메뉴 건너뛰기




Volumn 52, Issue 1, 2015, Pages 464-477

Protection of Radial Glial-Like Cells in the Hippocampus of APP/PS1 Mice: a Novel Mechanism of Memantine in the Treatment of Alzheimer’s Disease

Author keywords

Alzheimer s disease; Hippocampus; Memantine; Neurogenesis; Reelin

Indexed keywords

AMYLOID BETA PROTEIN; DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN; MEMANTINE; REELIN; AMYLOID PRECURSOR PROTEIN; APP PROTEIN, HUMAN; BROXURIDINE; DISC1 PROTEIN, MOUSE; GLIAL FIBRILLARY ACIDIC PROTEIN; NERVE CELL ADHESION MOLECULE; NERVE PROTEIN; PRESENILIN 1; REELIN PROTEIN; SCLEROPROTEIN; SERINE PROTEINASE; SOX2 PROTEIN, MOUSE; TRANSCRIPTION FACTOR SOX;

EID: 84937855279     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-014-8875-6     Document Type: Article
Times cited : (27)

References (52)
  • 1
    • 33746310315 scopus 로고    scopus 로고
    • Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD28XnsFymsbY%3D, PID: 16876668
    • Blennow K, de Leon MJ, Zetterberg H (2006) Alzheimer’s disease. Lancet 368(9533):387–403
    • (2006) Lancet , vol.368 , Issue.9533 , pp. 387-403
    • Blennow, K.1    de Leon, M.J.2    Zetterberg, H.3
  • 2
    • 60549089207 scopus 로고    scopus 로고
    • APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
    • COI: 1:CAS:528:DC%2BD1MXitFKlu7k%3D, PID: 19225519
    • Nikolaev A, McLaughlin T, O’Leary DD, Tessier-Lavigne M (2009) APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 457(7232):981–989
    • (2009) Nature , vol.457 , Issue.7232 , pp. 981-989
    • Nikolaev, A.1    McLaughlin, T.2    O’Leary, D.D.3    Tessier-Lavigne, M.4
  • 3
    • 4544276254 scopus 로고    scopus 로고
    • Multiple cognitive deficits during the transition to Alzheimer’s disease
    • COI: 1:STN:280:DC%2BD2cvhvFCkuw%3D%3D, PID: 15324363
    • Backman L, Jones S, Berger AK, Laukka EJ, Small BJ (2004) Multiple cognitive deficits during the transition to Alzheimer’s disease. J Intern Med 256(3):195–204
    • (2004) J Intern Med , vol.256 , Issue.3 , pp. 195-204
    • Backman, L.1    Jones, S.2    Berger, A.K.3    Laukka, E.J.4    Small, B.J.5
  • 5
    • 84867363438 scopus 로고    scopus 로고
    • The function of BMP4 during neurogenesis in the adult hippocampus in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3sXhtFKksb8%3D, PID: 22698853
    • Xu H, Huang W, Wang Y, Sun W, Tang J, Li D, Xu P, Guo L, Yin ZQ, Fan X (2013) The function of BMP4 during neurogenesis in the adult hippocampus in Alzheimer’s disease. Ageing Res Rev 12(1):157–164
    • (2013) Ageing Res Rev , vol.12 , Issue.1 , pp. 157-164
    • Xu, H.1    Huang, W.2    Wang, Y.3    Sun, W.4    Tang, J.5    Li, D.6    Xu, P.7    Guo, L.8    Yin, Z.Q.9    Fan, X.10
  • 6
    • 23244458855 scopus 로고    scopus 로고
    • Adult neurogenesis in the mammalian central nervous system
    • COI: 1:CAS:528:DC%2BD2MXosVegtLs%3D, PID: 16022595
    • Ming GL, Song H (2005) Adult neurogenesis in the mammalian central nervous system. Annu Rev Neurosci 28:223–250
    • (2005) Annu Rev Neurosci , vol.28 , pp. 223-250
    • Ming, G.L.1    Song, H.2
  • 7
    • 65249124662 scopus 로고    scopus 로고
    • Recruitment of adult-generated neurons into functional hippocampal networks contributes to updating and strengthening of spatial memory
    • COI: 1:CAS:528:DC%2BD1MXkvFeht78%3D, PID: 19321751
    • Trouche S, Bontempi B, Roullet P, Rampon C (2009) Recruitment of adult-generated neurons into functional hippocampal networks contributes to updating and strengthening of spatial memory. Proc Natl Acad Sci U S A 106(14):5919–5924
