
    • (2012) J Clinic Oncol , vol.30 , Issue.18 SUPPL.
    • Chi, Y.J.1
  • 32
    • 84896035661 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with second mutation in the EGFR kinase ddomain
    • Pao W (2004) Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with second mutation in the EGFR kinase ddomain. PloS Med 2:2129-2139
    • (2004) PloS Med , vol.2 , pp. 2129-2139
    • Pao, W.1
  • 33
    • 84873677937 scopus 로고    scopus 로고
    • Activity of afatinib/cetuximab in patients (pts) with EGFR mutant non-small cell lung cancer (NSCLC) and acquired resistance (AR) to EGFR inhibitors
    • abstr. 1227
    • Janjigian YY, Smit EF, Horn L, et al. (2012) Activity of afatinib/cetuximab in patients (pts) with EGFR mutant non-small cell lung cancer (NSCLC) and acquired resistance (AR) to EGFR inhibitors. Ann Oncol 23:(Suppl 9) abstr. 1227
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 9
    • Janjigian, Y.Y.1    Smit, E.F.2    Horn, L.3
  • 34
    • 77954584507 scopus 로고    scopus 로고
    • Neratinib, an irreversible Pan-ErB receptor tyrosine kinase inhibitor: Result of phase II trial in patients with advanced Non-small-cell lung cancer
    • Sequist LV, Besse B (2010) Neratinib, an irreversible Pan-ErB receptor tyrosine kinase inhibitor: result of phase II trial in patients with advanced Non-small-cell lung cancer. J Clin Oncol 18:3076-3083
    • (2010) J Clin Oncol , vol.18 , pp. 3076-3083
    • Sequist, L.V.1    Besse, B.2
  • 35
    • 77953930730 scopus 로고    scopus 로고
    • Gefinitib or chemotherapy for non-small-cell lung cancer with mutated EGFR
    • Maemondo M, Inoue A (2010) Gefinitib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Eng J Med 362:2380-2388
    • (2010) N Eng J Med , vol.362 , pp. 2380-2388
    • Maemondo, M.1    Inoue, A.2
  • 36
    • 84857969863 scopus 로고    scopus 로고
    • Chipping away the lung cancer genome
    • Pao W, Hutchinson KE (2012) Chipping away the lung cancer genome. Nat Med 18:349.351
    • (2012) Nat Med , vol.18 , pp. 349-351
    • Pao, W.1    Hutchinson, K.E.2
  • 37
    • 81755185464 scopus 로고    scopus 로고
    • Hepatocyte growth factor expression in EGFR mutant lung cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in japanase cohort
    • Yano S, Yamada T (2011) Hepatocyte growth factor expression in EGFR mutant lung cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in japanase cohort. J Thorac Oncol 6:2011-2017
    • (2011) J Thorac Oncol , vol.6 , pp. 2011-2017
    • Yano, S.1    Yamada, T.2
  • 38
    • 80052437758 scopus 로고    scopus 로고
    • New strategies on overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer
    • Oxnard GR, Arcila ME (2011) New strategies on overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer. Clin Cancer Res 17:5530-5537
    • (2011) Clin Cancer Res , vol.17 , pp. 5530-5537
    • Oxnard, G.R.1    Arcila, M.E.2
  • 39
    • 84875950992 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase inhibitor -resistant disease
    • Ohashi K, Maruvka YE (2013) Epidermal growth factor receptor tyrosine kinase inhibitor -resistant disease. J Clin Oncol 31:1070-1080
    • (2013) J Clin Oncol , vol.31 , pp. 1070-1080
    • Ohashi, K.1    Maruvka, Y.E.2
  • 40
    • 23844545810 scopus 로고    scopus 로고
    • Platelet-derived growth factor-A is an essential and autocrine regulators of vascular endothelial growth factor expression in non-small cell lung carcinomas
    • Shikada Y (2005) Platelet-derived growth factor-A is an essential and autocrine regulators of vascular endothelial growth factor expression in non-small cell lung carcinomas. Cancer Res 6:7241-7248
    • (2005) Cancer Res , vol.6 , pp. 7241-7248
    • Shikada, Y.1
  • 41
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small cell lung cancer
    • Sandler A (2006) Paclitaxel-carboplatin alone or with bevacizumab for non-small cell lung cancer. N Eng J Med 24:2542-2550
    • (2006) N Eng J Med , vol.24 , pp. 2542-2550
    • Sandler, A.1
  • 42
    • 77955268612 scopus 로고    scopus 로고
    • Safety and efficacy of first line bevacizumab based in advanced non-squamosus non-small cell lung cancer (SAIL MO19390) Phase 4 study
    • Crino L, Dansin E (2010) Safety and efficacy of first line bevacizumab based in advanced non-squamosus non-small cell lung cancer (SAIL MO19390) Phase 4 study. Lancet Oncol 8:733-740
    • (2010) Lancet Oncol , vol.8 , pp. 733-740
    • Crino, L.1    Dansin, E.2
  • 43
    • 75749111747 scopus 로고    scopus 로고
