메뉴 건너뛰기




Volumn 6, Issue , 2015, Pages

A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae

Author keywords

[No Author keywords available]

Indexed keywords

HAEMOPHILUS VACCINE; BACTERIAL DNA; SITE SPECIFIC DNA METHYLTRANSFERASE (ADENINE SPECIFIC);

EID: 84938068933     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms8828     Document Type: Article
Times cited : (97)

References (70)
  • 1
    • 57349152081 scopus 로고    scopus 로고
    • Otitis media: Prospects for prevention
    • Haggard, M. Otitis media: prospects for prevention. Vaccine 26(Suppl 7): G20-G24 (2008).
    • (2008) Vaccine , vol.26 , pp. G20-G24
    • Haggard, M.1
  • 2
    • 64349088719 scopus 로고    scopus 로고
    • Determinants of phase variation rate and the fitness implications of differing rates for bacterial pathogens and commensals
    • Bayliss, C. D. Determinants of phase variation rate and the fitness implications of differing rates for bacterial pathogens and commensals. FEMS Microbiol. Rev. 33, 504-520 (2009).
    • (2009) FEMS Microbiol. Rev. , vol.33 , pp. 504-520
    • Bayliss, C.D.1
  • 3
    • 33845648557 scopus 로고    scopus 로고
    • Bacterial contingency loci: The role of simple sequence DNA repeats in bacterial adaptation
    • Moxon, R., Bayliss, C. & Hood, D. Bacterial contingency loci: the role of simple sequence DNA repeats in bacterial adaptation. Annu. Rev. Genet. 40, 307-333 (2006).
    • (2006) Annu. Rev. Genet. , vol.40 , pp. 307-333
    • Moxon, R.1    Bayliss, C.2    Hood, D.3
  • 4
    • 59949095428 scopus 로고    scopus 로고
    • Simple sequence repeats in Haemophilus influenzae
    • Power, P. M. et al. Simple sequence repeats in Haemophilus influenzae. Infect. Genet. Evol. 9, 216-228 (2009).
    • (2009) Infect. Genet. Evol. , vol.9 , pp. 216-228
    • Power, P.M.1
  • 5
    • 0000361948 scopus 로고    scopus 로고
    • Repeat-associated phase variable genes in the complete genome sequence of Neisseria meningitidis strain MC58
    • Saunders, N. J. et al. Repeat-associated phase variable genes in the complete genome sequence of Neisseria meningitidis strain MC58. Mol. Microbiol. 37, 207-215 (2000).
    • (2000) Mol. Microbiol. , vol.37 , pp. 207-215
    • Saunders, N.J.1
  • 6
    • 34548569008 scopus 로고    scopus 로고
    • Haemophilus influenzae phasevarions have evolved from type III DNA restriction systems into epigenetic regulators of gene expression
    • Fox, K. L. et al. Haemophilus influenzae phasevarions have evolved from type III DNA restriction systems into epigenetic regulators of gene expression. Nucleic Acids Res. 35, 5242-5252 (2007).
    • (2007) Nucleic Acids Res. , vol.35 , pp. 5242-5252
    • Fox, K.L.1
  • 7
    • 66349122956 scopus 로고    scopus 로고
    • Phasevarions mediate random switching of gene expression in pathogenic Neisseria
    • Srikhanta, Y. N. et al. Phasevarions mediate random switching of gene expression in pathogenic Neisseria. PLoS Pathog. 5, e1000400 (2009).
    • (2009) PLoS Pathog. , vol.5
    • Srikhanta, Y.N.1
  • 8
    • 76949108806 scopus 로고    scopus 로고
    • The phasevarion: Phase variation of type III DNA methyltransferases controls coordinated switching in multiple genes
    • Srikhanta, Y. N., Fox, K. L. & Jennings, M. P. The phasevarion: phase variation of type III DNA methyltransferases controls coordinated switching in multiple genes. Nat. Rev. Microbiol. 8, 196-206 (2010).
    • (2010) Nat. Rev. Microbiol. , vol.8 , pp. 196-206
    • Srikhanta, Y.N.1    Fox, K.L.2    Jennings, M.P.3
  • 9
    • 82655180443 scopus 로고    scopus 로고
    • Phasevarion mediated epigenetic gene regulation in Helicobacter pylori
    • Srikhanta, Y. N. et al. Phasevarion mediated epigenetic gene regulation in Helicobacter pylori. PLoS ONE 6, e27569 (2011).