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.14 , pp. 5919-5924
    • Trouche, S.1    Bontempi, B.2    Roullet, P.3    Rampon, C.4
  • 8
    • 69449084425 scopus 로고    scopus 로고
    • The Alzheimer’s disease drug memantine increases the number of radial glia-like progenitor cells in adult hippocampus
    • PID: 19115386
    • Namba T, Maekawa M, Yuasa S, Kohsaka S, Uchino S (2009) The Alzheimer’s disease drug memantine increases the number of radial glia-like progenitor cells in adult hippocampus. Glia 57(10):1082–1090
    • (2009) Glia , vol.57 , Issue.10 , pp. 1082-1090
    • Namba, T.1    Maekawa, M.2    Yuasa, S.3    Kohsaka, S.4    Uchino, S.5
  • 10
    • 79959681732 scopus 로고    scopus 로고
    • In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics
    • COI: 1:CAS:528:DC%2BC3MXotVars78%3D, PID: 21664664
    • Bonaguidi MA, Wheeler MA, Shapiro JS, Stadel RP, Sun GJ, Ming GL, Song H (2011) In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics. Cell 145(7):1142–1155
    • (2011) Cell , vol.145 , Issue.7 , pp. 1142-1155
    • Bonaguidi, M.A.1    Wheeler, M.A.2    Shapiro, J.S.3    Stadel, R.P.4    Sun, G.J.5    Ming, G.L.6    Song, H.7
  • 12
    • 1842527386 scopus 로고    scopus 로고
    • Radial glia serve as neuronal progenitors in all regions of the central nervous system
    • COI: 1:CAS:528:DC%2BD2cXjtValtLo%3D, PID: 15046721
    • Anthony TE, Klein C, Fishell G, Heintz N (2004) Radial glia serve as neuronal progenitors in all regions of the central nervous system. Neuron 41(6):881–890
    • (2004) Neuron , vol.41 , Issue.6 , pp. 881-890
    • Anthony, T.E.1    Klein, C.2    Fishell, G.3    Heintz, N.4
  • 14
    • 77955368742 scopus 로고    scopus 로고
    • Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging
    • COI: 1:CAS:528:DC%2BC3cXms1alt7w%3D, PID: 20452319
    • Lugert S, Basak O, Knuckles P, Haussler U, Fabel K, Gotz M, Haas CA, Kempermann G, Taylor V, Giachino C (2010) Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging. Cell Stem Cell 6(5):445–456
    • (2010) Cell Stem Cell , vol.6 , Issue.5 , pp. 445-456
    • Lugert, S.1    Basak, O.2    Knuckles, P.3    Haussler, U.4    Fabel, K.5    Gotz, M.6    Haas, C.A.7    Kempermann, G.8    Taylor, V.9    Giachino, C.10
  • 15
    • 84868148959 scopus 로고    scopus 로고
    • A unifying hypothesis on mammalian neural stem cell properties in the adult hippocampus
    • COI: 1:CAS:528:DC%2BC38XlsFCrt7c%3D, PID: 22503352
    • Bonaguidi MA, Song J, Ming GL, Song H (2012) A unifying hypothesis on mammalian neural stem cell properties in the adult hippocampus. Curr Opin Neurobiol 22(5):754–761
    • (2012) Curr Opin Neurobiol , vol.22 , Issue.5 , pp. 754-761
    • Bonaguidi, M.A.1    Song, J.2    Ming, G.L.3    Song, H.4
  • 16
    • 79959677311 scopus 로고    scopus 로고
    • The pessimist’s and optimist’s views of adult neurogenesis
    • COI: 1:CAS:528:DC%2BC3MXotVakuro%3D, PID: 21703445
    • Kempermann G (2011) The pessimist’s and optimist’s views of adult neurogenesis. Cell 145(7):1009–1011
    • (2011) Cell , vol.145 , Issue.7 , pp. 1009-1011
    • Kempermann, G.1
  • 17
    • 84859882643 scopus 로고    scopus 로고
    • Efficacy of memantine in delaying clinical worsening in Alzheimer’s disease (AD): responder analyses of nine clinical trials with patients with moderate to severe AD
    • PID: 22513699