    • The role of monoclonal antibody in combination with first-line chemotherapy in Asian patients with advanced Non-small cell lung cancer the role of monoclonal antibody in combination with first-line chemotherapy in Asian patients with advanced Non-small cell lung cancer
    • Cho BC, Kim BH, Soo RA (2010) The role of monoclonal antibody in combination with first-line chemotherapy in Asian patients with advanced Non-small cell lung cancer the role of monoclonal antibody in combination with first-line chemotherapy in Asian patients with advanced Non-small cell lung cancer. Yonsei Med J 1:1-8
    • (2010) Yonsei Med J , vol.1 , pp. 1-8
    • Cho, B.C.1    Kim, B.H.2    Soo, R.A.3
  • 44
    • 68949127256 scopus 로고    scopus 로고
    • Efficacy and safety of axitinib (AG-013736 AG) in patients with advanced Non-small-cell lung cancer: Results from phase II study
    • Schiller JH, Larson T (2009) Efficacy and safety of axitinib (AG-013736 AG) in patients with advanced Non-small-cell lung cancer: results from phase II study. J Clin Oncol 23:3836-3841
    • (2009) J Clin Oncol , vol.23 , pp. 3836-3841
    • Schiller, J.H.1    Larson, T.2
  • 45
    • 65349186800 scopus 로고    scopus 로고
    • Aflibercept(AVE0005) an alternative strategy for inhibiting tumour angiogenesis by vascular endothelial growth factors
    • Chue QS (2009) Aflibercept(AVE0005) an alternative strategy for inhibiting tumour angiogenesis by vascular endothelial growth factors. Expert Opin Biol Ther 2:263-271
    • (2009) Expert Opin Biol Ther , vol.2 , pp. 263-271
    • Chue, Q.S.1
  • 46
    • 73949092851 scopus 로고    scopus 로고
    • Randomised, double-blind trial of carboplatin and paclitaxel with either daily oral cediranib or placebo in advanced non-small cell lung cancer: NCIC clinical trial group BR24 study
    • Goss GD (2010) Randomised, double-blind trial of carboplatin and paclitaxel with either daily oral cediranib or placebo in advanced non-small cell lung cancer: NCIC clinical trial group BR24 study. J Clin Oncol 1:49-55
    • (2010) J Clin Oncol , vol.1 , pp. 49-55
    • Goss, G.D.1
  • 47
    • 0037102369 scopus 로고    scopus 로고
    • ZD6474 inhibits vascular endothelial growth factor signalling, angiogenesis, and tumor growth following oral administration
    • Wedge SR (2002) ZD6474 inhibits vascular endothelial growth factor signalling, angiogenesis, and tumor growth following oral administration. Cancer Res 62:4645-4655
    • (2002) Cancer Res , vol.62 , pp. 4645-4655
    • Wedge, S.R.1
  • 48
    • 70350655546 scopus 로고    scopus 로고
    • Phase II study of continuous daily sunitinib dosing in patients with previously treated advanced non-small cell lung cancer
    • Novello S (2009) Phase II study of continuous daily sunitinib dosing in patients with previously treated advanced non-small cell lung cancer. Br J Cancer 9:1543-1548
    • (2009) Br J Cancer , vol.9 , pp. 1543-1548
    • Novello, S.1
  • 49
    • 70349304196 scopus 로고    scopus 로고
    • Phase II, multicenter, uncontrolled trial of single -agent sorafenib in patients with relapsed or refractory, advanced non -small cell lung cancer
    • Blumenschein GR Jr (2009) Phase II, multicenter, uncontrolled trial of single -agent sorafenib in patients with relapsed or refractory, advanced non -small cell lung cancer. J Clin Oncol 26:4274-4280
    • (2009) J Clin Oncol , vol.26 , pp. 4274-4280
    • Blumenschein Jr., G.R.1
  • 50
    • 33749000911 scopus 로고    scopus 로고
    • AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet -derived gowth facror and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts
    • Polverino A (2006) AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet -derived gowth facror and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer Res 17:8715-8721
    • (2006) Cancer Res , vol.17 , pp. 8715-8721
    • Polverino, A.1
  • 51
    • 79955795090 scopus 로고    scopus 로고
    • Randomised open label phase II study of motesanib or bevacizumab in combination with paclitaxel and carboplatin (P/C) for advanced nonsquamosus non-small cell lung cancer (NSCLC)
    • Blumenschein GR, Kabbinavar F (2011) Randomised open label phase II study of motesanib or bevacizumab in combination with paclitaxel and carboplatin (P/C) for advanced nonsquamosus non-small cell lung cancer (NSCLC). Ann Oncol 9:2057-2067
    • (2011) Ann Oncol , vol.9 , pp. 2057-2067
    • Blumenschein, G.R.1    Kabbinavar, F.2
  • 52
    • 84857882376 scopus 로고    scopus 로고
    • Antiangiogenic agents in the the treatment of non-small cell lung cancer:Where do we stand and where are we headed?