    • (2011) PLoS ONE , vol.6
    • Srikhanta, Y.N.1
  • 10
    • 17344370012 scopus 로고    scopus 로고
    • The phasevarion: A genetic system controlling coordinated, random switching of expression of multiple genes
    • Srikhanta, Y. N., Maguire, T. L., Stacey, K. J., Grimmond, S. M. & Jennings, M. P. The phasevarion: A genetic system controlling coordinated, random switching of expression of multiple genes. Proc. Natl Acad. Sci. USA 102, 5547-5551 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 5547-5551
    • Srikhanta, Y.N.1    Maguire, T.L.2    Stacey, K.J.3    Grimmond, S.M.4    Jennings, M.P.5
  • 11
    • 0024278335 scopus 로고
    • Type III DNA restriction and modification systems EcoP1 and EcoP15. Nucleotide sequence of the EcoP1 operon, the EcoP15 mod gene and some EcoP1 mod mutants
    • Humbelin, M. et al. Type III DNA restriction and modification systems EcoP1 and EcoP15. Nucleotide sequence of the EcoP1 operon, the EcoP15 mod gene and some EcoP1 mod mutants. J. Mol. Biol. 200, 23-29 (1988).
    • (1988) J. Mol. Biol. , vol.200 , pp. 23-29
    • Humbelin, M.1
  • 12
    • 0031971083 scopus 로고    scopus 로고
    • Functional analysis of conserved motifs in type III restriction-modification enzymes
    • Saha, S., Ahmad, I., Reddy, Y. V., Krishnamurthy, V. & Rao, D. N. Functional analysis of conserved motifs in type III restriction-modification enzymes. Biol. Chem. 379, 511-517 (1998).
    • (1998) Biol. Chem. , vol.379 , pp. 511-517
    • Saha, S.1    Ahmad, I.2    Reddy, Y.V.3    Krishnamurthy, V.4    Rao, D.N.5
  • 14
    • 84919773076 scopus 로고    scopus 로고
    • ModM DNA methyltransferase methylome analysis reveals a potential role for Moraxella catarrhalis phasevarions in otitis media
    • Blakeway, L. V. et al. ModM DNA methyltransferase methylome analysis reveals a potential role for Moraxella catarrhalis phasevarions in otitis media. FASEB J. 28, 5197-5207 (2014).
    • (2014) FASEB J. , vol.28 , pp. 5197-5207
    • Blakeway, L.V.1
  • 15
    • 84858780445 scopus 로고    scopus 로고
    • Origin of the diversity in DNA recognition domains in phasevarion associated modA genes of pathogenic Neisseria and Haemophilus influenzae
    • Gawthorne, J. A., Beatson, S. A., Srikhanta, Y. N., Fox, K. L. & Jennings, M. P. Origin of the diversity in DNA recognition domains in phasevarion associated modA genes of pathogenic Neisseria and Haemophilus influenzae. PLoS ONE 7, e32337 (2012).
    • (2012) PLoS ONE , vol.7
    • Gawthorne, J.A.1    Beatson, S.A.2    Srikhanta, Y.N.3    Fox, K.L.4    Jennings, M.P.5
  • 16
    • 84930226213 scopus 로고    scopus 로고
    • Specificity of the ModA11, ModA12 and ModD1 epigenetic regulator N6-adenine DNA methyltransferases of Neisseria meningitidis
    • Seib, K. L. et al. Specificity of the ModA11, ModA12 and ModD1 epigenetic regulator N6-adenine DNA methyltransferases of Neisseria meningitidis. Nucleic Acids Res. 43, 4150-4162 (2015).
    • (2015) Nucleic Acids Res. , vol.43 , pp. 4150-4162
    • Seib, K.L.1
  • 17
    • 84896529902 scopus 로고    scopus 로고
    • Selection for phase variation of LOS biosynthetic genes frequently occurs in progression of non-typeable Haemophilus influenzae infection from the nasopharynx to the middle ear of human patients
    • Fox, K. L. et al. Selection for phase variation of LOS biosynthetic genes frequently occurs in progression of non-typeable Haemophilus influenzae infection from the nasopharynx to the middle ear of human patients. PLoS ONE 9, e90505 (2014).
    • (2014) PLoS ONE , vol.9
    • Fox, K.L.1
  • 18
    • 70649112124 scopus 로고    scopus 로고
    • Epitope mapping immunodominant regions of the PilA protein of nontypeable Haemophilus influenzae (NTHI) to facilitate the design of two novel chimeric vaccine candidates
    • Novotny, L. A. et al. Epitope mapping immunodominant regions of the PilA protein of nontypeable Haemophilus influenzae (NTHI) to facilitate the design of two novel chimeric vaccine candidates. Vaccine 28, 279-289 (2009).