    • Hellweg R, Wirth Y, Janetzky W, Hartmann S (2012) Efficacy of memantine in delaying clinical worsening in Alzheimer’s disease (AD): responder analyses of nine clinical trials with patients with moderate to severe AD. Int J Geriatr Psychiatry 27(6):651–656
    • (2012) Int J Geriatr Psychiatry , vol.27 , Issue.6 , pp. 651-656
    • Hellweg, R.1    Wirth, Y.2    Janetzky, W.3    Hartmann, S.4
  • 18
    • 80051601025 scopus 로고    scopus 로고
    • Memantine in moderate to severe Alzheimer’s disease: an observational post-marketing study
    • COI: 1:CAS:528:DC%2BC3MXps1egsb4%3D, PID: 21461744
    • Rainer M, Wuschitz A, Jagsch C, Erb C, Chirikdjian JJ, Mucke HA (2011) Memantine in moderate to severe Alzheimer’s disease: an observational post-marketing study. J Neural Transm 118(8):1255–1259
    • (2011) J Neural Transm , vol.118 , Issue.8 , pp. 1255-1259
    • Rainer, M.1    Wuschitz, A.2    Jagsch, C.3    Erb, C.4    Chirikdjian, J.J.5    Mucke, H.A.6
  • 19
    • 0029006317 scopus 로고
    • Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus
    • COI: 1:CAS:528:DyaK2MXmt1aqu7s%3D, PID: 7790933
    • Cameron HA, McEwen BS, Gould E (1995) Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus. J Neurosci 15(6):4687–4692
    • (1995) J Neurosci , vol.15 , Issue.6 , pp. 4687-4692
    • Cameron, H.A.1    McEwen, B.S.2    Gould, E.3
  • 20
    • 0344862095 scopus 로고    scopus 로고
    • Inhibition of NMDA receptors induces delayed neuronal maturation and sustained proliferation of progenitor cells during neocortical development
    • COI: 1:CAS:528:DC%2BD3sXps1eku7c%3D, PID: 14635219
    • Hirasawa T, Wada H, Kohsaka S, Uchino S (2003) Inhibition of NMDA receptors induces delayed neuronal maturation and sustained proliferation of progenitor cells during neocortical development. J Neurosci Res 74(5):676–687
    • (2003) J Neurosci Res , vol.74 , Issue.5 , pp. 676-687
    • Hirasawa, T.1    Wada, H.2    Kohsaka, S.3    Uchino, S.4
  • 21
    • 0035134536 scopus 로고    scopus 로고
    • NMDA receptor antagonist treatment induces a long-lasting increase in the number of proliferating cells, PSA-NCAM-immunoreactive granule neurons and radial glia in the adult rat dentate gyrus
    • COI: 1:STN:280:DC%2BD3M3isFyhsQ%3D%3D, PID: 11168558
    • Nacher J, Rosell DR, Alonso-Llosa G, McEwen BS (2001) NMDA receptor antagonist treatment induces a long-lasting increase in the number of proliferating cells, PSA-NCAM-immunoreactive granule neurons and radial glia in the adult rat dentate gyrus. Eur J Neurosci 13(3):512–520
    • (2001) Eur J Neurosci , vol.13 , Issue.3 , pp. 512-520
    • Nacher, J.1    Rosell, D.R.2    Alonso-Llosa, G.3    McEwen, B.S.4
  • 22
    • 79959781594 scopus 로고    scopus 로고
    • Disrupted-in-Schizophrenia-1 (Disc1) is necessary for migration of the pyramidal neurons during mouse hippocampal development
    • COI: 1:CAS:528:DC%2BC3MXotVeisbs%3D, PID: 21540240
    • Tomita K, Kubo K, Ishii K, Nakajima K (2011) Disrupted-in-Schizophrenia-1 (Disc1) is necessary for migration of the pyramidal neurons during mouse hippocampal development. Hum Mol Genet 20(14):2834–2845
    • (2011) Hum Mol Genet , vol.20 , Issue.14 , pp. 2834-2845
    • Tomita, K.1    Kubo, K.2    Ishii, K.3    Nakajima, K.4
  • 23
    • 84881552864 scopus 로고    scopus 로고
    • Reelin signaling in development, maintenance, and plasticity of neural networks
    • COI: 1:CAS:528:DC%2BC3sXisVygsLk%3D, PID: 23352928
    • Stranahan AM, Erion JR, Wosiski-Kuhn M (2013) Reelin signaling in development, maintenance, and plasticity of neural networks. Ageing Res Rev 12(3):815–822