    • Aggarwall C (2012) Antiangiogenic agents in the the treatment of non-small cell lung cancer:where do we stand and where are we headed? Cancer Biol Ther 5:247-263
    • (2012) Cancer Biol Ther , vol.5 , pp. 247-263
    • Aggarwall, C.1
  • 53
    • 34547638047 scopus 로고    scopus 로고
    • Identification of the transforming EML4-ALK fusion gene in non -small cell lung cancer
    • Soda M (2007) Identification of the transforming EML4-ALK fusion gene in non -small cell lung cancer. Nature 448:561-567
    • (2007) Nature , vol.448 , pp. 561-567
    • Soda, M.1
  • 54
    • 78049353081 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase: Role in specifis tumours, and development of small molecule inhibitors for cancer therapy
    • Ardini E, Magnaghi P (2010) Anaplastic lymphoma kinase: role in specifis tumours, and development of small molecule inhibitors for cancer therapy. Cencer letters 299:81-94
    • (2010) Cencer Letters , vol.299 , pp. 81-94
    • Ardini, E.1    Magnaghi, P.2
  • 55
    • 63849163410 scopus 로고    scopus 로고
    • Increased MET gene copy number negatively affects survival of surgical resected non-small-cell lung cancer patients
    • Capuzzo F, Marchetti A (2009) Increased MET gene copy number negatively affects survival of surgical resected non-small-cell lung cancer patients. J Clin Oncol 27:1667-1674
    • (2009) J Clin Oncol , vol.27 , pp. 1667-1674
    • Capuzzo, F.1    Marchetti, A.2
  • 56
    • 84863338079 scopus 로고    scopus 로고
    • ROS1 rearrangements define a unique molecular class of lung cancer
    • Bergethon K, Shaw AT (2012) ROS1 rearrangements define a unique molecular class of lung cancer. J Clin Oncol 30:863-870
    • (2012) J Clin Oncol , vol.30 , pp. 863-870
    • Bergethon, K.1    Shaw, A.T.2
  • 57
    • 44849126091 scopus 로고    scopus 로고
    • Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors
    • McDermott U (2008) Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors. Cancer Res 68:3389-3395
    • (2008) Cancer Res , vol.68 , pp. 3389-3395
    • McDermott, U.1
  • 58
    • 79251490374 scopus 로고    scopus 로고
    • New driver mutations in non-small-cell lung cancer
    • Pao W, Girard N (2011) New driver mutations in non-small-cell lung cancer. Lancet Oncol 12:175-180
    • (2011) Lancet Oncol , vol.12 , pp. 175-180
    • Pao, W.1    Girard, N.2
  • 59
    • 64849101672 scopus 로고    scopus 로고
    • Cell culture modelling of genotype-directed sensitivity to selective kinase inhibitors: Targeting the anaplastic lymphoma kinase (ALK)
    • Settleman J (2009) Cell culture modelling of genotype-directed sensitivity to selective kinase inhibitors: targeting the anaplastic lymphoma kinase (ALK). Semin Oncol S36-41
    • (2009) Semin Oncol
    • Settleman, J.1
  • 60
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibitions in nonsmall cell lung cancer
    • Kwak EL (2010) Anaplastic lymphoma kinase inhibitions in nonsmall cell lung cancer. N Eng J Med 363:1693-1703
    • (2010) N Eng J Med , vol.363 , pp. 1693-1703
    • Kwak, E.L.1
  • 61
    • 80051731527 scopus 로고    scopus 로고
    • Crizotinib: An anaplastic lymphoma kinase inhibitor
    • Gadgeel M, Bepler G (2011) Crizotinib: an anaplastic lymphoma kinase inhibitor. Future Oncol 8:947-953
    • (2011) Future Oncol , vol.8 , pp. 947-953
    • Gadgeel, M.1    Bepler, G.2
  • 62
    • 84973358089 scopus 로고    scopus 로고
    • Clinical activity of the ALK inhibitor LDK378 in advanced, ALK-positive NSCLC
    • Abstr 8010
    • Alice Tsang S, Ranee Mehra (2013) Clinical activity of the ALK inhibitor LDK378 in advanced, ALK-positive NSCLC. J Clin Oncol 31:(suppl) Abstr 8010
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Alice Tsang, S.1    Mehra, R.2
  • 63
    • 85026233640 scopus 로고    scopus 로고