    • (2009) Vaccine , vol.28 , pp. 279-289
    • Novotny, L.A.1
  • 19
    • 0028049505 scopus 로고
    • Nasopharyngeal colonization with nontypeable Haemophilus influenzae and recurrent otitis media. Tonawanda/Williamsville Pediatrics
    • Harabuchi, Y. et al. Nasopharyngeal colonization with nontypeable Haemophilus influenzae and recurrent otitis media. Tonawanda/Williamsville Pediatrics. J. Infect. Dis. 170, 862-866 (1994).
    • (1994) J. Infect. Dis. , vol.170 , pp. 862-866
    • Harabuchi, Y.1
  • 20
    • 0030999628 scopus 로고    scopus 로고
    • Relationship between nasopharyngeal colonization and the development of otitis media in children. Tonawanda/Williamsville Pediatrics
    • Faden, H. et al. Relationship between nasopharyngeal colonization and the development of otitis media in children. Tonawanda/Williamsville Pediatrics. J. Infect. Dis. 175, 1440-1445 (1997).
    • (1997) J. Infect. Dis. , vol.175 , pp. 1440-1445
    • Faden, H.1
  • 21
    • 84871222928 scopus 로고    scopus 로고
    • The methylomes of six bacteria
    • Murray, I. A. et al. The methylomes of six bacteria. Nucleic Acids Res. 40, 11450-11462 (2012).
    • (2012) Nucleic Acids Res. , vol.40 , pp. 11450-11462
    • Murray, I.A.1
  • 22
    • 84857877933 scopus 로고    scopus 로고
    • Characterization of DNA methyltransferase specificities using single-molecule, real-time DNA sequencing
    • Clark, T. A. et al. Characterization of DNA methyltransferase specificities using single-molecule, real-time DNA sequencing. Nucleic Acids Res. 40, e29 (2012).
    • (2012) Nucleic Acids Res. , vol.40 , pp. e29
    • Clark, T.A.1
  • 23
    • 0015192625 scopus 로고
    • DNA restriction and modification mechanisms in bacteria
    • Boyer, H. W. DNA restriction and modification mechanisms in bacteria. Ann. Rev. Microbiol. 25, 153-176 (1971).
    • (1971) Ann. Rev. Microbiol. , vol.25 , pp. 153-176
    • Boyer, H.W.1
  • 24
    • 0021111764 scopus 로고
    • DNA restriction-modification enzymes of phage P1 and plasmid p15B. Subunit functions and structural homologies
    • Hadi, S. M., Bachi, B., Iida, S. & Bickle, T. A. DNA restriction-modification enzymes of phage P1 and plasmid p15B. Subunit functions and structural homologies. J. Mol. Biol. 165, 19-34 (1983).
    • (1983) J. Mol. Biol. , vol.165 , pp. 19-34
    • Hadi, S.M.1    Bachi, B.2    Iida, S.3    Bickle, T.A.4
  • 25
    • 75549086595 scopus 로고    scopus 로고
    • REBASE - A database for DNA restriction and modification: Enzymes, genes and genomes
    • Roberts, R. J., Vincze, T., Posfai, J. & Macelis, D. REBASE-a database for DNA restriction and modification: enzymes, genes and genomes. Nucleic Acids Res. 38, D234-D236 (2010).
    • (2010) Nucleic Acids Res. , vol.38 , pp. D234-D236
    • Roberts, R.J.1    Vincze, T.2    Posfai, J.3    Macelis, D.4
  • 26
    • 0023695038 scopus 로고
    • Human bactericidal antibody response to outer membrane protein P2 of nontypeable Haemophilus influenzae
    • Murphy, T. F. & Bartos, L. C. Human bactericidal antibody response to outer membrane protein P2 of nontypeable Haemophilus influenzae. Infect. Immun. 56, 2673-2679 (1988).
    • (1988) Infect. Immun. , vol.56 , pp. 2673-2679
    • Murphy, T.F.1    Bartos, L.C.2
  • 27
    • 0033021078 scopus 로고    scopus 로고
    • Protection against development of otitis media induced by nontypeable Haemophilus influenzae by both active and passive immunization in a chinchilla model of virus-bacterium superinfection
    • Bakaletz, L. O. et al. Protection against development of otitis media induced by nontypeable Haemophilus influenzae by both active and passive immunization in a chinchilla model of virus-bacterium superinfection. Infect. Immun. 67, 2746-2762 (1999).
