Structure and biosynthesis of fumosorinone, a new protein tyrosine phosphatase 1B inhibitor firstly isolated from the entomogenous fungus Isaria fumosorosea

Fungal Genetics and Biology

Volumn 81, Issue , 2015, Pages 191-200

  Liu, Linxia ^a   Zhang, Jun ^a   Chen, Chuan ^a   Teng, Jitao ^a   Wang, Chengshu ^b   Luo, Duqiang ^a  

^a HEBEI UNIVERSITY   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

Biosynthesis; Fumosorinone; Isaria fumosorosea; Natural product; PKS NPRS; Protein tyrosine phosphatase 1B inhibitor

Indexed keywords

CYTOCHROME P450; FUMOSORINONE; INSULIN RECEPTOR; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; UNCLASSIFIED DRUG; ENZYME INHIBITOR; FUNGAL DNA; HYDROXAMIC ACID; PROTEIN TYROSINE PHOSPHATASE 1B; PYRIDONE DERIVATIVE;

AGROBACTERIUM; ARTICLE; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; FUNGAL GENE; FUNGAL GENOME; FUNGUS; GENE CLUSTER; IC50; ISARIA FUMOSOROSEA; NONHUMAN; PKS NRPS GENE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; DNA SEQUENCE; ELECTROSPRAY MASS SPECTROMETRY; GENE INACTIVATION; GENETICS; HYPOCREALES; METABOLISM; MOLECULAR GENETICS; MULTIGENE FAMILY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

BIOSYNTHETIC PATHWAYS; DNA, FUNGAL; ENZYME INHIBITORS; GENE KNOCKOUT TECHNIQUES; HYDROXAMIC ACIDS; HYPOCREALES; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MULTIGENE FAMILY; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; PYRIDONES; SEQUENCE ANALYSIS, DNA; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84937912122     PISSN: 10871845     EISSN: 10960937     Source Type: Journal    
DOI: 10.1016/j.fgb.2015.03.009     Document Type: Article

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