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Volumn 37, Issue 12, 2014, Pages 2567-2577

Rapid assessment of oxygen transfer impact for Corynebacterium glutamicum

Author keywords

BioLector; Bioprocess optimization; Maximum oxygen transfer capacity; Multi parameter calibration; Oxygen limitation; RAMOS

Indexed keywords

AMINO ACIDS; BATCH DATA PROCESSING; OXYGEN;

EID: 84937965703     PISSN: 16157591     EISSN: 16157605     Source Type: Journal    
DOI: 10.1007/s00449-014-1234-1     Document Type: Article
Times cited : (22)

References (41)
  • 1
    • 0028926047 scopus 로고
    • Energetics of bacterial growth: balance of anabolic and catabolic reactions
    • 1:CAS:528:DyaK2MXkvVGmur0%3D
    • Russell JB, Cook GM (1995) Energetics of bacterial growth: balance of anabolic and catabolic reactions. Microbiol Rev 59(1):48-62
    • (1995) Microbiol Rev , vol.59 , Issue.1 , pp. 48-62
    • Russell, J.B.1    Cook, G.M.2
  • 2
    • 0025786078 scopus 로고
    • Oxidative stress responses in Escherichia coli and Salmonella typhimurium
    • 1:CAS:528:DyaK38Xht1CntL8%3D
    • Farr SB, Kogoma T (1991) Oxidative stress responses in Escherichia coli and Salmonella typhimurium. Microbiol Rev 55(4):561-585
    • (1991) Microbiol Rev , vol.55 , Issue.4 , pp. 561-585
    • Farr, S.B.1    Kogoma, T.2
  • 3
    • 33746136706 scopus 로고    scopus 로고
    • Oxygen limitation is a pitfall during screening for industrial strains
    • doi: 10.1007/s00253-006-0414-6 1:CAS:528:DC%2BD28XhtVKrtLvI
    • Zimmermann HF, Anderlei T, Büchs J et al (2006) Oxygen limitation is a pitfall during screening for industrial strains. Appl Microbiol Biotechnol 72(6):1157-1160. doi: 10.1007/s00253-006-0414-6
    • (2006) Appl Microbiol Biotechnol , vol.72 , Issue.6 , pp. 1157-1160
    • Zimmermann, H.F.1    Anderlei, T.2    Büchs, J.3
  • 4
    • 0035101827 scopus 로고    scopus 로고
    • Device for sterile online measurement of the oxygen transfer rate in shaking flasks
    • 1:CAS:528:DC%2BD3MXit1Cit70%3D
    • Anderlei T, Büchs J (2001) Device for sterile online measurement of the oxygen transfer rate in shaking flasks. Biochem Eng J 7(2):157-162
    • (2001) Biochem Eng J , vol.7 , Issue.2 , pp. 157-162
    • Anderlei, T.1    Büchs, J.2
  • 5
    • 27444432006 scopus 로고    scopus 로고
    • Characterization of oxygen transfer conditions and their effects on Phaffia rhodozyma growth and carotenoid production in shake-flask cultures
    • doi: 10.1016/j.bej.2005.08.031
    • Liu Y, Wu J, Ho K (2006) Characterization of oxygen transfer conditions and their effects on Phaffia rhodozyma growth and carotenoid production in shake-flask cultures. Biochem Eng J 27(3):331-335. doi: 10.1016/j.bej.2005.08.031
    • (2006) Biochem Eng J , vol.27 , Issue.3 , pp. 331-335
    • Liu, Y.1    Wu, J.2    Ho, K.3
  • 6
    • 4043119663 scopus 로고    scopus 로고
    • Effect of oxygen limitation and medium composition on Escherichia coli fermentation in shake-flask cultures
    • doi: 10.1021/bp034282t 1:CAS:528:DC%2BD2cXjvFSgt78%3D