    • (1999) Infect. Immun. , vol.67 , pp. 2746-2762
    • Bakaletz, L.O.1
  • 28
    • 0031170799 scopus 로고    scopus 로고
    • Relative immunogenicity and efficacy of two synthetic chimeric peptides of fimbrin as vaccinogens against nasopharyngeal colonization by nontypeable Haemophilus influenzae in the chinchilla
    • Bakaletz, L. O., Leake, E. R., Billy, J. M. & Kaumaya, P. T. Relative immunogenicity and efficacy of two synthetic chimeric peptides of fimbrin as vaccinogens against nasopharyngeal colonization by nontypeable Haemophilus influenzae in the chinchilla. Vaccine 15, 955-961 (1997).
    • (1997) Vaccine , vol.15 , pp. 955-961
    • Bakaletz, L.O.1    Leake, E.R.2    Billy, J.M.3    Kaumaya, P.T.4
  • 29
    • 17644402144 scopus 로고    scopus 로고
    • Outer membrane protein P6 of nontypeable Haemophilus influenzae is a potent and selective inducer of human macrophage proinflammatory cytokines
    • Berenson, C. S., Murphy, T. F., Wrona, C. T. & Sethi, S. Outer membrane protein P6 of nontypeable Haemophilus influenzae is a potent and selective inducer of human macrophage proinflammatory cytokines. Infect. Immun. 73, 2728-2735 (2005).
    • (2005) Infect. Immun. , vol.73 , pp. 2728-2735
    • Berenson, C.S.1    Murphy, T.F.2    Wrona, C.T.3    Sethi, S.4
  • 30
    • 0022975886 scopus 로고
    • Identification of a 16,600-dalton outer membrane protein on nontypeable Haemophilus influenzae as a target for human serum bactericidal antibody
    • Murphy, T. F. et al. Identification of a 16,600-dalton outer membrane protein on nontypeable Haemophilus influenzae as a target for human serum bactericidal antibody. J. Clin. Invest. 78, 1020-1027 (1986).
    • (1986) J. Clin. Invest. , vol.78 , pp. 1020-1027
    • Murphy, T.F.1
  • 31
    • 0029910860 scopus 로고    scopus 로고
    • Biological activity of serum antibodies to a nonacylated form of lipoprotein D of Haemophilus influenzae
    • Akkoyunlu, M., Janson, H., Ruan, M. & Forsgren, A. Biological activity of serum antibodies to a nonacylated form of lipoprotein D of Haemophilus influenzae. Infect. Immun. 64, 4586-4592 (1996).
    • (1996) Infect. Immun. , vol.64 , pp. 4586-4592
    • Akkoyunlu, M.1    Janson, H.2    Ruan, M.3    Forsgren, A.4
  • 32
    • 0030831570 scopus 로고    scopus 로고
    • The acylated form of protein D of Haemophilus influenzae is more immunogenic than the nonacylated form and elicits an adjuvant effect when it is used as a carrier conjugated to polyribosyl ribitol phosphate
    • Akkoyunlu, M., Melhus, A., Capiau, C., van Opstal, O. & Forsgren, A. The acylated form of protein D of Haemophilus influenzae is more immunogenic than the nonacylated form and elicits an adjuvant effect when it is used as a carrier conjugated to polyribosyl ribitol phosphate. Infect. Immun. 65, 5010-5016 (1997).
    • (1997) Infect. Immun. , vol.65 , pp. 5010-5016
    • Akkoyunlu, M.1    Melhus, A.2    Capiau, C.3    Van Opstal, O.4    Forsgren, A.5
  • 33
    • 0345714757 scopus 로고    scopus 로고
    • Human antibodies specific for the highmolecular-weight adhesion proteins of nontypeable Haemophilus influenzae mediate opsonophagocytic activity
    • Winter, L. E. & Barenkamp, S. J. Human antibodies specific for the highmolecular-weight adhesion proteins of nontypeable Haemophilus influenzae mediate opsonophagocytic activity. Infect. Immun. 71, 6884-6891 (2003).
