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Volumn 5, Issue , 2015, Pages

IRGM1 enhances B16 melanoma cell metastasis through PI3K-Rac1 mediated epithelial mesenchymal transition

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; IFI1 PROTEIN, MOUSE; NEUROPEPTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; RAC1 PROTEIN; RAC1 PROTEIN, MOUSE;

EID: 84937862539     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep12357     Document Type: Article
Times cited : (20)

References (36)
  • 2
    • 34248223535 scopus 로고    scopus 로고
    • A high-throughput study in melanoma identifies epithelial-mesenchymal transition as a major determinant of metastasis
    • Alonso, S. R. et al. A high-throughput study in melanoma identifies epithelial-mesenchymal transition as a major determinant of metastasis. Cancer Res 67, 3450-60 (2007).
    • (2007) Cancer Res , vol.67 , pp. 3450-3460
    • Alonso, S.R.1
  • 3
    • 84885377160 scopus 로고    scopus 로고
    • A switch in the expression of embryonic EMT-inducers drives the development of malignant melanoma
    • Caramel, J. et al. A switch in the expression of embryonic EMT-inducers drives the development of malignant melanoma. Cancer Cell 24, 466-80 (2013).
    • (2013) Cancer Cell , vol.24 , pp. 466-480
    • Caramel, J.1
  • 4
    • 0142240338 scopus 로고    scopus 로고
    • Immune control of tuberculosis by IFN-gamma-inducible LRG-47
    • MacMicking, J. D., Taylor, G. A., McKinney, J. D. Immune control of tuberculosis by IFN-gamma-inducible LRG-47. Science 302, 654-9 (2003).
    • (2003) Science , vol.302 , pp. 654-659
    • MacMicking, J.D.1    Taylor, G.A.2    McKinney, J.D.3
  • 5
    • 54549089752 scopus 로고    scopus 로고
    • The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death
    • Feng, C. G. et al. The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death. Nat Immunol 9, 1279-87 (2008).
    • (2008) Nat Immunol , vol.9 , pp. 1279-1287
    • Feng, C.G.1
  • 6
    • 77952304848 scopus 로고    scopus 로고
    • Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cells
    • Xu, H. et al. Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cells. FASEB J 24, 1583-92 (2010).
    • (2010) FASEB J , vol.24 , pp. 1583-1592
    • Xu, H.1
  • 7
    • 79960810509 scopus 로고    scopus 로고
    • Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling
    • King, K. Y. et al. Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. Blood 118, 1525-33 (2011).
    • (2011) Blood , vol.118 , pp. 1525-1533
    • King, K.Y.1
  • 8
    • 84869418270 scopus 로고    scopus 로고
    • Immune-related GTPase M (IRGM1) regulates neuronal autophagy in a mouse model of stroke
    • He, S. et al. Immune-related GTPase M (IRGM1) regulates neuronal autophagy in a mouse model of stroke. Autophagy 8, 1621-7 (2012).
    • (2012) Autophagy , vol.8 , pp. 1621-1627
    • He, S.1
  • 9
    • 84945451398 scopus 로고    scopus 로고
    • IFNg-induced Irgm1 promotes tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1-dependent autophagy
    • Dong, H. et al. IFNg-induced Irgm1 promotes tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1-dependent autophagy. Oncogene (2015).
    • (2015) Oncogene
    • Dong, H.1
  • 10
    • 76149089546 scopus 로고    scopus 로고
    • Regulation of macrophage motility by Irgm1
    • Henry, S. C. et al. Regulation of macrophage motility by Irgm1. J Leukoc Biol 87, 333-43 (2010).
    • (2010) J Leukoc Biol , vol.87 , pp. 333-343
    • Henry, S.C.1
  • 11
    • 84878665114 scopus 로고    scopus 로고
    • IRGM1 regulates oxidized LDL uptake by macrophage via actin-dependent receptor internalization during atherosclerosis
    • Xia, F. et al. IRGM1 regulates oxidized LDL uptake by macrophage via actin-dependent receptor internalization during atherosclerosis. Sci Rep 3, 1867 (2013).