    • Losen M, Frölich B, Pohl M et al (2004) Effect of oxygen limitation and medium composition on Escherichia coli fermentation in shake-flask cultures. Biotechnol Prog 20(4):1062-1068. doi: 10.1021/bp034282t
    • (2004) Biotechnol Prog , vol.20 , Issue.4 , pp. 1062-1068
    • Losen, M.1    Frölich, B.2    Pohl, M.3
  • 7
    • 58149473705 scopus 로고    scopus 로고
    • Bioreactor scale-up and oxygen transfer rate in microbial processes: an overview
    • doi: 10.1016/j.biotechadv.2008.10.006 1:CAS:528:DC%2BD1MXntVOgtA%3D%3D
    • Garcia-Ochoa F, Gomez E (2009) Bioreactor scale-up and oxygen transfer rate in microbial processes: an overview. Biotechnol Adv 27(2):153-176. doi: 10.1016/j.biotechadv.2008.10.006
    • (2009) Biotechnol Adv , vol.27 , Issue.2 , pp. 153-176
    • Garcia-Ochoa, F.1    Gomez, E.2
  • 8
    • 84861343057 scopus 로고    scopus 로고
    • Advances in shaking technologies
    • doi: 10.1016/j.tibtech.2012.03.001
    • Klöckner W, Büchs J (2012) Advances in shaking technologies. Trends Biotechnol 30(6):307-314. doi: 10.1016/j.tibtech.2012.03.001
    • (2012) Trends Biotechnol , vol.30 , Issue.6 , pp. 307-314
    • Klöckner, W.1    Büchs, J.2
  • 9
    • 1042287173 scopus 로고    scopus 로고
    • Online respiration activity measurement (OTR, CTR, RQ) in shake flasks
    • doi: 10.1016/S1369-703X(03)00181-5 1:CAS:528:DC%2BD2cXhtFWls7g%3D
    • Anderlei T, Zang W, Papaspyrou M et al (2004) Online respiration activity measurement (OTR, CTR, RQ) in shake flasks. Biochem Eng J 17(3):187-194. doi: 10.1016/S1369-703X(03)00181-5
    • (2004) Biochem Eng J , vol.17 , Issue.3 , pp. 187-194
    • Anderlei, T.1    Zang, W.2    Papaspyrou, M.3
  • 10
    • 79851490029 scopus 로고    scopus 로고
    • A review of advanced small-scale parallel bioreactor technology for accelerated process development: current state and future need
    • doi: 10.1002/btpr.522 1:CAS:528:DC%2BC3MXivF2murY%3D
    • Bareither R, Pollard D (2011) A review of advanced small-scale parallel bioreactor technology for accelerated process development: current state and future need. Biotechnol Prog 27(1):2-14. doi: 10.1002/btpr.522
    • (2011) Biotechnol Prog , vol.27 , Issue.1 , pp. 2-14
    • Bareither, R.1    Pollard, D.2
  • 11
    • 35648967032 scopus 로고    scopus 로고
    • Microtiter plates as mini-bioreactors: miniaturization of fermentation methods
    • doi: 10.1016/j.tim.2007.09.004 1:CAS:528:DC%2BD2sXht1KktbrK
    • Duetz WA (2007) Microtiter plates as mini-bioreactors: miniaturization of fermentation methods. Trends Microbiol 15(10):469-475. doi: 10.1016/j.tim.2007.09.004
    • (2007) Trends Microbiol , vol.15 , Issue.10 , pp. 469-475
    • Duetz, W.A.1
  • 12
    • 77956132496 scopus 로고    scopus 로고
    • Milliliter-scale stirred tank reactors for the cultivation of microorganisms
    • doi: 10.1016/S0065-2164(10)73003-3 1:CAS:528:DC%2BC3cXhsFKgu73O
    • Hortsch R, Weuster-Botz D (2010) Milliliter-scale stirred tank reactors for the cultivation of microorganisms. Adv Appl Microbiol 73:61-82. doi: 10.1016/S0065-2164(10)73003-3
    • (2010) Adv Appl Microbiol , vol.73 , pp. 61-82
    • Hortsch, R.1    Weuster-Botz, D.2
  • 13
    • 36749028275 scopus 로고    scopus 로고