    • (2003) Infect. Immun. , vol.71 , pp. 6884-6891
    • Winter, L.E.1    Barenkamp, S.J.2
  • 34
    • 33846160934 scopus 로고    scopus 로고
    • Antibodies specific for the high-molecularweight adhesion proteins of nontypeable Haemophilus influenzae are opsonophagocytic for both homologous and heterologous strains
    • Winter, L. E. & Barenkamp, S. J. Antibodies specific for the high-molecularweight adhesion proteins of nontypeable Haemophilus influenzae are opsonophagocytic for both homologous and heterologous strains. Clin. Vaccine Immunol. 13, 1333-1342 (2006).
    • (2006) Clin. Vaccine Immunol. , vol.13 , pp. 1333-1342
    • Winter, L.E.1    Barenkamp, S.J.2
  • 35
    • 67650398272 scopus 로고    scopus 로고
    • Antibodies specific for the Hia adhesion proteins of nontypeable Haemophilus influenzae mediate opsonophagocytic activity
    • Winter, L. E. & Barenkamp, S. J. Antibodies specific for the Hia adhesion proteins of nontypeable Haemophilus influenzae mediate opsonophagocytic activity. Clin. Vaccine Immunol. 16, 1040-1046 (2009).
    • (2009) Clin. Vaccine Immunol. , vol.16 , pp. 1040-1046
    • Winter, L.E.1    Barenkamp, S.J.2
  • 36
    • 84880514393 scopus 로고    scopus 로고
    • Kinetic analysis and evaluation of the mechanisms involved in the resolution of experimental nontypeable Haemophilus influenzae-induced otitis media after transcutaneous immunization
    • Novotny, L. A., Clements, J. D. & Bakaletz, L. O. Kinetic analysis and evaluation of the mechanisms involved in the resolution of experimental nontypeable Haemophilus influenzae-induced otitis media after transcutaneous immunization. Vaccine 31, 3417-3426 (2012).
    • (2012) Vaccine , vol.31 , pp. 3417-3426
    • Novotny, L.A.1    Clements, J.D.2    Bakaletz, L.O.3
  • 37
    • 0033514494 scopus 로고    scopus 로고
    • Variation in expression of the Haemophilus influenzae HMW adhesins: A prokaryotic system reminiscent of eukaryotes
    • Dawid, S., Barenkamp, S. J. & St. Geme, J. W. Variation in expression of the Haemophilus influenzae HMW adhesins: A prokaryotic system reminiscent of eukaryotes. Proc. Natl Acad. Sci. USA 96, 1077-1082 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 1077-1082
    • Dawid, S.1    Barenkamp, S.J.2    St. Geme, J.W.3
  • 38
    • 84939642616 scopus 로고    scopus 로고
    • Selection and counter-selection of Hia expression reveals a key role for phase-variable expression of this adhesin in infection caused by non-typeable Haemophilus influenzae
    • Atack, J. M. et al. Selection and counter-selection of Hia expression reveals a key role for phase-variable expression of this adhesin in infection caused by non-typeable Haemophilus influenzae. J. Infect. Dis.. doi:10.1093/infdis/jiv103 (2015).
    • (2015) J. Infect. Dis.
    • Atack, J.M.1
  • 39
    • 84891796097 scopus 로고    scopus 로고
    • ProteomeXchange provides globally coordinated proteomics data submission and dissemination
    • Vizcaino, J. A. et al. ProteomeXchange provides globally coordinated proteomics data submission and dissemination. Nat. Biotechnol. 32, 223-226 (2014).
    • (2014) Nat. Biotechnol. , vol.32 , pp. 223-226
    • Vizcaino, J.A.1
  • 40
    • 0031963491 scopus 로고    scopus 로고
    • Secretion of the Haemophilus influenzae HMW1 and HMW2 adhesins involves a periplasmic intermediate and requires the HMWB and HMWC proteins
    • St Geme, J. W. & Grass, S. Secretion of the Haemophilus influenzae HMW1 and HMW2 adhesins involves a periplasmic intermediate and requires the HMWB and HMWC proteins. Mol. Microbiol. 27, 617-630 (1998).
    • (1998) Mol. Microbiol. , vol.27 , pp. 617-630
    • St Geme, J.W.1    Grass, S.2
  • 41
    • 84903176083 scopus 로고    scopus 로고
    • Phasevarions mediate epigenetic regulation of antimicrobial susceptibility in Neisseria meningitidis
    • Jen, F. E., Seib, K. L. & Jennings, M. P. Phasevarions mediate epigenetic regulation of antimicrobial susceptibility in Neisseria meningitidis. Antimicrob. Agents Chemother. 58, 4219-4221 (2014).
