Single-translocation and double-chimeric transcripts: Detection of NUP98-HOXA9 in myeloid leukemias with hOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15)

Blood

Volumn 99, Issue 4, 2002, Pages 1428-1433

  Fujino, Takashi ^a,b,c,d   Suzuki, Akitaka ^a,b,c,d   Ito, Yoshikazu ^a,b,c,d   Ohyashiki, Kazuma ^a,b,c,d   Hatano, Yoshiaki ^a,b,c,d   Miura, Ikuo ^a,b,c,d   Nakamura, Takuro ^a,b,c,d  

^a CANCER INSTITUTE   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c TOKYO MEDICAL UNIVERSITY   (Japan)

^d AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HOMEODOMAIN PROTEIN; HYBRID PROTEIN; NUCLEOPORIN; NUCLEOPORIN 98; PROTEIN HOXA9; PROTEIN NUP98 HOXA9; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ARTICLE; CHIMERA; CHROMOSOME 11P; CHROMOSOME 7P; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; FUSION GENE; GENE LOCATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INTRON; MYELOID LEUKEMIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING;

EID: 0037082502     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.4.1428     Document Type: Article

References (36)

1. Chromosomal translocations in human cancer
2. Oncogenic transcription factors in the human acute leukemias
3. NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15)
4. NUP98-HOXD13 gene fusion in therapy-related acute myelogenous leukemia
5. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15; p15) in human myeloid leukaemia
6. The t(7;11)(15p;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9
7. Molecular heterogeneity of the NUP98/HOXA9 fusion transcript in myelodys-plastic syndromes associated with t(7;11)(1:)(p15; p15)
8. Chronic myelomonocytic leukemia with t(7;11)(p15;p15) and NUP98/HOXA9 fusion
9. The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10
10. The inv(11)(p15q22) chromosome translocation of therapy-related myelodysplasia with NUP98-DDX10 and DDX10-NUP98 fusion transcripts
11. 11p15 translocations involving the NUP98 gene in childhood therapy-related acute myeloid leukemia/myelodysplastic syndrome
12. The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS genes and is recurrent in T-cell acute lymphocytic leukemia
13. The t(11;20) (p15;q15) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion
14. t(9;11)(p22;p15) in acute myeloid leukemia results in a fusion between NUP98 and the gene encoding transcriptional coactivators p52 and p75-lens epithelium-derived growth factor (LEDGF)
15. The role of HOX homeobox genes in normal and leukemic hematopoiesis
16. Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
17. Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias
18. Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis 1a but not Pbx1b
19. Hoxa9 immortalizes a granulocyte-macrophage colony-stimulating factor-dependent promyelocyte capable of biphenotypic differentiation to neutrophils or macrophages, independent of enforced Meis expression
20. t(7;11)(p15;p15) chronic myeloid leukemia developed into blastic transformation showing a novel NUP98/HOXA11 fusion
21. Ecotropic murine leukemia virus DNA content of normal and lymphomatous tissues of BXH-2 recombinant mice
22. CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity
23. NUP98-HOXA9 expression in hematopoietic stem cells induce chronic and acute leukemias in mice
24. Extra specificity from extra-denticle: The partnership between HOX and PBX/EXD homeodomain proteins
25. Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins
26. The Abd-B-like Hox homeodomain proteins can be subdivided by the ability to form complexes with Pbx1a on a novel DNA target
27. Collaboration of Meis1 with the human leukemia-specific fusion gene NUP98-HOXD13 causes acute myeloid leukemia (AML) in mice: A model of NUP98-associated human leukemia
28. A class act: Conservation of homeodomain protein functions
29. Initiation of rhombomeric Hoxb4 expression requires induction by somites and a retinoid pathway
30. Breaking colinearity in the mouse HoxD complex
31. Alternative splicing of pre-mRNA: Developmental consequences and mechanism of regulation
32. Genomic structure and sequence analysis of human HOXA-9
33. Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing
34. The influence of 5′ and 3′ end structures on pre-mRNA metabolism
35. Alternative poly(A) site selection in complex transcription units: Means to an end?
36. Amegakaryocytic thrombocytopenia and radio-ulnar synostosis are associated with HOXA11 mutation