Class i histone deacetylase inhibitor valproic acid reverses cognitive deficits in a mouse model of septic encephalopathy

Neurochemical Research

Volumn 38, Issue 11, 2013, Pages 2440-2449

  Wu, Jing ^a   Dong, Lin ^a   Zhang, Mingqiang ^a   Jia, Min ^a   Zhang, Guangfeng ^a   Qiu, Lili ^a   Ji, Muhuo ^a   Yang, Jianjun ^a  

^a JINLING HOSPITAL   (China)

Author keywords

BDNF; Cognition; Histone deacetylase; Inflammation; Sepsis

Indexed keywords

AMMONIA; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CASPASE 3; INTERLEUKIN 1BETA; INTERLEUKIN 6; K 252A; MALONALDEHYDE; POSTSYNAPTIC DENSITY PROTEIN 95; TUMOR NECROSIS FACTOR ALPHA; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN DISEASE; CHRONIC DRUG ADMINISTRATION; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HIPPOCAMPUS; LEARNING DISORDER; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SEPSIS ASSOCIATED ENCEPHALOPATHY; SIGNAL TRANSDUCTION; SPATIAL LEARNING; SURVIVAL RATE; SYNAPSE; WESTERN BLOTTING;

ANIMALS; BRAIN DISEASES; BRAIN-DERIVED NEUROTROPHIC FACTOR; CARBAZOLES; CECUM; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; HISTONE DEACETYLASE INHIBITORS; INDOLE ALKALOIDS; LIGATION; MALE; MICE; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; PUNCTURES; RECEPTOR, TRKB; SEPSIS; SIGNAL TRANSDUCTION; VALPROIC ACID;

EID: 84886931913     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-013-1159-0     Document Type: Article

References (32)