    • (2013) Sci Rep , vol.3 , pp. 1867
    • Xia, F.1
  • 12
    • 0034668172 scopus 로고    scopus 로고
    • Induction and regulation of epithelial-mesenchymal transitions
    • Boyer, B., Valles, A. M., Edme, N. Induction and regulation of epithelial-mesenchymal transitions. Biochem Pharmacol 60, 1091-9 (2000).
    • (2000) Biochem Pharmacol , vol.60 , pp. 1091-1099
    • Boyer, B.1    Valles, A.M.2    Edme, N.3
  • 13
    • 27844461512 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in development and cancer: Role of phosphatidylinositol 3' kinase/AKT pathways
    • Larue, L., Bellacosa, A. Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways. Oncogene 24, 7443-54 (2005).
    • (2005) Oncogene , vol.24 , pp. 7443-7454
    • Larue, L.1    Bellacosa, A.2
  • 14
    • 67650996754 scopus 로고    scopus 로고
    • Biomarkers for epithelial-mesenchymal transitions
    • Zeisberg, M., Neilson, E. G. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 119, 1429-37 (2009).
    • (2009) J Clin Invest , vol.119 , pp. 1429-1437
    • Zeisberg, M.1    Neilson, E.G.2
  • 15
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri, R., Weinberg, R. A. The basics of epithelial-mesenchymal transition. J Clin Invest 119, 1420-8 (2009).
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 16
    • 77956459044 scopus 로고    scopus 로고
    • Rac and Rho GTPases in cancer cell motility control
    • Parri, M., Chiarugi, P. Rac and Rho GTPases in cancer cell motility control. Cell Commun Signal 8, 23 (2010).
    • (2010) Cell Commun Signal , vol.8 , pp. 23
    • Parri, M.1    Chiarugi, P.2
  • 17
    • 84885172096 scopus 로고    scopus 로고
    • Mutant B-RAF regulates a Rac-dependent cadherin switch in melanoma
    • 44
    • Monaghan-Benson, E., Burridge, K. Mutant B-RAF regulates a Rac-dependent cadherin switch in melanoma. Oncogene 32, 4836-44 (2013).
    • (2013) Oncogene , vol.32 , pp. 4836
    • Monaghan-Benson, E.1    Burridge, K.2
  • 18
    • 67651174262 scopus 로고    scopus 로고
    • Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3, 4)P(2) and PtdIns(3, 4, 5)P(3) promotes immunity to mycobacteria
    • Tiwari, S., Choi, H. P., Matsuzawa, T., Pypaert, M., MacMicking, J. D. Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3, 4)P(2) and PtdIns(3, 4, 5)P(3) promotes immunity to mycobacteria. Nat Immunol 10, 907-17 (2009).
    • (2009) Nat Immunol , vol.10 , pp. 907-917
    • Tiwari, S.1    Choi, H.P.2    Matsuzawa, T.3    Pypaert, M.4    MacMicking, J.D.5
  • 19
    • 77949732178 scopus 로고    scopus 로고
    • The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1
    • Cain, R. J., Vanhaesebroeck, B., Ridley, A. J. The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1. J Cell Biol 188, 863-76 (2010).
    • (2010) J Cell Biol , vol.188 , pp. 863-876
    • Cain, R.J.1    Vanhaesebroeck, B.2    Ridley, A.J.3
  • 20
    • 57349126316 scopus 로고    scopus 로고
    • Inhibitory effect of capsaicin on B16-F10 melanoma cell migration via the phosphatidylinositol 3-kinase/Akt/Rac1 signal pathway
    • Shin, D. H., Kim, O. H., Jun, H. S., Kang, M. K. Inhibitory effect of capsaicin on B16-F10 melanoma cell migration via the phosphatidylinositol 3-kinase/Akt/Rac1 signal pathway. Exp Mol Med 40, 486-94 (2008).
