Additional aberrations of the ETV6 and RUNX1 genes have no prognostic impact in 229 t(12;21)(p13;q22)-positive B-cell precursor acute lymphoblastic leukaemias treated according to the NOPHO-ALL-2000 protocol

Leukemia Research

Volumn 36, Issue 7, 2012, Pages 936-938

  Barbany, Gisela ^a   Andersen, Mette K ^b   Autio, Kirsti ^c   Borgström, Georg ^c   Franco, Lucia Cavalier ^d   Golovleva, Irina ^e   Heim, Sverre ^f   Heinonen, Kristina ^g   Hovland, Randi ^h   Johansson, Bertil ⁱ   Johannsson, Johann H ^j   Kjeldsen, Eigil ^k   Nordgren, Ann ^l   Palmqvist, Lars ^a   Forestier, Erik ^m,n  

^a KAROLINSKA INSTITUTE   (Sweden)

^b International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

^c UNIVERSITY OF HELSINKI   (Finland)

^d UPPSALA UNIVERSITY   (Sweden)

^e UMEÅ UNIVERSITY HOSPITAL   (Sweden)

^f OSLO UNIVERSITY HOSPITAL   (Norway)

^g UNIVERSITY OF OSLO   (Norway)

^h KUOPIO UNIVERSITY HOSPITAL   (Finland)

ⁱ HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^j LUND UNIVERSITY HOSPITAL   (Sweden)

^k LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^l AARHUS UNIVERSITY HOSPITAL   (Denmark)

^m SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

ⁿ UMEÅ UNIVERSITY   (Sweden)

more..

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR ETV6; TRANSCRIPTION FACTOR RUNX1;

ACUTE LYMPHOBLASTIC LEUKEMIA; CANCER SURVIVAL; CHROMOSOME ABERRATION; CHROMOSOME TRANSLOCATION 12; DENMARK; DISEASE FREE SURVIVAL; ETV6 GENE; EVENT FREE SURVIVAL; FINLAND; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DELETION; GENE FUSION; HUMAN; ICELAND; LETTER; LEUKEMIA RELAPSE; LEUKOCYTE COUNT; NORWAY; OVERALL SURVIVAL; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RUNX1 GENE; SWEDEN; TRISOMY 21; TUMOR GENE;

ADOLESCENT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHILD; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 21; CLINICAL TRIALS AS TOPIC; COHORT STUDIES; CORE BINDING FACTOR ALPHA 2 SUBUNIT; DENMARK; FINLAND; HUMANS; ICELAND; INFANT; MUTATION; NORWAY; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-ETS; REPRESSOR PROTEINS; SWEDEN; TRANSLOCATION, GENETIC;

EID: 84862321772     PISSN: 01452126     EISSN: 18735835     Source Type: Journal    
DOI: 10.1016/j.leukres.2012.03.024     Document Type: Letter

References (8)

1. Harbott J., Viehmann S., Borkhardt A., Henze G., Lampert F. Incidence of TEL/AML1 fusion gene analyzed consecutively in children with acute lymphoblastic leukemia in relapse. Blood 1997, 90:4933-4937.
2. Seeger K., Buchwald D., Peter A., Taube T., von Stackelberg A., Schmitt G., et al. TEL-AML1 fusion in relapsed childhood acute lymphoblastic leukemia. Blood 1999, 94:374-376.
3. Forestier E., Heyman M., Andersen M.K., Autio K., Blennow E., Borgstrom G., et al. Outcome of ETV6/RUNX1-positive childhood acute lymphoblastic leukaemia in the NOPHO-ALL-1992 protocol: frequent late relapses but good overall survival. Br J Haematol 2008, 140:665-672.
4. Attarbaschi A., Mann G., Konig M., Dworzak M.N., Trebo M.M., Muhlegger N., et al. Incidence and relevance of secondary chromosome abnormalities in childhood TEL/AML1+ acute lymphoblastic leukemia: an interphase FISH analysis. Leukemia 2004, 18:1611-1616.
5. Stams W.A., Beverloo H.B., den Boer M.L., de Menezes R.X., Stigter R.L., van Drunen E., et al. Incidence of additional genetic changes in the TEL and AML1 genes in DCOG and COALL-treated t(12;21)-positive pediatric ALL, and their relation with drug sensitivity and clinical outcome. Leukemia 2006, 20:410-416.
6. Peter A., Heiden T., Taube T., Korner G., Seeger K. Interphase FISH on TEL/AML1 positive acute lymphoblastic leukemia relapses - analysis of clinical relevance of additional TEL and AML1 copy number changes. Eur J Haematol 2009, 83:420-432.
7. Moorman A.V., Konn Z.J., Barber K.E., Wright S.L., Stewart A.R., Parker H., et al. The spectrum and prognostic relevance of additional abnormalities, involving 12p and 21q, in children with ETV6-RUNX1 positive acute lymphoblastic leukaemia (ALL). Blood (ASH Annual Meeting Abstracts) 2008, 112:430.
8. Ko D.H., Jeon Y., Kang H.J., Park K.D., Shin H.Y., Kim H.K., et al. Native ETV6 deletions accompanied by ETV6-RUNX1 rearrangements are associated with a favourable prognosis in childhood acute lymphoblastic leukaemia: a candidate for prognostic marker. Br J Haematol 2011, 155:530-533.