The potential of AOP networks for reproductive and developmental toxicity assay development

Reproductive Toxicology

Volumn 56, Issue , 2015, Pages 52-55

  Knapen, Dries ^a   Vergauwen, Lucia ^a   Villeneuve, Daniel L ^b   Ankley, Gerald T ^b  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Adverse outcome pathway; AOP network; Assay development; Embryonic and larval development; Reproduction

Indexed keywords

ANDROGEN RECEPTOR ANTAGONIST; CYTOCHROME P450; ESTROGEN RECEPTOR ANTAGONIST; G PROTEIN COUPLED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ADVERSE OUTCOME; ADVERSE OUTCOME PATHWAY NETWORK; ANIMAL TESTING ALTERNATIVE; ANIMAL TESTING REFINEMENT; ARTICLE; DECISION MAKING; DEVELOPMENTAL TOXICITY; FISH; INTRACELLULAR SIGNALING; KNOWLEDGE BASE; NONHUMAN; PREDICTION; PROCESS DEVELOPMENT; REPRODUCTIVE TOXICITY; SCREENING TEST; TOXICITY ASSAY; VALIDATION STUDY; ANIMAL; BIOLOGICAL MODEL; COMPUTER SIMULATION; DRUG EFFECTS; EMBRYO DEVELOPMENT; FEMALE; FETUS DEVELOPMENT; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; HUMAN; PREGNANCY; PROCEDURES; REPRODUCTION; RISK ASSESSMENT; SIGNAL TRANSDUCTION; SYSTEM ANALYSIS; TOXICITY TESTING;

ANIMALIA;

ANIMAL TESTING ALTERNATIVES; ANIMALS; COMPUTER SIMULATION; EMBRYONIC DEVELOPMENT; FEMALE; FETAL DEVELOPMENT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE REGULATORY NETWORKS; HUMANS; KNOWLEDGE BASES; MODELS, BIOLOGICAL; PREGNANCY; REPRODUCTION; RISK ASSESSMENT; SIGNAL TRANSDUCTION; SYSTEMS INTEGRATION; TOXICITY TESTS;

EID: 84937975869     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2015.04.003     Document Type: Article

References (12)

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