    • Twenty-four-well plate miniature bioreactor high-throughput system: assessment for microbial cultivations
    • doi: 10.1002/bit.21484 1:CAS:528:DC%2BD2sXhtlWitLrI
    • Isett K, George H, Herber W et al (2007) Twenty-four-well plate miniature bioreactor high-throughput system: assessment for microbial cultivations. Biotechnol Bioeng 98(5):1017-1028. doi: 10.1002/bit.21484
    • (2007) Biotechnol Bioeng , vol.98 , Issue.5 , pp. 1017-1028
    • Isett, K.1    George, H.2    Herber, W.3
  • 14
    • 84868259526 scopus 로고    scopus 로고
    • An automated workflow for enhancing microbial bioprocess optimization on a novel microbioreactor platform
    • doi: 10.1186/1475-2859-11-144 1:CAS:528:DC%2BC3sXhsFyitbg%3D
    • Rohe P, Venkanna D, Kleine B et al (2012) An automated workflow for enhancing microbial bioprocess optimization on a novel microbioreactor platform. Microb Cell Fact 11(1):144. doi: 10.1186/1475-2859-11-144
    • (2012) Microb Cell Fact , vol.11 , Issue.1 , pp. 144
    • Rohe, P.1    Venkanna, D.2    Kleine, B.3
  • 15
    • 67649716663 scopus 로고    scopus 로고
    • Validation of a high-throughput fermentation system based on online monitoring of biomass and fluorescence in continuously shaken microtiter plates
    • doi: 10.1186/1475-2859-8-31
    • Kensy F, Zang E, Faulhammer C et al (2009) Validation of a high-throughput fermentation system based on online monitoring of biomass and fluorescence in continuously shaken microtiter plates. Microb Cell Fact 8:31. doi: 10.1186/1475-2859-8-31
    • (2009) Microb Cell Fact , vol.8 , pp. 31
    • Kensy, F.1    Zang, E.2    Faulhammer, C.3
  • 16
    • 68149131918 scopus 로고    scopus 로고
    • The baffled microtiter plate: increased oxygen transfer and improved online monitoring in small scale fermentations
    • doi: 10.1002/bit.22341 1:CAS:528:DC%2BD1MXptVGqs74%3D
    • Funke M, Diederichs S, Kensy F et al (2009) The baffled microtiter plate: increased oxygen transfer and improved online monitoring in small scale fermentations. Biotechnol Bioeng 103(6):1118-1128. doi: 10.1002/bit.22341
    • (2009) Biotechnol Bioeng , vol.103 , Issue.6 , pp. 1118-1128
    • Funke, M.1    Diederichs, S.2    Kensy, F.3
  • 17
    • 78149303999 scopus 로고    scopus 로고
    • Bioprocess control in microscale: scalable fermentations in disposable and user-friendly microfluidic systems
    • doi: 10.1186/1475-2859-9-86
    • Funke M, Buchenauer A, Mokwa W et al (2010) Bioprocess control in microscale: scalable fermentations in disposable and user-friendly microfluidic systems. Microb Cell Fact 9:86. doi: 10.1186/1475-2859-9-86
    • (2010) Microb Cell Fact , vol.9 , pp. 86
    • Funke, M.1    Buchenauer, A.2    Mokwa, W.3
  • 18
    • 74549211232 scopus 로고    scopus 로고
    • Scale-up from microtiter plate to laboratory fermenter: evaluation by online monitoring techniques of growth and protein expression in Escherichia coli and Hansenula polymorpha fermentations
    • doi: 10.1186/1475-2859-8-68
    • Kensy F, Engelbrecht C, Büchs J (2009) Scale-up from microtiter plate to laboratory fermenter: evaluation by online monitoring techniques of growth and protein expression in Escherichia coli and Hansenula polymorpha fermentations. Microb Cell Fact 8:68. doi: 10.1186/1475-2859-8-68