    • (2013) Ageing Res Rev , vol.12 , Issue.3 , pp. 815-822
    • Stranahan, A.M.1    Erion, J.R.2    Wosiski-Kuhn, M.3
  • 26
    • 47749092769 scopus 로고    scopus 로고
    • Decreased hippocampal cell proliferation correlates with increased expression of BMP4 in the APPswe/PS1DeltaE9 mouse model of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD1cXpslKnsro%3D, PID: 18398851
    • Li D, Tang J, Xu H, Fan X, Bai Y, Yang L (2008) Decreased hippocampal cell proliferation correlates with increased expression of BMP4 in the APPswe/PS1DeltaE9 mouse model of Alzheimer’s disease. Hippocampus 18(7):692–698
    • (2008) Hippocampus , vol.18 , Issue.7 , pp. 692-698
    • Li, D.1    Tang, J.2    Xu, H.3    Fan, X.4    Bai, Y.5    Yang, L.6
  • 27
    • 3042680192 scopus 로고    scopus 로고
    • Spatiotemporal heterogeneity of CNS radial glial cells and their transition to restricted precursors
    • COI: 1:CAS:528:DC%2BD2cXlt1ens7s%3D, PID: 15223331
    • Li H, Babiarz J, Woodbury J, Kane-Goldsmith N, Grumet M (2004) Spatiotemporal heterogeneity of CNS radial glial cells and their transition to restricted precursors. Dev Biol 271(2):225–238
    • (2004) Dev Biol , vol.271 , Issue.2 , pp. 225-238
    • Li, H.1    Babiarz, J.2    Woodbury, J.3    Kane-Goldsmith, N.4    Grumet, M.5
  • 28
    • 33645222291 scopus 로고    scopus 로고
    • Notch1 signaling regulates radial glia differentiation through multiple transcriptional mechanisms
    • COI: 1:CAS:528:DC%2BD28XjsVClsbs%3D, PID: 16554461
    • Patten BA, Sardi SP, Koirala S, Nakafuku M, Corfas G (2006) Notch1 signaling regulates radial glia differentiation through multiple transcriptional mechanisms. J Neurosci 26(12):3102–3108
    • (2006) J Neurosci , vol.26 , Issue.12 , pp. 3102-3108
    • Patten, B.A.1    Sardi, S.P.2    Koirala, S.3    Nakafuku, M.4    Corfas, G.5
  • 29
    • 84872498439 scopus 로고    scopus 로고
    • Signaling mechanisms regulating adult neural stem cells and neurogenesis
    • COI: 1:CAS:528:DC%2BC38XhsVSlt7jM, PID: 22982587
    • Faigle R, Song H (2013) Signaling mechanisms regulating adult neural stem cells and neurogenesis. Biochim Biophys Acta 1830(2):2435–2448
    • (2013) Biochim Biophys Acta , vol.1830 , Issue.2 , pp. 2435-2448
    • Faigle, R.1    Song, H.2
  • 30
    • 68949173926 scopus 로고    scopus 로고
    • Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation
    • COI: 1:CAS:528:DC%2BD1MXpvFygsbs%3D, PID: 19536110
    • Wu HM, Tzeng NS, Qian L, Wei SJ, Hu X, Chen SH, Rawls SM, Flood P, Hong JS, Lu RB (2009) Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation. Neuropsychopharmacology 34(10):2344–2357
    • (2009) Neuropsychopharmacology , vol.34 , Issue.10 , pp. 2344-2357
    • Wu, H.M.1    Tzeng, N.S.2    Qian, L.3    Wei, S.J.4    Hu, X.5    Chen, S.H.6    Rawls, S.M.7    Flood, P.8    Hong, J.S.9    Lu, R.B.10
  • 31
    • 84875375493 scopus 로고    scopus 로고
    • DISC1-related signaling pathways in adult neurogenesis of the hippocampus
    • COI: 1:CAS:528:DC%2BC3sXisVSnu7g%3D, PID: 23353011
    • Wu Q, Li Y, Xiao B (2013) DISC1-related signaling pathways in adult neurogenesis of the hippocampus. Gene 518(2):223–230
    • (2013) Gene , vol.518 , Issue.2 , pp. 223-230
    • Wu, Q.1    Li, Y.2    Xiao, B.3
  • 33
    • 84862806815 scopus 로고    scopus 로고
    • Pharmacotherapies for Alzheimer’s disease: beyond cholinesterase inhibitors
    • COI: 1:CAS:528:DC%2BC38XjtV2qtro%3D, PID: 22198801
