Reduced expression of MUTYH with suppressive activity against mutations caused by 8-hydroxyguanine is a novel predictor of a poor prognosis in human gastric cancer

Journal of Pathology

Volumn 225, Issue 3, 2011, Pages 414-423

  Shinmura, Kazuya ^a   Goto, Masanori ^a   Suzuki, Masaya ^a   Tao, Hong ^a   Yamada, Hidetaka ^a   Igarashi, Hisaki ^a   Matsuura, Shun ^a   Maeda, Matsuyoshi ^b   Konno, Hiroyuki ^a   Matsuda, Tomonari ^c   Sugimura, Haruhiko ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOYOHASHI MUNICIPAL HOSPITAL   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

8 hydroxyguanine; base excision repair; gastric cancer; mutation frequency; MUTYH; poor prognosis; supF forward mutation assay

Indexed keywords

8 HYDROXYGUANINE; DNA GLYCOSYLASE MUTY; MESSENGER RNA;

ADULT; ARTICLE; CANCER CELL CULTURE; CANCER STAGING; CANCER SURVIVAL; CELL PROLIFERATION; DNA CLEAVAGE; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CANCER;

AGED; CELL TRANSFORMATION, NEOPLASTIC; DNA GLYCOSYLASES; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GUANINE; HUMANS; MALE; MIDDLE AGED; MUTATION; NEOPLASM PROTEINS; NEOPLASM STAGING; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; STOMACH NEOPLASMS; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 80054773609     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2953     Document Type: Article

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