1. Iwashyna TJ, Ely EW, Smith DM et al (2010) Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA 304(16):1787-1794. doi: 10.1001/jama.2010.1553
2. Iwashyna TJ, Cooke CR, Wunsch H et al (2012) Population burden of long-term survivorship after severe sepsis in older Americans. J Am Geriatr Soc 60(6):1070-1077. doi: 10.1111/j.1532-5415.2012.03989.x
3. Gofton TE, Young GB (2012) Sepsis-associated encephalopathy. Nat Rev Neurol 8(10):557-566. doi: 10.1038/nrneurol.2012.183
4. Granger JI, Ratti PL, Datta SC et al (2013) Sepsis-induced morbidity in mice: effects on body temperature, body weight, cage activity, social behavior and cytokines in brain. Psychoneuroendocrinology 38(7):1047-1057. doi: 10.1016/j.psyneuen.2012.10.010
5. Peleg S, Sananbenesi F, Zovoilis A et al (2010) Altered histone acetylation is associated with age-dependent memory impairment in mice. Science 328(5979):753-756. doi: 10.1126/science.1186088
6. Guan JS, Haggarty SJ, Giacometti E et al (2009) HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459(7243):55-60. doi: 10.1038/nature07925
7. Gräff J, Rei D, Guan JS et al (2012) An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature 483(7388):222-226. doi: 10.1038/nature10849
8. Gräff J, Tsai LH (2013) Histone acetylation: molecular mnemonics on the chromatin. Nat Rev Neurosci 14(2):97-111. doi: 10.1038/nrn3427
9. Ji MH, Zhu XL, Liu FF et al (2012) Alpha 2A-adrenoreceptor blockade improves sepsis-induced acute lung injury accompanied with depressed high mobility group box-1 levels in rats. Cytokine 60(3):639-645. doi: 10.1016/j.cyto.2012.08.002
10. Kilgore M, Miller CA, Fass DM et al (2010) Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology 35(4):870-880. doi: 10.1038/npp.2009.197
11. Koike H, Fukumoto K, Iijima M et al (2013) Role of BDNF/TrkB signaling in antidepressant-like effects of a group II metabotropic glutamate receptor antagonist in animal models of depression. Behav Brain Res 238:48-52. doi: 10.1016/j.bbr.2012.10.023
12. Wan Y, Xu J, Ma D et al (2007) Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus. Anesthesiology 106(3):436-443
13. Head BP, Patel HH, Niesman IR et al (2009) Inhibition of p75 neurotrophin receptor attenuates isoflurane-mediated neuronal apoptosis in the neonatal central nervous system. Anesthesiology 110(4):813-825. doi: 10.1097/ALN. 0b013e31819b602b
14. Mombelli M, Lugrin J, Rubino I et al (2011) Histone deacetylase inhibitors impair antibacterial defenses of macrophages. J Infect Dis 204(9):1367-1374. doi: 10.1093/infdis/jir553
15. Shakespear MR, Halili MA, Irvine KM et al (2011) Histone deacetylases as regulators of inflammation and immunity. Trends Immunol 32(7):335-343. doi: 10.1016/j.it.2011.04.001
16. Roger T, Lugrin J, Le Roy D et al (2011) Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection. Blood 117(4):1205-1217. doi: 10.1182/blood-2010-05-284711
17. Dash PK, Orsi SA, Zhang M et al (2010) Valproate administered after traumatic brain injury provides neuroprotection and improves cognitive function in rats. PLoS One (6):e11383. doi: 10.1371/journal.pone.0011383
18. Kazantsev AG, Thompson LM (2008) Therapeutic application of histone deacetylase inhibitors for central nervous system disorders. Nat Rev Drug Discov 7(10):854-868. doi: 10.1038/nrd2681
19. Li Y, Liu B, Gu X et al (2012) Creating a "pro-survival" phenotype through epigenetic modulation. Surgery 152(3):455-464. doi: 10.1016/j.surg.2012.06.036
20. Sailhamer EA, Li Y, Smith EJ et al (2008) Acetylation: a novel method for modulation of the immune response following trauma/hemorrhage and inflammatory second hit in animals and humans. Surgery 144(2):204-216. doi: 10.1016/j.surg.2008.03.034
21. Peng GS, Li G, Tzeng NS et al (2005) Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia. Brain Res Mol Brain Res 134(1):162-169
22. Imamura Y, Wang H, Matsumoto N et al (2011) Interleukin-1β causes long-term potentiation deficiency in a mouse model of septic encephalopathy. Neuroscience 187:63-69. doi: 10.1016/j.neuroscience.2011.04.063
23. Comim CM, Barichello T, Grandgirard D et al (2013) Caspase-3 mediates in part hippocampal apoptosis in sepsis. Mol Neurobiol 47(1):394-398. doi: 10.1007/s12035-012-8354-x
24. Yokoo H, Chiba S, Tomita K et al (2012) Neurodegenerative evidence in mice brains with cecal ligation and puncture-induced sepsis: preventive effect of the free radical scavenger edaravone. PLoS One 7(12):e51539. doi: 10.1371/journal.pone.0051539
25. Suda S, Katsura K, Kanamaru T et al (2013) Valproic acid attenuates ischemia-reperfusion injury in the rat brain through inhibition of oxidative stress and inflammation. Eur J Pharmacol 707(1-3):26-31. doi: 10.1016/j.ejphar.2013.03.020
26. Devi L, Ohno M (2012) 7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease. Neuropsychopharmacology 37(2):434-444. doi: 10.1038/npp.2011.191
27. Diógenes MJ, Costenla AR, Lopes LV et al (2011) Enhancement of LTP in aged rats is dependent on endogenous BDNF. Neuropsychopharmacology 36(9):1823-1836. doi: 10.1038/npp.2011.64
28. Zeng Y, Tan M, Kohyama J et al (2011) Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging. J Neurosci 31(49):17800-17810. doi: 10.1523/JNEUROSCI.3878-11
29. Bardai FH, D'Mello SR (2011) Selective toxicity by HDAC3 in neurons: regulation by Akt and GSK3beta. J Neurosci 31(5):1746-1751. doi: 10.1523/JNEUROSCI.5704-10.2011
30. Kim MS, Akhtar MW, Adachi M et al (2012) An essential role for histone deacetylase 4 in synaptic plasticity and memory formation. J Neurosci 32(32):10879-10886. doi: 10.1523/JNEUROSCI.2089-12.2012
31. Pandey UB, Nie Z, Batlevi Y et al (2007) HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 447(7146):859-863
32. Lewis C, Deshpande A, Tesar GE et al (2012) Valproate-induced hyperammonemic encephalopathy: a brief review. Curr Med Res Opin 28(6):1039-1042. doi: 10.1185/03007995.2012.694362