Germline ETV6 Mutations Confer Susceptibility to Acute Lymphoblastic Leukemia and Thrombocytopenia

PLoS Genetics

Volumn 11, Issue 6, 2015, Pages

  Topka, Sabine ^a   Vijai, Joseph ^a   Walsh, Michael F ^b   Jacobs, Lauren ^a   Maria, Ann ^a   Villano, Danylo ^a   Gaddam, Pragna ^a   Wu, Gang ^b   McGee, Rose B ^b   Quinn, Emily ^b   Inaba, Hiroto ^b   Hartford, Christine ^b   Pui, Ching hon ^b   Pappo, Alberto ^b   Edmonson, Michael ^b   Zhang, Michael Y ^c   Stepensky, Polina ^d   Steinherz, Peter ^a   Schrader, Kasmintan ^e   Lincoln, Anne ^a   Bussel, James ^f   Lipkin, Steve M ^f   Goldgur, Yehuda ^g   Harit, Mira ^d   Stadler, Zsofia K ^a   Mullighan, Charles ^b   Weintraub, Michael ^d   Shimamura, Akiko ^c,h   Zhang, Jinghui ^b   Downing, James R ^b   Nichols, Kim E ^b   Offit, Kenneth ^a,f   more..

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

^d HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^f WEILL CORNELL MEDICAL COLLEGE   (United States)

^g NEW YORK STRUCTURAL BIOLOGY CENTER   (United States)

^h SEATTLE CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; TRANSCRIPTION FACTOR PAX5; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR ETS; TRANSCRIPTION FACTOR ETV6;

ACUTE LYMPHOBLASTIC LEUKEMIA; ACUTE MYELOBLASTIC LEUKEMIA; ALLELE; ARTICLE; BTG1 GENE; CANCER SUSCEPTIBILITY; CHROMOSOME BAND; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; ETV6 ONCOGENE; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; GENE REARRANGEMENT; GENE TARGETING; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GERMLINE MUTATION; HETEROZYGOSITY; HUMAN; HUMAN CELL; HUMAN RELATION; IKZF1 GENE; KINDRED; LEUKEMIA CELL; LEUKEMOGENESIS; MEAN CORPUSCULAR VOLUME; MUTATIONAL ANALYSIS; MYELODYSPLASTIC SYNDROME; NUCLEAR LOCALIZATION SIGNAL; ONCOGENE; PAX5 GENE; PHENOTYPE; RB1 GENE; SINGLE NUCLEOTIDE POLYMORPHISM; THROMBOCYTOPENIA; TRANSCRIPTION REGULATION; AMINO ACID SEQUENCE; CASE CONTROL STUDY; CHEMISTRY; GENETICS; HELA CELL LINE; METABOLISM; MISSENSE MUTATION; MOLECULAR GENETICS;

AMINO ACID SEQUENCE; CASE-CONTROL STUDIES; GERM-LINE MUTATION; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTO-ONCOGENE PROTEINS C-ETS; REPRESSOR PROTEINS; THROMBOCYTOPENIA;

EID: 84937779216     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1005262     Document Type: Article

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