    • Final results from AR197-209: A global randomised placebo -controlled phase II clinical trial of erlotinib PLUS ARQ197 versus erlotinib plus placebo in previously treated EGFR- inhibitor naive patients with advanced non-small cell lung cancer (NSCLC)
    • Abstr 3630
    • Sequist LV, Akerley Wl (2010) Final results from AR197-209: a global randomised placebo -controlled phase II clinical trial of erlotinib PLUS ARQ197 versus erlotinib plus placebo in previously treated EGFR- inhibitor naive patients with advanced non-small cell lung cancer (NSCLC). Ann Oncol 21:(Suppl.8) Abstr 3630
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 8
    • Sequist, L.V.1    Akerley, W.2
  • 64
    • 84874345305 scopus 로고    scopus 로고
    • The role of MET receptor tyrosine kinase in Non-small cell lung cancer and clinical development of targeted anti-MET agents
    • Robinson KW, Sandler AB (2013) The role of MET receptor tyrosine kinase in Non-small cell lung cancer and clinical development of targeted anti-MET agents. Oncologist 18:115-122
    • (2013) Oncologist , vol.18 , pp. 115-122
    • Robinson, K.W.1    Sandler, A.B.2
  • 65
    • 56749173617 scopus 로고    scopus 로고
    • Bevacizumab and erlotinib: A promising new approach to the treatment of advanced NSCLC
    • Herbst RS, Sandler A (2008) Bevacizumab and erlotinib: a promising new approach to the treatment of advanced NSCLC. Oncologist 13:1166-1176
    • (2008) Oncologist , vol.13 , pp. 1166-1176
    • Herbst, R.S.1    Sandler, A.2
  • 66
    • 65649132497 scopus 로고    scopus 로고
    • A phase III multicenter, placebo-controlled, double-blind, randomised clinical trial to evaluate the efficacy of bevacizumab(Avastin) in combination with erlotinib (Tarceva) compared with chemotherapy alone for treatment of advanced non-small cell lung cancer after failure of standard first line chemotherapy
    • Haisworth J (2008) A phase III multicenter, placebo-controlled, double-blind, randomised clinical trial to evaluate the efficacy of bevacizumab(Avastin) in combination with erlotinib (Tarceva) compared with chemotherapy alone for treatment of advanced non-small cell lung cancer after failure of standard first line chemotherapy. J Thorac Oncol 3:(Suppl.4)
    • (2008) J Thorac Oncol , vol.3 , Issue.SUPPL. 4
    • Haisworth, J.1
  • 67
    • 78449274913 scopus 로고    scopus 로고
    • Overall survival (OS) in ATLAS, a phase IIIb trial comparing bevacizumab(B) therapy with or without erlotinib(E) after completion of chemoterapy with B for first line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC)
    • abstr 7526
    • Kabbinavar F, Miller VA (2010) Overall survival (OS) in ATLAS, a phase IIIb trial comparing bevacizumab(B) therapy with or without erlotinib(E) after completion of chemoterapy with B for first line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC) J Clin Oncol 28:(Suppl 15)abstr 7526
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL. 15
    • Kabbinavar, F.1    Miller, V.A.2
  • 68
    • 70349725169 scopus 로고    scopus 로고
    • S0536: Carboplatin, paclitaxel, cetuximab and bevacizumab followed by cetuximab and bevacizumab maintenance in advanced NSCLC: A SWOG phase II study
    • abstr 8015
    • Gandara D (2009) S0536: carboplatin, paclitaxel, cetuximab and bevacizumab followed by cetuximab and bevacizumab maintenance in advanced NSCLC: a SWOG phase II study. J Clin Oncol 27:(Suppl.15) abstr 8015
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. 51
    • Gandara, D.1
  • 69
    • 77953114837 scopus 로고    scopus 로고
    • A phase II study of erlotinib and sorafenib in chemotherapy-naive patients with locally advanced/metastatic non-small cell lung cancer
    • Lind JS, Dingemans AMC (2009) A phase II study of erlotinib and sorafenib in chemotherapy-naive patients with locally advanced/metastatic non-small cell lung cancer. Clin Cancer Res 16:3078-3087