    • (2009) Microb Cell Fact , vol.8 , pp. 68
    • Kensy, F.1    Engelbrecht, C.2    Büchs, J.3
  • 19
    • 84862689750 scopus 로고    scopus 로고
    • Improved L-lysine production with Corynebacterium glutamicum and systemic insight into citrate synthase flux and activity
    • doi: 10.1002/bit.24486
    • van Ooyen J, Noack S, Bott M et al (2012) Improved L-lysine production with Corynebacterium glutamicum and systemic insight into citrate synthase flux and activity. Biotechnol Bioeng 109(8):2070-2081. doi: 10.1002/bit.24486
    • (2012) Biotechnol Bioeng , vol.109 , Issue.8 , pp. 2070-2081
    • Van Ooyen, J.1    Noack, S.2    Bott, M.3
  • 20
    • 77950891988 scopus 로고    scopus 로고
    • Importance of NADPH supply for improved l-valine formation in Corynebacterium glutamicum
    • Bartek T, Blombach B, Zönnchen E et al (2009) Importance of NADPH supply for improved l-valine formation in Corynebacterium glutamicum. Biotechnol Progr 26(2):361-371. doi: 10.1002/btpr.345
    • (2009) Biotechnol Progr , vol.26 , Issue.2 , pp. 361-371
    • Bartek, T.1    Blombach, B.2    Zönnchen, E.3
  • 21
    • 43949108572 scopus 로고    scopus 로고
    • Corynebacterium glutamicum tailored for high-yield l-valine production
    • doi: 10.1007/s00253-008-1444-z 1:CAS:528:DC%2BD1cXlvF2kurs%3D
    • Blombach B, Schreiner ME, Bartek T et al (2008) Corynebacterium glutamicum tailored for high-yield l-valine production. Appl Microbiol Biotechnol 79(3):471-479. doi: 10.1007/s00253-008-1444-z
    • (2008) Appl Microbiol Biotechnol , vol.79 , Issue.3 , pp. 471-479
    • Blombach, B.1    Schreiner, M.E.2    Bartek, T.3
  • 22
    • 77952889404 scopus 로고    scopus 로고
    • Engineering of sugar metabolism of Corynebacterium glutamicum for production of amino acid l-alanine under oxygen deprivation
    • doi: 10.1007/s00253-010-2493-7 1:CAS:528:DC%2BC3cXmtFKrs7s%3D
    • Jojima T, Fujii M, Mori E et al (2010) Engineering of sugar metabolism of Corynebacterium glutamicum for production of amino acid l-alanine under oxygen deprivation. Appl Microbiol Biotechnol 87(1):159-165. doi: 10.1007/s00253-010-2493-7
    • (2010) Appl Microbiol Biotechnol , vol.87 , Issue.1 , pp. 159-165
    • Jojima, T.1    Fujii, M.2    Mori, E.3
  • 23
    • 4644247295 scopus 로고    scopus 로고
    • Metabolic analysis of Corynebacterium glutamicum during lactate and succinate productions under oxygen deprivation conditions
    • doi: 10.1159/000079827 1:CAS:528:DC%2BD2cXnslGmtrc%3D
    • Inui M, Murakami S, Okino S et al (2004) Metabolic analysis of Corynebacterium glutamicum during lactate and succinate productions under oxygen deprivation conditions. J Mol Microbiol Biotechnol 7(4):182-196. doi: 10.1159/000079827
    • (2004) J Mol Microbiol Biotechnol , vol.7 , Issue.4 , pp. 182-196
    • Inui, M.1    Murakami, S.2    Okino, S.3
  • 24
    • 84861139695 scopus 로고    scopus 로고
    • Toward homosuccinate fermentation: metabolic engineering of Corynebacterium glutamicum for anaerobic production of succinate from glucose and formate