    • (2008) Exp Mol Med , vol.40 , pp. 486-494
    • Shin, D.H.1    Kim, O.H.2    Jun, H.S.3    Kang, M.K.4
  • 21
    • 84866077979 scopus 로고    scopus 로고
    • PI3K p110alpha isoform-dependent Rho GTPase Rac1 activation mediates H2S-promoted endothelial cell migration via actin cytoskeleton reorganization
    • Zhang, L. J., Tao, B. B., Wang, M. J., Jin, H. M., Zhu, Y. C. PI3K p110alpha isoform-dependent Rho GTPase Rac1 activation mediates H2S-promoted endothelial cell migration via actin cytoskeleton reorganization. PLoS One 7, e44590 (2012).
    • (2012) PLoS One , vol.7 , pp. e44590
    • Zhang, L.J.1    Tao, B.B.2    Wang, M.J.3    Jin, H.M.4    Zhu, Y.C.5
  • 22
    • 84887421660 scopus 로고    scopus 로고
    • Tumor metastasis: Moving new biological insights into the clinic
    • Wan, L., Pantel, K., Kang, Y. Tumor metastasis: moving new biological insights into the clinic. Nat Med 19, 1450-64 (2013).
    • (2013) Nat Med , vol.19 , pp. 1450-1464
    • Wan, L.1    Pantel, K.2    Kang, Y.3
  • 23
    • 84925434998 scopus 로고    scopus 로고
    • C6-ceramide nanoliposome suppresses tumor metastasis by eliciting PI3K and PKCzeta tumor-suppressive activities and regulating integrin affinity modulation
    • Zhang, P. et al. C6-ceramide nanoliposome suppresses tumor metastasis by eliciting PI3K and PKCzeta tumor-suppressive activities and regulating integrin affinity modulation. Sci Rep 5, 9275 (2015).
    • (2015) Sci Rep , vol.5 , pp. 9275
    • Zhang, P.1
  • 24
    • 84920470307 scopus 로고    scopus 로고
    • PI3K signalling is required for a TGFbeta-induced epithelial-mesenchymal-like transition (EMT-like) in human melanoma cells
    • Schlegel, N. C., von Planta, A., Widmer, D. S., Dummer, R., Christofori, G. PI3K signalling is required for a TGFbeta-induced epithelial-mesenchymal-like transition (EMT-like) in human melanoma cells. Exp Dermatol 24, 22-8 (2015).
    • (2015) Exp Dermatol , vol.24 , pp. 22-28
    • Schlegel, N.C.1    Von Planta, A.2    Widmer, D.S.3    Dummer, R.4    Christofori, G.5
  • 25
    • 35848947564 scopus 로고    scopus 로고
    • Activation of FAK/PI3K/Rac1 signaling controls actin reorganization and inhibits cell motility in human cancer cells
    • Kallergi, G., Agelaki, S., Markomanolaki, H., Georgoulias, V., Stournaras, C. Activation of FAK/PI3K/Rac1 signaling controls actin reorganization and inhibits cell motility in human cancer cells. Cell Physiol Biochem 20, 977-86 (2007).
    • (2007) Cell Physiol Biochem , vol.20 , pp. 977-986
    • Kallergi, G.1    Agelaki, S.2    Markomanolaki, H.3    Georgoulias, V.4    Stournaras, C.5
  • 26
    • 84891354826 scopus 로고    scopus 로고
    • PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1
    • Ebi, H. et al. PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1. Proc Natl Acad Sci USA 110, 21124-9 (2013).
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 21124-21129
    • Ebi, H.1
  • 27
    • 84872536378 scopus 로고    scopus 로고
    • RAC1P29S is a spontaneously activating cancer-associated GTPase
    • Davis, M. J. et al. RAC1P29S is a spontaneously activating cancer-associated GTPase. Proc Natl Acad Sci USA 110, 912-7 (2013).
