Mitochondrial DNA damage by bleomycin induces AML cell death

Apoptosis

Volumn 20, Issue 6, 2015, Pages 811-820

  Yeung, ManTek ^a   Hurren, Rose ^a   Nemr, Carine ^a   Wang, Xiaoming ^a   Hershenfeld, Samantha ^a   Gronda, Marcela ^a   Liyanage, Sanduni ^a   Wu, Yan ^a   Augustine, Jeevan ^a   Lee, Eric A ^b   Spagnuolo, Paul A ^b   Southall, Noel ^c   Chen, Catherine ^c   Zheng, Wei ^c   Jeyaraju, Danny V ^a   Minden, Mark D ^a   Laposa, Rebecca ^d   Schimmer, Aaron D ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF WATERLOO   (Canada)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

AML; Bleomycin; Mitochondria; Mitochondrial DNA; Mitochondrial DNA damage

Indexed keywords

ANTINEOPLASTIC ANTIBIOTIC; BLEOMYCIN; MITOCHONDRIAL DNA;

ANIMAL; CANCER TRANSPLANTATION; CELL DEATH; CELL PROLIFERATION; DNA DAMAGE; DRUG EFFECTS; HUMAN; LEUKEMIA, MYELOID, ACUTE; METABOLISM; MITOCHONDRION; SCID MOUSE; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; DNA DAMAGE; DNA, MITOCHONDRIAL; HETEROGRAFTS; HUMANS; LEUKEMIA, MYELOID, ACUTE; MICE, SCID; MITOCHONDRIA; NEOPLASM TRANSPLANTATION;

EID: 84937765233     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-015-1119-z     Document Type: Article

References (26)

1. Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J et al (1981) Sequence and organization of the human mitochondrial genome. Nature 290:457-465
2. Sawyer DE, Van Houten B (1999) Repair of DNA damage in mitochondria. Mutat Res 434:161-176
3. Wallace DC (2010) Mitochondrial DNA mutations in disease and aging. Environ Mol Mutagen 51:440-450
4. Weissman L, de Souza-Pinto NC, Stevnsner T, Bohr VA (2007) DNA repair, mitochondria, and neurodegeneration. Neuroscience 145:1318-1329
5. Skrtic M, Sriskanthadevan S, Jhas B, Gebbia M, Wang X, Wang Z et al (2011) Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell 20:674-688
6. Lagadinou ED, Sach A, Callahan K, Rossi RM, Neering SJ, Minhajuddin M et al (2013) BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells. Cell Stem Cell 12:329-341
7. Chen J, Stubbe J (2005) Bleomycins: towards better therapeutics. Nat Rev Cancer 5:102-112
8. Froudarakis M, Hatzimichael E, Kyriazopoulou L, Lagos K, Pappas P, Tzakos AG et al (2013) Revisiting bleomycin from pathophysiology to safe clinical use. Crit Rev Oncol Hematol 87:90-100
9. Santos JH, Meyer JN, Mandavilli BS, Van Houten B (2006) Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells. Methods Mol Biol 314:183-199
10. Bellarosa D, Ciucci A, Bullo A, Nardelli F, Manzini S, Maggi CA et al (2001) Apoptotic events in a human ovarian cancer cell line exposed to anthracyclines. J Pharmacol Exp Therapy 296:276-283
11. Xing J, Chen M, Wood CG, Lin J, Spitz MR, Ma J et al (2008) Mitochondrial DNA content: its genetic heritability and association with renal cell carcinoma. J Natl Cancer Inst 100:1104-1112
12. Fonseca SB, Pereira MP, Mourtada R, Gronda M, Horton KL, Hurren R et al (2011) Rerouting chlorambucil to mitochondria combats drug deactivation and resistance in cancer cells. Chem Biol 18:445-453
13. Wisnovsky SP, Wilson JJ, Radford RJ, Pereira MP, Chan MR, Laposa RR et al (2013) Targeting mitochondrial DNA with a platinum-based anticancer agent. Chem Biol 20:1323-1328
14. Brar SS, Meyer JN, Bortner CD, Van Houten B, Martin WJ 2nd (2012) Mitochondrial DNA-depleted A549 cells are resistant to bleomycin. Am J Physiol Lung Cell Mol Physiol 303:L413-L424
15. Chamberlain GR, Tulumello DV, Kelley SO (2013) Targeted delivery of doxorubicin to mitochondria. ACS Chem Biol 8:1389-1395
16. Li M, Li Y, Yin Q, Mi R, Chen L, Du J et al (2014) Treatment with cyclophosphamide, vindesine, cytarabine, dexamethasone and bleomycin in patients with relapsed/refractory diffuse large B-cell lymphoma. Leuk Lymphoma 55:1578-1583
17. Tobias JS, Monson K, Gupta N, Macdougall H, Glaholm J, Hutchison I et al (2010) Chemoradiotherapy for locally advanced head and neck cancer: 10-year follow-up of the UK head and neck (UKHAN1) trial. Lancet Oncol 11:66-74
18. Katsumata N, Yoshikawa H, Kobayashi H, Saito T, Kuzuya K, Nakanishi T et al (2013) Phase III randomised controlled trial of neoadjuvant chemotherapy plus radical surgery vs radical surgery alone for stages IB2, IIA2, and IIB cervical cancer: a Japan Clinical Oncology Group trial (JCOG 0102). Br J Cancer 108:1957-1963
19. Aragona AM, Cuneo N, Soderini AH, Alcoba E, Greco A, Reyes C et al (2012) Tailoring the treatment of locally advanced squamous cell carcinoma of the vulva: neoadjuvant chemotherapy followed by radical surgery: results from a multicenter study. Int J Gynecol Cancer 22:1258-1263
20. Sikic BI (1986) Biochemical and cellular determinants of bleomycin cytotoxicity. Cancer Surv 5:81-91
21. Cort A, Timur M, Ozdemir E, Kucuksayan E, Ozben T (2012) Synergistic anticancer activity of curcumin and bleomycin: an in vitro study using human malignant testicular germ cells. Mol Med Rep 5:1481-1486
22. Sidik K, Smerdon MJ (1990) Bleomycin-induced DNA damage and repair in human cells permeabilized with lysophosphatidylcholine. Cancer Res 50:1613-1619
23. Stivala LA, Prosperi E, Rossi R, Bianchi L (1993) Involvement of proliferating cell nuclear antigen in DNA repair after damage induced by genotoxic agents in human fibroblasts. Carcinogenesis 14:2569-2573
24. Muller C, Calsou P, Salles B (2000) The activity of the DNA-dependent protein kinase (DNA-PK) complex is determinant in the cellular response to nitrogen mustards. Biochimie 82:25-28
25. Sleijfer S (2001) Bleomycin-induced pneumonitis. Chest 120:617-624
26. Azambuja E, Fleck JF, Batista RG, Menna Barreto SS (2005) Bleomycin lung toxicity: who are the patients with increased risk? Pulm Pharmacol Ther 18:363-366