    • (2014) Antimicrob. Agents Chemother. , vol.58 , pp. 4219-4221
    • Jen, F.E.1    Seib, K.L.2    Jennings, M.P.3
  • 42
    • 84899743436 scopus 로고    scopus 로고
    • Antibodies to the HMW1/HMW2 and Hia adhesins of nontypeable Haemophilus influenzae mediate broad-based opsonophagocytic killing of homologous and heterologous strains
    • Winter, L. E. & Barenkamp, S. J. Antibodies to the HMW1/HMW2 and Hia adhesins of nontypeable Haemophilus influenzae mediate broad-based opsonophagocytic killing of homologous and heterologous strains. Clin. Vaccine Immunol. 21, 613-621 (2014).
    • (2014) Clin. Vaccine Immunol. , vol.21 , pp. 613-621
    • Winter, L.E.1    Barenkamp, S.J.2
  • 43
    • 0027998545 scopus 로고
    • Identification of a locus involved in the utilization of iron by Haemophilus influenzae
    • Sanders, J. D., Cope, L. D. & Hansen, E. J. Identification of a locus involved in the utilization of iron by Haemophilus influenzae. Infect. Immun. 62, 4515-4525 (1994).
    • (1994) Infect. Immun. , vol.62 , pp. 4515-4525
    • Sanders, J.D.1    Cope, L.D.2    Hansen, E.J.3
  • 44
    • 33750469363 scopus 로고    scopus 로고
    • Complex role of hemoglobin and hemoglobin-haptoglobin binding proteins in Haemophilus influenzae virulence in the infant rat model of invasive infection
    • Seale, T. W. et al. Complex role of hemoglobin and hemoglobin-haptoglobin binding proteins in Haemophilus influenzae virulence in the infant rat model of invasive infection. Infect. Immun. 74, 6213-6225 (2006).
    • (2006) Infect. Immun. , vol.74 , pp. 6213-6225
    • Seale, T.W.1
  • 45
    • 0026750045 scopus 로고
    • Identification of two iron-repressed periplasmic proteins in Haemophilus influenzae
    • Harkness, R. E., Chong, P. & Klein, M. H. Identification of two iron-repressed periplasmic proteins in Haemophilus influenzae. J. Bacteriol. 174, 2425-2430 (1992).
    • (1992) J. Bacteriol. , vol.174 , pp. 2425-2430
    • Harkness, R.E.1    Chong, P.2    Klein, M.H.3
  • 46
    • 0032898512 scopus 로고    scopus 로고
    • The Yfe system of Yersinia pestis transports iron and manganese and is required for full virulence of plague
    • Bearden, S. W. & Perry, R. D. The Yfe system of Yersinia pestis transports iron and manganese and is required for full virulence of plague. Mol. Microbiol. 32, 403-414 (1999).
    • (1999) Mol. Microbiol. , vol.32 , pp. 403-414
    • Bearden, S.W.1    Perry, R.D.2
  • 47
    • 84877939990 scopus 로고    scopus 로고
    • Characterization of an ntrX mutant of Neisseria gonorrhoeae reveals a response regulator that controls expression of respiratory enzymes in oxidase-positive proteobacteria
    • Atack, J. M. et al. Characterization of an ntrX mutant of Neisseria gonorrhoeae reveals a response regulator that controls expression of respiratory enzymes in oxidase-positive proteobacteria. J. Bacteriol. 195, 2632-2641 (2013).
    • (2013) J. Bacteriol. , vol.195 , pp. 2632-2641
    • Atack, J.M.1
  • 48
    • 84865330965 scopus 로고    scopus 로고
    • Anaerobic Pseudomonas aeruginosa and other obligately anaerobic bacterial biofilms growing in the thick airway mucus of chronically infected cystic fibrosis patients: An emerging paradigm or 'Old Hat'?
    • Su, S. & Hassett, D. J. Anaerobic Pseudomonas aeruginosa and other obligately anaerobic bacterial biofilms growing in the thick airway mucus of chronically infected cystic fibrosis patients: an emerging paradigm or 'Old Hat'? Expert Opin. Ther. Targets 16, 859-873 (2012).
    • (2012) Expert Opin. Ther. Targets , vol.16 , pp. 859-873
    • Su, S.1    Hassett, D.J.2
  • 49
    • 68049132805 scopus 로고    scopus 로고
    • Chinchilla as a robust, reproducible and polymicrobial model of otitis media and its prevention
    • Bakaletz, L. O. Chinchilla as a robust, reproducible and polymicrobial model of otitis media and its prevention. Expert Rev. Vaccines 8, 1063-1082 (2009).