    • doi: 10.1128/AEM.07790-11 1:CAS:528:DC%2BC38XmtFeitbk%3D
    • Litsanov B, Brocker M, Bott M (2012) Toward homosuccinate fermentation: metabolic engineering of Corynebacterium glutamicum for anaerobic production of succinate from glucose and formate. Appl Environ Microbiol 78(9):3325-3337. doi: 10.1128/AEM.07790-11
    • (2012) Appl Environ Microbiol , vol.78 , Issue.9 , pp. 3325-3337
    • Litsanov, B.1    Brocker, M.2    Bott, M.3
  • 25
    • 84858734045 scopus 로고    scopus 로고
    • Real-time determination of intracellular oxygen in bacteria using a genetically encoded FRET-based biosensor
    • doi: 10.1186/1741-7007-10-28 1:CAS:528:DC%2BC38Xos12msb0%3D
    • Potzkei J, Kunze M, Drepper T et al (2012) Real-time determination of intracellular oxygen in bacteria using a genetically encoded FRET-based biosensor. BMC Biol 10:28. doi: 10.1186/1741-7007-10-28
    • (2012) BMC Biol , vol.10 , pp. 28
    • Potzkei, J.1    Kunze, M.2    Drepper, T.3
  • 26
    • 79961052652 scopus 로고    scopus 로고
    • 3rd edn. Spektrum Akademischer Verlag Heidelberg
    • Chmiel H (ed) (2011) Bioprozesstechnik, 3rd edn. Spektrum Akademischer Verlag, Heidelberg
    • (2011) Bioprozesstechnik
    • Chmiel, H.1
  • 27
    • 0035812463 scopus 로고    scopus 로고
    • Optical method for the determination of the oxygen-transfer capacity of small bioreactors based on sulfite oxidation
    • 1:CAS:528:DC%2BD3MXlvFKktbk%3D
    • Hermann R, Walther N, Maier U et al (2001) Optical method for the determination of the oxygen-transfer capacity of small bioreactors based on sulfite oxidation. Biotechnol Bioeng 74(5):355-363
    • (2001) Biotechnol Bioeng , vol.74 , Issue.5 , pp. 355-363
    • Hermann, R.1    Walther, N.2    Maier, U.3
  • 28
    • 27844568703 scopus 로고    scopus 로고
    • Quasi-continuous combined scattered light and fluorescence measurements: a novel measurement technique for shaken microtiter plates
    • doi: 10.1002/bit.20573 1:CAS:528:DC%2BD2MXhtVygsLrI
    • Samorski M, Müller-Newen G, Büchs J (2005) Quasi-continuous combined scattered light and fluorescence measurements: a novel measurement technique for shaken microtiter plates. Biotechnol Bioeng 92(1):61-68. doi: 10.1002/bit.20573
    • (2005) Biotechnol Bioeng , vol.92 , Issue.1 , pp. 61-68
    • Samorski, M.1    Müller-Newen, G.2    Büchs, J.3
  • 29
    • 58149397920 scopus 로고    scopus 로고
    • Acetohydroxyacid synthase, a novel target for improvement of l-lysine production by Corynebacterium glutamicum
    • doi: 10.1128/AEM.01844-08 1:CAS:528:DC%2BD1MXktlejsb8%3D
    • Blombach B, Hans S, Bathe B et al (2009) Acetohydroxyacid synthase, a novel target for improvement of l-lysine production by Corynebacterium glutamicum. Appl Environ Microbiol 75(2):419-427. doi: 10.1128/AEM.01844-08
    • (2009) Appl Environ Microbiol , vol.75 , Issue.2 , pp. 419-427
    • Blombach, B.1    Hans, S.2    Bathe, B.3
  • 30
    • 0027164654 scopus 로고
    • Isoleucine synthesis in Corynebacterium glutamicum: molecular analysis of the ilvB-ilvN-ilvC operon
    • 1:CAS:528:DyaK2cXhvVCr