    • Tayeb HO, Yang HD, Price BH, Tarazi FI (2012) Pharmacotherapies for Alzheimer’s disease: beyond cholinesterase inhibitors. Pharmacol Ther 134(1):8–25
    • (2012) Pharmacol Ther , vol.134 , Issue.1 , pp. 8-25
    • Tayeb, H.O.1    Yang, H.D.2    Price, B.H.3    Tarazi, F.I.4
  • 34
    • 33744500234 scopus 로고    scopus 로고
    • Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity
    • PID: 16817864
    • Volbracht C, van Beek J, Zhu C, Blomgren K, Leist M (2006) Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity. Eur J Neurosci 23(10):2611–2622
    • (2006) Eur J Neurosci , vol.23 , Issue.10 , pp. 2611-2622
    • Volbracht, C.1    van Beek, J.2    Zhu, C.3    Blomgren, K.4    Leist, M.5
  • 35
    • 77951498581 scopus 로고    scopus 로고
    • New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
    • COI: 1:CAS:528:DC%2BC3cXktVGjtrc%3D, PID: 20354534
    • Deng W, Aimone JB, Gage FH (2010) New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci 11(5):339–350
    • (2010) Nat Rev Neurosci , vol.11 , Issue.5 , pp. 339-350
    • Deng, W.1    Aimone, J.B.2    Gage, F.H.3
  • 36
    • 34250889839 scopus 로고    scopus 로고
    • Adult hippocampal neurogenesis, synaptic plasticity and memory: facts and hypotheses
    • COI: 1:CAS:528:DC%2BD2sXnsV2hu7s%3D, PID: 17593874
    • Bruel-Jungerman E, Rampon C, Laroche S (2007) Adult hippocampal neurogenesis, synaptic plasticity and memory: facts and hypotheses. Rev Neurosci 18(2):93–114
    • (2007) Rev Neurosci , vol.18 , Issue.2 , pp. 93-114
    • Bruel-Jungerman, E.1    Rampon, C.2    Laroche, S.3
  • 37
    • 33646551422 scopus 로고    scopus 로고
    • Alzheimer’s disease drugs promote neurogenesis
    • COI: 1:CAS:528:DC%2BD28XkvVygs7k%3D, PID: 16580645
    • Jin K, Xie L, Mao XO, Greenberg DA (2006) Alzheimer’s disease drugs promote neurogenesis. Brain Res 1085(1):183–188
    • (2006) Brain Res , vol.1085 , Issue.1 , pp. 183-188
    • Jin, K.1    Xie, L.2    Mao, X.O.3    Greenberg, D.A.4
  • 38
    • 61649088370 scopus 로고    scopus 로고
    • NMDA receptor antagonist memantine promotes cell proliferation and production of mature granule neurons in the adult hippocampus
    • COI: 1:CAS:528:DC%2BD1MXjt1SmsLc%3D, PID: 19367785
    • Maekawa M, Namba T, Suzuki E, Yuasa S, Kohsaka S, Uchino S (2009) NMDA receptor antagonist memantine promotes cell proliferation and production of mature granule neurons in the adult hippocampus. Neurosci Res 63(4):259–266
    • (2009) Neurosci Res , vol.63 , Issue.4 , pp. 259-266
    • Maekawa, M.1    Namba, T.2    Suzuki, E.3    Yuasa, S.4    Kohsaka, S.5    Uchino, S.6
  • 39
    • 84877285151 scopus 로고    scopus 로고
    • Role of neuroinflammation in adult neurogenesis and Alzheimer disease: therapeutic approaches
    • Fuster-Matanzo A, Llorens-Martin M, Hernandez F, Avila J (2013) Role of neuroinflammation in adult neurogenesis and Alzheimer disease: therapeutic approaches. Mediat Inflamm 2013:260925
    • (2013) Mediat Inflamm , vol.2013 , pp. 260925
    • Fuster-Matanzo, A.1    Llorens-Martin, M.2    Hernandez, F.3    Avila, J.4
  • 40
    • 84897977837 scopus 로고    scopus 로고
    • Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC2cXlvFWitrc%3D, PID: 23930978
    • Cai Z, Hussain MD, Yan LJ (2014) Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer’s disease. Int J Neurosci 124(5):307–321
    • (2014) Int J Neurosci , vol.124 , Issue.5 , pp. 307-321
    • Cai, Z.1    Hussain, M.D.2    Yan, L.J.3
  • 42
    • 84880189661 scopus 로고    scopus 로고