    • (2009) Expert Rev. Vaccines , vol.8 , pp. 1063-1082
    • Bakaletz, L.O.1
  • 51
    • 0028122022 scopus 로고
    • Genes encoding high-molecular-weight adhesion proteins of nontypeable Haemophilus influenzae are part of gene clusters
    • Barenkamp, S. J. & St Geme, J. W. Genes encoding high-molecular-weight adhesion proteins of nontypeable Haemophilus influenzae are part of gene clusters. Infect. Immun. 62, 3320-3328 (1994).
    • (1994) Infect. Immun. , vol.62 , pp. 3320-3328
    • Barenkamp, S.J.1    St Geme, J.W.2
  • 52
    • 53649111906 scopus 로고    scopus 로고
    • Serial Isolates of persistent Haemophilus influenzae in patients with chronic obstructive pulmonary disease express diminishing quantities of the HMW1 and HMW2 adhesins
    • Cholon, D. M. et al. Serial Isolates of persistent Haemophilus influenzae in patients with chronic obstructive pulmonary disease express diminishing quantities of the HMW1 and HMW2 adhesins. Infect. Immun. 76, 4463-4468 (2008).
    • (2008) Infect. Immun. , vol.76 , pp. 4463-4468
    • Cholon, D.M.1
  • 53
    • 1842372027 scopus 로고    scopus 로고
    • Transcription of genes encoding iron and heme acquisition proteins of Haemophilus influenzae during acute otitis media
    • Whitby, P. W., Sim, K. E., Morton, D. J., Patel, J. A. & Stull, T. L. Transcription of genes encoding iron and heme acquisition proteins of Haemophilus influenzae during acute otitis media. Infect. Immun. 65, 4696-4700 (1997).
    • (1997) Infect. Immun. , vol.65 , pp. 4696-4700
    • Whitby, P.W.1    Sim, K.E.2    Morton, D.J.3    Patel, J.A.4    Stull, T.L.5
  • 54
    • 0021351203 scopus 로고
    • Oxygen toxicity, oxygen radicals, transition metals and disease
    • Halliwell, B. & Gutteridge, J. M. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem. J. 219, 1-14 (1984).
    • (1984) Biochem. J. , vol.219 , pp. 1-14
    • Halliwell, B.1    Gutteridge, J.M.2
  • 55
    • 0344420187 scopus 로고    scopus 로고
    • Identification of dimethyl sulfoxide reductase in Actinobacillus pleuropneumoniae and its role in infection
    • Baltes, N., Hennig-Pauka, I., Jacobsen, I., Gruber, A. D. & Gerlach, G. F. Identification of dimethyl sulfoxide reductase in Actinobacillus pleuropneumoniae and its role in infection. Infect. Immun. 71, 6784-6792 (2003).
    • (2003) Infect. Immun. , vol.71 , pp. 6784-6792
    • Baltes, N.1    Hennig-Pauka, I.2    Jacobsen, I.3    Gruber, A.D.4    Gerlach, G.F.5
  • 56
    • 84864487648 scopus 로고    scopus 로고
    • Changes in the Staphylococcus aureus transcriptome during early adaptation to the lung
    • Chaffin, D. O., Taylor, D., Skerrett, S. J. & Rubens, C. E. Changes in the Staphylococcus aureus transcriptome during early adaptation to the lung. PLoS ONE 7, e41329 (2012).
    • (2012) PLoS ONE , vol.7
    • Chaffin, D.O.1    Taylor, D.2    Skerrett, S.J.3    Rubens, C.E.4
  • 57
    • 0034307927 scopus 로고    scopus 로고
    • The relationship between glycogen synthesis, biofilm formation and virulence in Salmonella enteritidis
    • Bonafonte, M. A. et al. The relationship between glycogen synthesis, biofilm formation and virulence in Salmonella enteritidis. FEMS Microbiol. Lett. 191, 31-36 (2000).
    • (2000) FEMS Microbiol. Lett. , vol.191 , pp. 31-36
    • Bonafonte, M.A.1
  • 58
    • 0036134768 scopus 로고    scopus 로고
    • Biofilm formation and dispersal under the influence of the global regulator CsrA of Escherichia coli
    • Jackson, D. W. et al. Biofilm formation and dispersal under the influence of the global regulator CsrA of Escherichia coli. J. Bacteriol. 184, 290-301 (2002).
