A random six-phase switch regulates pneumococcal virulence via global epigenetic changes

Nature Communications

Volumn 5, Issue , 2014, Pages

  Manso, Ana Sousa ^a,b   Chai, Melissa H ^c   Atack, John M ^d   Furi, Leonardo ^a,b   De Ste Croix, Megan ^a   Haigh, Richard ^a   Trappetti, Claudia ^c   Ogunniyi, Abiodun D ^c   Shewell, Lucy K ^d   Boitano, Matthew ^e   Clark, Tyson A ^e   Korlach, Jonas ^e   Blades, Matthew ^a   Mirkes, Evgeny ^a   Gorban, Alexander N ^a   Paton, James C ^c   Jennings, Michael P ^d   Oggioni, Marco R ^a,b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF SIENA   (Italy)

^c UNIVERSITY OF ADELAIDE   (Australia)

^d GRIFFITH UNIVERSITY   (Australia)

^e PACIFIC BIOSCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLASMID DNA; RESTRICTION ENDONUCLEASE; BACTERIAL PROTEIN;

BACTERIUM; GENE EXPRESSION; GENETIC ANALYSIS; GLOBAL CHANGE; INVASIVE SPECIES; MORBIDITY; MORTALITY; PHENOTYPE; VIRULENCE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GENOME; BACTERIAL VIRULENCE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; EXPERIMENTAL INFECTION; FEMALE; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE FREQUENCY; GENE REARRANGEMENT; GENE SEQUENCE; GENE SWITCHING; GENETIC RECOMBINATION; GENETIC VARIABILITY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PNEUMOCOCCAL INFECTION; ANIMAL; BAGG ALBINO MOUSE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; HUMAN; METABOLISM; MICROBIOLOGY; MOLECULAR GENETICS; PATHOGENICITY; STREPTOCOCCUS PNEUMONIAE; VIRULENCE;

BACTERIA (MICROORGANISMS); STREPTOCOCCUS PNEUMONIAE;

ANIMALS; BACTERIAL PROTEINS; DNA RESTRICTION-MODIFICATION ENZYMES; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PNEUMOCOCCAL INFECTIONS; STREPTOCOCCUS PNEUMONIAE; VIRULENCE;

EID: 84915787579     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms6055     Document Type: Article

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