    • Keilhauer C, Eggeling L, Sahm H (1993) Isoleucine synthesis in Corynebacterium glutamicum: molecular analysis of the ilvB-ilvN-ilvC operon. J Bacteriol 175(17):5595-5603
    • (1993) J Bacteriol , vol.175 , Issue.17 , pp. 5595-5603
    • Keilhauer, C.1    Eggeling, L.2    Sahm, H.3
  • 31
    • 16344367449 scopus 로고    scopus 로고
    • Oxygen transfer phenomena in 48-well microtiter plates: determination by optical monitoring of sulfite oxidation and verification by real-time measurement during microbial growth
    • doi: 10.1002/bit.20373 1:CAS:528:DC%2BD2MXitFyhtLY%3D
    • Kensy F, Zimmermann HF, Knabben I et al (2005) Oxygen transfer phenomena in 48-well microtiter plates: determination by optical monitoring of sulfite oxidation and verification by real-time measurement during microbial growth. Biotechnol Bioeng 89(6):698-708. doi: 10.1002/bit.20373
    • (2005) Biotechnol Bioeng , vol.89 , Issue.6 , pp. 698-708
    • Kensy, F.1    Zimmermann, H.F.2    Knabben, I.3
  • 32
    • 1042263304 scopus 로고    scopus 로고
    • Advances in understanding and modeling the gas-liquid mass transfer in shake flasks
    • doi: 10.1016/S1369-703X(03)00174-8 1:CAS:528:DC%2BD2cXhtFWls7w%3D
    • Maier U, Losen M, Büchs J (2004) Advances in understanding and modeling the gas-liquid mass transfer in shake flasks. Biochem Eng J 17(3):155-167. doi: 10.1016/S1369-703X(03)00174-8
    • (2004) Biochem Eng J , vol.17 , Issue.3 , pp. 155-167
    • Maier, U.1    Losen, M.2    Büchs, J.3
  • 33
    • 0042431982 scopus 로고    scopus 로고
    • The respiratory chain of Corynebacterium glutamicum
    • 1:CAS:528:DC%2BD3sXmslens7k%3D
    • Bott M, Niebisch A (2003) The respiratory chain of Corynebacterium glutamicum. J Biotechnol 104(1-3):129-153
    • (2003) J Biotechnol , vol.104 , Issue.1-3 , pp. 129-153
    • Bott, M.1    Niebisch, A.2
  • 34
    • 69249154275 scopus 로고    scopus 로고
    • Development and experimental verification of a genome-scale metabolic model for Corynebacterium glutamicum
    • doi: 10.1186/1475-2859-8-43
    • Shinfuku Y, Sorpitiporn N, Sono M et al (2009) Development and experimental verification of a genome-scale metabolic model for Corynebacterium glutamicum. Microb Cell Fact 8:43. doi: 10.1186/1475-2859-8-43
    • (2009) Microb Cell Fact , vol.8 , pp. 43
    • Shinfuku, Y.1    Sorpitiporn, N.2    Sono, M.3
  • 35
    • 84872197647 scopus 로고    scopus 로고
    • Production of l-lysine on different silage juices using genetically engineered Corynebacterium glutamicum
    • doi: 10.1016/j.jbiotec.2012.07.190 1:CAS:528:DC%2BC38Xht1aktL3P
    • Neuner A, Wagnera I, Siekerb T, Ulber R, Schneider K, Peifer S, Heinzle E (2013) Production of l-lysine on different silage juices using genetically engineered Corynebacterium glutamicum. J Biotechnol 163:217-224. doi: 10.1016/j.jbiotec.2012.07.190
    • (2013) J Biotechnol , vol.163 , pp. 217-224
    • Neuner, A.1    Wagnera, I.2    Siekerb, T.3    Ulber, R.4    Schneider, K.5    Peifer, S.6    Heinzle, E.7
  • 36
    • 0037560079 scopus 로고    scopus 로고
    • Kinetics of l-lysine fermentation: a continuous culture model incorporating oxygen uptake rate
    • doi: 10.1007/s00253-003-1266-y 1:CAS:528:DC%2BD3sXltVWgsro%3D