    • (2009) Clin Cancer Res , vol.16 , pp. 3078-3087
    • Lind, J.S.1    Dingemans, A.M.C.2
  • 70
    • 84887262315 scopus 로고    scopus 로고
    • A study of MPD3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic tumors
    • Abstr 3000
    • Herbst RS, Gordon MS et al. (2013) A study of MPD3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic tumors. J Clin Oncol 31:(suppl) Abstr 3000
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Herbst, R.S.1    Gordon, M.S.2
  • 71
    • 84862236855 scopus 로고    scopus 로고
    • Immune alterations and emerging immunotherapeutic approaches in lung cancer
    • Dasanu CA, Sethi N (2012) Immune alterations and emerging immunotherapeutic approaches in lung cancer. Expert Opin Biol 12:923-937
    • (2012) Expert Opin Biol , vol.12 , pp. 923-937
    • Dasanu, C.A.1    Sethi, N.2
  • 72
    • 11144358645 scopus 로고    scopus 로고
    • High frequency of mutations of the PIK3CA gene in human cancers
    • Samuels Y (2004) High frequency of mutations of the PIK3CA gene in human cancers. Science 304:554
    • (2004) Science , vol.304 , pp. 554
    • Samuels, Y.1
  • 73
    • 41849132829 scopus 로고    scopus 로고
    • Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung
    • Malaga D (2008) Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung. Cell cycle 7:665-669
    • (2008) Cell Cycle , vol.7 , pp. 665-669
    • Malaga, D.1
  • 74
    • 0036895599 scopus 로고    scopus 로고
    • Missense mutations of the BRAF gene in human lung adenocarcinoma
    • Naoki K (2002) Missense mutations of the BRAF gene in human lung adenocarcinoma. Cancer Res 62:7001-7003
    • (2002) Cancer Res , vol.62 , pp. 7001-7003
    • Naoki, K.1
  • 75
    • 48649107410 scopus 로고    scopus 로고
    • Novel MEK 1 mutation identified by mutational analysis of epidermal growth factor receptor signalling pathway genes in lung adenocarcinoma
    • Marks JL (2008) Novel MEK 1 mutation identified by mutational analysis of epidermal growth factor receptor signalling pathway genes in lung adenocarcinoma. Cancer Res 68:5524-5528
    • (2008) Cancer Res , vol.68 , pp. 5524-5528
    • Marks, J.L.1
  • 76
    • 40349106029 scopus 로고    scopus 로고
    • The potential role of mTOR inhibitors in non-small cell lung cancer
    • DOI 10.1634/theoncologist.2007-0171
    • Gridelli C, Maione P (2008) The potential Role of mTOR inhibitor sin Non-Small-Cell Lung Cancer. Oncologist 2:139-147 (Pubitemid 351342577)
    • (2008) Oncologist , vol.13 , Issue.2 , pp. 139-147
    • Gridelli, C.1    Maione, P.2    Rossi, A.3
  • 77
    • 84871228894 scopus 로고    scopus 로고
    • Everolimus synergizes with gefitinib in non-small-cell lung cancer cell lines resistant to epidermal growth factor receptor tyrosine kinase inhibitors
    • Dong S, Zhang XC (2012) Everolimus synergizes with gefitinib in non-small-cell lung cancer cell lines resistant to epidermal growth factor receptor tyrosine kinase inhibitors. Cancer Chemother Pharmacol 5:707-716
    • (2012) Cancer Chemother Pharmacol , vol.5 , pp. 707-716
    • Dong, S.1    Zhang, X.C.2
  • 78
    • 84857658325 scopus 로고    scopus 로고
    • Recent clinical developments and rationale for combining targeted agents in non-small cell lung cancer (NSCLC)
    • Belani CP, Goss G (2011) Recent clinical developments and rationale for combining targeted agents in non-small cell lung cancer (NSCLC). Cancer Treat Rev 38:173-178
    • (2011) Cancer Treat Rev , vol.38 , pp. 173-178
    • Belani, C.P.1    Goss, G.2
  • 79
    • 79954453453 scopus 로고    scopus 로고
    • NSCLC drug targets acquire New visibility
    • Frierich MJ (2011) NSCLC drug targets acquire New visibility. J Nat Cancer Inst 5:366
    • (2011) J Nat Cancer Inst , vol.5 , pp. 366
    • Frierich, M.J.1


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