    • Alzheimer’s disease immunotherapy: from in vitro amyloid immunomodulation to in vivo vaccination
    • COI: 1:CAS:528:DC%2BD28XotFKkt70%3D, PID: 16914882
    • Solomon B (2006) Alzheimer’s disease immunotherapy: from in vitro amyloid immunomodulation to in vivo vaccination. J Alzheimers Dis 9(3 Suppl):433–438
    • (2006) J Alzheimers Dis , vol.9 , pp. 433-438
    • Solomon, B.1
  • 43
    • 48949085739 scopus 로고    scopus 로고
    • Amyloid-beta immunisation for Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD1cXhtFWmsLrJ, PID: 18667360
    • Wisniewski T, Konietzko U (2008) Amyloid-beta immunisation for Alzheimer’s disease. Lancet Neurol 7(9):805–811
    • (2008) Lancet Neurol , vol.7 , Issue.9 , pp. 805-811
    • Wisniewski, T.1    Konietzko, U.2
  • 44
    • 84885444054 scopus 로고    scopus 로고
    • Microglia actions in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3sXhsFKjtLjL, PID: 24224195
    • Prokop S, Miller KR, Heppner FL (2013) Microglia actions in Alzheimer’s disease. Acta Neuropathol 126(4):461–477
    • (2013) Acta Neuropathol , vol.126 , Issue.4 , pp. 461-477
    • Prokop, S.1    Miller, K.R.2    Heppner, F.L.3
  • 46
    • 84862088615 scopus 로고    scopus 로고
    • Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC38Xnt1aksLs%3D, PID: 22584394
    • Biscaro B, Lindvall O, Tesco G, Ekdahl CT, Nitsch RM (2012) Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer’s disease. Neurodegener Dis 9(4):187–198
    • (2012) Neurodegener Dis , vol.9 , Issue.4 , pp. 187-198
    • Biscaro, B.1    Lindvall, O.2    Tesco, G.3    Ekdahl, C.T.4    Nitsch, R.M.5
  • 47
    • 84857008054 scopus 로고    scopus 로고
    • Microglia in the developing brain: a potential target with lifetime effects
    • PID: 22322212
    • Harry GJ, Kraft AD (2012) Microglia in the developing brain: a potential target with lifetime effects. Neurotoxicology 33(2):191–206
    • (2012) Neurotoxicology , vol.33 , Issue.2 , pp. 191-206
    • Harry, G.J.1    Kraft, A.D.2
  • 49
    • 70349130726 scopus 로고    scopus 로고
    • DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212
    • COI: 1:CAS:528:DC%2BD1MXhsVCjsrnL, PID: 19778506
    • Kim JY, Duan X, Liu CY, Jang MH, Guo JU, Pow-anpongkul N, Kang E, Song H, Ming GL (2009) DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron 63(6):761–773
    • (2009) Neuron , vol.63 , Issue.6 , pp. 761-773
    • Kim, J.Y.1    Duan, X.2    Liu, C.Y.3    Jang, M.H.4    Guo, J.U.5    Pow-anpongkul, N.6    Kang, E.7    Song, H.8    Ming, G.L.9
  • 50
    • 33845570614 scopus 로고    scopus 로고
    • Balance between neurogenesis and gliogenesis in the adult hippocampus: role for reelin
    • COI: 1:CAS:528:DC%2BD28Xht1OltrrP, PID: 17148951
    • Zhao S, Chai X, Frotscher M (2007) Balance between neurogenesis and gliogenesis in the adult hippocampus: role for reelin. Dev Neurosci 29(1–2):84–90
    • (2007) Dev Neurosci , vol.29 , Issue.1-2 , pp. 84-90
    • Zhao, S.1    Chai, X.2    Frotscher, M.3
  • 51
  • 52
    • 62349114345 scopus 로고    scopus 로고
    • Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling
    • COI: 1:CAS:528:DC%2BD1MXit1Gqt7Y%3D, PID: 19103804
    • Li G, Kataoka H, Coughlin SR, Pleasure SJ (2009) Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling. Development 136(2):327–335
    • (2009) Development , vol.136 , Issue.2 , pp. 327-335
    • Li, G.1    Kataoka, H.2    Coughlin, S.R.3    Pleasure, S.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.