    • Ensari S, Lim HC (2003) Kinetics of l-lysine fermentation: a continuous culture model incorporating oxygen uptake rate. Appl Microbiol Biotechnol 62(1):35-40. doi: 10.1007/s00253-003-1266-y
    • (2003) Appl Microbiol Biotechnol , vol.62 , Issue.1 , pp. 35-40
    • Ensari, S.1    Lim, H.C.2
  • 37
    • 78649962189 scopus 로고    scopus 로고
    • Microfluidic biolector-microfluidic bioprocess control in microtiter plates
    • doi: 10.1002/bit.22825 1:CAS:528:DC%2BC3cXhtFSju7fF
    • Funke M, Buchenauer A, Schnakenberg U et al (2010) Microfluidic biolector-microfluidic bioprocess control in microtiter plates. Biotechnol Bioeng 107(3):497-505. doi: 10.1002/bit.22825
    • (2010) Biotechnol Bioeng , vol.107 , Issue.3 , pp. 497-505
    • Funke, M.1    Buchenauer, A.2    Schnakenberg, U.3
  • 38
    • 84914117921 scopus 로고    scopus 로고
    • The development and application of high throughput cultivation technology in bioprocess development
    • Long Q, Liu X, Yang Y, Li L, Harvey L, McNeil B, Bai Z (2014) The development and application of high throughput cultivation technology in bioprocess development. J Biotechnol. doi: 10.1016/j.biotec.2014.03.028
    • (2014) J Biotechnol
    • Long, Q.1    Liu, X.2    Yang, Y.3    Li, L.4    Harvey, L.5    McNeil, B.6    Bai, Z.7
  • 39
    • 79958248811 scopus 로고    scopus 로고
    • A new microfluidic concept for parallel operated millilitre-scale stirred-tank bioreactors
    • 1:CAS:528:DC%2BC3MXnsFOgu7g%3D
    • Gebhardt G, Hortsch R, Kaufmann K, Arnold M, Weuster-Botz D (2011) A new microfluidic concept for parallel operated millilitre-scale stirred-tank bioreactors. Biotechnol Prog 27:684-690
    • (2011) Biotechnol Prog , vol.27 , pp. 684-690
    • Gebhardt, G.1    Hortsch, R.2    Kaufmann, K.3    Arnold, M.4    Weuster-Botz, D.5
  • 40
    • 74549152645 scopus 로고    scopus 로고
    • High-throughput screening of Hansenula polymorpha clones in the batch compared with the controlled-release fed-batch mode on a small scale
    • doi: 10.1111/j.1567-1364.2009.00586.x 1:CAS:528:DC%2BC3cXhsFarurY%3D
    • Scheidle M, Jeude M, Dittrich B et al (2010) High-throughput screening of Hansenula polymorpha clones in the batch compared with the controlled-release fed-batch mode on a small scale. FEMS Yeast Res 10(1):83-92. doi: 10.1111/j.1567-1364.2009.00586.x
    • (2010) FEMS Yeast Res , vol.10 , Issue.1 , pp. 83-92
    • Scheidle, M.1    Jeude, M.2    Dittrich, B.3
  • 41
    • 84855796937 scopus 로고    scopus 로고
    • Glucose-limited high cell density cultivations from small to pilot plant scale using an enzyme-controlled glucose delivery system
    • doi: 10.1016/j.nbt.2011.11.004 1:CAS:528:DC%2BC38XovFylsQ%3D%3D
    • Glazyrina J, Krause M, Junne S et al (2012) Glucose-limited high cell density cultivations from small to pilot plant scale using an enzyme-controlled glucose delivery system. N Biotechnol 29(2):235-242. doi: 10.1016/j.nbt.2011.11.004
    • (2012) N Biotechnol , vol.29 , Issue.2 , pp. 235-242
    • Glazyrina, J.1    Krause, M.2    Junne, S.3


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