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 912-917
    • Davis, M.J.1
  • 28
    • 61649097480 scopus 로고    scopus 로고
    • Interferon-inducible immunity-related GTPase Irgm1 regulates IFN gammadependent host defense, lymphocyte survival and autophagy
    • Feng, C. G., Zheng, L., Lenardo, M. J., Sher, A. Interferon-inducible immunity-related GTPase Irgm1 regulates IFN gammadependent host defense, lymphocyte survival and autophagy. Autophagy 5, 232-4 (2009).
    • (2009) Autophagy , vol.5 , pp. 232-234
    • Feng, C.G.1    Zheng, L.2    Lenardo, M.J.3    Sher, A.4
  • 29
    • 33748506089 scopus 로고    scopus 로고
    • Human IRGM induces autophagy to eliminate intracellular mycobacteria
    • Singh, S. B., Davis, A. S., Taylor, G. A., Deretic, V. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 313, 1438-41 (2006).
    • (2006) Science , vol.313 , pp. 1438-1441
    • Singh, S.B.1    Davis, A.S.2    Taylor, G.A.3    Deretic, V.4
  • 30
    • 38449116497 scopus 로고    scopus 로고
    • Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47)
    • Henry, S. C. et al. Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47). J Immunol 179, 6963-72 (2007).
    • (2007) J Immunol , vol.179 , pp. 6963-6972
    • Henry, S.C.1
  • 31
    • 84874253948 scopus 로고    scopus 로고
    • IRGM in autophagy and viral infections
    • Petkova, D. S., Viret, C., Faure, M. IRGM in autophagy and viral infections. Front Immunol 3, 426 (2012).
    • (2012) Front Immunol , vol.3 , pp. 426
    • Petkova, D.S.1    Viret, C.2    Faure, M.3
  • 32
    • 19744378057 scopus 로고    scopus 로고
    • P47 GTPases regulate Toxoplasma gondii survival in activated macrophages
    • Butcher, B. A. et al. p47 GTPases regulate Toxoplasma gondii survival in activated macrophages. Infect Immun 73, 3278-86 (2005).
    • (2005) Infect Immun , vol.73 , pp. 3278-3286
    • Butcher, B.A.1
  • 33
    • 84931562961 scopus 로고    scopus 로고
    • Mechanisms of interferon-beta-induced inhibition of Toxoplasma gondii growth in murine macrophages and embryonic fibroblasts: Role of immunity-related GTPase M1 (IRGM1)
    • Mahmoud, M. E., Ui, F., Salman, D., Nishimura, M., Nishikawa, Y. Mechanisms of interferon-beta-induced inhibition of Toxoplasma gondii growth in murine macrophages and embryonic fibroblasts: role of immunity-related GTPase M1 (IRGM1). Cell Microbiol (2015). doi: 10.1111/cmi.12423
    • (2015) Cell Microbiol
    • Mahmoud, M.E.1    Ui, F.2    Salman, D.3    Nishimura, M.4    Nishikawa, Y.5
  • 34
    • 84863733664 scopus 로고    scopus 로고
    • Immune-related GTPase Irgm1 exacerbates experimental auto-immune encephalomyelitis by promoting the disruption of blood-brain barrier and blood-cerebrospinal fluid barrier
    • Wang, C. et al. Immune-related GTPase Irgm1 exacerbates experimental auto-immune encephalomyelitis by promoting the disruption of blood-brain barrier and blood-cerebrospinal fluid barrier. Mol Immunol 53, 43-51 (2013).
    • (2013) Mol Immunol , vol.53 , pp. 43-51
    • Wang, C.1
  • 35
    • 50449091647 scopus 로고    scopus 로고
    • Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease
    • McCarroll, S. A. et al. Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet 40, 1107-12 (2008).
    • (2008) Nat Genet , vol.40 , pp. 1107-1112
    • McCarroll, S.A.1
  • 36
    • 79952134938 scopus 로고    scopus 로고
    • A synonymous variant in IRGM alters a binding site for MIR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease
    • Brest, P. et al. A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease. Nat Genet 43, 242-5 (2011).
    • (2011) Nat Genet , vol.43 , pp. 242-245
    • Brest, P.1


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