    • (2002) J. Bacteriol. , vol.184 , pp. 290-301
    • Jackson, D.W.1
  • 59
    • 84876736471 scopus 로고    scopus 로고
    • Analysis of nontypeable Haemophilus influenzae phase variable genes during experimental human nasopharyngeal colonization
    • Poole, J. et al. Analysis of nontypeable Haemophilus influenzae phase variable genes during experimental human nasopharyngeal colonization. J. Infect. Dis. 208, 720-727 (2013).
    • (2013) J. Infect. Dis. , vol.208 , pp. 720-727
    • Poole, J.1
  • 60
    • 84862800046 scopus 로고    scopus 로고
    • Infant rat infection modifies phenotypic properties of an invasive nontypeable Haemophilus influenzae
    • Tsao, D., Nelson, K. L., Kim, D. & Smith, A. L. Infant rat infection modifies phenotypic properties of an invasive nontypeable Haemophilus influenzae. Microbes Infect. 14, 509-516 (2012).
    • (2012) Microbes Infect. , vol.14 , pp. 509-516
    • Tsao, D.1    Nelson, K.L.2    Kim, D.3    Smith, A.L.4
  • 61
    • 84915787579 scopus 로고    scopus 로고
    • A random six-phase switch regulates pneumococcal virulence via global epigenetic changes
    • Manso, A. S. et al. A random six-phase switch regulates pneumococcal virulence via global epigenetic changes. Nat. Commun. 5, 5055 (2014).
    • (2014) Nat. Commun. , vol.5 , pp. 5055
    • Manso, A.S.1
  • 62
    • 12444303202 scopus 로고    scopus 로고
    • Characterization of encapsulated and noncapsulated Haemophilus influenzae and determination of phylogenetic relationships by multilocus sequence typing
    • Meats, E. et al. Characterization of encapsulated and noncapsulated Haemophilus influenzae and determination of phylogenetic relationships by multilocus sequence typing. J. Clin. Microbiol. 41, 1623-1636 (2003).
    • (2003) J. Clin. Microbiol. , vol.41 , pp. 1623-1636
    • Meats, E.1
  • 63
    • 0037403514 scopus 로고    scopus 로고
    • High rates of recombination in otitis media isolates of non-typeable Haemophilus influenzae
    • Cody, A. J. et al. High rates of recombination in otitis media isolates of non-typeable Haemophilus influenzae. Infect. Genet. Evol. 3, 57-66 (2003).
    • (2003) Infect. Genet. Evol. , vol.3 , pp. 57-66
    • Cody, A.J.1
  • 65
    • 33845706489 scopus 로고    scopus 로고
    • Characterization of the OxyR regulon of Neisseria gonorrhoeae
    • Seib, K. L. et al. Characterization of the OxyR regulon of Neisseria gonorrhoeae. Mol. Microbiol. 63, 54-68 (2007).
    • (2007) Mol. Microbiol. , vol.63 , pp. 54-68
    • Seib, K.L.1
  • 66
    • 18544402593 scopus 로고    scopus 로고
    • Sexually dimorphic expression of protease nexin-1 and vanin-1 in the developing mouse gonad prior to overt differentiation suggests a role in mammalian sexual development
    • Grimmond, S. et al. Sexually dimorphic expression of protease nexin-1 and vanin-1 in the developing mouse gonad prior to overt differentiation suggests a role in mammalian sexual development. Hum. Mol. Genet. 9, 1553-1560 (2000).
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 1553-1560
    • Grimmond, S.1
  • 67
    • 0020539614 scopus 로고
    • A subtyping system for nontypable Haemophilus influenzae based on outer-membrane proteins
    • Murphy, T. F., Dudas, K. C., Mylotte, J. M. & Apicella, M. A. A subtyping system for nontypable Haemophilus influenzae based on outer-membrane proteins. J. Infect. Dis. 147, 838-846 (1983).
    • (1983) J. Infect. Dis. , vol.147 , pp. 838-846
    • Murphy, T.F.1    Dudas, K.C.2    Mylotte, J.M.3    Apicella, M.A.4
  • 69
    • 84891500105 scopus 로고    scopus 로고
    • Role of Neisseria meningitidis PorA and PorB expression in antimicrobial susceptibility
    • Peak, I. R., Jennings, C. D., Jen, F. E. & Jennings, M. P. Role of Neisseria meningitidis PorA and PorB expression in antimicrobial susceptibility. Antimicrob. Agents Chemother. 58, 614-616 (2014).
    • (2014) Antimicrob. Agents Chemother. , vol.58 , pp. 614-616
    • Peak, I.R.1    Jennings, C.D.2    Jen, F.E.3    Jennings, M.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.